' 
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A(60% as Beta-Carotene and 40% from Fish Liver Oil)
7,500 mcg
833%
Vitamin D3(as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
Top Medical Research Studies
9
Vitamin D3 modulates autoimmune response
Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis.
Study directly examines Vitamin D3
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Read More
9
Vitamin A deficiency worsens lupus nephritis
Hypovitaminosis A Drives the Progression of Tubulointerstitial Lupus Nephritis through Potentiating Predisease Cellular Autoreactivity.
Study findings are highly relevant
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Read More
9
Vitamin D3 mitigates autoimmune thyroiditis
Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.
High relevance to thyroiditis treatment
Our research aimed to understand how vitamin D3 affects autoimmune thyroiditis, particularly in the context of Hashimoto's thyroiditis, which is characterized by low levels of vitamin D3 in patients. We induced a model of autoimmune thyroiditis in female mice and treated them with vitamin D3 to see if it could alleviate the symptoms of this condition.
After 8 weeks of treatment, we observed that vitamin D3 significantly improved the condition of the thyroid in these mice. The inflammation that commonly accompanies autoimmune thyroiditis decreased, and levels of thyroid autoantibodies, which indicate the severity of the disorder, also dropped. Notably, the application of vitamin D3 inhibited the activity of harmful immune cells while promoting the function of protective cells, providing a better balance in the immune response.
Overall, our findings suggest that vitamin D3 supplementation could be a promising strategy to manage autoimmune thyroiditis by restoring immune balance and reducing inflammation. This not only enhances our understanding of the disease but also opens up potential avenues for treatment in humans facing similar issues with autoimmune disorders.
After 8 weeks of treatment, we observed that vitamin D3 significantly improved the condition of the thyroid in these mice. The inflammation that commonly accompanies autoimmune thyroiditis decreased, and levels of thyroid autoantibodies, which indicate the severity of the disorder, also dropped. Notably, the application of vitamin D3 inhibited the activity of harmful immune cells while promoting the function of protective cells, providing a better balance in the immune response.
Overall, our findings suggest that vitamin D3 supplementation could be a promising strategy to manage autoimmune thyroiditis by restoring immune balance and reducing inflammation. This not only enhances our understanding of the disease but also opens up potential avenues for treatment in humans facing similar issues with autoimmune disorders.
Read More
Most Useful Reviews
9.3
Significant relief
I ordered these vitamins for the first time as I have diabetes and suffer from numbness and aching legs at night. They have helped me considerably; I highly recommend them for diabetics.
Read More
9.3
Rapid improvement
This is not the first time I've ordered these for my mum, who has diabetes mellitus and experiences numbness and soreness in her legs at night. These vitamins have significantly helped her, with results visible within a week. I highly recommend them for diabetics.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.6
- All Researches
9
Vitamin A enhances rheumatoid arthritis treatment
Exploring the supplementary potential of all-trans retinoic acid with methotrexate in rheumatoid arthritis: modulation of synovial cell apoptosis and autophagy.
High relevance for arthritis treatment
We examined how well all-trans retinoic acid (ATRA) works alongside methotrexate (MTX) in treating rheumatoid arthritis. Our research focused on its ability to reduce the growth of synovial cells while promoting their death, which is essential in managing this condition.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
While MTX alone didn't significantly affect cell viability or apoptosis, the addition of ATRA showed impressive results. It not only inhibited cell growth but also triggered both apoptosis and autophagy via the ROS-JNK pathway. In tests with rats, this combination therapy notably improved results compared to MTX alone.
ATRA may be a valuable supplementary treatment for rheumatoid arthritis, especially since MTX alone has limited effectiveness on these specific cellular processes.
Read More
9
ATRA microparticles improve arthritis treatment
Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis.
Significant potential therapeutic relevance
We explored an innovative treatment for autoimmune arthritis using microparticles that release all-trans retinoic acid (ATRA), a form of vitamin A. This method aims to enhance immune responses in a targeted way, improving T cells that help reduce inflammation.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Our findings show that these microparticles, when injected into the joints of mice, decreased symptoms of the disease without completely suppressing the immune response. The approach appears promising for enhancing treatment in patients who don’t respond well to traditional therapies like DMARDs.
Read More
9
Vitamin A deficiency worsens lupus nephritis
Hypovitaminosis A Drives the Progression of Tubulointerstitial Lupus Nephritis through Potentiating Predisease Cellular Autoreactivity.
Study findings are highly relevant
We examined the impact of vitamin A deficiency (VAD) on the progression of lupus nephritis in a mouse model. By inducing VAD during pregnancy or after weaning, we discovered that both methods significantly worsened the condition, leading to higher mortality rates.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Interestingly, restoring vitamin A levels after weaning reduced mortality. This suggests that VAD accelerates lupus nephritis through increased immune cell activation and autoantibody production. However, effects were less pronounced when VAD was introduced post-weaning. Overall, the study highlights the potential dangers of vitamin A deficiency in autoimmune diseases.
Read More
9
Targeted therapy reduces RA symptoms
Engineered Platelet Microparticle-Membrane Camouflaged Nanoparticles for Targeting the Golgi Apparatus of Synovial Fibroblasts to Attenuate Rheumatoid Arthritis.
High relevance for arthritis treatment
We investigated a cutting-edge method using engineered nanoparticles to deliver all-trans retinoic acid (ATRA) directly to synovial fibroblasts in rheumatoid arthritis (RA). This approach utilizes a unique Golgi-targeting system to ensure effective treatment.
Our findings demonstrated that ATRA-loaded nanoparticles significantly disrupted pathogenic protein production in RA cells, leading to less inflammation and reduced joint damage in animal models. Overall, this targeted delivery method shows promise in effectively managing RA while being mindful of safety, as it caused minimal toxicity to major organs.
Our findings demonstrated that ATRA-loaded nanoparticles significantly disrupted pathogenic protein production in RA cells, leading to less inflammation and reduced joint damage in animal models. Overall, this targeted delivery method shows promise in effectively managing RA while being mindful of safety, as it caused minimal toxicity to major organs.
Read More
9
Vitamin D3 mitigates autoimmune thyroiditis
Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.
High relevance to thyroiditis treatment
Our research aimed to understand how vitamin D3 affects autoimmune thyroiditis, particularly in the context of Hashimoto's thyroiditis, which is characterized by low levels of vitamin D3 in patients. We induced a model of autoimmune thyroiditis in female mice and treated them with vitamin D3 to see if it could alleviate the symptoms of this condition.
After 8 weeks of treatment, we observed that vitamin D3 significantly improved the condition of the thyroid in these mice. The inflammation that commonly accompanies autoimmune thyroiditis decreased, and levels of thyroid autoantibodies, which indicate the severity of the disorder, also dropped. Notably, the application of vitamin D3 inhibited the activity of harmful immune cells while promoting the function of protective cells, providing a better balance in the immune response.
Overall, our findings suggest that vitamin D3 supplementation could be a promising strategy to manage autoimmune thyroiditis by restoring immune balance and reducing inflammation. This not only enhances our understanding of the disease but also opens up potential avenues for treatment in humans facing similar issues with autoimmune disorders.
After 8 weeks of treatment, we observed that vitamin D3 significantly improved the condition of the thyroid in these mice. The inflammation that commonly accompanies autoimmune thyroiditis decreased, and levels of thyroid autoantibodies, which indicate the severity of the disorder, also dropped. Notably, the application of vitamin D3 inhibited the activity of harmful immune cells while promoting the function of protective cells, providing a better balance in the immune response.
Overall, our findings suggest that vitamin D3 supplementation could be a promising strategy to manage autoimmune thyroiditis by restoring immune balance and reducing inflammation. This not only enhances our understanding of the disease but also opens up potential avenues for treatment in humans facing similar issues with autoimmune disorders.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.3
Significant relief
I ordered these vitamins for the first time as I have diabetes and suffer from numbness and aching legs at night. They have helped me considerably; I highly recommend them for diabetics.
9.3
Rapid improvement
This is not the first time I've ordered these for my mum, who has diabetes mellitus and experiences numbness and soreness in her legs at night. These vitamins have significantly helped her, with results visible within a week. I highly recommend them for diabetics.
