Last update
3/26/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Moderately Good
Based on 100 Reviews
7.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
7,500 mcg
833%
Top Medical Research Studies
9
We explored how vitamin A affects our body’s response to cold, specifically looking at its role in transforming white fat into brown fat, a process known as browning. This transformation is significant, as it can help reduce obesity and improve metabolic health.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
Read More
Most Useful Reviews
6
Sees improvement in eyesight
26 people found this helpful
After six months of taking 75,000 IU daily, my eyesight has improved. Even when I catch a cold, my throat rarely hurts, and I believe my mucous membranes have truly strengthened. This alone doesn't suffice; I also consume a lot of protein and high doses of other vitamins and minerals.
Read More
8
Very effective during cold
11 people found this helpful
Good vitamin A that works very well during colds. It’s important to drink it together with D3 and C.
Read More
8
Prevented cold symptoms
9 people found this helpful
I use this for megavitamin therapy. Prior to starting it, I frequently caught colds and experienced sore throats. Thanks to this and vitamin C, I haven't had a cold in over a year. Recently, I caught a cold after feeling extremely tired, with a sore nose. I consistently take it with protein to avoid excessive intake.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
We explored how vitamin A affects our body’s response to cold, specifically looking at its role in transforming white fat into brown fat, a process known as browning. This transformation is significant, as it can help reduce obesity and improve metabolic health.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 100 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
6
Sees improvement in eyesight
26 people found this helpful
After six months of taking 75,000 IU daily, my eyesight has improved. Even when I catch a cold, my throat rarely hurts, and I believe my mucous membranes have truly strengthened. This alone doesn't suffice; I also consume a lot of protein and high doses of other vitamins and minerals.
Read More
8
Very effective during cold
11 people found this helpful
Good vitamin A that works very well during colds. It’s important to drink it together with D3 and C.
Read More
8
Prevented cold symptoms
9 people found this helpful
I use this for megavitamin therapy. Prior to starting it, I frequently caught colds and experienced sore throats. Thanks to this and vitamin C, I haven't had a cold in over a year. Recently, I caught a cold after feeling extremely tired, with a sore nose. I consistently take it with protein to avoid excessive intake.
Read More
7
Effective for cold
8 people found this helpful
Half a year has passed since I took one tablet every night. When I have a sore throat or feel discomfort, taking 2 tablets prevents it from worsening and helps me heal. I haven't used any cold medicine recently. This product has excellent effects, such as reduced eyestrain, clearer vision, and a nicer appearance of my eyes. Although the price has risen sharply, I wish to continue taking it. My field of vision became clear, and the redness and turbidity of my eyes disappeared, enhancing my makeup. I've been using it for over 3 months without issues.
Read More
7
Effective in winter
6 people found this helpful
I tend to have dry mucous membranes in my throat and nose, often leading to colds. I started with a small amount, but only realised its effect on dryness when I increased my intake to 25,000 to 50,000 IU. My supplement intake increases in winter, and thanks to it, I seldom catch colds.
Read More
Frequently Asked Questions
8
Effective against cold
1 people found this helpful
Works great for me. I take this daily, but at the first sign of a cold or virus, I increase to 100,000 IU for three days and see a significant difference compared to not taking it!
9
Effective for cold
5 people found this helpful
I have been on a high protein diet for several years and take vitamin A every night, usually 1 tablet. When my throat feels uncomfortable, I take 2 tablets. I also take over 5g of vitamin C, and the signs of a cold usually disappear by the next morning. It is an essential supplement.
10
Strengthened throat
I'm enjoying it without any issues. While excess vitamin A may irritate the skin, I haven't noticed any reactions so far. Taking one tablet daily appears to have strengthened my throat's mucous membrane, and I no longer get colds there.
8
Very effective during cold
11 people found this helpful
Good vitamin A that works very well during colds. It’s important to drink it together with D3 and C.
8
Helpful for throat
4 people found this helpful
Dr. Megavita Fujikawa recommends this supplement. It is tasteless, small, and easy to take. For many years, when I have a cold or throat irritation, I take 2 tablets daily, which help protect mucous membranes. However, temporary higher doses are better as they might cause nosebleeds. It's crucial to monitor symptoms and adjust the dosage accordingly.
9
We explored how vitamin A affects our body’s response to cold, specifically looking at its role in transforming white fat into brown fat, a process known as browning. This transformation is significant, as it can help reduce obesity and improve metabolic health.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
References
- Fenzl A, Kulterer OC, Spirk K, Mitulović G, Marculescu R, et al. Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis. Mol Metab. 2020;42:101088. 10.1016/j.molmet.2020.101088
Data last updated:
