Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.3
USERS' SCORE
Good
Based on 9 Reviews
8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A(60% as Beta-Carotene and 40% from Fish Liver Oil)
7,500 mcg
833%
Vitamin D3(as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
Top Medical Research Studies
9
We explored how vitamin A affects our body’s response to cold, specifically looking at its role in transforming white fat into brown fat, a process known as browning. This transformation is significant, as it can help reduce obesity and improve metabolic health.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
Read More
8
We explored how 25-hydroxyvitamin D3 (25OHD), a form of vitamin D, influences upper respiratory tract infections (URTIs), commonly known as colds. In a carefully designed clinical study, we followed 428 participants aged 45 to 74 over a 16-week period. They were randomly assigned to receive either 10 μg of 25OHD daily or a placebo, all while maintaining a double-blind setup to ensure accurate results.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
Read More
8
We delved into the effects of vitamin D on cold symptoms among military recruits during their training. In two comprehensive studies, we observed over 1,600 military recruits to see how their vitamin D levels impacted their likelihood of upper respiratory tract infections (URTIs) throughout the seasons.
In the first study, only 21% of recruits were found to have sufficient vitamin D levels during winter. Notably, those with adequate vitamin D were 40% less likely to experience URTIs compared to those who were deficient. Each URTI typically caused three missed training days, indicating a significant impact on their training schedules.
Following this, we conducted a randomized controlled trial with 250 men simulating sunlight exposure or providing oral vitamin D3 supplementation. Our goal was to see how both methods affected overall vitamin D levels and, subsequently, URTI symptoms. Remarkably, both strategies successfully brought participants to sufficient vitamin D levels. Compared to those who received a placebo, those getting vitamin D3 experienced a 15% reduction in the severity of cold symptoms and a 36% decrease in the number of days with URTI.
Interestingly, we found that both methods—simulated sunlight and oral supplementation—were equally effective, and neither had a significant impact on specific immune response markers.
In the first study, only 21% of recruits were found to have sufficient vitamin D levels during winter. Notably, those with adequate vitamin D were 40% less likely to experience URTIs compared to those who were deficient. Each URTI typically caused three missed training days, indicating a significant impact on their training schedules.
Following this, we conducted a randomized controlled trial with 250 men simulating sunlight exposure or providing oral vitamin D3 supplementation. Our goal was to see how both methods affected overall vitamin D levels and, subsequently, URTI symptoms. Remarkably, both strategies successfully brought participants to sufficient vitamin D levels. Compared to those who received a placebo, those getting vitamin D3 experienced a 15% reduction in the severity of cold symptoms and a 36% decrease in the number of days with URTI.
Interestingly, we found that both methods—simulated sunlight and oral supplementation—were equally effective, and neither had a significant impact on specific immune response markers.
Read More
Most Useful Reviews
10
Effective emergency aid
While supporting the body during viral attacks, I used this as emergency protection at the first signs of illness. Whenever my children show symptoms, I give them vitamin C and D. Recently, I learned that D and A build immunity. For my youngest, I separately tried A + D3 + C, and after just one dose, they did not get sick! I'm excited to continue this during the cold season.
Read More
9
Copes well with cold
I took this to combat a cold, and it worked wonderfully! After using it, I felt better within a day.
Read More
9
Prevents cold symptoms
Small and easy to swallow, this supplement is particularly convenient. Previously, my immune system was weak, and I would develop cold symptoms a few days after others caught a cold. However, since taking this, I've managed to maintain my health even when those around me were unwell. I intend to continue using it.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.3
- All Researches
9
We explored how vitamin A affects our body’s response to cold, specifically looking at its role in transforming white fat into brown fat, a process known as browning. This transformation is significant, as it can help reduce obesity and improve metabolic health.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
In our investigation, we conducted cold exposure studies involving both mice and humans. We observed that exposure to cold led to an increase in circulating vitamin A, also known as retinol, and its transporter protein, Rbp. However, in mice lacking this protein, we found that their ability to adapt to the cold and promote thermogenesis—essentially, generating heat through fat—was severely compromised.
Interestingly, we also noted that stimulating human fat cells with retinol heightened the expression of genes associated with thermogenesis and boosted mitochondrial activity, which is vital for burning fat. In humans, the rise in vitamin A during cold exposure hinted at improved fat utilization.
Overall, our findings revealed that not only are vitamin A levels responsive to cold, but effective transportation of this vitamin is crucial for cold-induced fat browning and the body's ability to generate heat.
Read More
8
We delved into the effects of vitamin D on cold symptoms among military recruits during their training. In two comprehensive studies, we observed over 1,600 military recruits to see how their vitamin D levels impacted their likelihood of upper respiratory tract infections (URTIs) throughout the seasons.
In the first study, only 21% of recruits were found to have sufficient vitamin D levels during winter. Notably, those with adequate vitamin D were 40% less likely to experience URTIs compared to those who were deficient. Each URTI typically caused three missed training days, indicating a significant impact on their training schedules.
Following this, we conducted a randomized controlled trial with 250 men simulating sunlight exposure or providing oral vitamin D3 supplementation. Our goal was to see how both methods affected overall vitamin D levels and, subsequently, URTI symptoms. Remarkably, both strategies successfully brought participants to sufficient vitamin D levels. Compared to those who received a placebo, those getting vitamin D3 experienced a 15% reduction in the severity of cold symptoms and a 36% decrease in the number of days with URTI.
Interestingly, we found that both methods—simulated sunlight and oral supplementation—were equally effective, and neither had a significant impact on specific immune response markers.
In the first study, only 21% of recruits were found to have sufficient vitamin D levels during winter. Notably, those with adequate vitamin D were 40% less likely to experience URTIs compared to those who were deficient. Each URTI typically caused three missed training days, indicating a significant impact on their training schedules.
Following this, we conducted a randomized controlled trial with 250 men simulating sunlight exposure or providing oral vitamin D3 supplementation. Our goal was to see how both methods affected overall vitamin D levels and, subsequently, URTI symptoms. Remarkably, both strategies successfully brought participants to sufficient vitamin D levels. Compared to those who received a placebo, those getting vitamin D3 experienced a 15% reduction in the severity of cold symptoms and a 36% decrease in the number of days with URTI.
Interestingly, we found that both methods—simulated sunlight and oral supplementation—were equally effective, and neither had a significant impact on specific immune response markers.
Read More
8
Vitamin D3 aids cold symptom relief
We explored the potential benefits of vitamin D3, specifically 25-hydroxyvitamin D, on cold symptoms among people with insufficient or deficient levels of this essential nutrient. The study was well-designed, involving a randomized, double-blind, placebo-controlled method where participants received either 10 μg of vitamin D3 or a placebo over 16 weeks.
During the study, we used a tool called the Wisconsin Upper Respiratory Symptom Survey-21, which helped us collect data on physical signs and symptoms of upper respiratory tract infections (URTI). We observed that participants who took vitamin D3 experienced significantly lower scores for symptoms like runny nose, sneezing, and head congestion compared to those on a placebo. Additionally, their overall quality of life, except for the ability to breathe easily, improved when they were taking vitamin D3.
However, it's important to note that the number of cold occurrences and the use of other medications, like antibiotics and pain relievers, showed no significant difference between the two groups. Overall, our findings suggest that adequate intake of vitamin D3 can indeed help reduce certain cold symptoms and enhance quality of life when a cold strikes.
During the study, we used a tool called the Wisconsin Upper Respiratory Symptom Survey-21, which helped us collect data on physical signs and symptoms of upper respiratory tract infections (URTI). We observed that participants who took vitamin D3 experienced significantly lower scores for symptoms like runny nose, sneezing, and head congestion compared to those on a placebo. Additionally, their overall quality of life, except for the ability to breathe easily, improved when they were taking vitamin D3.
However, it's important to note that the number of cold occurrences and the use of other medications, like antibiotics and pain relievers, showed no significant difference between the two groups. Overall, our findings suggest that adequate intake of vitamin D3 can indeed help reduce certain cold symptoms and enhance quality of life when a cold strikes.
Read More
8
We explored how 25-hydroxyvitamin D3 (25OHD), a form of vitamin D, influences upper respiratory tract infections (URTIs), commonly known as colds. In a carefully designed clinical study, we followed 428 participants aged 45 to 74 over a 16-week period. They were randomly assigned to receive either 10 μg of 25OHD daily or a placebo, all while maintaining a double-blind setup to ensure accurate results.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Effective emergency aid
While supporting the body during viral attacks, I used this as emergency protection at the first signs of illness. Whenever my children show symptoms, I give them vitamin C and D. Recently, I learned that D and A build immunity. For my youngest, I separately tried A + D3 + C, and after just one dose, they did not get sick! I'm excited to continue this during the cold season.
Read More
9
Copes well with cold
I took this to combat a cold, and it worked wonderfully! After using it, I felt better within a day.
Read More
9
Prevents cold symptoms
Small and easy to swallow, this supplement is particularly convenient. Previously, my immune system was weak, and I would develop cold symptoms a few days after others caught a cold. However, since taking this, I've managed to maintain my health even when those around me were unwell. I intend to continue using it.
Read More
7.5
Strengthens immunity
2 people found this helpful
My favourite vitamin A+D3 contains 7500 mcg of vitamin A, essential for strengthening the immune system, especially for colds and eyesight. Vitamin D is vital for calcium absorption. They are crucial for the entire body and strong bones. The capsules are small and easy to swallow, with no aftertaste. The quality is superb; I highly recommend purchasing!
Read More
7.5
Prevents colds
1 people found this helpful
I am very pleased with the combination of these vitamins! Vitamin D3 is particularly beneficial as it aids the absorption of calcium and phosphorus, regulating their levels in the blood and bones. This combination helps prevent colds, skin diseases, vision problems, and diabetes.
Read More
Frequently Asked Questions
9
Copes well with cold
I took this to combat a cold, and it worked wonderfully! After using it, I felt better within a day.
10
Effective emergency aid
While supporting the body during viral attacks, I used this as emergency protection at the first signs of illness. Whenever my children show symptoms, I give them vitamin C and D. Recently, I learned that D and A build immunity. For my youngest, I separately tried A + D3 + C, and after just one dose, they did not get sick! I'm excited to continue this during the cold season.
7.5
Immune support during colds
The quality of this supplement is excellent as always! Vitamins A and D3 complement each other well, supporting vision and strengthening the immune system during colds. I take one capsule daily and plan to repurchase, as the brand offers high quality. The capsules are easy to swallow, and packaging is conveniently compact. I hope to see results once I finish this course.
9
Prevents cold symptoms
Small and easy to swallow, this supplement is particularly convenient. Previously, my immune system was weak, and I would develop cold symptoms a few days after others caught a cold. However, since taking this, I've managed to maintain my health even when those around me were unwell. I intend to continue using it.
6
Helps with colds
1 people found this helpful
I prefer this option for colds and to improve skin quality when it feels dry. It effectively addresses skin issues and is beneficial for treating my cold symptoms.
8
We delved into the effects of vitamin D on cold symptoms among military recruits during their training. In two comprehensive studies, we observed over 1,600 military recruits to see how their vitamin D levels impacted their likelihood of upper respiratory tract infections (URTIs) throughout the seasons.
In the first study, only 21% of recruits were found to have sufficient vitamin D levels during winter. Notably, those with adequate vitamin D were 40% less likely to experience URTIs compared to those who were deficient. Each URTI typically caused three missed training days, indicating a significant impact on their training schedules.
Following this, we conducted a randomized controlled trial with 250 men simulating sunlight exposure or providing oral vitamin D3 supplementation. Our goal was to see how both methods affected overall vitamin D levels and, subsequently, URTI symptoms. Remarkably, both strategies successfully brought participants to sufficient vitamin D levels. Compared to those who received a placebo, those getting vitamin D3 experienced a 15% reduction in the severity of cold symptoms and a 36% decrease in the number of days with URTI.
Interestingly, we found that both methods—simulated sunlight and oral supplementation—were equally effective, and neither had a significant impact on specific immune response markers.
In the first study, only 21% of recruits were found to have sufficient vitamin D levels during winter. Notably, those with adequate vitamin D were 40% less likely to experience URTIs compared to those who were deficient. Each URTI typically caused three missed training days, indicating a significant impact on their training schedules.
Following this, we conducted a randomized controlled trial with 250 men simulating sunlight exposure or providing oral vitamin D3 supplementation. Our goal was to see how both methods affected overall vitamin D levels and, subsequently, URTI symptoms. Remarkably, both strategies successfully brought participants to sufficient vitamin D levels. Compared to those who received a placebo, those getting vitamin D3 experienced a 15% reduction in the severity of cold symptoms and a 36% decrease in the number of days with URTI.
Interestingly, we found that both methods—simulated sunlight and oral supplementation—were equally effective, and neither had a significant impact on specific immune response markers.
8
Vitamin D3 aids cold symptom relief
We explored the potential benefits of vitamin D3, specifically 25-hydroxyvitamin D, on cold symptoms among people with insufficient or deficient levels of this essential nutrient. The study was well-designed, involving a randomized, double-blind, placebo-controlled method where participants received either 10 μg of vitamin D3 or a placebo over 16 weeks.
During the study, we used a tool called the Wisconsin Upper Respiratory Symptom Survey-21, which helped us collect data on physical signs and symptoms of upper respiratory tract infections (URTI). We observed that participants who took vitamin D3 experienced significantly lower scores for symptoms like runny nose, sneezing, and head congestion compared to those on a placebo. Additionally, their overall quality of life, except for the ability to breathe easily, improved when they were taking vitamin D3.
However, it's important to note that the number of cold occurrences and the use of other medications, like antibiotics and pain relievers, showed no significant difference between the two groups. Overall, our findings suggest that adequate intake of vitamin D3 can indeed help reduce certain cold symptoms and enhance quality of life when a cold strikes.
During the study, we used a tool called the Wisconsin Upper Respiratory Symptom Survey-21, which helped us collect data on physical signs and symptoms of upper respiratory tract infections (URTI). We observed that participants who took vitamin D3 experienced significantly lower scores for symptoms like runny nose, sneezing, and head congestion compared to those on a placebo. Additionally, their overall quality of life, except for the ability to breathe easily, improved when they were taking vitamin D3.
However, it's important to note that the number of cold occurrences and the use of other medications, like antibiotics and pain relievers, showed no significant difference between the two groups. Overall, our findings suggest that adequate intake of vitamin D3 can indeed help reduce certain cold symptoms and enhance quality of life when a cold strikes.
8
We explored how 25-hydroxyvitamin D3 (25OHD), a form of vitamin D, influences upper respiratory tract infections (URTIs), commonly known as colds. In a carefully designed clinical study, we followed 428 participants aged 45 to 74 over a 16-week period. They were randomly assigned to receive either 10 μg of 25OHD daily or a placebo, all while maintaining a double-blind setup to ensure accurate results.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
References
- Fenzl A, Kulterer OC, Spirk K, Mitulović G, Marculescu R, et al. Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis. Mol Metab. 2020;42:101088. doi:10.1016/j.molmet.2020.101088
- Harrison SE, Oliver SJ, Kashi DS, Carswell AT, Edwards JP, et al. Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training. Med Sci Sports Exerc. 2021;53:1505. doi:10.1249/MSS.0000000000002604
- Shimizu Y, Ito Y, Uotsu N, Yui K. Intake of 25-Hydroxyvitamin D May Reduce the Severity of Upper Respiratory Tract Infection: Post hoc Analysis of a Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study. Nutrients. 2020;12. doi:10.3390/nu12123769
- Shimizu Y, Ito Y, Yui K, Egawa K, Orimo H. Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study. J Nutr Health Aging. 2018;22:491. doi:10.1007/s12603-017-0952-x
