' 
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.3
USERS' SCORE
Good
Based on 35 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Calcium (from Aquamin®)
80 mg
6%
UC-II® Standardized Chicken Cartilage(Providing 10 mg Total Collagen, including Undenatured Type II Collagen)
40 mg
†
Aquamin® (Seaweed Derived Minerals) (Lithothamnium spp.) (Whole Plant)
250 mg
†
Top Medical Research Studies
9
GSZD reduces RA symptoms effectively
decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF-κB signalling to suppress osteoclastogenesis.
Study shows strong treatment potential.
We explored the effects of decoction (GSZD) on bone erosion linked to rheumatoid arthritis (RA) in a rat model. Our study involved various groups receiving either GSZD or standard treatments, monitoring changes in paw volume and arthritic severity.
The findings showed that GSZD significantly improved inflammatory symptoms and reduced joint tissue erosion. It decreased markers of osteoclasts and enhanced protective factors, suggesting promising potential for GSZD as a supplement in treating RA without pronounced adverse effects.
The findings showed that GSZD significantly improved inflammatory symptoms and reduced joint tissue erosion. It decreased markers of osteoclasts and enhanced protective factors, suggesting promising potential for GSZD as a supplement in treating RA without pronounced adverse effects.
Read More
8
Rosa multiflora extract reduces arthritis
Petroleum ether extractive of the hips of Rosa multiflora ameliorates collagen-induced arthritis in rats.
Moderate relevance for arthritis treatment
We investigated the efficacy of a petroleum ether extract from the hips of Rosa multiflora in treating collagen-induced arthritis in rats. The study used a control group, treated with various doses of the extract, and compared it against a well-known medication.
The results showed that the highest dose effectively reduced arthritis severity and paw swelling. It also appeared to inhibit inflammation markers and boost antioxidant enzyme levels. However, the precise mechanisms of how the extract works and its key components need further research.
The results showed that the highest dose effectively reduced arthritis severity and paw swelling. It also appeared to inhibit inflammation markers and boost antioxidant enzyme levels. However, the precise mechanisms of how the extract works and its key components need further research.
Read More
8
CCFM1074 benefits arthritis management
CCFM1074 Alleviates Collagen-Induced Arthritis in Rats Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota.
Findings relevant to autoimmune research
We assessed the effects of collagen supplements, specifically strain CCFM1074, on arthritis in rats. This study utilized a robust method that examined the immune responses, gut microbiota, and various metabolites.
Our findings revealed that CCFM1074 successfully reduced symptoms of arthritis, enhancing beneficial immune responses while modulating gut microbiota and metabolites. Meanwhile, another strain, CCFM1075, did not show significant benefits.
Overall, CCFM1074 appears to balance immune functions and improve gut health, suggesting its potential role in managing autoimmune disorders.
Our findings revealed that CCFM1074 successfully reduced symptoms of arthritis, enhancing beneficial immune responses while modulating gut microbiota and metabolites. Meanwhile, another strain, CCFM1075, did not show significant benefits.
Overall, CCFM1074 appears to balance immune functions and improve gut health, suggesting its potential role in managing autoimmune disorders.
Read More
Most Useful Reviews
9.5
Therapeutic effect
While marketed for cartilage strengthening, I utilise it for "relapsed polychondritis," an autoimmune disorder I've suffered from for six years. This disorder is caused by collagen type 2 producing autoantibodies. I've proven that UC-II acts therapeutically with my body, and I am nearly fully recovered but take it daily for prevention.
Read More
9.5
Parents feel great
Great collagen for joints and more! I ordered it with glucosamine and hyaluronic acid to support my parents' joint health. Prior to this, my mother had taken collagen types 1 and 3. Since starting this supplement, they've experienced no side effects and are very pleased with the improvement; their stiffness has vanished and they feel fantastic!
Read More
9.5
Highly effective
I have suffered from knee degeneration for years and tried many glucosamine and collagen supplements. None have been as effective as Now Food UC-II. I will definitely re-order this product.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.3
- All Researches
9
BD400 may alleviate rheumatoid arthritis
BD400 protects from collagen-induced arthritis through histidine metabolism.
Significant findings with autoimmune application.
We explored how the collagen supplement BD400 affects rheumatoid arthritis (RA) using a collagen-induced arthritis rat model.
Our findings indicated that BD400 significantly reduced arthritis symptoms, including joint swelling and inflammation. It also positively influenced gut health by restoring intestinal permeability and altering gut microbiota composition.
Ultimately, our study suggests that BD400 can slow the progression of RA by down-regulating certain inflammatory factors and enhancing gut barrier function, presenting an interesting potential for autoimmune disorder management.
Our findings indicated that BD400 significantly reduced arthritis symptoms, including joint swelling and inflammation. It also positively influenced gut health by restoring intestinal permeability and altering gut microbiota composition.
Ultimately, our study suggests that BD400 can slow the progression of RA by down-regulating certain inflammatory factors and enhancing gut barrier function, presenting an interesting potential for autoimmune disorder management.
Read More
9
GSZD reduces RA symptoms effectively
decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF-κB signalling to suppress osteoclastogenesis.
Study shows strong treatment potential.
We explored the effects of decoction (GSZD) on bone erosion linked to rheumatoid arthritis (RA) in a rat model. Our study involved various groups receiving either GSZD or standard treatments, monitoring changes in paw volume and arthritic severity.
The findings showed that GSZD significantly improved inflammatory symptoms and reduced joint tissue erosion. It decreased markers of osteoclasts and enhanced protective factors, suggesting promising potential for GSZD as a supplement in treating RA without pronounced adverse effects.
The findings showed that GSZD significantly improved inflammatory symptoms and reduced joint tissue erosion. It decreased markers of osteoclasts and enhanced protective factors, suggesting promising potential for GSZD as a supplement in treating RA without pronounced adverse effects.
Read More
8
CCFM1074 benefits arthritis management
CCFM1074 Alleviates Collagen-Induced Arthritis in Rats Balancing Treg/Th17 and Modulating the Metabolites and Gut Microbiota.
Findings relevant to autoimmune research
We assessed the effects of collagen supplements, specifically strain CCFM1074, on arthritis in rats. This study utilized a robust method that examined the immune responses, gut microbiota, and various metabolites.
Our findings revealed that CCFM1074 successfully reduced symptoms of arthritis, enhancing beneficial immune responses while modulating gut microbiota and metabolites. Meanwhile, another strain, CCFM1075, did not show significant benefits.
Overall, CCFM1074 appears to balance immune functions and improve gut health, suggesting its potential role in managing autoimmune disorders.
Our findings revealed that CCFM1074 successfully reduced symptoms of arthritis, enhancing beneficial immune responses while modulating gut microbiota and metabolites. Meanwhile, another strain, CCFM1075, did not show significant benefits.
Overall, CCFM1074 appears to balance immune functions and improve gut health, suggesting its potential role in managing autoimmune disorders.
Read More
8
CoQ10 nanoparticles reduce arthritis symptoms
Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting.
High relevance for autoimmune treatment
We examined the anti-inflammatory properties of liposome/gold hybrid nanoparticles that contain Coenzyme Q10 (LGNP-CoQ10) in a model of rheumatoid arthritis in mice. Over 10 weeks, we treated the mice with LGNP-CoQ10 and noted that it significantly reduced inflammation and levels of specific pro-inflammatory factors.
Moreover, the treatment showed a decrease in pro-inflammatory cell populations, indicating a reduced inflammatory response that could benefit those suffering from rheumatoid arthritis. Our findings highlight the promising therapeutic potential of LGNP-CoQ10 in managing inflammatory autoimmune disorders.
Moreover, the treatment showed a decrease in pro-inflammatory cell populations, indicating a reduced inflammatory response that could benefit those suffering from rheumatoid arthritis. Our findings highlight the promising therapeutic potential of LGNP-CoQ10 in managing inflammatory autoimmune disorders.
Read More
8
Hsp65 shows promise for arthritis
Hsp65-Producing Prevents Antigen-Induced Arthritis in Mice.
High relevance for autoimmune disease
We explored how Hsp65, a protein delivered by beneficial bacteria, can help prevent arthritis in mice. In our study, continuous delivery in the gut led to the creation of regulatory T cells that successfully blocked the onset of arthritis. We observed reduced clinical signs of arthritis and lower inflammation markers, like IL-17 and anti-collagen antibodies. This approach appears to modify gut bacteria and enhance immune tolerance, suggesting Hsp65 could potentially be a new tool for treating autoimmune diseases.
Read More
User Reviews
USERS' SCORE
Good
Based on 35 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Therapeutic effect
While marketed for cartilage strengthening, I utilise it for "relapsed polychondritis," an autoimmune disorder I've suffered from for six years. This disorder is caused by collagen type 2 producing autoantibodies. I've proven that UC-II acts therapeutically with my body, and I am nearly fully recovered but take it daily for prevention.
Read More
9.5
Parents feel great
Great collagen for joints and more! I ordered it with glucosamine and hyaluronic acid to support my parents' joint health. Prior to this, my mother had taken collagen types 1 and 3. Since starting this supplement, they've experienced no side effects and are very pleased with the improvement; their stiffness has vanished and they feel fantastic!
Read More
9.5
Highly effective
I have suffered from knee degeneration for years and tried many glucosamine and collagen supplements. None have been as effective as Now Food UC-II. I will definitely re-order this product.
9.5
Improved running
Excellent product! I was an elite middle-distance runner but struggled since I turned 40. I had noticeable creaking in my knees, especially when going up and down stairs. After trying various supplements, I started taking this collagen almost two years ago. Within a month, the creaking ceased, and my running gait is much improved. Although I'm not as fast as before, I'm certainly enjoying running again.
Read More
9.5
Elasticity and relief
I am ordering for the second time. Initially persuaded by a friend, I experienced remarkable results by the end of the first course—I felt as if I were jumping with agility! My joints gained elasticity, stopped cracking, and the painful knee discomfort diminished in cold weather. After a year, I decided to repeat the course. I noted no discomfort during use, and the effects seem to accumulate over time. My co-workers, inspired by my experience, have also chosen to order this product. I highly recommend it!
Read More
