Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
USERS' SCORE
Good
Based on 60 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Calcium (from Aquamin®)
80 mg
6%
UC-II® Standardized Chicken Cartilage(Providing 10 mg Total Collagen, including Undenatured Type II Collagen)
40 mg
†
Aquamin® (Seaweed Derived Minerals) (Lithothamnium spp.) (Whole Plant)
250 mg
†
Top Medical Research Studies
9
Collagen may alleviate knee OA symptoms
We explored the effects of collagen-based supplements on knee osteoarthritis (OA) by analyzing data from 11 randomized controlled trials, involving 870 participants.
The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.
Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.
Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
Read More
8
Collagen supplement benefits knee osteoarthritis
We conducted a robust multicenter, double-blind trial involving 212 patients with knee osteoarthritis to assess the effectiveness and safety of the Artneo complex, which contains undenatured type II collagen.
Participants were divided into two groups: one received the collagen supplement for 180 days, while the other was given a placebo. Our findings indicated a significant improvement in pain, quality of life, and reduction of NSAID use among those taking the collagen compared to the placebo group.
Overall, the study supports the use of Artneo collagen as a beneficial treatment for knee osteoarthritis.
Participants were divided into two groups: one received the collagen supplement for 180 days, while the other was given a placebo. Our findings indicated a significant improvement in pain, quality of life, and reduction of NSAID use among those taking the collagen compared to the placebo group.
Overall, the study supports the use of Artneo collagen as a beneficial treatment for knee osteoarthritis.
Read More
8
We conducted a thorough investigation into how collagen peptides can help alleviate knee joint osteoarthritis. Our double-blind, randomized clinical trial involved 100 participants and compared a new high-functional Type J bovine collagen against conventional collagen supplements over 90 days.
Participants reported improvements in pain levels, overall quality of life, and joint function. Notably, two doses of the new collagen were found to be just as effective as the standard treatment.
This exciting finding suggests that specific collagen supplements can provide meaningful benefits for those affected by osteoarthritis.
Participants reported improvements in pain levels, overall quality of life, and joint function. Notably, two doses of the new collagen were found to be just as effective as the standard treatment.
This exciting finding suggests that specific collagen supplements can provide meaningful benefits for those affected by osteoarthritis.
Read More
Most Useful Reviews
10
Life-changing supplement
164 people found this helpful
After enduring a debilitating neck injury for five years, I found only temporary relief through doctors prescribing NSAIDs. Learning about Type II collagen, I decided to try it. Just one week later, my pain ceased, and I experienced better sleep than I have in years. This has been a complete turnaround for me! If you are suffering from arthritis, I highly recommend trying this product.
Read More
9
Miraculous results
151 people found this helpful
NOW UC II has remarkably reduced my knee, hip, and shoulder pain! After numerous consultations and trying various treatments with no success, I started this product and saw a reduction in pain within two months. I initially thought the improvement came from another supplement, but when I stopped UC-II, my pain returned. Restarting it brought relief once again. It has restored my quality of life significantly.
Read More
10
Avoided surgery
46 people found this helpful
This product saved me from needing a knee replacement! I've suffered from severe arthritis in my left knee and had been walking with a cane for 23 years. After starting NOW UC11, I was sceptical but decided to try it. Within a week, the pain that was excruciating began to lessen. Two months later, my knee pain is gone, and I enjoy improved mobility. Coming from spending a fortune on CBD, the affordability of this product makes it a life changer.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
- All Researches
9
We looked into how BD400 could potentially help with collagen-induced arthritis (CIA) in rats. Using a model to mimic the disease, we observed that BD400 significantly reduced arthritis scores and paw swelling.
It also decreased harmful inflammatory markers and improved gut health by enhancing intestinal barrier function. Essentially, BD400 seems to help alter gut bacteria and metabolism, which may slow down the progression of rheumatoid arthritis.
It also decreased harmful inflammatory markers and improved gut health by enhancing intestinal barrier function. Essentially, BD400 seems to help alter gut bacteria and metabolism, which may slow down the progression of rheumatoid arthritis.
Read More
9
Collagen may alleviate knee OA symptoms
We explored the effects of collagen-based supplements on knee osteoarthritis (OA) by analyzing data from 11 randomized controlled trials, involving 870 participants.
The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.
Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.
Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
Read More
We evaluated how a nutritional supplement containing hydrolyzed collagen and other ingredients affects osteoarthritis (OA) pain. In a multicenter study involving 186 participants, we found that after 6 months, participants reported a significant decrease in pain and improved physical function. Specifically, scores on self-perceived pain and functional indices showed notable improvement, indicating that the supplement may effectively help manage OA symptoms. Importantly, the treatment was well-tolerated with no severe adverse events reported.
Read More
9
Collagen peptides may prevent osteoarthritis
We examined how collagen peptides derived from Atlantic salmon impact osteoarthritis development. Using both controlled laboratory conditions and an animal model, we observed that these peptides improve cartilage health by reducing inflammation and promoting collagen production.
The results indicated enhanced tolerance to pain in rats and decreases in inflammatory markers. Despite these positive findings, more research is needed to fully understand the mechanisms behind these benefits.
Overall, collagen peptides could be a promising dietary option for managing osteoarthritis.
The results indicated enhanced tolerance to pain in rats and decreases in inflammatory markers. Despite these positive findings, more research is needed to fully understand the mechanisms behind these benefits.
Overall, collagen peptides could be a promising dietary option for managing osteoarthritis.
Read More
We explored how a dietary supplement combining undenatured type II collagen and Boswellia Serrata affects dogs with mild to moderate osteoarthritis. In this thorough study, 60 dogs participated in a randomized, double-blind trial where they received either the supplement or a placebo for eight weeks.
Our findings showed that dogs receiving the collagen supplement reported improved mobility within just four weeks. This significant benefit highlights the potential of these supplements in enhancing joint health and managing pain. Without the supplement, however, the dogs faced heightened risk of pain crises and decreased mobility.
Our findings showed that dogs receiving the collagen supplement reported improved mobility within just four weeks. This significant benefit highlights the potential of these supplements in enhancing joint health and managing pain. Without the supplement, however, the dogs faced heightened risk of pain crises and decreased mobility.
Read More
User Reviews
USERS' SCORE
Good
Based on 60 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
10
Life-changing supplement
164 people found this helpful
After enduring a debilitating neck injury for five years, I found only temporary relief through doctors prescribing NSAIDs. Learning about Type II collagen, I decided to try it. Just one week later, my pain ceased, and I experienced better sleep than I have in years. This has been a complete turnaround for me! If you are suffering from arthritis, I highly recommend trying this product.
Read More
9
Miraculous results
151 people found this helpful
NOW UC II has remarkably reduced my knee, hip, and shoulder pain! After numerous consultations and trying various treatments with no success, I started this product and saw a reduction in pain within two months. I initially thought the improvement came from another supplement, but when I stopped UC-II, my pain returned. Restarting it brought relief once again. It has restored my quality of life significantly.
Read More
10
Avoided surgery
46 people found this helpful
This product saved me from needing a knee replacement! I've suffered from severe arthritis in my left knee and had been walking with a cane for 23 years. After starting NOW UC11, I was sceptical but decided to try it. Within a week, the pain that was excruciating began to lessen. Two months later, my knee pain is gone, and I enjoy improved mobility. Coming from spending a fortune on CBD, the affordability of this product makes it a life changer.
Read More
9
Impressive results
38 people found this helpful
I have severe arthritis in my finger joints, causing significant pain and stiffness. After trying a product featuring various types of collagen without success, I switched to NOW UC-II. Within a week, my pain and stiffness diminished. I can now perform tasks I couldn’t before, and the results are impressively satisfying.
Read More
9
Pain relief
26 people found this helpful
Life saver! I've been taking these for psoriatic arthritis for about six months, and it’s working nicely! I've been able to stop taking narcotic painkillers.
Read More
Frequently Asked Questions
9
Relief from joints
3 people found this helpful
I have rheumatoid arthritis, and this collagen is my saviour. After a month, my joints felt relief, and I strongly recommend it!
7.5
Mobility improvement noted
2 people found this helpful
I bought this collagen for my husband due to arthritis and limited joint mobility. After taking one tablet daily for a month alongside vitamin C and daily exercise therapy, he is now able to fasten his seatbelt independently, which he couldn’t do before.
7.5
Knee pain improvement
1 people found this helpful
My knee started to hurt due to degenerative arthritis. After using this product for two months paired with rehabilitation exercises, I’ve noticed substantial improvement.
9
Inflammation improved significantly
2 people found this helpful
The quality is excellent, and UC-II has substantially helped my knee joints. Following knee surgery that caused cartilage issues, I've experienced notable improvement in inflammation; I plan to continue using it.
10
Improved walking
1 people found this helpful
My 71-year-old mother, who has arthritis and knee pain, reports that she can walk without experiencing severe pain after using this product.
10
Significant relief
1 people found this helpful
Amazing for arthritis! This product has reduced the arthritis in my fingers by about 50%, which is such a relief!
9
Knee flexibility restored
This product has truly helped me regain my knees. Initially, I had significant discomfort and trouble standing after bending down. Although I’m over 40, I did not expect I’d be coping with arthritis! After trying this alongside UC-II, I regained flexibility in my knees. I truly believe this is due to these products and would recommend them to others.
0
No improvement noted
I have rheumatoid arthritis and feel there is absolutely no help.
10
Pain disappearance
1 people found this helpful
The pain from my ankle arthritis has vanished when used alongside MSM.
7.5
Improved mobility
1 people found this helpful
I've been taking this since iHerb stocked it. Just one a day helps my mobility as I have arthritis. I combine it with other joint supplements, such as glucosamine and celadrin, which keeps me walking with a stick instead of using a wheel-walker.
8
Collagen supplement benefits knee osteoarthritis
We conducted a robust multicenter, double-blind trial involving 212 patients with knee osteoarthritis to assess the effectiveness and safety of the Artneo complex, which contains undenatured type II collagen.
Participants were divided into two groups: one received the collagen supplement for 180 days, while the other was given a placebo. Our findings indicated a significant improvement in pain, quality of life, and reduction of NSAID use among those taking the collagen compared to the placebo group.
Overall, the study supports the use of Artneo collagen as a beneficial treatment for knee osteoarthritis.
Participants were divided into two groups: one received the collagen supplement for 180 days, while the other was given a placebo. Our findings indicated a significant improvement in pain, quality of life, and reduction of NSAID use among those taking the collagen compared to the placebo group.
Overall, the study supports the use of Artneo collagen as a beneficial treatment for knee osteoarthritis.
9
Collagen may alleviate knee OA symptoms
We explored the effects of collagen-based supplements on knee osteoarthritis (OA) by analyzing data from 11 randomized controlled trials, involving 870 participants.
The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.
Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
The findings demonstrated that those taking collagen experienced significant improvements in both function and pain scores compared to a placebo group.
Specifically, results indicated an average reduction in pain and improved functionality, suggesting that collagen supplementation can be beneficial for managing OA symptoms.
8
We explored the effects of oral chicken collagen supplements on arthritis in a study with Wistar rats.
The results showed that various forms of collagen significantly reduced pain sensitivity and cartilage damage linked to osteoarthritis.
Particularly, the protease-soluble type II collagen (PSCC-II) proved to be effective in improving bone health and reducing inflammation, showing better results compared to untreated rats.
Overall, this study suggests that collagen supplements could offer promising benefits for arthritis management.
The results showed that various forms of collagen significantly reduced pain sensitivity and cartilage damage linked to osteoarthritis.
Particularly, the protease-soluble type II collagen (PSCC-II) proved to be effective in improving bone health and reducing inflammation, showing better results compared to untreated rats.
Overall, this study suggests that collagen supplements could offer promising benefits for arthritis management.
7
We examined the impact of daily collagen peptide (CP) supplementation on pain, functionality, and mental health in middle-aged active adults over a period of 6 to 9 months. Conducting a double-blind randomized control trial, we found that 10 grams of CP daily helped improve daily activities and pain in high-frequency exercisers.
Additionally, mental health scores improved significantly with 10 grams over the entire duration, while physical health scores improved for women taking 20 grams over 3 to 9 months. Overall, collagen supplementation showed promising benefits in enhancing both physical and mental well-being.
Additionally, mental health scores improved significantly with 10 grams over the entire duration, while physical health scores improved for women taking 20 grams over 3 to 9 months. Overall, collagen supplementation showed promising benefits in enhancing both physical and mental well-being.
References
- Yang Y, Hong Q, Zhang X, Liu Z. BD400 protects from collagen-induced arthritis through histidine metabolism. Front Immunol. 2025;16:1518181. 10.3389/fimmu.2025.1518181
- Genç AS, Yılmaz AK, Anıl B, Korkmaz Salkılıç E, Akdemir E, et al. Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study. Jt Dis Relat Surg. 2025;36:85. 10.52312/jdrs.2025.1965
- Stabile M, Fracassi L, Lacitignola L, Garcia-Pedraza E, Girelli CR, et al. Effects of a feed supplement, containing undenatured type II collagen (UC II®) and Boswellia Serrata, in the management of mild/moderate mobility disorders in dogs: A randomized, double-blind, placebo controlled, cross-over study. PLoS One. 2024;19:e0305697. 10.1371/journal.pone.0305697
- Dobenecker B, Böswald LF, Reese S, Steigmeier-Raith S, Trillig L, et al. The oral intake of specific Bioactive Collagen Peptides (BCP) improves gait and quality of life in canine osteoarthritis patients-A translational large animal model for a nutritional therapy option. PLoS One. 2024;19:e0308378. 10.1371/journal.pone.0308378
- Simental-Mendía M, Ortega-Mata D, Acosta-Olivo CA, Simental-Mendía LE, Peña-Martínez VM, et al. Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials. Clin Exp Rheumatol. 2025;43:126. 10.55563/clinexprheumatol/kflfr5
- Zhao Q, Li Z, Liu Z, Zhao X, Fan Y, et al. Preparation, typical structural characteristics and relieving effects on osteoarthritis of squid cartilage type II collagen peptides. Food Res Int. 2024;191:114697. 10.1016/j.foodres.2024.114697
- Yu M, Park C, Son YB, Jo SE, Jeon SH, et al. Time-Dependent Effect of Eggshell Membrane on Monosodium-Iodoacetate-Induced Osteoarthritis: Early-Stage Inflammation Control and Late-Stage Cartilage Protection. Nutrients. 2024;16. 10.3390/nu16121885
- Alekseeva LI, Kashevarova NG, Taskina EA, Strebkova EA, Korotkova TA, et al. [Efficacy and safety of undenatured type II collagen in patients with knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial]. Ter Arkh. 2024;96:500. 10.26442/00403660.2024.05.202788
- Devasia S, Joseph JT, P S S, Koizumi S, Clarke L, et al. Management and Amelioration of Knee Joint Osteoarthritis in Adults Using a Novel High-Functional Bovine Collagen Peptide as a Nutritional Therapy: A Double-Blind, Prospective, Multicentric, Randomized, Active and Placebo Controlled, Five-Arm, Clinical Study to Evaluate the Efficacy, Safety, and Tolerability. Cartilage. 2024;15:363. 10.1177/19476035231221211
- Puigdellívol Grifell J, Comellas Berenguer C, Steinbacher G, Kranjcec T, Álvarez Díaz P, et al. Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction. J Diet Suppl. 2024;21:374. 10.1080/19390211.2023.2284982
- Thomas DT, Prabhakar AJ, Eapen C, Patel VD, Palaniswamy V, et al. Comparison of Single and Combined Treatment with Exercise Therapy and Collagen Supplementation on Early Knee Arthritis among Athletes-A Quasi-Randomized Trial. Int J Environ Res Public Health. 2023;20. 10.3390/ijerph20237088
- Chen NF, Lin YY, Yao ZK, Tseng CC, Liu YW, et al. Oral Administration of Protease-Soluble Chicken Type II Collagen Ameliorates Anterior Cruciate Ligament Transection-Induced Osteoarthritis in Rats. Nutrients. 2023;15. 10.3390/nu15163589
- Kviatkovsky SA, Hickner RC, Cabre HE, Small SD, Ormsbee MJ. Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults. J Int Soc Sports Nutr. 2023;20:2243252. 10.1080/15502783.2023.2243252
- Kwon SB, Chinta G, Kundimi S, Kim S, Cho YD, et al. A Blend of and Extracts Alleviates Monosodium Iodoacetate (MIA)-Induced Osteoarthritic Pain and Joint Inflammation in Rats. J Am Nutr Assoc. 2024;43:48. 10.1080/27697061.2023.2209880
- Chen CC, Chang SS, Chang CH, Hu CC, Nakao Y, et al. Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions. Nutr J. 2023;22:17. 10.1186/s12937-023-00837-w
- Luo X, Liu W, Zhao M, Liu T, Xiong F, et al. A novel Atlantic salmon (Salmo salar) bone collagen peptide delays osteoarthritis development by inhibiting cartilage matrix degradation and anti-inflammatory. Food Res Int. 2022;162:112148. 10.1016/j.foodres.2022.112148
