We explored the effects of all-trans retinoic acid (atRA) on atherosclerosis in rabbits fed a high-fat diet. In an experiment where rabbits were divided into groups, some received atRA while others received atorvastatin or both.
We found that atRA effectively reduced plaque size, comparable to atorvastatin, and their combination was even more effective. Additionally, atRA improved the serum lipid profile, suggesting it could be a valuable tool in managing cholesterol levels.
Read More
9
Vitamin A may help cholesterol levels
Chronic vitamin A-enriched diet feeding regulates hypercholesterolaemia through transcriptional regulation of reverse cholesterol transport pathway genes in obese rat model of WNIN/GR-Ob strain.
We examined the effects of a vitamin A-enriched diet on cholesterol levels in glucose-intolerant obese rats. Over a 14-week period, we fed two groups of rats—one received a standard diet, while the other enjoyed the vitamin A boost.
Our findings revealed that the vitamin A diet successfully lowered high cholesterol levels and improved HDL cholesterol, but it worked through different mechanisms than previously thought. Importantly, while we did see positive changes, the study indicates that the benefits may vary based on individual factors.
Read More
8
Vitamin A lowers cholesterol in rats
Vitamin A-enriched diet modulates reverse cholesterol transport in hypercholesterolemic obese rats of the WNIN/Ob strain.
We explored how vitamin A affects cholesterol levels in obese rats with high cholesterol. By administering different doses of vitamin A, we found that a dose of 52 mg/kg significantly decreased the unhealthy HDL-cholesterol levels after 20 weeks. This feeding regimen increased the expression of proteins that help with cholesterol transport. However, the lean rats didn’t show similar benefits. The findings suggest that vitamin A might offer a way to improve cholesterol metabolism in obese individuals, but more research is needed before making any human recommendations.
Read More
Most Useful Reviews
7.5
Asthenopia noticeably improved
7 people found this helpful
I started with two capsules (50,000 IU) daily from 10,000 IU, and my asthenopia has improved considerably. This high-protein diet allows me to spend my days comfortably without experiencing adverse effects.
Read More
7.5
Asthma symptoms alleviated
21 people found this helpful
Vitamin A is necessary for mucous membranes, so I purchased it for my husband, who suffers from severe asthma. He couldn't sleep well due to breathlessness, but after taking 100,000 IU daily for about a month, it became much easier for him. His daytime cough has also significantly decreased. However, it’s important to consume vitamin K alongside high doses of vitamin A.
Read More
7.5
Skin healing noted
3 people found this helpful
I've taken this for about a month; for years, I had slow healing of skin wounds. After taking it, my condition has improved considerably. Initially, I blamed my issues on immunity, but it seems to be related to vitamin A deficiency due to poor diet. I only took 25000 IU every other day, but the high content appears to strain my liver. While this dosage is effective, I sometimes feel dizzy or have digestion difficulties. If you're concerned about liver burden, consider liver nutrients alongside it.
We explored the effects of all-trans retinoic acid (atRA) on atherosclerosis in rabbits fed a high-fat diet. In an experiment where rabbits were divided into groups, some received atRA while others received atorvastatin or both.
We found that atRA effectively reduced plaque size, comparable to atorvastatin, and their combination was even more effective. Additionally, atRA improved the serum lipid profile, suggesting it could be a valuable tool in managing cholesterol levels.
Read More
9
Vitamin A may help cholesterol levels
Chronic vitamin A-enriched diet feeding regulates hypercholesterolaemia through transcriptional regulation of reverse cholesterol transport pathway genes in obese rat model of WNIN/GR-Ob strain.
We examined the effects of a vitamin A-enriched diet on cholesterol levels in glucose-intolerant obese rats. Over a 14-week period, we fed two groups of rats—one received a standard diet, while the other enjoyed the vitamin A boost.
Our findings revealed that the vitamin A diet successfully lowered high cholesterol levels and improved HDL cholesterol, but it worked through different mechanisms than previously thought. Importantly, while we did see positive changes, the study indicates that the benefits may vary based on individual factors.
Read More
8
Vitamin A lowers cholesterol in rats
Vitamin A-enriched diet modulates reverse cholesterol transport in hypercholesterolemic obese rats of the WNIN/Ob strain.
We explored how vitamin A affects cholesterol levels in obese rats with high cholesterol. By administering different doses of vitamin A, we found that a dose of 52 mg/kg significantly decreased the unhealthy HDL-cholesterol levels after 20 weeks. This feeding regimen increased the expression of proteins that help with cholesterol transport. However, the lean rats didn’t show similar benefits. The findings suggest that vitamin A might offer a way to improve cholesterol metabolism in obese individuals, but more research is needed before making any human recommendations.
Read More
7
Vitamin A helps improve cholesterol
THE EFFECT OF APPLICATION OF ANTIOXIDANT THERAPY IN THE TREATMENT OF NON-ALKOHOLIC STEATOHEPATATIS IN CHORNOBYL NPP ACCIDENT SUFFERERS IN THE REMOTE PERIOD AFTER IRRADIATION.
We investigated how antioxidant therapy, including vitamins A and E, affects patients with non-alcoholic steatohepatitis (NASH) who were involved in the Chernobyl disaster.
By studying 72 patients through blood tests and ultrasounds before and after treatment, we found that this combined treatment improved antioxidant levels in the body.
It also resulted in lower cholesterol levels and better liver health overall. Thus, vitamin A therapy showed promise in managing cholesterol and other metabolic issues in these patients.
Read More
4
Vitamin A shows limited cholesterol effects
A comparative study of antioxidant vitamins and simvastatin in hypercholesterolimic rabbits.
We explored how antioxidant vitamins, particularly vitamin A, vitamin C, and vitamin E, impact cholesterol levels in rabbits fed high cholesterol diets.
In our research, we noted that while all treatment groups saw a reduction in total cholesterol and triglycerides, vitamin A did not perform as well as vitamin C, vitamin E, or simvastatin.
Ultimately, simvastatin stood out for significantly increasing beneficial HDL-C levels, while vitamin A showed limited effectiveness in comparison.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.4
All Reviews
Positive Reviews
Negative Reviews
7.5
Asthenopia noticeably improved
7 people found this helpful
I started with two capsules (50,000 IU) daily from 10,000 IU, and my asthenopia has improved considerably. This high-protein diet allows me to spend my days comfortably without experiencing adverse effects.
Read More
7.5
Asthma symptoms alleviated
21 people found this helpful
Vitamin A is necessary for mucous membranes, so I purchased it for my husband, who suffers from severe asthma. He couldn't sleep well due to breathlessness, but after taking 100,000 IU daily for about a month, it became much easier for him. His daytime cough has also significantly decreased. However, it’s important to consume vitamin K alongside high doses of vitamin A.
Read More
7.5
Skin healing noted
3 people found this helpful
I've taken this for about a month; for years, I had slow healing of skin wounds. After taking it, my condition has improved considerably. Initially, I blamed my issues on immunity, but it seems to be related to vitamin A deficiency due to poor diet. I only took 25000 IU every other day, but the high content appears to strain my liver. While this dosage is effective, I sometimes feel dizzy or have digestion difficulties. If you're concerned about liver burden, consider liver nutrients alongside it.
Read More
7.5
Improves dry eye syndrome
3 people found this helpful
I’m not certain, but it appears to work for me. Due to the high concentration, I take a tablet every 2-3 days, and my dry eye syndrome feels better. Previously, I tried lutein and astaxanthin without results, but vitamin A suits me well.
Read More
7.5
Sebum control achieved
2 people found this helpful
Eye fatigue has definitely decreased, and although I aimed to control sebum, reducing my oil paper usage by 30% without adverse reactions from the high dosage shows promise. I will continue to purchase due to its small size, which makes swallowing easy. I'm concerned about quality deterioration at high room temperature, so I refrigerate it with a desiccant upon receipt.
High cholesterol, or hyperlipidemia, is a medical condition characterized by an elevated level of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that’s essential for building healthy cells, but too much of it can lead to serious health issues, including heart disease and stroke. Cholesterol is carried through the blood by lipoproteins, with two main types being low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL, often referred to as "bad" cholesterol, can lead to the buildup of plaque in the arteries, while HDL, known as "good" cholesterol, helps carry cholesterol away from the arteries and back to the liver.
Factors contributing to high cholesterol can include poor diet, lack of exercise, obesity, smoking, and genetic predisposition. Regular health screenings are crucial, as high cholesterol often presents no overt symptoms. Maintaining a heart-healthy diet rich in fruits, vegetables, whole grains, and healthy fats, coupled with regular physical activity and avoiding tobacco, can help manage cholesterol levels effectively. In some cases, medications may be necessary to control high cholesterol, so consulting with a healthcare provider is key for tailored advice.
Vitamin A is a fat-soluble vitamin that's essential for several critical bodily functions, including vision, immune response, and cell differentiation. It comes in two primary forms: preformed vitamin A (retinol) found in animal products like liver, fish, and dairy, and provitamin A carotenoids, primarily found in colorful fruits and vegetables such as carrots, sweet potatoes, and spinach. The body can convert carotenoids into retinol, making these plant sources a valuable dietary option, especially for those following a vegetarian or vegan lifestyle.
Aside from its role in maintaining healthy vision—particularly in low-light conditions—vitamin A plays a significant role in skin health and the functioning of the heart, lungs, and kidneys. It also supports the immune system by promoting the development and function of white blood cells. While it's uncommon to experience a deficiency in countries where a balanced diet is accessible, a lack of vitamin A can lead to serious health problems, including night blindness and increased susceptibility to infections. In contrast, excessive intake of vitamin A, particularly through supplements, can be toxic and lead to several health issues, making it crucial to maintain a balanced intake.
Based on user reviews, the timeframe for seeing results from high-dose vitamin A supplements varies, but many users report noticeable improvements within a month. For instance, one user observed reduced post-acne scars and faster healing of wounds after taking the supplement for about a month Read Review. Another user found significant improvement in skin healing after a similar duration Read Review.
Some individuals experienced initial results even sooner; one user reported improvements in dry eyes just 10 days after starting the supplement Read Review. However, it's important to approach high doses with caution and ideally under the guidance of a healthcare professional, as responses can vary widely between individuals and could be accompanied by side effects if not managed properly Read Review.
Scientific research supports the idea that vitamin A may have a positive impact on cholesterol levels, particularly in specific populations or conditions such as obesity. For instance, a study examined the effects of a vitamin A-enriched diet on glucose-intolerant obese rats, revealing that this diet successfully lowered high cholesterol levels and improved HDL cholesterol over 14 weeks [3]. Another study found that vitamin A therapy improved antioxidant levels and resulted in lower cholesterol levels in patients with non-alcoholic steatohepatitis [1].
However, it's important to note that while some studies have shown promise, the overall effectiveness of vitamin A compared to other treatments appears limited. For example, research involving rabbits indicated that while vitamin A contributed to a reduction in cholesterol, it did not perform as well as other antioxidants like vitamin C or standard medications like simvastatin [5]. Additionally, while elevated doses of vitamin A showed benefits in obese rats, the lack of similar effects in lean rats suggests that the use of vitamin A for managing cholesterol may not be universally effective [4]. Thus, while vitamin A may offer some therapeutic potential for high cholesterol, further studies and caution are warranted before making broad recommendations.
Based on user reviews, many individuals report substantial improvements in a variety of symptoms after incorporating high-dose vitamin A into their routines. For instance, users have noted considerable relief from dry eye syndrome, with one person observing improvements just ten days into the regimen Read Review. Another user mentioned that their eye fatigue decreased significantly, as well as a reduction in sebum production, which contributed to a more comfortable daily experience Read Review. Additionally, several users have highlighted improvements in skin healing and the reduction of post-acne scars, along with benefits for conditions like asthma and persistent lung infections Read ReviewRead Review.
However, it's essential to note that responses to vitamin A can vary widely from person to person, and some users did encounter side effects like dizziness or concerns about liver burden Read Review. Others reported dissatisfaction as they did not experience significant improvements despite following recommendations Read Review. As always, it’s advisable to consult with a healthcare professional before starting high doses of any supplement, particularly vitamin A, due to its potency and the potential for adverse effects if mismanaged.
Based on user reviews, when combining this vitamin A supplement with other supplements for managing high cholesterol, many users emphasize the importance of including vitamin K and a protein-rich diet. One user noted that taking high doses of vitamin A should be supplemented with vitamin K to mitigate potential side effects and enhance overall effectiveness Read Review. Additionally, another reviewer mentioned that increasing protein intake is vital when taking high levels of vitamin A to avoid adverse effects Read Review.
However, some users reported mixed results with cholesterol levels, with one individual experiencing an unexpected rise in cholesterol after using the supplement, indicating that not all combinations may yield favorable outcomes Read Review. While there are recommendations for pairing vitamin A with other supplements and dietary changes, individual responses can vary significantly. Users often highlight the necessity of consulting with a healthcare professional before initiating any new supplement combination to ensure both safety and efficacy in addressing high cholesterol.
Users report varying experiences with Vitamin A dosages when treating conditions associated with high cholesterol and other health issues. Some individuals started at lower doses, like 10,000 IU, and then increased to 50,000 IU or even 100,000 IU daily, observing improvements in symptoms such as eye fatigue and dry skin (e.g., Read Review). However, users also stressed the importance of adherence to proper dosages and the need to consult healthcare professionals. One user noted an unexpected rise in cholesterol levels after taking the supplement, highlighting that high doses could potentially lead to adverse effects (e.g., Read Review).
It’s also noteworthy that some reviewers took Vitamin A alongside a high-protein diet, suggesting that nutritional context plays a significant role in how the supplement is metabolized (e.g., Read Review). While some found benefits from higher doses, they advised caution against exceeding recommended amounts. For those considering Vitamin A for cholesterol treatment or associated health issues, careful monitoring and possibly combining it with other supportive nutrients could be key to achieving positive outcomes while minimizing risks (e.g., Read Review).
7.5
Skin complexion improved
1 people found this helpful
A high-quality, affordable vitamin A in a significantly high dosage. Recommended by my dermatologist, these large doses mustn’t be taken without proper guidance. After a month, my post-acne scars have reduced, wounds heal faster, and my complexion has improved. However, pregnant women or those planning pregnancy should avoid them. The small capsule size makes it easy to take; I only need one per day.
7.5
Skin healing noted
3 people found this helpful
I've taken this for about a month; for years, I had slow healing of skin wounds. After taking it, my condition has improved considerably. Initially, I blamed my issues on immunity, but it seems to be related to vitamin A deficiency due to poor diet. I only took 25000 IU every other day, but the high content appears to strain my liver. While this dosage is effective, I sometimes feel dizzy or have digestion difficulties. If you're concerned about liver burden, consider liver nutrients alongside it.
6
Dry eyes improvement noted
2 people found this helpful
Very satisfied! I sought high-dose vitamin A to address dry eyes and skin inflammation. After finding this brand, one capsule daily lasts me 250 days. It's affordable even on a tight budget. After 10 days of use, my dry eyes showed some improvement.
2
Potential dangers noted
1 people found this helpful
I purchased a familiar dosage of the vitamin, but it's crucial to consume it strictly as directed by a doctor. Taking it without guidance can be hazardous, potentially worsening the condition or leading to serious issues such as cancer or infertility. Please read all the contraindications and indications before use.
7.5
Sebum control achieved
2 people found this helpful
Eye fatigue has definitely decreased, and although I aimed to control sebum, reducing my oil paper usage by 30% without adverse reactions from the high dosage shows promise. I will continue to purchase due to its small size, which makes swallowing easy. I'm concerned about quality deterioration at high room temperature, so I refrigerate it with a desiccant upon receipt.
1
Relieves asthma symptoms
10 people found this helpful
This product keeps me warm and aids my persistent lung infections. It has also alleviated my mild asthma effectively. The high dosage is wonderful and it truly works!
5
Minimal impact observed
1 people found this helpful
I was advised by my doctor to take vitamin A, but I don’t use it daily, as long-term use isn't recommended. Although this seems fine for high doses, I haven't noticed any significant improvement so far.
7.5
Asthma symptoms alleviated
21 people found this helpful
Vitamin A is necessary for mucous membranes, so I purchased it for my husband, who suffers from severe asthma. He couldn't sleep well due to breathlessness, but after taking 100,000 IU daily for about a month, it became much easier for him. His daytime cough has also significantly decreased. However, it’s important to consume vitamin K alongside high doses of vitamin A.
9
Corns healed remarkably
20 people found this helpful
Works well, but be cautious with high doses. I took this with a high-protein diet to treat my corns, which hadn't changed for years. They were fully healed in a few months. Initially, I took 4 tablets (100,000 IU) daily but felt overwhelming fatigue, prompting me to stop. After resting, my condition improved in about a week. Vitamin A can be harmful if not taken with carrier proteins, so I advise increasing protein intake with higher ingestion levels.
0
Increased cholesterol levels
I was disappointed to find out that this vitamin A contains oils, as I am vegan and prefer clean, oil-free eating. After taking it, my cholesterol levels unexpectedly rose, which has never been a concern for me before.
7.5
Asthenopia noticeably improved
7 people found this helpful
I started with two capsules (50,000 IU) daily from 10,000 IU, and my asthenopia has improved considerably. This high-protein diet allows me to spend my days comfortably without experiencing adverse effects.
9
Vitamin A may help cholesterol levels
Chronic vitamin A-enriched diet feeding regulates hypercholesterolaemia through transcriptional regulation of reverse cholesterol transport pathway genes in obese rat model of WNIN/GR-Ob strain.
We examined the effects of a vitamin A-enriched diet on cholesterol levels in glucose-intolerant obese rats. Over a 14-week period, we fed two groups of rats—one received a standard diet, while the other enjoyed the vitamin A boost.
Our findings revealed that the vitamin A diet successfully lowered high cholesterol levels and improved HDL cholesterol, but it worked through different mechanisms than previously thought. Importantly, while we did see positive changes, the study indicates that the benefits may vary based on individual factors.
7
Vitamin A helps improve cholesterol
THE EFFECT OF APPLICATION OF ANTIOXIDANT THERAPY IN THE TREATMENT OF NON-ALKOHOLIC STEATOHEPATATIS IN CHORNOBYL NPP ACCIDENT SUFFERERS IN THE REMOTE PERIOD AFTER IRRADIATION.
We investigated how antioxidant therapy, including vitamins A and E, affects patients with non-alcoholic steatohepatitis (NASH) who were involved in the Chernobyl disaster.
By studying 72 patients through blood tests and ultrasounds before and after treatment, we found that this combined treatment improved antioxidant levels in the body.
It also resulted in lower cholesterol levels and better liver health overall. Thus, vitamin A therapy showed promise in managing cholesterol and other metabolic issues in these patients.
4
Vitamin A shows limited cholesterol effects
A comparative study of antioxidant vitamins and simvastatin in hypercholesterolimic rabbits.
We explored how antioxidant vitamins, particularly vitamin A, vitamin C, and vitamin E, impact cholesterol levels in rabbits fed high cholesterol diets.
In our research, we noted that while all treatment groups saw a reduction in total cholesterol and triglycerides, vitamin A did not perform as well as vitamin C, vitamin E, or simvastatin.
Ultimately, simvastatin stood out for significantly increasing beneficial HDL-C levels, while vitamin A showed limited effectiveness in comparison.
8
Vitamin A lowers cholesterol in rats
Vitamin A-enriched diet modulates reverse cholesterol transport in hypercholesterolemic obese rats of the WNIN/Ob strain.
We explored how vitamin A affects cholesterol levels in obese rats with high cholesterol. By administering different doses of vitamin A, we found that a dose of 52 mg/kg significantly decreased the unhealthy HDL-cholesterol levels after 20 weeks. This feeding regimen increased the expression of proteins that help with cholesterol transport. However, the lean rats didn’t show similar benefits. The findings suggest that vitamin A might offer a way to improve cholesterol metabolism in obese individuals, but more research is needed before making any human recommendations.
References
Sarkisova EA, Chumak AA, Ovsyannikova LM, Alekhina LM, Nosach OV, et al. THE EFFECT OF APPLICATION OF ANTIOXIDANT THERAPY IN THE TREATMENT OF NON-ALKOHOLIC STEATOHEPATATIS IN CHORNOBYL NPP ACCIDENT SUFFERERS IN THE REMOTE PERIOD AFTER IRRADIATION. Probl Radiac Med Radiobiol. 2018;23:452. doi:10.33145/2304-8336-2018-23-452-461
Zarei L, Bahrami M, Farhad N, Froushani SMA, Abbasi A. All-trans retinoic acid effectively reduces atheroma plaque size in a rabbit model of high-fat-induced atherosclerosis. Adv Clin Exp Med. 2018;27:1631. doi:10.17219/acem/74552
Jeyakumar SM, Sheril A, Vajreswari A. Chronic vitamin A-enriched diet feeding regulates hypercholesterolaemia through transcriptional regulation of reverse cholesterol transport pathway genes in obese rat model of WNIN/GR-Ob strain. Indian J Med Res. 2016;144:238. doi:10.4103/0971-5916.195038
Prashanth A, Jeyakumar SM, Giridharan NV, Vajreswari A. Vitamin A-enriched diet modulates reverse cholesterol transport in hypercholesterolemic obese rats of the WNIN/Ob strain. J Atheroscler Thromb. 2014;21:1197.
Syed NI, Arshad S, Syed AA, Ahmad M, Khan FZ, et al. A comparative study of antioxidant vitamins and simvastatin in hypercholesterolimic rabbits. Pak J Pharm Sci. 2011;24:479.