Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.2
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Glutamine (Free-Form)
1 g (1,000 mg)
**
Top Medical Research Studies
9
We examined the effects of Lachnum-derived polysaccharides, specifically a modified compound known as LAG, on gastric ulcers in mice. The study involved treating mice with acute ulcers using different doses of LAG and another polysaccharide, LEP2a.
Our findings revealed that both compounds significantly reduced gastric mucosal damage and inflammation. LAG showed greater effectiveness, improving antioxidant levels and reducing harmful inflammatory markers. Essentially, these polysaccharides help protect the stomach lining by tackling oxidative stress and inflammation.
Our findings revealed that both compounds significantly reduced gastric mucosal damage and inflammation. LAG showed greater effectiveness, improving antioxidant levels and reducing harmful inflammatory markers. Essentially, these polysaccharides help protect the stomach lining by tackling oxidative stress and inflammation.
Read More
9
We examined the impact of N-acetyl-L-glutamine aluminum complex (KW-110) on gastric ulcers exacerbated by common painkillers, like aspirin and indomethacin, in rats. After inducing ulcers, we found that while certain NSAIDs worsened the situation, KW-110 significantly reduced their damaging effects. This treatment not only helped in healing the ulcers but also prevented further gastric lesions caused by these medications. Importantly, KW-110 did not alter the pain-relieving effects of the NSAIDs used.
Read More
8
We aimed to explore if alanyl-glutamine (AG), a special dipeptide known to support gut healing, can help treat ulcers caused by indomethacin in rats. In our study, we divided the rats into five groups to observe the effects of AG, with some receiving additional treatments.
The results revealed that AG helped raise the pH of gastric juice, much like pantoprazole did. However, while AG showed some beneficial effects, it was less effective in groups where dexamethasone was administered beforehand. Thus, the overall impact of AG, though promising, involves complexities that need further investigation.
The results revealed that AG helped raise the pH of gastric juice, much like pantoprazole did. However, while AG showed some beneficial effects, it was less effective in groups where dexamethasone was administered beforehand. Thus, the overall impact of AG, though promising, involves complexities that need further investigation.
Read More
Most Useful Reviews
9
Controls ulcerative colitis
1 people found this helpful
The BEST option for anyone with ulcerative colitis! Following a terrible car accident, my son developed this condition. With this supplement and other herbal remedies, his symptoms are nearly gone and under control. This has been crucial in managing the "liquid" in his stool, and it indeed provides additional necessary benefits.
Read More
9
Pain relief
This product works effectively for my stomach ulcers; whenever I experience pain, I take three capsules before bed. It heals the lining of my stomach from the inside.
Read More
7.5
Reduces stomach acid
The best advice for individuals with gastric ulcers. I woke up with excessive stomach acid during the night. Since using this, it has improved the visceral mucosa and smoothed the skin!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.2
- All Researches
9
We examined the effects of Lachnum-derived polysaccharides, specifically a modified compound known as LAG, on gastric ulcers in mice. The study involved treating mice with acute ulcers using different doses of LAG and another polysaccharide, LEP2a.
Our findings revealed that both compounds significantly reduced gastric mucosal damage and inflammation. LAG showed greater effectiveness, improving antioxidant levels and reducing harmful inflammatory markers. Essentially, these polysaccharides help protect the stomach lining by tackling oxidative stress and inflammation.
Our findings revealed that both compounds significantly reduced gastric mucosal damage and inflammation. LAG showed greater effectiveness, improving antioxidant levels and reducing harmful inflammatory markers. Essentially, these polysaccharides help protect the stomach lining by tackling oxidative stress and inflammation.
Read More
9
We examined the impact of N-acetyl-L-glutamine aluminum complex (KW-110) on gastric ulcers exacerbated by common painkillers, like aspirin and indomethacin, in rats. After inducing ulcers, we found that while certain NSAIDs worsened the situation, KW-110 significantly reduced their damaging effects. This treatment not only helped in healing the ulcers but also prevented further gastric lesions caused by these medications. Importantly, KW-110 did not alter the pain-relieving effects of the NSAIDs used.
Read More
9
We explored how L-arginine, a precursor for nitric oxide, influences gastric health and ulcer healing. In this study on rats, L-arginine reduced acute gastric lesions caused by substances like 100% ethanol. It also improved blood flow, but interestingly, other related amino acids, including L-glutamine, did not show a significant impact on ulcers.
We discovered that L-arginine accelerated the healing process and promoted new blood vessel formation around ulcers, indicating its beneficial effects. However, L-glutamine treatment did not deliver notable results, suggesting that other factors may play a larger role in ulcer management.
We discovered that L-arginine accelerated the healing process and promoted new blood vessel formation around ulcers, indicating its beneficial effects. However, L-glutamine treatment did not deliver notable results, suggesting that other factors may play a larger role in ulcer management.
Read More
8
We aimed to explore if alanyl-glutamine (AG), a special dipeptide known to support gut healing, can help treat ulcers caused by indomethacin in rats. In our study, we divided the rats into five groups to observe the effects of AG, with some receiving additional treatments.
The results revealed that AG helped raise the pH of gastric juice, much like pantoprazole did. However, while AG showed some beneficial effects, it was less effective in groups where dexamethasone was administered beforehand. Thus, the overall impact of AG, though promising, involves complexities that need further investigation.
The results revealed that AG helped raise the pH of gastric juice, much like pantoprazole did. However, while AG showed some beneficial effects, it was less effective in groups where dexamethasone was administered beforehand. Thus, the overall impact of AG, though promising, involves complexities that need further investigation.
Read More
8
We investigated how peptides from cattle abomasum help heal stomach damage in rats caused by aspirin. Over 22 days, we divided Wistar rats into groups—some received a control treatment while others got a native or heated extract of the abomasum after inducing mucosal damage.
Our findings revealed that both extracts significantly improved healing, reduced harmful substances in the blood, and normalized immune cell counts, indicating recovery. Rats treated with these extracts showed healthier stomach lining, with no signs of irritation. Overall, the abomasum extracts demonstrated promising antiulcer effects.
Our findings revealed that both extracts significantly improved healing, reduced harmful substances in the blood, and normalized immune cell counts, indicating recovery. Rats treated with these extracts showed healthier stomach lining, with no signs of irritation. Overall, the abomasum extracts demonstrated promising antiulcer effects.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Controls ulcerative colitis
1 people found this helpful
The BEST option for anyone with ulcerative colitis! Following a terrible car accident, my son developed this condition. With this supplement and other herbal remedies, his symptoms are nearly gone and under control. This has been crucial in managing the "liquid" in his stool, and it indeed provides additional necessary benefits.
Read More
9
Pain relief
This product works effectively for my stomach ulcers; whenever I experience pain, I take three capsules before bed. It heals the lining of my stomach from the inside.
Read More
7.5
Reduces stomach acid
The best advice for individuals with gastric ulcers. I woke up with excessive stomach acid during the night. Since using this, it has improved the visceral mucosa and smoothed the skin!
Read More
7.5
Effective treatment
I have used this product to treat stomach ulcers, and the effect is quite good.
Read More
7.5
Essential for UC
This product is fantastic for managing my ulcerative colitis flares. It's a must-have for anyone dealing with this inflammatory bowel issue, as this high-quality amino acid Glutamine helps to complement my diet.
Read More
Frequently Asked Questions
9
Pain relief
This product works effectively for my stomach ulcers; whenever I experience pain, I take three capsules before bed. It heals the lining of my stomach from the inside.
9
Controls ulcerative colitis
1 people found this helpful
The BEST option for anyone with ulcerative colitis! Following a terrible car accident, my son developed this condition. With this supplement and other herbal remedies, his symptoms are nearly gone and under control. This has been crucial in managing the "liquid" in his stool, and it indeed provides additional necessary benefits.
7.5
Essential for UC
This product is fantastic for managing my ulcerative colitis flares. It's a must-have for anyone dealing with this inflammatory bowel issue, as this high-quality amino acid Glutamine helps to complement my diet.
7.5
Reduces stomach acid
The best advice for individuals with gastric ulcers. I woke up with excessive stomach acid during the night. Since using this, it has improved the visceral mucosa and smoothed the skin!
9
We examined the effects of Lachnum-derived polysaccharides, specifically a modified compound known as LAG, on gastric ulcers in mice. The study involved treating mice with acute ulcers using different doses of LAG and another polysaccharide, LEP2a.
Our findings revealed that both compounds significantly reduced gastric mucosal damage and inflammation. LAG showed greater effectiveness, improving antioxidant levels and reducing harmful inflammatory markers. Essentially, these polysaccharides help protect the stomach lining by tackling oxidative stress and inflammation.
Our findings revealed that both compounds significantly reduced gastric mucosal damage and inflammation. LAG showed greater effectiveness, improving antioxidant levels and reducing harmful inflammatory markers. Essentially, these polysaccharides help protect the stomach lining by tackling oxidative stress and inflammation.
8
We aimed to explore if alanyl-glutamine (AG), a special dipeptide known to support gut healing, can help treat ulcers caused by indomethacin in rats. In our study, we divided the rats into five groups to observe the effects of AG, with some receiving additional treatments.
The results revealed that AG helped raise the pH of gastric juice, much like pantoprazole did. However, while AG showed some beneficial effects, it was less effective in groups where dexamethasone was administered beforehand. Thus, the overall impact of AG, though promising, involves complexities that need further investigation.
The results revealed that AG helped raise the pH of gastric juice, much like pantoprazole did. However, while AG showed some beneficial effects, it was less effective in groups where dexamethasone was administered beforehand. Thus, the overall impact of AG, though promising, involves complexities that need further investigation.
8
We explored the protective effects of glutamine on stomach health amidst H. pylori infections in Mongolian gerbils. For three months, we provided a diet rich in glutamine or marzulene, another protective substance.
The results were promising; both glutamine and marzulene significantly reduced harmful changes in the stomach lining. They helped diminish ammonia buildup, a toxin related to ulcers, thereby enhancing cell survival and reducing inflammation.
Our findings suggest that glutamine could serve as a preventative treatment for those at risk of H. pylori-related gastric conditions.
The results were promising; both glutamine and marzulene significantly reduced harmful changes in the stomach lining. They helped diminish ammonia buildup, a toxin related to ulcers, thereby enhancing cell survival and reducing inflammation.
Our findings suggest that glutamine could serve as a preventative treatment for those at risk of H. pylori-related gastric conditions.
8
We explored the effects of early enteral feeding combined with glutamine supplementation in 12 major burn patients. By utilizing gastroscopic and gastric juice analysis, we discovered that this method was both safe and effective in preventing stress ulcers. Remarkably, no stress ulcers appeared after multiple excision surgeries. Additionally, around 86 percent of the observed gastric abnormalities resolved within two weeks. Overall, early feeding along with glutamine appears to significantly reduce the risk of stress ulcers in patients with severe thermal injuries.
8
We investigated how peptides from cattle abomasum help heal stomach damage in rats caused by aspirin. Over 22 days, we divided Wistar rats into groups—some received a control treatment while others got a native or heated extract of the abomasum after inducing mucosal damage.
Our findings revealed that both extracts significantly improved healing, reduced harmful substances in the blood, and normalized immune cell counts, indicating recovery. Rats treated with these extracts showed healthier stomach lining, with no signs of irritation. Overall, the abomasum extracts demonstrated promising antiulcer effects.
Our findings revealed that both extracts significantly improved healing, reduced harmful substances in the blood, and normalized immune cell counts, indicating recovery. Rats treated with these extracts showed healthier stomach lining, with no signs of irritation. Overall, the abomasum extracts demonstrated promising antiulcer effects.
References
- Zhang X, Liu D, Ye Z, Chen X, Chen H, et al. Gastroprotective effect of the Lachnum polysaccharide and polysaccharide-dipeptide conjugates against gastric ulcer. Food Chem Toxicol. 2023;174:113661. doi:10.1016/j.fct.2023.113661
- El-Lekawy AM, Abdallah DM, El-Abhar HS. Alanyl-glutamine Heals Indomethacin-induced Gastric Ulceration in Rats Via Antisecretory and Anti-apoptotic Mechanisms. J Pediatr Gastroenterol Nutr. 2019;69:710. doi:10.1097/MPG.0000000000002474
- Chernukha IM, Bogatyrev AN, Dydykin AS, Aslanova MA, Fedulova LV. [Effect of polypeptides isolated from cattle abomasum on stomach regenerative processes in rats]. Vopr Pitan. 2014;83:26.
- Amagase K, Nakamura E, Endo T, Hayashi S, Hasumura M, et al. New frontiers in gut nutrient sensor research: prophylactic effect of glutamine against Helicobacter pylori-induced gastric diseases in Mongolian gerbils. J Pharmacol Sci. 2010;112:25.
- Yan R, Sun Y, Sun R. [Early enteral feeding and supplement of glutamine prevent occurrence of stress ulcer following severe thermal injury]. Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1995;11:189.
- Tanaka H, Shuto K, Marumo H. Effect of N-acetyl-L-glutamine aluminum complex (KW-110), an antiulcer agent, on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats. Jpn J Pharmacol. 1982;32:307.
- Moriga M, Aono M, Murakami M, Uchino H. The role of gastric mucosal hexosamine in aspirin-induced ulcers. Gastroenterol Jpn. 1980;15:1.
- Li W, Wang Y, Wang Y, Yang C, Lu Z, et al. Recurrent intestinal ulcer with bloody stool for >10 years in an adolescent boy of 15 years: A case report. Medicine (Baltimore). 2023;102:e34096. doi:10.1097/MD.0000000000034096
- Brzozowski T, Konturek SJ, Sliwowski Z, Drozdowicz D, Zaczek M, et al. Role of L-arginine, a substrate for nitric oxide-synthase, in gastroprotection and ulcer healing. J Gastroenterol. 1997;32:442.
- Sukumar P, Loo A, Magur E, Nandi J, Oler A, et al. Dietary supplementation of nucleotides and arginine promotes healing of small bowel ulcers in experimental ulcerative ileitis. Dig Dis Sci. 1997;42:1530.
