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SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.8
USERS' SCORE
Good
Based on 1 Review
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin E (as d-alpha Tocopheryl Acetate)
268 mg
1787%
Top Medical Research Studies
8
Vitamin E alleviates colitis diarrhea
Vitamin E alpha- and gamma-tocopherol mitigate colitis, protect intestinal barrier function and modulate the gut microbiota in mice.
Significant focus on diarrhea
We examined how different forms of vitamin E—specifically alpha-tocopherol (αT) and gamma-tocopherol-rich tocopherols (γTmT)—affect diarrhea in mice suffering from colitis. In our study, we used mice with dextran sulfate sodium (DSS)-induced colitis, which is known for causing inflammation and symptoms like diarrhea and fecal bleeding.
Our findings were promising. Both αT and γTmT significantly reduced diarrhea and fecal bleeding associated with colitis, while also lowering levels of a protein indicative of intestinal inflammation (IL-6). Moreover, these vitamin E forms protected the gut's barrier function, which is vital for maintaining digestive health. We saw significant improvements, particularly with γTmT, which also helped preserve beneficial gut bacteria that are often diminished in colitis.
It's important to highlight that while αT and γTmT were effective in this inflammatory context, they did not seem to affect the gut microbiota in healthy mice. Overall, these results suggest that vitamin E can be a useful ally in managing diarrhea associated with colitis, improving both intestinal health and microbial balance.
Our findings were promising. Both αT and γTmT significantly reduced diarrhea and fecal bleeding associated with colitis, while also lowering levels of a protein indicative of intestinal inflammation (IL-6). Moreover, these vitamin E forms protected the gut's barrier function, which is vital for maintaining digestive health. We saw significant improvements, particularly with γTmT, which also helped preserve beneficial gut bacteria that are often diminished in colitis.
It's important to highlight that while αT and γTmT were effective in this inflammatory context, they did not seem to affect the gut microbiota in healthy mice. Overall, these results suggest that vitamin E can be a useful ally in managing diarrhea associated with colitis, improving both intestinal health and microbial balance.
Read More
9
Vitamin E and probiotics combat diarrhea
Combining vitamin E metabolite 13'-carboxychromanol and a lactic acid bacterium synergistically mitigates colitis and colitis-associated dysbiosis in mice.
Important link between treatments
We investigated the potential of a vitamin E metabolite, 13'-carboxychromanol, in combination with a probiotic bacterium, Lactococcus lactis subsp. cremoris, to alleviate diarrhea associated with colitis in a mouse model. The study was structured to assess how this combination could impact symptoms like fecal bleeding and diarrhea, as well as changes in gut microbiota, when induced by a substance known as dextran sulfate sodium.
Interestingly, our findings showed that this combination significantly reduced the symptoms of colitis, particularly diarrhea, and helped maintain a healthier composition of gut bacteria. It appeared that the metabolite worked well alongside the probiotic, enhancing each other's effects without the negative outcomes usually seen when either treatment was used alone.
We observed that the success of this combination seemed linked to the presence of another metabolite produced during the process, which potentially plays a crucial role in its beneficial effects. This suggests that combining vitamin E with probiotics could offer promising new strategies in managing digestive issues like colitis.
Interestingly, our findings showed that this combination significantly reduced the symptoms of colitis, particularly diarrhea, and helped maintain a healthier composition of gut bacteria. It appeared that the metabolite worked well alongside the probiotic, enhancing each other's effects without the negative outcomes usually seen when either treatment was used alone.
We observed that the success of this combination seemed linked to the presence of another metabolite produced during the process, which potentially plays a crucial role in its beneficial effects. This suggests that combining vitamin E with probiotics could offer promising new strategies in managing digestive issues like colitis.
Read More
9
Vitamin E helps piglet immunity
Redox balance and immunity of piglets pre- and post-E. coli challenge after treatment with hemp or fish oil, and vitamin E.
Effectiveness not solely isolatable
In this study, we explored how vitamin E supplementation might influence diarrhea in young piglets, particularly during stressful times like weaning and infections. By giving 24 suckling piglets either fish oil or hemp oil along with vitamin E, we aimed to see how these treatments affected their immunity and oxidative stress after being exposed to E. coli.
We conducted blood tests before and after the piglets faced the E. coli challenge. Our findings indicated that vitamin E helped reduce lipid peroxidation, which is a sign of oxidative damage. Moreover, it improved the piglets’ immune responses after the challenge.
Notably, the hemp oil had an even more significant impact on boosting antioxidant enzyme activity compared to the fish oil. While our study suggests that combining hemp oil and vitamin E may reduce the chances of post-weaning diarrhea, it’s important to note the difficulty in isolating the effects of vitamin E alone given the combination with other treatments.
Overall, we discovered promising results that highlight the potential benefits of vitamin E and hemp oil for improving health and perhaps preventing diarrhea during weaning in piglets.
We conducted blood tests before and after the piglets faced the E. coli challenge. Our findings indicated that vitamin E helped reduce lipid peroxidation, which is a sign of oxidative damage. Moreover, it improved the piglets’ immune responses after the challenge.
Notably, the hemp oil had an even more significant impact on boosting antioxidant enzyme activity compared to the fish oil. While our study suggests that combining hemp oil and vitamin E may reduce the chances of post-weaning diarrhea, it’s important to note the difficulty in isolating the effects of vitamin E alone given the combination with other treatments.
Overall, we discovered promising results that highlight the potential benefits of vitamin E and hemp oil for improving health and perhaps preventing diarrhea during weaning in piglets.
Read More
Most Useful Reviews
5
Vitamin E benefits
In cases of thyroid gland issues, I must take vitamin courses, particularly vitamin E, which is excellent for women's health. It helps normalise cycles and improve hair, nails, and skin. Though beneficial, overdosing can occur, leading to symptoms such as drowsiness, abdominal pain, and diarrhoea. Consulting a specialist before use is advisable, especially for children, as it can accumulate in the body and cause adverse effects.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.8
9
Vitamin E and probiotics combat diarrhea
Combining vitamin E metabolite 13'-carboxychromanol and a lactic acid bacterium synergistically mitigates colitis and colitis-associated dysbiosis in mice.
Important link between treatments
We investigated the potential of a vitamin E metabolite, 13'-carboxychromanol, in combination with a probiotic bacterium, Lactococcus lactis subsp. cremoris, to alleviate diarrhea associated with colitis in a mouse model. The study was structured to assess how this combination could impact symptoms like fecal bleeding and diarrhea, as well as changes in gut microbiota, when induced by a substance known as dextran sulfate sodium.
Interestingly, our findings showed that this combination significantly reduced the symptoms of colitis, particularly diarrhea, and helped maintain a healthier composition of gut bacteria. It appeared that the metabolite worked well alongside the probiotic, enhancing each other's effects without the negative outcomes usually seen when either treatment was used alone.
We observed that the success of this combination seemed linked to the presence of another metabolite produced during the process, which potentially plays a crucial role in its beneficial effects. This suggests that combining vitamin E with probiotics could offer promising new strategies in managing digestive issues like colitis.
Interestingly, our findings showed that this combination significantly reduced the symptoms of colitis, particularly diarrhea, and helped maintain a healthier composition of gut bacteria. It appeared that the metabolite worked well alongside the probiotic, enhancing each other's effects without the negative outcomes usually seen when either treatment was used alone.
We observed that the success of this combination seemed linked to the presence of another metabolite produced during the process, which potentially plays a crucial role in its beneficial effects. This suggests that combining vitamin E with probiotics could offer promising new strategies in managing digestive issues like colitis.
Read More
9
Vitamin E helps piglet immunity
Redox balance and immunity of piglets pre- and post-E. coli challenge after treatment with hemp or fish oil, and vitamin E.
Effectiveness not solely isolatable
In this study, we explored how vitamin E supplementation might influence diarrhea in young piglets, particularly during stressful times like weaning and infections. By giving 24 suckling piglets either fish oil or hemp oil along with vitamin E, we aimed to see how these treatments affected their immunity and oxidative stress after being exposed to E. coli.
We conducted blood tests before and after the piglets faced the E. coli challenge. Our findings indicated that vitamin E helped reduce lipid peroxidation, which is a sign of oxidative damage. Moreover, it improved the piglets’ immune responses after the challenge.
Notably, the hemp oil had an even more significant impact on boosting antioxidant enzyme activity compared to the fish oil. While our study suggests that combining hemp oil and vitamin E may reduce the chances of post-weaning diarrhea, it’s important to note the difficulty in isolating the effects of vitamin E alone given the combination with other treatments.
Overall, we discovered promising results that highlight the potential benefits of vitamin E and hemp oil for improving health and perhaps preventing diarrhea during weaning in piglets.
We conducted blood tests before and after the piglets faced the E. coli challenge. Our findings indicated that vitamin E helped reduce lipid peroxidation, which is a sign of oxidative damage. Moreover, it improved the piglets’ immune responses after the challenge.
Notably, the hemp oil had an even more significant impact on boosting antioxidant enzyme activity compared to the fish oil. While our study suggests that combining hemp oil and vitamin E may reduce the chances of post-weaning diarrhea, it’s important to note the difficulty in isolating the effects of vitamin E alone given the combination with other treatments.
Overall, we discovered promising results that highlight the potential benefits of vitamin E and hemp oil for improving health and perhaps preventing diarrhea during weaning in piglets.
Read More
9
Vitamin E mitigates intestinal damage
Effect of antioxidant supplementation on digestive enzymes in radiation induced intestinal damage in rats.
Moderate relevance to diarrhea
Our study focused on the impact of radiation on the digestive system and whether adding antioxidant vitamins—with a particular emphasis on vitamin E—could help reduce intestinal damage and its consequences, such as diarrhea. We designed an experiment with Swiss Albino rats, dividing them into six different groups. This included control groups and those exposed to radiation who received various antioxidant supplements, including vitamin A, C, E, and lycopene.
After the rats were exposed to gamma radiation, we closely examined their intestinal health and the activity of digestive enzymes. We found that the intestinal lining is particularly sensitive to radiation, resulting in significant damage. The results indicated that vitamin E stood out as the most effective supplement in protecting against this damage. While our main focus was on intestinal health, it is important to note that we didn’t observe data specific to diarrhea, but the overall findings suggest that vitamin E may offer broader protective benefits in digestive issues stemming from radiation exposure.
In summary, incorporating antioxidant vitamins, especially vitamin E, appears beneficial in preventing intestinal injury due to radiation, potentially influencing conditions like diarrhea indirectly through enhanced gut health.
After the rats were exposed to gamma radiation, we closely examined their intestinal health and the activity of digestive enzymes. We found that the intestinal lining is particularly sensitive to radiation, resulting in significant damage. The results indicated that vitamin E stood out as the most effective supplement in protecting against this damage. While our main focus was on intestinal health, it is important to note that we didn’t observe data specific to diarrhea, but the overall findings suggest that vitamin E may offer broader protective benefits in digestive issues stemming from radiation exposure.
In summary, incorporating antioxidant vitamins, especially vitamin E, appears beneficial in preventing intestinal injury due to radiation, potentially influencing conditions like diarrhea indirectly through enhanced gut health.
Read More
8
Vitamin E improves piglet gut health
Maternal Supplementation of Vitamin E or Its Combination with Hydroxytyrosol Increases the Gut Health and Short Chain Fatty Acids of Piglets at Weaning.
Study highlights vitamin E’s effectiveness
We explored how dietary vitamin E supplementation affects piglet gut health and the occurrence of diarrhea during weaning. In the study, Iberian sows were given vitamin E, hydroxytyrosol, or a combination of both from gestation. This approach allowed us to assess their impact on the piglets' fecal characteristics and overall intestinal health.
Our findings revealed that vitamin E supplementation significantly increased the levels of beneficial short-chain fatty acids (SCFAs), such as isobutyric acid and butyric acid. These acids are crucial for promoting gut health and may help reduce the likelihood of diarrhea, which is a common challenge for piglets as they transition to solid food. In contrast, while hydroxytyrosol was also tested, it tended to show less effectiveness in improving SCFA levels compared to vitamin E alone.
These results suggest that enhancing the diet of pregnant sows with vitamin E can lead to healthier piglets with better gut stability and a lower risk of diarrhea at weaning. We observed that vitamin E's role is essential in promoting intestinal balance and supporting piglet growth, emphasizing its potential benefits for livestock management.
Our findings revealed that vitamin E supplementation significantly increased the levels of beneficial short-chain fatty acids (SCFAs), such as isobutyric acid and butyric acid. These acids are crucial for promoting gut health and may help reduce the likelihood of diarrhea, which is a common challenge for piglets as they transition to solid food. In contrast, while hydroxytyrosol was also tested, it tended to show less effectiveness in improving SCFA levels compared to vitamin E alone.
These results suggest that enhancing the diet of pregnant sows with vitamin E can lead to healthier piglets with better gut stability and a lower risk of diarrhea at weaning. We observed that vitamin E's role is essential in promoting intestinal balance and supporting piglet growth, emphasizing its potential benefits for livestock management.
Read More
8
Vitamin E aids piglet diarrhea
The nanocomposites of modified attapulgite with vitamin E and mannan oligosaccharide regulated the intestinal epithelial barrier and improved intestinal microbiota composition to prevent diarrhea in weaned piglets.
Moderately high relevance score
We conducted a study to see how a combination of mannan oligosaccharides (MOS), vitamin E, and attapulgite (a clay mineral) could affect diarrhea in weaned piglets. Our research involved 135 participants, divided into five groups: one received standard feed, another traditional antibiotic substitutes, and three received varying amounts of the MOS and vitamin E mixtures. We aimed to assess growth, diarrhea frequency, and gut health among the piglets.
We observed that the special formulation containing the highest amount of MOS (called SLK5) significantly reduced the frequency of diarrhea among the piglets compared to others. Notably, piglets that received SLK5 exhibited improved intestinal health, showing a boost in the survival rate and a more favorable gut microbiome.
What's especially promising is that the increased levels of vitamin E in this mix likely played a vital role in enhancing the gut barrier function and supporting beneficial bacteria. This means that incorporating vitamin E into piglet diets may offer a natural alternative to antibiotics for managing diarrhea and promoting gut health.
We observed that the special formulation containing the highest amount of MOS (called SLK5) significantly reduced the frequency of diarrhea among the piglets compared to others. Notably, piglets that received SLK5 exhibited improved intestinal health, showing a boost in the survival rate and a more favorable gut microbiome.
What's especially promising is that the increased levels of vitamin E in this mix likely played a vital role in enhancing the gut barrier function and supporting beneficial bacteria. This means that incorporating vitamin E into piglet diets may offer a natural alternative to antibiotics for managing diarrhea and promoting gut health.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.2
5
Vitamin E benefits
In cases of thyroid gland issues, I must take vitamin courses, particularly vitamin E, which is excellent for women's health. It helps normalise cycles and improve hair, nails, and skin. Though beneficial, overdosing can occur, leading to symptoms such as drowsiness, abdominal pain, and diarrhoea. Consulting a specialist before use is advisable, especially for children, as it can accumulate in the body and cause adverse effects.
Read More
