NOW Supplements UC-II Type II Collagen

Collagen may alleviate knee OA symptoms

Possibly Effective

Based on 16 Researches

Simental-Mendía M, Ortega-Mata D, Acosta-Olivo CA, Simental-Mendía LE, Peña-Martínez VM, et al. Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials. Clin Exp Rheumatol. 2025;43:126. doi:10.55563/clinexprheumatol/kflfr5

We explored the effects of collagen-based supplements on knee osteoarthritis (OA) by analyzing data from 11 randomized controlled trials, involving 870 participants.

The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.

Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.

Life-changing supplement

Most Useful Review

164 people found this helpful

After enduring a debilitating neck injury for five years, I found only temporary relief through doctors prescribing NSAIDs. Learning about Type II collagen, I decided to try it. Just one week later, my pain ceased, and I experienced better sleep than I have in years. This has been a complete turnaround for me! If you are suffering from arthritis, I highly recommend trying this product.

Athlete’s Foot details

My sister and I have taken it for two months, and now our feet no longer hurt. We will continue to take it.

Autoimmune Disorder details

GSZD reduces RA symptoms effectively

Based on 7 Researches

Wei SJ, Zhang Q, Xiang YJ, Peng LY, Peng W, et al. decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF-κB signalling to suppress osteoclastogenesis. Pharm Biol. 2021;59:262. doi:10.1080/13880209.2021.1876100

We explored the effects of decoction (GSZD) on bone erosion linked to rheumatoid arthritis (RA) in a rat model. Our study involved various groups receiving either GSZD or standard treatments, monitoring changes in paw volume and arthritic severity.

The findings showed that GSZD significantly improved inflammatory symptoms and reduced joint tissue erosion. It decreased markers of osteoclasts and enhanced protective factors, suggesting promising potential for GSZD as a supplement in treating RA without pronounced adverse effects.

Therapeutic effect

Most Useful Review

27 people found this helpful

While marketed for cartilage strengthening, I utilise it for "relapsed polychondritis," an autoimmune disorder I've suffered from for six years. This disorder is caused by collagen type 2 producing autoantibodies. I've proven that UC-II acts therapeutically with my body, and I am nearly fully recovered but take it daily for prevention.

Chronic Cough details

Completely healthy now

1 people found this helpful

I like collagen and take it in courses with breaks. It's effective for my knee osteoarthritis. I’ve combined it with Boswellia, B vitamins, and Omega-3. After six years of chronic illness, I was restored in two years and now feel completely healthy. Supplements have become crucial for me. If my story helps you, I’m glad!

Cold details

It really works! My knees no longer fear the cold. It has become an essential item for me—I've come to rely on it completely!

Diabetes details

2 people found this helpful

An excellent form of collagen for joints. I have multiple spinal fractures and associated issues - protrusions, coxarthrosis, etc. I've tried numerous chondroprotectors in various forms for extended periods. Currently, these capsules are the best in my experience. Considering my type 2 diabetes mellitus, collagen is optimal, as glucosamine and chondroitin-based chondroprotectors worsen diabetes. A large package lasts for a lengthy course of four months. Overall, it turns out to be cost-effective. My order was well packaged and arrived safely in four weeks to Yekaterinburg. I would appreciate a like if this review was helpful to you. Thank you for your attention.

Multiple Sclerosis details

Painkiller elimination

I took this supplement for two months based on my rheumatologist's advice, alongside medicinal treatments and vitamin D (I have unspecified reactive arthropathy). The results have been remarkable; I've managed to completely stop using painkillers. However, it’s important to note that collagen might be detrimental if you have rheumatic conditions such as systemic scleroderma or systemic sclerosis. Therefore, consulting a doctor before use is essential.

Pelvic Pain details

266 people found this helpful

Amazing effect and results. For a long time, I struggled to find the right balance of collagen to support my joint tissues. This product has been a lifesaver. Within a month, my knees stopped hurting, and after two months, I forgot about the clicks in my knees and the internal "dryness." A friend with a knee injury also stopped experiencing pain after a month. Initially, I felt unusual in my stomach, but that went away after a few weeks.

Cardiovascular Disease details

Collagen source shows varying effectiveness

Based on 5 Researches

Liu H, Yang Y, Liu Y, Cui L, Fu L, et al. Various bioactive peptides in collagen hydrolysate from salmo salar skin and the combined inhibitory effects on atherosclerosis in vitro and in vivo. Food Res Int. 2022;157:111281. doi:10.1016/j.foodres.2022.111281

We explored the beneficial effects of collagen hydrolysate derived from salmon skin on atherosclerosis, a key contributor to cardiovascular diseases. The study showed that this collagen extract exhibits promising anti-inflammatory and antioxidant properties.

In tests with mice, it effectively reduced arterial thickening and plaque formation without side effects, comparable to the effects of aspirin. However, the results indicate that while collagen from salmon skin has potential, more research is needed before making definitive claims.

Joint restoration

Most Useful Review

8 people found this helpful

Type II collagen is crucial for joint health, involved in the structure of cartilage and intervertebral discs. With age, collagen decreases. This supplement aids in breaking down and regenerating collagen effectively, thus helping counter joint diseases. I take it on an empty stomach and have faced no side effects, with my knee pain now resolved.

Flu details

4 people found this helpful

Good day, purchasers! I ordered this collagen for my mother, who has serious knee issues with almost no joint fluid. While miracles are scarce, I remain hopeful! Thankfully, the pain has subsided a bit, making movement easier! I intend to buy more if it continues to help! I recommend this for early-stage arthrosis; the capsules are convenient and easy to swallow, even for the elderly. Best wishes for health!

Headache details

It’s effective. Taking it alongside glucosamine can enhance relief from knee headaches.

Frozen Shoulder details

Our father mentioned that not only did his knee joints feel less painful after use, but his shoulders also improved significantly. The product supplements the ingredients our joints lack, and the effect is commendable. It is suitable for all ages, does not affect eating habits, and the packaging is excellent.

Menopause details

Immediate improvement

Wonderful! Very high quality with good ingredients. I plan to order again for menopause as I have experienced an improvement in joint feelings, with an immediate effect.

Osteoporosis details

Beneficial for elderly

This product does wonders for my mum’s osteoporosis. She has experienced positive effects since taking it.

Constipation details

I truly appreciate these probiotics. Consuming nuts like cashews and peanuts typically leads to constipation for me, but since taking these probiotics alongside those nuts, I've not experienced any constipation issues.

High Cholesterol details

2 people found this helpful

The best product of its kind! I’ve tried many collagen brands, but NOW's is the most effective for me. Just 40 mg daily makes my knees flexible again, like oiling the joints. I also absorb Calcium and Magnesium from Aquamin’s seaweed better. No stomach irritation at all. I highly recommend this product for joint health.

Allergies details

No discomfort experienced

I bought this for my husband, who often suffered from knee pain, and since he’s been taking it, everything has normalised. He takes it in the morning on an empty stomach, and it hasn't caused him any allergies or discomfort. I recommend it for its reasonable price.

Kidney Stones details

Improved joint movement

It was effective. Due to overuse in marathons and triathlons, my meniscus was damaged, leading to joint discomfort. However, after continuing to take this, my joints have moved more smoothly for a year, and the excess fluid on my knees has decreased. Although not entirely cured, movement has gradually become easier. I particularly appreciate the improvement as it feels like a twofold benefit since my skin condition has also improved.

Rheumatoid Arthritis details

Sleep significantly improved

Based on 10 Researches

GSZD shows anti-RA potential

We investigated the effects of GSZD, a traditional decoction, on bone erosion in a rat model of rheumatoid arthritis. Fifty rats were divided into control and treatment groups. Over 21 days, those receiving GSZD showed improved signs of inflammation and reduced joint damage compared to controls.

Specifically, GSZD lowered osteoclast numbers and enhanced protective factors, indicating its potential as a treatment option for rheumatoid arthritis. This study suggests GSZD could serve as a valuable supplement in managing RA symptoms.

7.5

Knees stopped hurting

Most Useful Review

122 people found this helpful

I began taking collagen on my rheumatologist's advice due to my rheumatoid arthritis. After 10 days, my knees stopped hurting and my hands felt easier. While miracles don’t happen and damaged joints can't be restored, at least my mobility has improved. If you have joint pain, don’t delay treatment! I highly recommend it!

Sleep Apnea details

The quality of my sleep has greatly improved since starting this product, and I find the price very reasonable.

Tendonitis details

Notable tendon benefit

27 people found this helpful

I have tried nearly every supplement for healing tendonitis. However, this specific collagen type has been the only one providing significant benefits to the damaged tendon in my knee.

Chronic Fatigue Syndrome details

Excessive fatigue diminished

1 people found this helpful

After just a week, I already feel a difference; no longer do I experience excessive fatigue in my knee. I will continue taking it, hoping for further benefits, and I thank God I'm much better now!

Food Poisoning details

Significant progress observed

Now Foods UC-II Joint Health capsules have become my mother's favourite. This product provides undenatured type II collagen that supports healthy joints. After two months, my mother, who suffers from hip joint issues, has experienced significant improvement. I find the quality excellent and have started purchasing it regularly because of its effectiveness.

Knee Pain details

Collagen supplements improve knee pain

Possibly Effective

Based on 16 Researches

Genç AS, Yılmaz AK, Anıl B, Korkmaz Salkılıç E, Akdemir E, et al. The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study. BMC Musculoskelet Disord. 2025;26:17. doi:10.1186/s12891-024-08244-w

We investigated whether collagen supplements could ease pain and improve quality of life for patients with knee meniscus issues. This randomized, double-blind, placebo-controlled study involved 32 participants, half receiving collagen and half a placebo.

After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.

Surprisingly effective

Most Useful Review

25 people found this helpful

After a month of taking this supplement, the crunch and discomfort in my knees and injured elbow vanished. I noticed improvement in my lower back as well, which has a classic L3-L4 hernia. I was pleasantly surprised by this effect and will continue using it.

Nausea details

Initially, I experienced discomfort, but after some time eating, it improved significantly, and I felt no nausea! I have repurchased it a second time, and the effect is remarkable!

Acne details