Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
USERS' SCORE
Good
Based on 10 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin E (as d-alpha Tocopheryl Acetate)
268 mg
1787%
Top Medical Research Studies
2
We explored the relationship between vitamin E and heart attack risk through a two-sample mendelian randomization study. Using genetic variations from nearly 8,000 individuals of European descent, we dug into whether higher levels of vitamin E could protect against coronary artery disease (CAD) and myocardial infarction (MI).
Contrary to some previous beliefs about its benefits, our results suggested that increased vitamin E levels were actually associated with a higher risk of both CAD and MI. This means it's time to rethink the safety and effectiveness of vitamin E supplements for heart health.
Contrary to some previous beliefs about its benefits, our results suggested that increased vitamin E levels were actually associated with a higher risk of both CAD and MI. This means it's time to rethink the safety and effectiveness of vitamin E supplements for heart health.
Read More
9
We examined how vitamin E affects individuals with diabetes and the specific Haptoglobin 2-2 genotype, who are at greater risk for heart problems. By analyzing data from two trials, we found that taking vitamin E significantly reduced the risk of heart events like strokes and heart attacks in these patients.
The study suggests that screening diabetics for the Haptoglobin genotype and offering vitamin E as treatment could improve heart health and even extend life expectancy by three years for those affected.
The study suggests that screening diabetics for the Haptoglobin genotype and offering vitamin E as treatment could improve heart health and even extend life expectancy by three years for those affected.
Read More
8
Vitamin E reduces heart attack risk
We explored the effects of dietary vitamin E on heart attack and overall health by analyzing data from over 39,000 participants in the NHANES survey from 2003 to 2018. Our findings indicated that a higher intake of vitamin E was linked to a lower risk of cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E had significantly lower odds of developing cardiovascular issues, including heart attacks. However, the impact on cardiovascular mortality wasn't as strong. This suggests that while vitamin E-rich diets could enhance heart health, further research is necessary for clearer conclusions.
Specifically, those consuming more than 9.86 mg of vitamin E had significantly lower odds of developing cardiovascular issues, including heart attacks. However, the impact on cardiovascular mortality wasn't as strong. This suggests that while vitamin E-rich diets could enhance heart health, further research is necessary for clearer conclusions.
Read More
Most Useful Reviews
9
Protects against heart attack
22 people found this helpful
Wonderful! The strongest antioxidant, 400 IU daily protects significantly against heart attack and improves overall health. It cleanses the blood of harmful fats, which enhances circulation and ensures good cholesterol remains unoxidised. Vitamin E is vital for reproductive health, delays menopause, alleviates symptoms of premenstrual syndrome, and promotes healthy internal organ function. I take it with omega acids for better absorption, and I've noticed smoother skin. I recommend consulting your doctor for advice.
Read More
9
Supports heart health
22 people found this helpful
The most valuable women's vitamin! The strongest antioxidant, 400 IU daily protects against heart attack. Vitamin E purifies blood from unhealthy fats to improve blood circulation and is non-toxic compared to blood thinners. It enhances protein synthesis, interstitial breathing, and cellular metabolism. Best absorbed with fat, I take it alongside omega acids to combat premature wrinkles.
Read More
9
Aids heart recovery
4 people found this helpful
I take vitamin E with every meal, recommended by natural health sources for heart health. My recent hospital assessment showed I no longer need cardioversion as my sinus rhythm is now normal. While vitamin E isn't my only treatment, I believe it has contributed significantly to my heart's improvement.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
- All Researches
9
We explored how an innovative hydrogel enhanced heart repair after a heart attack. This injectable hydrogel includes α-tocopherol, a form of vitamin E. In our study using a rabbit model, we implanted the hydrogel after inducing a heart attack.
Four weeks later, the results were promising. We noticed improved heart function and reduced damage to heart tissue. This suggests that the hydrogel, enriched with vitamin E, plays a vital role in helping the heart recover better after an injury.
Four weeks later, the results were promising. We noticed improved heart function and reduced damage to heart tissue. This suggests that the hydrogel, enriched with vitamin E, plays a vital role in helping the heart recover better after an injury.
Read More
9
β-Cryptoxanthin outperforming vitamin E
We investigated how three antioxidant compounds—β-cryptoxanthin, astaxanthin, and vitamin E—affect heart damage from ischemia-reperfusion injury in mice.
Mice were treated with these compounds before inducing heart injury.
Results showed that all treatments reduced heart damage, but β-cryptoxanthin was the most effective, shrinking heart injury by 60% compared to vitamin E and astaxanthin.
Ultimately, while vitamin E showed some benefits, β-cryptoxanthin stood out in reducing oxidative stress and cellular damage more effectively.
Mice were treated with these compounds before inducing heart injury.
Results showed that all treatments reduced heart damage, but β-cryptoxanthin was the most effective, shrinking heart injury by 60% compared to vitamin E and astaxanthin.
Ultimately, while vitamin E showed some benefits, β-cryptoxanthin stood out in reducing oxidative stress and cellular damage more effectively.
Read More
9
We examined how vitamin E affects individuals with diabetes and the specific Haptoglobin 2-2 genotype, who are at greater risk for heart problems. By analyzing data from two trials, we found that taking vitamin E significantly reduced the risk of heart events like strokes and heart attacks in these patients.
The study suggests that screening diabetics for the Haptoglobin genotype and offering vitamin E as treatment could improve heart health and even extend life expectancy by three years for those affected.
The study suggests that screening diabetics for the Haptoglobin genotype and offering vitamin E as treatment could improve heart health and even extend life expectancy by three years for those affected.
Read More
9
We aimed to explore how a combination of quercetin and vitamin E (alpha-tocopherol) may impact heart function in rats experiencing induced heart attacks. After treatment, all the essential heart enzyme levels returned to normal, suggesting these natural compounds might help stabilize heart membranes and reduce damage.
This is particularly hopeful for patients with heart conditions, as the combination proved to be more effective than either quercetin or vitamin E alone.
However, it’s important to note that while results are promising, further studies are necessary to fully understand these effects in humans.
This is particularly hopeful for patients with heart conditions, as the combination proved to be more effective than either quercetin or vitamin E alone.
However, it’s important to note that while results are promising, further studies are necessary to fully understand these effects in humans.
Read More
8
Vitamin E reduces heart attack risk
We explored the effects of dietary vitamin E on heart attack and overall health by analyzing data from over 39,000 participants in the NHANES survey from 2003 to 2018. Our findings indicated that a higher intake of vitamin E was linked to a lower risk of cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E had significantly lower odds of developing cardiovascular issues, including heart attacks. However, the impact on cardiovascular mortality wasn't as strong. This suggests that while vitamin E-rich diets could enhance heart health, further research is necessary for clearer conclusions.
Specifically, those consuming more than 9.86 mg of vitamin E had significantly lower odds of developing cardiovascular issues, including heart attacks. However, the impact on cardiovascular mortality wasn't as strong. This suggests that while vitamin E-rich diets could enhance heart health, further research is necessary for clearer conclusions.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Protects against heart attack
22 people found this helpful
Wonderful! The strongest antioxidant, 400 IU daily protects significantly against heart attack and improves overall health. It cleanses the blood of harmful fats, which enhances circulation and ensures good cholesterol remains unoxidised. Vitamin E is vital for reproductive health, delays menopause, alleviates symptoms of premenstrual syndrome, and promotes healthy internal organ function. I take it with omega acids for better absorption, and I've noticed smoother skin. I recommend consulting your doctor for advice.
Read More
9
Supports heart health
22 people found this helpful
The most valuable women's vitamin! The strongest antioxidant, 400 IU daily protects against heart attack. Vitamin E purifies blood from unhealthy fats to improve blood circulation and is non-toxic compared to blood thinners. It enhances protein synthesis, interstitial breathing, and cellular metabolism. Best absorbed with fat, I take it alongside omega acids to combat premature wrinkles.
Read More
9
Aids heart recovery
4 people found this helpful
I take vitamin E with every meal, recommended by natural health sources for heart health. My recent hospital assessment showed I no longer need cardioversion as my sinus rhythm is now normal. While vitamin E isn't my only treatment, I believe it has contributed significantly to my heart's improvement.
Read More
9
Versatile health benefits
1 people found this helpful
This E-400 product is fantastic; I've used it for years. It affords numerous health benefits, including heart health, antioxidant support, and reproductive health. Overall, this supplement is crucial for robust health, and I've found great prices on iHerb for it.
Read More
7.5
Relieves heart pain
1 people found this helpful
Excellent preparation, both in dosage and quantity. I took Vitamin E to improve my heart's function due to pain I experienced, and it significantly helped alleviate that discomfort. I'm considering switching to 100 IU, which NOW seems to provide.
Read More
Frequently Asked Questions
9
Aids heart recovery
4 people found this helpful
I take vitamin E with every meal, recommended by natural health sources for heart health. My recent hospital assessment showed I no longer need cardioversion as my sinus rhythm is now normal. While vitamin E isn't my only treatment, I believe it has contributed significantly to my heart's improvement.
7.5
Relieves heart pain
1 people found this helpful
Excellent preparation, both in dosage and quantity. I took Vitamin E to improve my heart's function due to pain I experienced, and it significantly helped alleviate that discomfort. I'm considering switching to 100 IU, which NOW seems to provide.
7.5
Maintains heart health
1 people found this helpful
I have used NOW Natural E-400 with mixed tocopherols for years. It helps keep my cholesterol in check, and I initially started it for heart protection. My doctor confirms my heart and cholesterol levels are good, so it must be effective. NOW Foods offers quality products at reasonable prices.
9
Protects against heart attack
22 people found this helpful
Wonderful! The strongest antioxidant, 400 IU daily protects significantly against heart attack and improves overall health. It cleanses the blood of harmful fats, which enhances circulation and ensures good cholesterol remains unoxidised. Vitamin E is vital for reproductive health, delays menopause, alleviates symptoms of premenstrual syndrome, and promotes healthy internal organ function. I take it with omega acids for better absorption, and I've noticed smoother skin. I recommend consulting your doctor for advice.
9
Supports heart health
22 people found this helpful
The most valuable women's vitamin! The strongest antioxidant, 400 IU daily protects against heart attack. Vitamin E purifies blood from unhealthy fats to improve blood circulation and is non-toxic compared to blood thinners. It enhances protein synthesis, interstitial breathing, and cellular metabolism. Best absorbed with fat, I take it alongside omega acids to combat premature wrinkles.
7.5
Prevents heart disease
3 people found this helpful
Vitamin E is a powerful antioxidant that inhibits excessive cell oxidation and protects heart health. It helps to lower blood pressure and triglycerides, prevents platelet aggregation, dilates blood vessels, and safeguards vascular endothelial cells.
8
Vitamin E reduces heart attack risk
We explored the effects of dietary vitamin E on heart attack and overall health by analyzing data from over 39,000 participants in the NHANES survey from 2003 to 2018. Our findings indicated that a higher intake of vitamin E was linked to a lower risk of cardiovascular disease and reduced all-cause mortality.
Specifically, those consuming more than 9.86 mg of vitamin E had significantly lower odds of developing cardiovascular issues, including heart attacks. However, the impact on cardiovascular mortality wasn't as strong. This suggests that while vitamin E-rich diets could enhance heart health, further research is necessary for clearer conclusions.
Specifically, those consuming more than 9.86 mg of vitamin E had significantly lower odds of developing cardiovascular issues, including heart attacks. However, the impact on cardiovascular mortality wasn't as strong. This suggests that while vitamin E-rich diets could enhance heart health, further research is necessary for clearer conclusions.
2
We explored the relationship between vitamin E and heart attack risk through a two-sample mendelian randomization study. Using genetic variations from nearly 8,000 individuals of European descent, we dug into whether higher levels of vitamin E could protect against coronary artery disease (CAD) and myocardial infarction (MI).
Contrary to some previous beliefs about its benefits, our results suggested that increased vitamin E levels were actually associated with a higher risk of both CAD and MI. This means it's time to rethink the safety and effectiveness of vitamin E supplements for heart health.
Contrary to some previous beliefs about its benefits, our results suggested that increased vitamin E levels were actually associated with a higher risk of both CAD and MI. This means it's time to rethink the safety and effectiveness of vitamin E supplements for heart health.
9
We examined how vitamin E affects individuals with diabetes and the specific Haptoglobin 2-2 genotype, who are at greater risk for heart problems. By analyzing data from two trials, we found that taking vitamin E significantly reduced the risk of heart events like strokes and heart attacks in these patients.
The study suggests that screening diabetics for the Haptoglobin genotype and offering vitamin E as treatment could improve heart health and even extend life expectancy by three years for those affected.
The study suggests that screening diabetics for the Haptoglobin genotype and offering vitamin E as treatment could improve heart health and even extend life expectancy by three years for those affected.
8
We explored the effect of vitamin E on heart attack risk by analyzing 16 randomized controlled trials. Our findings show that when taken alone, vitamin E supplementation may significantly decrease the incidence of myocardial infarction, particularly fatal cases. Specifically, the results indicated a reduction from 3.4% in the control group to 3.0% in those receiving vitamin E. However, it appears that combining vitamin E with other antioxidants does not provide any significant benefits for heart health.
References
- Zeng Q, Liao M, Li Y, She F, Zhang P. Association between dietary vitamin E intake and incident cardiovascular disease, cardiovascular, and all-cause mortality: A prospective cohort study using NHANES 2003-2018 data. Int J Cardiol Cardiovasc Risk Prev. 2025;24:200340. 10.1016/j.ijcrp.2024.200340
- Zhang F, Zhang Y, Qian S, Qian X, Jiao J, et al. Injectable and Conductive Nanomicelle Hydrogel with α-Tocopherol Encapsulation for Enhanced Myocardial Infarction Repair. ACS Nano. 2024;18:10216. 10.1021/acsnano.4c00509
- Wang T, Xu L. Circulating Vitamin E Levels and Risk of Coronary Artery Disease and Myocardial Infarction: A Mendelian Randomization Study. Nutrients. 2019;11. 10.3390/nu11092153
- Pongkan W, Takatori O, Ni Y, Xu L, Nagata N, et al. β-Cryptoxanthin exerts greater cardioprotective effects on cardiac ischemia-reperfusion injury than astaxanthin by attenuating mitochondrial dysfunction in mice. Mol Nutr Food Res. 2017;61. 10.1002/mnfr.201601077
- Loffredo L, Perri L, Di Castelnuovo A, Iacoviello L, De Gaetano G, et al. Supplementation with vitamin E alone is associated with reduced myocardial infarction: a meta-analysis. Nutr Metab Cardiovasc Dis. 2015;25:354. 10.1016/j.numecd.2015.01.008
- Shukla SK, Sharma SB, Singh UR. Pre-treatment with α-tocopherol and Terminalia arjuna ameliorates, pro-inflammatory cytokines, cardiac and apoptotic markers in myocardial infracted rats. Redox Rep. 2015;20:49. 10.1179/1351000214Y.0000000104
- Rodrigo R, Hasson D, Prieto JC, Dussaillant G, Ramos C, et al. The effectiveness of antioxidant vitamins C and E in reducing myocardial infarct size in patients subjected to percutaneous coronary angioplasty (PREVEC Trial): study protocol for a pilot randomized double-blind controlled trial. Trials. 2014;15:192. 10.1186/1745-6215-15-192
- Vardi M, Blum S, Levy AP. Haptoglobin genotype and cardiovascular outcomes in diabetes mellitus - natural history of the disease and the effect of vitamin E treatment. Meta-analysis of the medical literature. Eur J Intern Med. 2012;23:628. 10.1016/j.ejim.2012.04.009
- Rautiainen S, Akesson A, Levitan EB, Morgenstern R, Mittleman MA, et al. Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women. Am J Clin Nutr. 2010;92:1251. 10.3945/ajcn.2010.29371
- Blum S, Vardi M, Brown JB, Russell A, Milman U, et al. Vitamin E reduces cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype. Pharmacogenomics. 2010;11:675. 10.2217/pgs.10.17
- Punithavathi VR, Prince PS. Pretreatment with a combination of quercetin and alpha-tocopherol ameliorates adenosine triphosphatases and lysosomal enzymes in myocardial infarcted rats. Life Sci. 2010;86:178. 10.1016/j.lfs.2009.11.021
