We aimed to understand how all-trans retinoic acid (ATRA), a form of vitamin A, influences lung cancer development caused by benzo(a)pyrene (B(a)P) exposure in mice. The study involved a thorough examination of the overall health of the mice, including body and organ weights, blood tests, and tissue analysis for any signs of damage or inflammation.
In our observations, B(a)P significantly harmed the mice, leading to weight loss and increased organ weight, particularly in the liver and lungs. Blood analysis revealed a concerning decrease in healthy blood cells and an increase in inflammatory markers, indicating an unhealthy state. However, we found that when these mice were treated with ATRA, their conditions improved remarkably.
The treated mice regained weight, saw improvements in their blood parameters, and exhibited lower levels of cancer-related inflammation. Notably, the expression of the COX-2 gene—an important player in inflammation and cancer—was dramatically reduced with ATRA treatment in both lung and liver tissues. This suggests that ATRA effectively counteracts the inflammatory effects and may help prevent the initial stages of cancer caused by B(a)P exposure.
Overall, our findings highlight the potential of vitamin A in mitigating some of the risks associated with lung cancer development due to environmental carcinogens, supporting further exploration of its role in cancer prevention.
Read More
8
Vitamin A's role in lung cancer
An Efficient Suppression of EGFR and B-Raf mRNA Overexpression in the Lung of Benzo[a]pyrene-induced mice by Cationic Lipo-ATRA Nanoformulation.
We explored how vitamin A, specifically all-trans retinoic acid (ATRA), could impact lung cancer by studying mice that were induced with lung cancer through benzo[a]pyrene. We gave some mice a traditional form of ATRA and others a novel cationic liposome formulation, lipo-ATRA, to see which one would perform better in reducing the expression of certain cancer-related genes.
The results showed that the cationic lipo-ATRA treatment significantly improved the availability of ATRA in lung tissues and effectively suppressed the expression levels of the epidermal growth factor receptor (EGFR) and B-Raf genes. These genes are known to play a crucial role in cancer development, so their suppression suggests a positive effect of ATRA, especially in its nanoformulation.
Our findings indicate that lipo-ATRA could be a promising strategy for managing lung cancer by targeting specific oncogenes. This research provides valuable insights into potential avenues for improving cancer treatments using vitamin A.
Read More
8
Vitamin A's therapeutic effects on SACC
Increased retinoic acid signaling decreases lung metastasis in salivary adenoid cystic carcinoma by inhibiting the noncanonical Notch1 pathway.
We investigated how vitamin A, specifically in the form of all-trans retinoic acid (ATRA), impacts lung metastasis in salivary adenoid cystic carcinoma (SACC). This study highlighted the significant role of the retinoic acid signaling pathway in potentially controlling cancer spread. Through advanced techniques like single-cell RNA sequencing, we identified various cell types present in both primary tumors and lung metastases, helping us understand the aggressive nature of this cancer.
Our findings suggested that ATRA works by correcting abnormal cell differentiation caused by faulty Notch1 or MYB genes. Additionally, we discovered that a deficiency in the retinoic acid system might contribute to the increased likelihood of lung metastasis. By focusing on how ATRA affects these cancer cells, we highlighted the vitamin’s importance in both the diagnosis and treatment of SACC.
Overall, this research emphasizes that boosting our vitamin A system could play a crucial role in managing the challenges posed by lung cancer metastasis in adenoid cystic carcinoma. The study opens up avenues for further exploration into vitamin A as a therapeutic option for patients struggling with this type of cancer.
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Most Useful Reviews
9
Tumour markers normalised
13 people found this helpful
I have taken Vitamin A for five years as advised by my doctor to lower lung cancer marker levels. Initially, I took high doses but now manage with 75,000 IU daily, supporting my recovery and normalising my tumour markers.
Read More
7.5
High dose essential
14 people found this helpful
Due to my family's history with asthma and lung cancer, I require high doses of Vitamin A. I found it beneficial in managing my asthma symptoms, and I plan to continue taking it as I experienced quick recovery from severe coughing fits.
Read More
7.5
Improved respiratory health
10 people found this helpful
Vitamin A has significantly alleviated my lung issues and mild asthma. The higher dosage has helped, and it keeps me warm. I'm pleased with how well it works for my respiratory problems.
We aimed to understand how all-trans retinoic acid (ATRA), a form of vitamin A, influences lung cancer development caused by benzo(a)pyrene (B(a)P) exposure in mice. The study involved a thorough examination of the overall health of the mice, including body and organ weights, blood tests, and tissue analysis for any signs of damage or inflammation.
In our observations, B(a)P significantly harmed the mice, leading to weight loss and increased organ weight, particularly in the liver and lungs. Blood analysis revealed a concerning decrease in healthy blood cells and an increase in inflammatory markers, indicating an unhealthy state. However, we found that when these mice were treated with ATRA, their conditions improved remarkably.
The treated mice regained weight, saw improvements in their blood parameters, and exhibited lower levels of cancer-related inflammation. Notably, the expression of the COX-2 gene—an important player in inflammation and cancer—was dramatically reduced with ATRA treatment in both lung and liver tissues. This suggests that ATRA effectively counteracts the inflammatory effects and may help prevent the initial stages of cancer caused by B(a)P exposure.
Overall, our findings highlight the potential of vitamin A in mitigating some of the risks associated with lung cancer development due to environmental carcinogens, supporting further exploration of its role in cancer prevention.
Read More
8
ACR enhances lung cancer treatment
Acyclic Retinoid Inhibits the EGFR/AKT Signaling Pathway and Cancels Cisplatin-resistant Cell Characteristics.
We explored the potential of acyclic retinoid (ACR), a derivative of vitamin A, in treating lung cancer, particularly focusing on non-small cell lung cancer (NSCLC) and cisplatin-resistant cells. This research is vital because NSCLC is one of the leading causes of cancer-related deaths, and treatments like cisplatin often face challenges due to resistance.
In our study, we observed that ACR can significantly inhibit the EGFR/AKT signaling pathway, which is heavily involved in the progression of lung cancer. We treated human NSCLC A549 cells, as well as cisplatin-resistant A549 (A549CR) cells, with ACR alone and in combination with cisplatin. We assessed various factors including cell viability, apoptosis rates, and the levels of crucial signaling proteins.
The results revealed that ACR not only decreased cell viability but also enhanced the sensitivity of both NSCLC and resistant cells to cisplatin treatment. This suggests that ACR could play an important role in improving therapeutic outcomes for lung cancer patients, especially those who have developed resistance to current treatments.
Our findings indicate that incorporating ACR into treatment regimens may provide an innovative strategy for tackling lung cancer and managing cisplatin resistance, which is a significant hurdle in current cancer therapies.
Read More
8
Vitamin A's role in lung cancer
An Efficient Suppression of EGFR and B-Raf mRNA Overexpression in the Lung of Benzo[a]pyrene-induced mice by Cationic Lipo-ATRA Nanoformulation.
We explored how vitamin A, specifically all-trans retinoic acid (ATRA), could impact lung cancer by studying mice that were induced with lung cancer through benzo[a]pyrene. We gave some mice a traditional form of ATRA and others a novel cationic liposome formulation, lipo-ATRA, to see which one would perform better in reducing the expression of certain cancer-related genes.
The results showed that the cationic lipo-ATRA treatment significantly improved the availability of ATRA in lung tissues and effectively suppressed the expression levels of the epidermal growth factor receptor (EGFR) and B-Raf genes. These genes are known to play a crucial role in cancer development, so their suppression suggests a positive effect of ATRA, especially in its nanoformulation.
Our findings indicate that lipo-ATRA could be a promising strategy for managing lung cancer by targeting specific oncogenes. This research provides valuable insights into potential avenues for improving cancer treatments using vitamin A.
Read More
8
Vitamin A's Mixed Effects on Cancer
A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment.
We explored the impact of retinoic acid, a form of vitamin A, on lung cancer growth in our study. By administering all-trans-retinoic acid (ATRA) to mice, we found that while it reduced cancer growth in immune-competent mice, it did not have the same effect in those with compromised immune systems. This led us to consider the important role the tumor microenvironment plays in cancer treatment.
We observed that depleting CD8 T cells nullified the positive effects of ATRA, indicating the necessity of a healthy immune response in combatting lung cancer. Additionally, when we combined ATRA with immune checkpoint inhibitors—the drugs that block cancer's ability to evade the immune system—it did not enhance anti-tumor effects as hoped.
To find a solution, we turned to an RARγ agonist, known as IRX4647. When we paired IRX4647 with an anti-PD-L1 blockade, we saw significant tumor suppression, particularly in resisting cancer models. This combination treatment resulted in increased CD4 T cells in tumors, which suggests a shift in the immune landscape that could support fighting cancer.
Despite these promising results, it's worth noting that IRX4647 alone did not demonstrate strong effects on lung cancer growth in laboratory settings. Our findings underscore the complexity of cancer treatment and the need for clinical trials to evaluate RARγ agonists further in combination with existing therapies.
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8
Vitamin A's role in lung cancer
Diet as a Factor Supporting Lung Cancer Treatment-A Systematic Review.
We examined how vitamin A, along with other antioxidants, may play a role in the treatment of lung cancer. Our review of various studies highlighted that vitamin A, as part of a broader antioxidant defense, has potential benefits, but its specific impact on lung cancer on its own remains less clear.
The studies we evaluated suggest that a combination of antioxidants, including vitamin C, vitamin E, selenium, and zinc, work together to strengthen the body's defense mechanisms against damage. Moreover, we noted that vitamin A might enhance overall health when included in a supportive dietary plan, especially alongside treatments like chemotherapy and radiotherapy.
Increased intake of protein and omega-3 fatty acids is also emphasized, as they can improve the quality of life and functional outcomes for lung cancer patients. Although vitamin A shows promise as part of a nutritional approach to lung cancer treatment, isolating its specific effects is challenging due to the simultaneous involvement of other nutrients.
I have taken Vitamin A for five years as advised by my doctor to lower lung cancer marker levels. Initially, I took high doses but now manage with 75,000 IU daily, supporting my recovery and normalising my tumour markers.
Read More
7.5
High dose essential
14 people found this helpful
Due to my family's history with asthma and lung cancer, I require high doses of Vitamin A. I found it beneficial in managing my asthma symptoms, and I plan to continue taking it as I experienced quick recovery from severe coughing fits.
Read More
7.5
Improved respiratory health
10 people found this helpful
Vitamin A has significantly alleviated my lung issues and mild asthma. The higher dosage has helped, and it keeps me warm. I'm pleased with how well it works for my respiratory problems.
Read More
6
Treats gastrointestinal diseases
1 people found this helpful
Larger doses of Vitamin A are beneficial for treating gastrointestinal conditions associated with lung cancer, such as Crohn's disease and colitis. I find using 25,000 IU necessary during illness, reducing my symptoms effectively.
Read More
6
Reduced nosebleeds
I've been on Vitamin A for five months, primarily as a precaution against cancer, but I encountered nosebleeds initially. I've since decreased my intake to one pill every five or six days, which seems to work without further issues.
Lung cancer is a type of cancer that begins in the lungs, which are vital organs located in the chest responsible for breathing and oxygen exchange. There are two primary types of lung cancer: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). NSCLC accounts for about 85% of lung cancer cases and typically grows slower than SCLC, which is more aggressive and spreads quickly. Common risk factors for lung cancer include smoking, exposure to secondhand smoke, radon gas, and certain occupational hazards, making it essential to take preventive measures if you are at risk.
Symptoms of lung cancer can be subtle in the early stages, often including a persistent cough, chest pain, breathlessness, weight loss, and coughing up blood. Given that many individuals may not experience noticeable symptoms until the disease has progressed, regular check-ups and screenings are crucial, especially for those at higher risk. Treatment options for lung cancer may involve surgery, chemotherapy, radiation therapy, targeted therapy, or a combination of these approaches, depending on the cancer's type and stage. As research advances, new treatments are being developed, offering hope for improved survival rates and quality of life for those diagnosed.
Vitamin A is a fat-soluble vitamin that's essential for several critical bodily functions, including vision, immune response, and cell differentiation. It comes in two primary forms: preformed vitamin A (retinol) found in animal products like liver, fish, and dairy, and provitamin A carotenoids, primarily found in colorful fruits and vegetables such as carrots, sweet potatoes, and spinach. The body can convert carotenoids into retinol, making these plant sources a valuable dietary option, especially for those following a vegetarian or vegan lifestyle.
Aside from its role in maintaining healthy vision—particularly in low-light conditions—vitamin A plays a significant role in skin health and the functioning of the heart, lungs, and kidneys. It also supports the immune system by promoting the development and function of white blood cells. While it's uncommon to experience a deficiency in countries where a balanced diet is accessible, a lack of vitamin A can lead to serious health problems, including night blindness and increased susceptibility to infections. In contrast, excessive intake of vitamin A, particularly through supplements, can be toxic and lead to several health issues, making it crucial to maintain a balanced intake.
Based on user reviews, the length of time it takes to see results from taking Vitamin A, particularly in relation to lung cancer, can vary. Some users report improvements in their lung function and symptoms after just a few months of use. For instance, one user mentioned taking Vitamin A for five months and noticing benefits, although they initially faced side effects like nosebleeds (Read Review). Another user stated that they have been on Vitamin A for five years, which has helped to normalize their tumor markers, suggesting that longer-term use can also lead to significant improvements (Read Review).
In general, users seem to experience varying timelines for results, with some finding quick relief from symptoms such as coughing after changing their dosage (Read Review) while others emphasize the importance of ongoing use over years for better outcomes (Read Review). Therefore, the time frame for seeing results might range from a few weeks to years, depending on individual circumstances and health status.
Research supports the potential of vitamin A and its derivatives, particularly all-trans retinoic acid (ATRA), in the treatment of lung cancer. Studies indicate that ATRA can inhibit cancer growth and enhance the efficacy of conventional treatments like cisplatin, especially in cases of non-small cell lung cancer (NSCLC) and cisplatin-resistant cells [1]. Additionally, formulations like cationic lipo-ATRA have shown promise in delivering ATRA more effectively to lung tumors, thus potentially improving treatment outcomes [8].
However, the overall impact of vitamin A on lung cancer risk and treatment remains complex. While some studies suggest it may help in reducing recurrence and improving clinical responses, others indicate no significant improvement in overall survival rates for lung cancer patients [6]. Furthermore, certain cohorts have shown concerning associations, such as increased lung cancer risk with higher vitamin A intake among smokers [7]. These findings highlight the necessity for further research to fully understand the role of vitamin A in lung cancer treatment and prevention.
Users report a range of improvements in their respiratory symptoms after incorporating Vitamin A into their health regimen. Several individuals noted significant benefits for conditions such as asthma and general lung function. For example, one user indicated that Vitamin A has alleviated both their lung issues and mild asthma, stating a higher dosage has improved their respiratory problems and overall warmth (Read Review). Another user specifically highlighted a quick recovery from severe coughing fits, which they attribute to high doses of Vitamin A, reflecting a notable improvement in managing asthma symptoms (Read Review).
Additionally, long-term use appears to contribute to better outcomes, with some users seeing normalization of tumor markers over extended periods. One reviewer, who has taken Vitamin A for five years, mentioned it supports recovery and has been pivotal in managing their lung cancer symptoms effectively (Read Review). While experiences vary, the collective anecdotal evidence suggests that Vitamin A can significantly ease respiratory issues for some users—though individual results may differ based on health conditions and adherence to dosage recommendations.
Users report mixed experiences when combining Vitamin A with other supplements while managing lung cancer. Several reviews emphasize the importance of high doses of Vitamin A for alleviating symptoms related to respiratory conditions. One reviewer noted significant benefits from high doses, claiming it improved lung issues and mild asthma while maintaining overall warmth (Read Review). Another user, who has taken Vitamin A for five years under a doctor's advice, mentioned normalization of tumor markers, suggesting that a consistent regimen can have positive effects on lung cancer management (Read Review).
Additionally, some users have combined Vitamin A with other vitamins as a preventive measure against lung cancer. One reviewer recommended a regimen that includes not only Vitamin A but also high doses of vitamins E, C, and D as part of their treatment plan, citing potential benefits in lung cancer prevention (Read Review). This holistic approach implies that vitamin combinations could be advantageous, although individual results can vary based on specific health contexts.
Based on user reviews, the appropriate dose of Vitamin A for treating lung cancer varies widely among individuals. One user reported taking 75,000 IU daily, mentioning that this dosage was advised by their doctor to lower lung cancer marker levels and support recovery Read Review. In contrast, another user found that taking 25,000 IU during illness significantly reduced symptoms related to gastrointestinal conditions linked to lung cancer Read Review. However, user experiences also highlight the need for adjustments; one user decreased their intake to taking a pill every five or six days after initially encountering nosebleeds Read Review.
Overall, while some users advocate for high doses to alleviate symptoms associated with lung conditions, others suggest a more cautious approach. It's crucial to consult with a healthcare provider to tailor the dosage based on individual health needs and reactions to the supplement. Additionally, users recommend incorporating Vitamin A as part of a broader regimen that includes other vitamins for comprehensive support Read Review.
6
Reduced nosebleeds
I've been on Vitamin A for five months, primarily as a precaution against cancer, but I encountered nosebleeds initially. I've since decreased my intake to one pill every five or six days, which seems to work without further issues.
9
Tumour markers normalised
13 people found this helpful
I have taken Vitamin A for five years as advised by my doctor to lower lung cancer marker levels. Initially, I took high doses but now manage with 75,000 IU daily, supporting my recovery and normalising my tumour markers.
7.5
High dose essential
14 people found this helpful
Due to my family's history with asthma and lung cancer, I require high doses of Vitamin A. I found it beneficial in managing my asthma symptoms, and I plan to continue taking it as I experienced quick recovery from severe coughing fits.
6
Boosted immunity
16 people found this helpful
Vitamin A is crucial for immune and lung function, especially during infections. I recommend a daily regimen as outlined by Dr Linus Pauling, incorporating multivitamins and high doses of Vitamin A, E, C, and D. This treatment could help with lung cancer prevention.
7.5
Improved respiratory health
10 people found this helpful
Vitamin A has significantly alleviated my lung issues and mild asthma. The higher dosage has helped, and it keeps me warm. I'm pleased with how well it works for my respiratory problems.
6
Treats gastrointestinal diseases
1 people found this helpful
Larger doses of Vitamin A are beneficial for treating gastrointestinal conditions associated with lung cancer, such as Crohn's disease and colitis. I find using 25,000 IU necessary during illness, reducing my symptoms effectively.
8
ACR enhances lung cancer treatment
Acyclic Retinoid Inhibits the EGFR/AKT Signaling Pathway and Cancels Cisplatin-resistant Cell Characteristics.
We explored the potential of acyclic retinoid (ACR), a derivative of vitamin A, in treating lung cancer, particularly focusing on non-small cell lung cancer (NSCLC) and cisplatin-resistant cells. This research is vital because NSCLC is one of the leading causes of cancer-related deaths, and treatments like cisplatin often face challenges due to resistance.
In our study, we observed that ACR can significantly inhibit the EGFR/AKT signaling pathway, which is heavily involved in the progression of lung cancer. We treated human NSCLC A549 cells, as well as cisplatin-resistant A549 (A549CR) cells, with ACR alone and in combination with cisplatin. We assessed various factors including cell viability, apoptosis rates, and the levels of crucial signaling proteins.
The results revealed that ACR not only decreased cell viability but also enhanced the sensitivity of both NSCLC and resistant cells to cisplatin treatment. This suggests that ACR could play an important role in improving therapeutic outcomes for lung cancer patients, especially those who have developed resistance to current treatments.
Our findings indicate that incorporating ACR into treatment regimens may provide an innovative strategy for tackling lung cancer and managing cisplatin resistance, which is a significant hurdle in current cancer therapies.
8
Vitamin A delivery in lung cancer
Liposome nano-formulation with cationic polar lipid DOTAP and cholesterol as a suitable pH-responsive carrier for molecular therapeutic drug (all-trans retinoic acid) delivery to lung cancer cells.
We explored the effectiveness of all-trans retinoic acid (ATRA), a form of vitamin A, as a treatment for lung cancer, focusing on how it can be delivered more effectively to tumors. ATRA is known to have poor bioavailability and faces challenges with drug resistance, so we utilized a specially designed nano-formulation called lipo-ATRA, which uses cationic lipids.
In our study, we created lipo-ATRA using DOTAP, cholesterol, and ATRA in specific ratios to improve its delivery to lung cancer cells. We found that this formulation was stable and released ATRA more effectively in acidic environments, such as those found in many tumors. A significant finding was that ATRA uptake was seven times higher in lung cancer cells treated with lipo-ATRA compared to those receiving free ATRA.
Furthermore, we observed that lipo-ATRA treatment resulted in a marked decrease in cell viability after 48 hours compared to the free ATRA treatment. Our results indicate that using this nano-formulated carrier not only enhances the release of ATRA at acidic pH levels but also improves its uptake by lung cancer cells, signifying a promising approach for targeted therapy.
In summary, the study demonstrates that the lipo-ATRA formulation with DOTAP is a suitable tool for delivering vitamin A effectively to lung cancer cells, potentially improving treatment outcomes.
7
Retinoids show promise, limited scope
Retinoids in cancer chemoprevention and therapy: Meta-analysis of randomized controlled trials.
We conducted a thorough examination of how retinoids, which are derivatives of vitamin A, impact lung cancer treatment. In our analysis, we looked at data from 39 randomized controlled trials that included over 15,000 patients.
Our findings revealed that patients treated with retinoids showed a reduced rate of cancer recurrence and improved clinical responses compared to those who did not receive these treatments. However, it is important to note that when it came to overall survival rates, development of cancer, disease progression, and event-free survival, there were no significant improvements tied to retinoid treatment.
Specifically for lung cancer, the study indicated that patients experienced benefits from retinoids. Yet, these results also align with other types of cancers, like acute promyelocytic leukemia and renal cell carcinoma. In contrast, we did not find significant therapeutic effects for several other cancers, including head and neck cancer and melanoma.
Overall, while vitamin A plays a notable role in potentially preventing cancer recurrence and improving patients' responses to treatment, it does not enhance overall survival in lung cancer patients. Further research is encouraged to explore the effectiveness of retinoids in a broader range of cancers.
4
Vitamin A shows no protective benefit
Associations of Dietary Intakes of Carotenoids and Vitamin A with Lung Cancer Risk in a Low-Income Population in the Southeastern United States.
We looked into how vitamin A affects lung cancer risk, specifically within a diverse group of over 65,000 participants in the Southern Community Cohort Study. This large-scale research included 1,204 cases of lung cancer and focused on dietary habits involving carotenoids and vitamin A.
Interestingly, we found that individuals diagnosed with lung cancer reported lower intake of vitamin A and carotenoids compared to those without cancer. However, the overall results indicated no significant protective benefits of these nutrients against lung cancer risk.
In fact, we noted that current smokers showed a concerning positive association between dietary vitamin A intake and lung cancer risk. The data revealed that higher vitamin A consumption was linked to a 23% increase in risk for these individuals. Furthermore, African Americans consuming more vitamin A had an even greater risk for developing adenocarcinoma.
We also discovered that former smokers who consumed higher amounts of lycopene, another carotenoid, faced an increased lung cancer risk. Additionally, β-cryptoxanthin was positively associated with the risk of squamous carcinoma.
The findings suggest that more research is needed to explore these associations further, particularly considering the mixed outcomes surrounding vitamin A and lung cancer.
References
Motoyama M, Shigefuku R, Tanaka N, Nishizawa M, Oshio K, et al. Acyclic Retinoid Inhibits the EGFR/AKT Signaling Pathway and Cancels Cisplatin-resistant Cell Characteristics. Anticancer Res. 2025;45:433. 10.21873/anticanres.17432
Mariammal BGV, Wilson Devarajan D, Singaram V, Ravichandran R, Chandrasekharan G, et al. An Efficient Suppression of EGFR and B-Raf mRNA Overexpression in the Lung of Benzo[a]pyrene-induced mice by Cationic Lipo-ATRA Nanoformulation. Recent Pat Nanotechnol. 2025;19:131. 10.2174/0118722105246143231016105620
Wei CH, Huang L, Kreh B, Liu X, Tyutyunyk-Massey L, et al. A novel retinoic acid receptor-γ agonist antagonizes immune checkpoint resistance in lung cancers by altering the tumor immune microenvironment. Sci Rep. 2023;13:14907. 10.1038/s41598-023-41690-5
Polański J, Świątoniowska-Lonc N, Kołaczyńska S, Chabowski M. Diet as a Factor Supporting Lung Cancer Treatment-A Systematic Review. Nutrients. 2023;15. 10.3390/nu15061477
Zhou MJ, Yang JJ, Ma TY, Feng GX, Wang XL, et al. Increased retinoic acid signaling decreases lung metastasis in salivary adenoid cystic carcinoma by inhibiting the noncanonical Notch1 pathway. Exp Mol Med. 2023;55:597. 10.1038/s12276-023-00957-7
Chen S, Hu Q, Tao X, Xia J, Wu T, et al. Retinoids in cancer chemoprevention and therapy: Meta-analysis of randomized controlled trials. Front Genet. 2022;13:1065320. 10.3389/fgene.2022.1065320
Sun Y, Wu J, Yoon HS, Buchowski MS, Cai H, et al. Associations of Dietary Intakes of Carotenoids and Vitamin A with Lung Cancer Risk in a Low-Income Population in the Southeastern United States. Cancers (Basel). 2022;14. 10.3390/cancers14205159
Grace VMB, Wilson DD, Guruvayoorappan C, Danisha JP, Bonati L. Liposome nano-formulation with cationic polar lipid DOTAP and cholesterol as a suitable pH-responsive carrier for molecular therapeutic drug (all-trans retinoic acid) delivery to lung cancer cells. IET Nanobiotechnol. 2021;15:380. 10.1049/nbt2.12028
Grace VMB, Wilson DD, Anushya R. Regulation of inflammation and COX-2 gene expression in benzo (a) pyrene induced lung carcinogenesis in mice by all trans retinoic acid (ATRA). Life Sci. 2021;285:119967. 10.1016/j.lfs.2021.119967