' 
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (from Retinyl Palmitate and Fish Liver Oil)
7,500 mcg
833%
Top Medical Research Studies
8
Vitamin A linked to uric acid
Associations of Serum Retinol and α-Tocopherol Levels with Uric Acid Concentrations: Analysis of a Population-Based, Nationally Representative Sample.
Moderate relevance; mixed findings
We explored the connections between vitamin A, specifically serum retinol, and uric acid levels to determine how this relationship might impact gout. Our analysis involved 6,023 participants from the Korean National Health and Nutrition Examination Survey, focusing on how different levels of vitamin A affect uric acid concentrations.
Our findings showed that higher serum retinol levels were positively associated with increased uric acid levels in both men and women. The difference between the highest and lowest vitamin A levels corresponded to noteworthy increases in uric acid concentrations. Additionally, the risk of hyperuricemia, a key factor in gout, rose with higher retinol levels regardless of sex.
However, we found that while serum α-tocopherol (vitamin E) seemed related to uric acid levels, this link disappeared once we accounted for retinol's effect. This indicates that vitamin A has a more significant direct impact on uric acid levels than vitamin E does. To potentially prevent issues related to high uric acid—such as gout—it's essential to maintain retinol levels within safe limits.
Our findings showed that higher serum retinol levels were positively associated with increased uric acid levels in both men and women. The difference between the highest and lowest vitamin A levels corresponded to noteworthy increases in uric acid concentrations. Additionally, the risk of hyperuricemia, a key factor in gout, rose with higher retinol levels regardless of sex.
However, we found that while serum α-tocopherol (vitamin E) seemed related to uric acid levels, this link disappeared once we accounted for retinol's effect. This indicates that vitamin A has a more significant direct impact on uric acid levels than vitamin E does. To potentially prevent issues related to high uric acid—such as gout—it's essential to maintain retinol levels within safe limits.
Read More
7
Vitamin A's role in gout
Independent association of serum retinol and β-carotene levels with hyperuricemia: A national population study.
Association of vitamins with gout
We explored the connection between vitamin A, specifically retinol, and β-carotene, with hyperuricemia and gout within a large group of American adults. Our analysis utilized data from the Third National Health and Nutrition Examination Survey, involving over 14,000 participants aged 20 and older. With this substantial sample size, we aimed to understand how different levels of these vitamins affect serum uric acid (UA) levels, which are directly linked to gout occurrences.
Our results revealed an interesting dynamic: as serum retinol levels increased, we noted a linear rise in serum UA, suggesting that higher vitamin A may contribute to hyperuricemia—a key risk factor for gout. For β-carotene, however, the story shifted. Increasing levels of this vitamin were associated with a decrease in serum UA levels, hinting at a potential protective effect against hyperuricemia.
These findings raise concerns about the role of vitamin A supplementation in contributing to high hyperuricemia rates in the US population. Meanwhile, the favorable association of β-carotene could open doors for further research into its role as a preventive measure against gout. While our study does not investigate vitamin A's effectiveness as a treatment, it clearly indicates a complex relationship that deserves more attention in future research endeavors.
Our results revealed an interesting dynamic: as serum retinol levels increased, we noted a linear rise in serum UA, suggesting that higher vitamin A may contribute to hyperuricemia—a key risk factor for gout. For β-carotene, however, the story shifted. Increasing levels of this vitamin were associated with a decrease in serum UA levels, hinting at a potential protective effect against hyperuricemia.
These findings raise concerns about the role of vitamin A supplementation in contributing to high hyperuricemia rates in the US population. Meanwhile, the favorable association of β-carotene could open doors for further research into its role as a preventive measure against gout. While our study does not investigate vitamin A's effectiveness as a treatment, it clearly indicates a complex relationship that deserves more attention in future research endeavors.
Read More
Most Useful Reviews
8.8
Pain prevention
To manage gout attacks, I had been using medications to lower uric acid levels. However, I came across a suggestion by Iwamitsu Mitsuishi that vitamin A could alleviate pain. Initially, I took 3 to 6 liver oil tablets from other brands daily, but with this product's high IU value, I now only require 1 or sometimes 2 tablets a day. Combining it with 2g of vitamin C seems even more beneficial.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
Vitamin A linked to uric acid
Associations of Serum Retinol and α-Tocopherol Levels with Uric Acid Concentrations: Analysis of a Population-Based, Nationally Representative Sample.
Moderate relevance; mixed findings
We explored the connections between vitamin A, specifically serum retinol, and uric acid levels to determine how this relationship might impact gout. Our analysis involved 6,023 participants from the Korean National Health and Nutrition Examination Survey, focusing on how different levels of vitamin A affect uric acid concentrations.
Our findings showed that higher serum retinol levels were positively associated with increased uric acid levels in both men and women. The difference between the highest and lowest vitamin A levels corresponded to noteworthy increases in uric acid concentrations. Additionally, the risk of hyperuricemia, a key factor in gout, rose with higher retinol levels regardless of sex.
However, we found that while serum α-tocopherol (vitamin E) seemed related to uric acid levels, this link disappeared once we accounted for retinol's effect. This indicates that vitamin A has a more significant direct impact on uric acid levels than vitamin E does. To potentially prevent issues related to high uric acid—such as gout—it's essential to maintain retinol levels within safe limits.
Our findings showed that higher serum retinol levels were positively associated with increased uric acid levels in both men and women. The difference between the highest and lowest vitamin A levels corresponded to noteworthy increases in uric acid concentrations. Additionally, the risk of hyperuricemia, a key factor in gout, rose with higher retinol levels regardless of sex.
However, we found that while serum α-tocopherol (vitamin E) seemed related to uric acid levels, this link disappeared once we accounted for retinol's effect. This indicates that vitamin A has a more significant direct impact on uric acid levels than vitamin E does. To potentially prevent issues related to high uric acid—such as gout—it's essential to maintain retinol levels within safe limits.
Read More
7
Vitamin A's role in gout
Independent association of serum retinol and β-carotene levels with hyperuricemia: A national population study.
Association of vitamins with gout
We explored the connection between vitamin A, specifically retinol, and β-carotene, with hyperuricemia and gout within a large group of American adults. Our analysis utilized data from the Third National Health and Nutrition Examination Survey, involving over 14,000 participants aged 20 and older. With this substantial sample size, we aimed to understand how different levels of these vitamins affect serum uric acid (UA) levels, which are directly linked to gout occurrences.
Our results revealed an interesting dynamic: as serum retinol levels increased, we noted a linear rise in serum UA, suggesting that higher vitamin A may contribute to hyperuricemia—a key risk factor for gout. For β-carotene, however, the story shifted. Increasing levels of this vitamin were associated with a decrease in serum UA levels, hinting at a potential protective effect against hyperuricemia.
These findings raise concerns about the role of vitamin A supplementation in contributing to high hyperuricemia rates in the US population. Meanwhile, the favorable association of β-carotene could open doors for further research into its role as a preventive measure against gout. While our study does not investigate vitamin A's effectiveness as a treatment, it clearly indicates a complex relationship that deserves more attention in future research endeavors.
Our results revealed an interesting dynamic: as serum retinol levels increased, we noted a linear rise in serum UA, suggesting that higher vitamin A may contribute to hyperuricemia—a key risk factor for gout. For β-carotene, however, the story shifted. Increasing levels of this vitamin were associated with a decrease in serum UA levels, hinting at a potential protective effect against hyperuricemia.
These findings raise concerns about the role of vitamin A supplementation in contributing to high hyperuricemia rates in the US population. Meanwhile, the favorable association of β-carotene could open doors for further research into its role as a preventive measure against gout. While our study does not investigate vitamin A's effectiveness as a treatment, it clearly indicates a complex relationship that deserves more attention in future research endeavors.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Pain prevention
To manage gout attacks, I had been using medications to lower uric acid levels. However, I came across a suggestion by Iwamitsu Mitsuishi that vitamin A could alleviate pain. Initially, I took 3 to 6 liver oil tablets from other brands daily, but with this product's high IU value, I now only require 1 or sometimes 2 tablets a day. Combining it with 2g of vitamin C seems even more beneficial.
Read More
