' 
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A(60% as Beta-Carotene and 40% from Fish Liver Oil)
7,500 mcg
833%
Vitamin D3(as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
Top Medical Research Studies
9
Vitamin A and allergy management
Retinoic Acid (RA): A Critical Immunoregulatory Molecule in Asthma and Allergies.
Direct effect on allergies discussed
Our exploration into the effects of vitamin A, particularly its active form known as retinoic acid, revealed some interesting insights regarding allergies. Vitamin A plays a key role in our immune system by helping to regulate immune responses, which is crucial for managing allergic reactions.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
Read More
9
Vitamin A shows promise for allergies
Mould allergen Alt a 1 spiked with the micronutrient retinoic acid reduces Th2 response and ameliorates Alternaria allergy in BALB/c mice.
Highly relevant to allergy treatment
We investigated the effects of retinoic acid (RA), a form of vitamin A, on allergies, particularly focusing on the mould allergen Alt a 1. By examining how RA interacts with this allergen, we aimed to understand if it could help alleviate allergic reactions.
Our study involved assessing the RA and Alt a 1 complex in various settings, including lab tests with immune cells from individuals allergic to Alternaria, and experiments using sensitized mice. We found that when Alt a 1 was bound to RA, it significantly decreased certain immune responses associated with allergies, particularly the release of a key marker called IL-13 from immune cells.
Interestingly, this RA complex reduced the allergen's ability to bind to IgE, the antibody responsible for allergic reactions, suggesting that RA may mask allergic triggers. In our mouse experiments, those treated with the RA-bound allergen had fewer severe allergic reactions compared to those treated with the regular allergen.
Overall, our findings point towards the potential of using RA in therapies aimed at managing Alternaria allergies, suggesting a new, promising strategy for enhancing allergic immunotherapy.
Our study involved assessing the RA and Alt a 1 complex in various settings, including lab tests with immune cells from individuals allergic to Alternaria, and experiments using sensitized mice. We found that when Alt a 1 was bound to RA, it significantly decreased certain immune responses associated with allergies, particularly the release of a key marker called IL-13 from immune cells.
Interestingly, this RA complex reduced the allergen's ability to bind to IgE, the antibody responsible for allergic reactions, suggesting that RA may mask allergic triggers. In our mouse experiments, those treated with the RA-bound allergen had fewer severe allergic reactions compared to those treated with the regular allergen.
Overall, our findings point towards the potential of using RA in therapies aimed at managing Alternaria allergies, suggesting a new, promising strategy for enhancing allergic immunotherapy.
Read More
9
9cisRA alters dendritic cell function
9-cis-Retinoic acid induces a distinct regulatory dendritic cell phenotype that modulates murine delayed-type allergy.
Moderate relevance in allergy treatment
We explored the impact of 9-cis-retinoic acid (9cisRA) on dendritic cells and their role in handling delayed-type allergies, particularly in hand eczema. Through our investigation, we found that 9cisRA creates a unique type of dendritic cell that plays a crucial part in reducing allergic responses.
These modified cells were shown to promote the formation of regulatory T cells, which help calm inflammation. However, while 9cisRA aids in adjusting immune responses, the study reveals these effects may not be strong enough to significantly improve allergic conditions on their own.
These modified cells were shown to promote the formation of regulatory T cells, which help calm inflammation. However, while 9cisRA aids in adjusting immune responses, the study reveals these effects may not be strong enough to significantly improve allergic conditions on their own.
Read More
Most Useful Reviews
10
Zero allergy symptoms
I experience allergies unexpectedly throughout the year, manifesting as sneezing and a runny nose. During allergy season, I take one of these in the morning and one at night, resulting in complete symptom relief. I can’t be without it.
Read More
8.8
Positive effect
I enjoyed the product from NOW Foods. The package includes 100 capsules, sufficient for 3.5 months, as we took 1 capsule daily. It contains Vitamin A from fish liver and 1000 units of Vitamin D. It did not trigger any allergies. My son took it for acne, and combined with other treatments, the rashes reduced significantly. The effect has been positive, and the quality is excellent.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
- All Researches
9.5
Effective immunotherapy for food allergies
Therapeutic reversal of food allergen sensitivity by mature retinoic acid-differentiated dendritic cell induction of LAG3CD49bFoxp3 regulatory T cells.
High relevance due to findings
We assessed whether dendritic cell immunotherapy could potentially reverse food allergy sensitivities in mouse models. By using mature retinoic acid-stimulated dendritic cells, we aimed to see if they could induce regulatory T cells that help manage allergic responses.
The results were promising, showing an impressive reduction in anaphylactic reactions to allergens by up to 90%, alongside other beneficial effects. This suggests that such treatments could be valuable in clinical settings for promoting tolerance in food allergies, particularly through the creation of Foxp3 regulatory T cells.
The results were promising, showing an impressive reduction in anaphylactic reactions to allergens by up to 90%, alongside other beneficial effects. This suggests that such treatments could be valuable in clinical settings for promoting tolerance in food allergies, particularly through the creation of Foxp3 regulatory T cells.
Read More
9
Vitamin A and allergy management
Retinoic Acid (RA): A Critical Immunoregulatory Molecule in Asthma and Allergies.
Direct effect on allergies discussed
Our exploration into the effects of vitamin A, particularly its active form known as retinoic acid, revealed some interesting insights regarding allergies. Vitamin A plays a key role in our immune system by helping to regulate immune responses, which is crucial for managing allergic reactions.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
Research indicates that retinoic acid can promote the development of regulatory T cells, which are essential for maintaining balance in our immune system. These T cells help to suppress excessive immune responses that can lead to allergies. Additionally, they assist in managing inflammatory responses, which is particularly important for conditions like asthma and allergic reactions.
Notably, studies have shown that levels of retinoic acid are often lower in individuals suffering from asthma and allergies. Moreover, introducing retinoic acid as a treatment has been found to alleviate symptoms associated with allergies and reduce airway inflammation. This suggests that boosting retinoic acid levels in the body might be a promising therapeutic approach for those dealing with allergic conditions.
Overall, we conclude that vitamin A—through its derivative retinoic acid—holds significant potential for improving allergy management by enhancing immune regulation.
Read More
9
Vitamin A shows promise for allergies
Mould allergen Alt a 1 spiked with the micronutrient retinoic acid reduces Th2 response and ameliorates Alternaria allergy in BALB/c mice.
Highly relevant to allergy treatment
We investigated the effects of retinoic acid (RA), a form of vitamin A, on allergies, particularly focusing on the mould allergen Alt a 1. By examining how RA interacts with this allergen, we aimed to understand if it could help alleviate allergic reactions.
Our study involved assessing the RA and Alt a 1 complex in various settings, including lab tests with immune cells from individuals allergic to Alternaria, and experiments using sensitized mice. We found that when Alt a 1 was bound to RA, it significantly decreased certain immune responses associated with allergies, particularly the release of a key marker called IL-13 from immune cells.
Interestingly, this RA complex reduced the allergen's ability to bind to IgE, the antibody responsible for allergic reactions, suggesting that RA may mask allergic triggers. In our mouse experiments, those treated with the RA-bound allergen had fewer severe allergic reactions compared to those treated with the regular allergen.
Overall, our findings point towards the potential of using RA in therapies aimed at managing Alternaria allergies, suggesting a new, promising strategy for enhancing allergic immunotherapy.
Our study involved assessing the RA and Alt a 1 complex in various settings, including lab tests with immune cells from individuals allergic to Alternaria, and experiments using sensitized mice. We found that when Alt a 1 was bound to RA, it significantly decreased certain immune responses associated with allergies, particularly the release of a key marker called IL-13 from immune cells.
Interestingly, this RA complex reduced the allergen's ability to bind to IgE, the antibody responsible for allergic reactions, suggesting that RA may mask allergic triggers. In our mouse experiments, those treated with the RA-bound allergen had fewer severe allergic reactions compared to those treated with the regular allergen.
Overall, our findings point towards the potential of using RA in therapies aimed at managing Alternaria allergies, suggesting a new, promising strategy for enhancing allergic immunotherapy.
Read More
9
9cisRA alters dendritic cell function
9-cis-Retinoic acid induces a distinct regulatory dendritic cell phenotype that modulates murine delayed-type allergy.
Moderate relevance in allergy treatment
We explored the impact of 9-cis-retinoic acid (9cisRA) on dendritic cells and their role in handling delayed-type allergies, particularly in hand eczema. Through our investigation, we found that 9cisRA creates a unique type of dendritic cell that plays a crucial part in reducing allergic responses.
These modified cells were shown to promote the formation of regulatory T cells, which help calm inflammation. However, while 9cisRA aids in adjusting immune responses, the study reveals these effects may not be strong enough to significantly improve allergic conditions on their own.
These modified cells were shown to promote the formation of regulatory T cells, which help calm inflammation. However, while 9cisRA aids in adjusting immune responses, the study reveals these effects may not be strong enough to significantly improve allergic conditions on their own.
Read More
9
Encapsulated vitamin A improves immunity
Liposome encapsulated all trans retinoic acid (ATRA) has enhanced immunomodulatory and inflammation reducing activities in mice model.
High relevance for immunotherapy
We explored the effects of all trans retinoic acid (ATRA), a form of vitamin A, on the immune system and inflammation using a mice model. Encapsulating ATRA in liposomes improved its effectiveness compared to free ATRA.
Our findings revealed that both forms increased immune responses, but the encapsulated version showed stronger immunostimulatory and anti-inflammatory effects. This was demonstrated through various parameters, like antibody levels and responses to inflammation. While both types showed benefits, liposome-encapsulated ATRA emerged as the superior option in managing immune and inflammatory conditions in the studied mice.
Our findings revealed that both forms increased immune responses, but the encapsulated version showed stronger immunostimulatory and anti-inflammatory effects. This was demonstrated through various parameters, like antibody levels and responses to inflammation. While both types showed benefits, liposome-encapsulated ATRA emerged as the superior option in managing immune and inflammatory conditions in the studied mice.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Zero allergy symptoms
I experience allergies unexpectedly throughout the year, manifesting as sneezing and a runny nose. During allergy season, I take one of these in the morning and one at night, resulting in complete symptom relief. I can’t be without it.
8.8
Positive effect
I enjoyed the product from NOW Foods. The package includes 100 capsules, sufficient for 3.5 months, as we took 1 capsule daily. It contains Vitamin A from fish liver and 1000 units of Vitamin D. It did not trigger any allergies. My son took it for acne, and combined with other treatments, the rashes reduced significantly. The effect has been positive, and the quality is excellent.
Read More
