Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
USERS' SCORE
Good
Based on 4 Reviews
8.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Thiamin (from Thiamin HCl) (Vitamin B-1)
100 mg
8333%
Riboflavin (Vitamin B-2)
100 mg
7692%
Niacin (Vitamin B-3) (as Niacinamide)
100 mg
625%
Vitamin B-6 (from Pyridoxine HCl)
100 mg
5882%
Folate
680 mcg DFE(400 mcg folic acid)
170%
Vitamin B-12 (as Cyanocobalamin)
100 mcg
4167%
Biotin
100 mcg
333%
Pantothenic Acid (from Calcium Pantothenate)
100 mg
2000%
Choline (from Choline Bitartrate)
35 mg
6%
Inositol
100 mg
†
PABA (Para-Aminobenzoic Acid)
10 mg
†
Top Medical Research Studies
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
Read More
7
We investigated the connection between vitamin B6 and alcohol-associated liver disease (ALD) using a mouse model. Through a detailed analysis of the gut microbiota, we observed that disruptions significantly lowered vitamin B6 production. This reduction heightened oxidative stress and worsened liver damage. Our results indicate that maintaining vitamin B6 levels could be vital in protecting against ALD progression by influencing important metabolic processes. Despite some promising findings, the protective effects of vitamin B6 against ALD warrant further exploration before drawing definitive conclusions.
Read More
7
Vitamin B and Folate Related to Mortality
We explored how serum folate and vitamin B levels relate to all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Utilizing data from the Third National Health and Nutrition Examination Survey, we followed nearly 3,636 MASLD subjects for over 20 years.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Read More
Most Useful Reviews
7.5
Supports liver health
1 people found this helpful
Daily health is important for me as I have a tendency towards liver disease. I've purchased this for health care and found it useful and harmless.
Read More
7.5
Enhances liver function
Vitamin B-100 is vital for energy production and metabolism, essential for liver health and overall body function. It helps regulate nervous and cardiovascular systems, aiding in the management of liver disease.
Read More
6
Reduces stress
Both my mother-in-law and I take these supplements, which help alleviate anxiety, nervous tension, and liver disease symptoms. They promote better digestion due to their high fibre content.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
- All Researches
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
Read More
8
Antioxidants may protect liver health
We explored the impact of four potential protective agents—ATP, thiamine pyrophosphate, melatonin, and Liv-52—against liver damage caused by the antibiotic pyrazinamide in a rat model.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
Read More
7
Vitamin B and Folate Related to Mortality
We explored how serum folate and vitamin B levels relate to all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Utilizing data from the Third National Health and Nutrition Examination Survey, we followed nearly 3,636 MASLD subjects for over 20 years.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Read More
7
We investigated the connection between vitamin B6 and alcohol-associated liver disease (ALD) using a mouse model. Through a detailed analysis of the gut microbiota, we observed that disruptions significantly lowered vitamin B6 production. This reduction heightened oxidative stress and worsened liver damage. Our results indicate that maintaining vitamin B6 levels could be vital in protecting against ALD progression by influencing important metabolic processes. Despite some promising findings, the protective effects of vitamin B6 against ALD warrant further exploration before drawing definitive conclusions.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Supports liver health
1 people found this helpful
Daily health is important for me as I have a tendency towards liver disease. I've purchased this for health care and found it useful and harmless.
Read More
7.5
Enhances liver function
Vitamin B-100 is vital for energy production and metabolism, essential for liver health and overall body function. It helps regulate nervous and cardiovascular systems, aiding in the management of liver disease.
Read More
6
Reduces stress
Both my mother-in-law and I take these supplements, which help alleviate anxiety, nervous tension, and liver disease symptoms. They promote better digestion due to their high fibre content.
Read More
7.5
Eases myalgia
Excellent vitamins! I’ve used them multiple times alongside my husband. They are beneficial for myalgia and vascular issues, particularly for supporting liver disease.
Read More
Frequently Asked Questions
6
Reduces stress
Both my mother-in-law and I take these supplements, which help alleviate anxiety, nervous tension, and liver disease symptoms. They promote better digestion due to their high fibre content.
7.5
Enhances liver function
Vitamin B-100 is vital for energy production and metabolism, essential for liver health and overall body function. It helps regulate nervous and cardiovascular systems, aiding in the management of liver disease.
7.5
Supports liver health
1 people found this helpful
Daily health is important for me as I have a tendency towards liver disease. I've purchased this for health care and found it useful and harmless.
7.5
Eases myalgia
Excellent vitamins! I’ve used them multiple times alongside my husband. They are beneficial for myalgia and vascular issues, particularly for supporting liver disease.
8
Antioxidants may protect liver health
We explored the impact of four potential protective agents—ATP, thiamine pyrophosphate, melatonin, and Liv-52—against liver damage caused by the antibiotic pyrazinamide in a rat model.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
In a carefully designed study with 36 rats split into various treatment groups, we administered these compounds alongside pyrazinamide for four weeks.
Our findings showed that these treatments effectively protected liver tissues from damage due to oxidative stress, as measured by various biochemical and histopathological analyses.
This suggests a promising avenue for enhancing liver health during pyrazinamide therapy.
9
Methylcobalamin protects against liver failure
We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.
7
Vitamin B and Folate Related to Mortality
We explored how serum folate and vitamin B levels relate to all-cause mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). Utilizing data from the Third National Health and Nutrition Examination Survey, we followed nearly 3,636 MASLD subjects for over 20 years.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
Our findings indicated that lower levels of these vitamins were tied to a higher risk of mortality. Specifically, individuals with serum vitamin B and folate levels above the median experienced significant reductions in mortality risk, underscoring the potential importance of these nutrients for liver health.
References
- Ciftel S, Ciftel S, Altuner D, Huseynova G, Yucel N, et al. Effects of adenosine triphosphate, thiamine pyrophosphate, melatonin, and liv-52 on subacute pyrazinamide proliferation hepatotoxicity in rats. BMC Pharmacol Toxicol. 2025;26:67. doi:10.1186/s40360-025-00901-7
- Xu W, Wang Y, Cui S, Zheng Q, Lin Y, et al. Methylcobalamin protects against liver failure via engaging gasdermin E. Nat Commun. 2025;16:1233. doi:10.1038/s41467-024-54826-6
- Zhu J, Liao X, Du L, Lv P, Deng J. Associations of serum folate and vitamin B levels with all-cause mortality among patients with metabolic dysfunction associated steatotic liver disease: a prospective cohort study. Front Endocrinol (Lausanne). 2024;15:1426103. doi:10.3389/fendo.2024.1426103
- Shen H, Zhou L, Yang Y, Shu H, Wu D, et al. The gut microbiota-produced vitamin B6 mitigates alcohol-associated liver disease by attenuating hepatic oxidative stress damage. Hepatol Commun. 2025;9. doi:10.1097/HC9.0000000000000599
