Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.3
USERS' SCORE
Good
Based on 17 Reviews
8.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Riboflavin (Vitamin B-2)
100 mg
7692%
Top Medical Research Studies
9.5
Riboflavin effective for pediatric migraines
We conducted a retrospective observational study involving 42 children and adolescents aged 6 to 18 years suffering from migraines. Our aim was to see how effective riboflavin, a safe and affordable nutraceutical, could be in reducing headache symptoms.
After administering weight-based doses of riboflavin, we observed substantial decreases in the frequency, intensity, and duration of headaches, along with reduced medication usage and fewer missed school days. These findings suggest that riboflavin can be a beneficial option for pediatric migraine management.
After administering weight-based doses of riboflavin, we observed substantial decreases in the frequency, intensity, and duration of headaches, along with reduced medication usage and fewer missed school days. These findings suggest that riboflavin can be a beneficial option for pediatric migraine management.
Read More
9
We investigated how Vitamin B2 supplementation could affect migraines. In a thorough review of available studies, we found that taking 400 mg of Vitamin B2 daily for three months significantly reduced the number of migraine days, duration, frequency, and pain intensity.
We analyzed data from eight randomized trials involving 673 participants. The findings suggest that Vitamin B2 can be a helpful non-pharmaceutical option for people seeking to lessen the burden of migraines.
We analyzed data from eight randomized trials involving 673 participants. The findings suggest that Vitamin B2 can be a helpful non-pharmaceutical option for people seeking to lessen the burden of migraines.
Read More
9.5
Peripheral cannabinoids show promise
We explored how peripheral cannabinoids could help reduce the suffering from migraines and related headaches. In mouse models, we found that these cannabinoids significantly prevented behaviors and biochemical changes linked to increased pain sensitivity from long-term treatment with a common migraine trigger.
Interestingly, while these compounds worked best when given beforehand, they showed no signs of causing additional pain sensitivity themselves. This suggests a promising new direction for migraine treatment that doesn't come with the central nervous system side effects of traditional cannabinoids.
Interestingly, while these compounds worked best when given beforehand, they showed no signs of causing additional pain sensitivity themselves. This suggests a promising new direction for migraine treatment that doesn't come with the central nervous system side effects of traditional cannabinoids.
Read More
Most Useful Reviews
10
Life-changing relief
142 people found this helpful
Vitamin B2 has transformed my life. After years of chronic migraines and various failed treatments, I decided to try B2 to lessen my migraine frequency. To my astonishment, it worked! I now experience about one migraine a week and even went 18 days without one. It's a must-try for anyone suffering frequent migraines.
Read More
9
Research leads to success
66 people found this helpful
After struggling for over fifty years with headache issues, I sought alternatives to medications such as Topamax due to their side effects. Upon researching, I discovered a combination of Vitamin B2, Butterbur, and Feverfew that effectively prevents migraine headaches without side effects. My hair has even improved in texture.
Read More
9
Effective migraine relief
45 people found this helpful
Decrease Migraines—safe and effective. I had terrible migraine headaches several times a week. After reading research studies recommending 400mg of B-2 daily to reduce migraine frequency, I tried it. Three months later, I’m thrilled to say it works. My rescue medication usage dropped from twice a week to twice a month, which has greatly improved my quality of life. My headaches are less frequent and less intense. If you suffer from migraines, this safe supplement could enhance your quality of life.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.3
- All Researches
9.5
Peripheral cannabinoids show promise
We explored how peripheral cannabinoids could help reduce the suffering from migraines and related headaches. In mouse models, we found that these cannabinoids significantly prevented behaviors and biochemical changes linked to increased pain sensitivity from long-term treatment with a common migraine trigger.
Interestingly, while these compounds worked best when given beforehand, they showed no signs of causing additional pain sensitivity themselves. This suggests a promising new direction for migraine treatment that doesn't come with the central nervous system side effects of traditional cannabinoids.
Interestingly, while these compounds worked best when given beforehand, they showed no signs of causing additional pain sensitivity themselves. This suggests a promising new direction for migraine treatment that doesn't come with the central nervous system side effects of traditional cannabinoids.
Read More
9.5
Riboflavin effective for pediatric migraines
We conducted a retrospective observational study involving 42 children and adolescents aged 6 to 18 years suffering from migraines. Our aim was to see how effective riboflavin, a safe and affordable nutraceutical, could be in reducing headache symptoms.
After administering weight-based doses of riboflavin, we observed substantial decreases in the frequency, intensity, and duration of headaches, along with reduced medication usage and fewer missed school days. These findings suggest that riboflavin can be a beneficial option for pediatric migraine management.
After administering weight-based doses of riboflavin, we observed substantial decreases in the frequency, intensity, and duration of headaches, along with reduced medication usage and fewer missed school days. These findings suggest that riboflavin can be a beneficial option for pediatric migraine management.
Read More
9
We investigated the effects of galcanezumab, a CGRP monoclonal antibody, on migraine headaches in a group of patients. After three months of treatment, we found that those who benefited from the therapy showed a decrease in migraine days and changes in brain connectivity.
Specifically, the treatment responders exhibited reduced connectivity among various brain regions, indicating a shift toward a calmer state of cortical function. However, the non-responders did not show similar changes, suggesting that this medication may not work for everyone.
Specifically, the treatment responders exhibited reduced connectivity among various brain regions, indicating a shift toward a calmer state of cortical function. However, the non-responders did not show similar changes, suggesting that this medication may not work for everyone.
Read More
9
We reviewed the impact of nutraceuticals on headache management, focusing particularly on riboflavin (B2). This vitamin shows promise for preventing migraines in adults, although its effectiveness in children remains unverified.
Adverse reactions to riboflavin are generally minimal, making it a safe option. While other substances like Coenzyme Q10 and magnesium also exhibit some efficacy with low side effects, caution is advised for feverfew due to uncertain safety.
Thus, while we identified potential benefits, it's essential to approach these treatments with care and consultation.
Adverse reactions to riboflavin are generally minimal, making it a safe option. While other substances like Coenzyme Q10 and magnesium also exhibit some efficacy with low side effects, caution is advised for feverfew due to uncertain safety.
Thus, while we identified potential benefits, it's essential to approach these treatments with care and consultation.
Read More
9
We investigated how Vitamin B2 supplementation could affect migraines. In a thorough review of available studies, we found that taking 400 mg of Vitamin B2 daily for three months significantly reduced the number of migraine days, duration, frequency, and pain intensity.
We analyzed data from eight randomized trials involving 673 participants. The findings suggest that Vitamin B2 can be a helpful non-pharmaceutical option for people seeking to lessen the burden of migraines.
We analyzed data from eight randomized trials involving 673 participants. The findings suggest that Vitamin B2 can be a helpful non-pharmaceutical option for people seeking to lessen the burden of migraines.
Read More
User Reviews
USERS' SCORE
Good
Based on 17 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Life-changing relief
142 people found this helpful
Vitamin B2 has transformed my life. After years of chronic migraines and various failed treatments, I decided to try B2 to lessen my migraine frequency. To my astonishment, it worked! I now experience about one migraine a week and even went 18 days without one. It's a must-try for anyone suffering frequent migraines.
Read More
9
Research leads to success
66 people found this helpful
After struggling for over fifty years with headache issues, I sought alternatives to medications such as Topamax due to their side effects. Upon researching, I discovered a combination of Vitamin B2, Butterbur, and Feverfew that effectively prevents migraine headaches without side effects. My hair has even improved in texture.
Read More
9
Effective migraine relief
45 people found this helpful
Decrease Migraines—safe and effective. I had terrible migraine headaches several times a week. After reading research studies recommending 400mg of B-2 daily to reduce migraine frequency, I tried it. Three months later, I’m thrilled to say it works. My rescue medication usage dropped from twice a week to twice a month, which has greatly improved my quality of life. My headaches are less frequent and less intense. If you suffer from migraines, this safe supplement could enhance your quality of life.
Read More
7.5
Sinus headache relief
41 people found this helpful
Amazing. My allergist recommended this after I struggled with sinus issues and relied on Zyrtec-D for years. This has been the only remedy that alleviates my sinus headaches when I don’t take Zyrtec-D. Even 1000mg of Advil failed to help. I highly recommend it!
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7.5
Significant reduction observed
3 people found this helpful
In conjunction with Magnesium Glycinate, I've noticed a marked decline in my migraines. I take four capsules each morning alongside 400mg of magnesium, dividing it into two doses, which has decreased my migraine frequency from several weekly to possibly one monthly.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Szabo E, Bolo NR, Borsook D, Burstein R, Ashina S. Peripherally acting anti-CGRP monoclonal antibodies attenuate cortical resting-state connectivity in migraine patients. Cephalalgia. 2025;45:3331024241313377. 10.1177/03331024241313377
- Tepper SJ, Tepper K. Nutraceuticals and Headache 2024: Riboflavin, Coenzyme Q10, Feverfew, Magnesium, Melatonin, and Butterbur. Curr Pain Headache Rep. 2025;29:33. 10.1007/s11916-025-01358-3
- Tavasoli A, Rezazadeh M, Kachuei M. Eyebrow bleeding as a rare migraine symptom: a case report. Ann Med Surg (Lond). 2024;86:7377. 10.1097/MS9.0000000000002655
- Son H, Zhang Y, Shannonhouse J, Gomez R, Kim YS. PACAP38/mast-cell-specific receptor axis mediates repetitive stress-induced headache in mice. J Headache Pain. 2024;25:87. 10.1186/s10194-024-01786-3
- Kaur K, Hernandez V, Al Hajaj SW, Ebrahim AM, Razack M, et al. The Efficacy of Herbal Supplements and Nutraceuticals for Prevention of Migraine: Can They Help?. Cureus. 2021;13:e14868. 10.7759/cureus.14868
- Chen YS, Lee HF, Tsai CH, Hsu YY, Fang CJ, et al. Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr Neurosci. 2022;25:1801. 10.1080/1028415X.2021.1904542
- Yamamoto T, Mulpuri Y, Izraylev M, Li Q, Simonian M, et al. Selective targeting of peripheral cannabinoid receptors prevents behavioral symptoms and sensitization of trigeminal neurons in mouse models of migraine and medication overuse headache. Pain. 2021;162:2246. 10.1097/j.pain.0000000000002214
- Vikelis M, Dermitzakis EV, Vlachos GS, Soldatos P, Spingos KC, et al. Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis. J Clin Med. 2020;10. 10.3390/jcm10010067
- Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. 10.1016/j.pediatrneurol.2020.09.009
- Onofri A, Necozione S, Tozzi E. Complementary and alternative medicine (CAM) in headache of children and adolescents: open-label Italian study. Clin Ter. 2020;171:e393. 10.7417/CT.2020.2246
- Cesarone MR, Dugall M, Hu S, Belcaro G, Hosoi M, et al. Episodic primary migraine headache: supplementary prophylaxis with Pycnogenol® prevents attacks and controls oxidative stress. Panminerva Med. 2020;62:102. 10.23736/S0031-0808.19.03745-5
- Chu H, Hu B. [Triple acupuncture method at cervical Jiaji (EX-B 2) for cervicogenic headache: a randomized controlled trial]. Zhongguo Zhen Jiu. 2016;36:29.
- Namazi N, Heshmati J, Tarighat-Esfanjani A. Supplementation with Riboflavin (Vitamin B2) for Migraine Prophylaxis in Adults and Children: A Review. Int J Vitam Nutr Res. 2015;85:79. 10.1024/0300-9831/a000225
- Rahimdel A, Zeinali A, Yazdian-Anari P, Hajizadeh R, Arefnia E. Effectiveness of Vitamin B2 versus Sodium Valproate in Migraine Prophylaxis: a randomized clinical trial. Electron Physician. 2015;7:1344. 10.14661/1344
