I have psoriatic Arthritis on top of bursitis and restless legs syndrome. Been using this complex for over a week and have noticed dramatic changes in the calves. It has decreased the restlessness by 90%. It has given me more energy but does take time for the body to regulate the vitamins but not too long. I pulse the pills on the weekends and will notice the difference without it. I am on medication management with serotonin and the B-50 complex works in tandem very well. The urine will be yellow, which is normal from the riboflavin; the complimentary effects of B1 and B12 has increased dopamine lessening my headaches and the proper need for iron to get to the brain. I am more than satisfied with NowFoods B 50 complex. Have used their products in the past with outstanding results. I do agree that it's a little hard to swallow because of the lack of coating but, plenty of water is key. This product works! The flaking of psoriasis on my fingers have lessened dramatically but is still red and tender. It's going to take more time for that to clear up and there is no itching. Hope my review helps someone who is thinking about their health and this item