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NOW Supplements UC-II Type II Collagen
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 58 Reviews
8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Calcium (from Aquamin®)
80 mg
6%
UC-II® Standardized Chicken Cartilage(Providing 10 mg Total Collagen, including Undenatured Type II Collagen)
40 mg
Aquamin® (Seaweed Derived Minerals) (Lithothamnium spp.) (Whole Plant)
250 mg

Top Medical Research Studies

8
Collagen supplements improve knee pain
The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study.
Study shows positive initial results
We investigated whether collagen supplements could ease pain and improve quality of life for patients with knee meniscus issues. This randomized, double-blind, placebo-controlled study involved 32 participants, half receiving collagen and half a placebo.

After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
Read More
8
Collagen peptides effectively reduce knee pain
Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides.
Significant improvement in knee pain
We investigated the effects of specific collagen peptides on knee pain in athletes experiencing functional issues. Over 12 weeks, 139 participants took either 5 g of these peptides or a placebo daily.

Participants reported a noticeable reduction in activity-related pain, which was confirmed by physicians.

While resting pain also improved, it wasn't statistically significant. Additionally, those taking collagen needed fewer additional treatments. Overall, collagen peptides appear to be an effective option for managing knee pain during physical activity.
Read More
9
Collagen reduces knee osteoarthritis pain
Oral Administration of Protease-Soluble Chicken Type II Collagen Ameliorates Anterior Cruciate Ligament Transection-Induced Osteoarthritis in Rats.
Strong relevance for knee pain
This study set out to determine if oral collagen supplements could help treat knee pain linked to osteoarthritis caused by ACL injury in rats.

We found that different types of collagen, especially the protease-soluble chicken type II collagen, not only reduced pain sensitivity but also improved cartilage health.

Rats given collagen showed significant improvements compared to those who didn't receive it, leading to better joint function and less inflammation.

Overall, collagen treatment appears beneficial for managing knee pain related to osteoarthritis.
Read More

Most Useful Reviews

9.5
Surprisingly effective
After a month of taking this supplement, the crunch and discomfort in my knees and injured elbow vanished. I noticed improvement in my lower back as well, which has a classic L3-L4 hernia. I was pleasantly surprised by this effect and will continue using it.
Read More
9.5
Effective prevention drug
A good product, particularly for prevention. My knee has stopped hurting.
Read More
9
Knee pain relief
I waited before writing this. After a month of taking it, I've noticed that the ache in my knees has not returned. A few years ago, I tore tendons in both knees and tried glucosamine after physiotherapy, but it didn't help much. However, Type II Collagen seems to make my joints more supple and ready for action.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
  • All Researches
9
Collagen supplement reduces knee pain
Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction.
Promising for osteoarthritis management
We investigated the effects of a dietary supplement containing hydrolyzed collagen, chondroitin sulfate, glucosamine, turmeric extract, and devil's claw on knee pain and function in osteoarthritis patients.

In a study with 186 participants over six months, they reported a significant decrease in pain and improved joint function. Measures showed noticeable pain relief at both three and six months, as well as enhancements in overall functioning.

Comfortingly, there were no severe side effects noted during the observation period.
Read More
9
Collagen reduces knee osteoarthritis pain
Oral Administration of Protease-Soluble Chicken Type II Collagen Ameliorates Anterior Cruciate Ligament Transection-Induced Osteoarthritis in Rats.
Strong relevance for knee pain
This study set out to determine if oral collagen supplements could help treat knee pain linked to osteoarthritis caused by ACL injury in rats.

We found that different types of collagen, especially the protease-soluble chicken type II collagen, not only reduced pain sensitivity but also improved cartilage health.

Rats given collagen showed significant improvements compared to those who didn't receive it, leading to better joint function and less inflammation.

Overall, collagen treatment appears beneficial for managing knee pain related to osteoarthritis.
Read More
8
Collagen supplements improve knee pain
The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study.
Study shows positive initial results
We investigated whether collagen supplements could ease pain and improve quality of life for patients with knee meniscus issues. This randomized, double-blind, placebo-controlled study involved 32 participants, half receiving collagen and half a placebo.

After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
Read More
8
Collagen shows promise for knee pain
Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study.
High relevance due to credible structure
This clinical study aimed to evaluate how collagen supplements might ease knee pain related to osteoarthritis.

We involved 31 participants in a controlled setting, comparing those taking collagen with a placebo group over eight weeks.

The findings indicated that collagen supplementation led to improvements in pain levels and quality of life. Some aspects of physical function also showed positive changes, highlighting collagen's potential benefits for those suffering from knee issues.
Read More
8
NXT15906F6 helps reduce knee pain
A Blend of and Extracts Alleviates Monosodium Iodoacetate (MIA)-Induced Osteoarthritic Pain and Joint Inflammation in Rats.
Key findings on knee pain treatment.
We conducted a study to see how effective a herbal supplement, NXT15906F6 (also known as TamaFlex), is in reducing knee pain and joint inflammation, specifically in a rat model of osteoarthritis. The rats were divided into groups and received either this supplement or a standard medication called Celecoxib over 28 days.

Post-treatment results revealed that NXT15906F6 significantly decreased joint pain and inflammation, while also improving the overall joint condition. The study showed promising signs by reducing harmful proteins that can cause joint damage. This suggests that NXT15906F6 could be a beneficial option for managing knee pain more effectively.
Read More

User Reviews

USERS' SCORE
Good
Based on 58 Reviews
8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9.5
Surprisingly effective
After a month of taking this supplement, the crunch and discomfort in my knees and injured elbow vanished. I noticed improvement in my lower back as well, which has a classic L3-L4 hernia. I was pleasantly surprised by this effect and will continue using it.
9.5
Effective prevention drug
A good product, particularly for prevention. My knee has stopped hurting.
9
Knee pain relief
I waited before writing this. After a month of taking it, I've noticed that the ache in my knees has not returned. A few years ago, I tore tendons in both knees and tried glucosamine after physiotherapy, but it didn't help much. However, Type II Collagen seems to make my joints more supple and ready for action.
Read More
9.5
Improved discomfort
I’ve repurchased this product numerous times. My mother’s knee discomfort improved significantly after taking it. The small capsules are convenient to swallow, making it a very good product overall.
9.5
Quick results
After taking glucosamine, the discomfort in my knees persisted, but after a little over a week, it vanished. I'm very pleased with the results.
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