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Supplement Facts
Serving Size: 1 Chewable Tablet
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
The product is found useful for the following medical conditions
Common Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.4
USERS' SCORE
Excellent
Based on 27 Reviews
9
8
Vitamin D3 improves cold symptoms
Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study.
Most Relevant Research
We conducted a thorough investigation into how 25-hydroxyvitamin D3, commonly referred to as vitamin D3, impacts upper respiratory tract infections (URTIs), particularly the common cold. This study was carried out as a randomized, double-blind, placebo-controlled trial, engaging 428 participants, all aged between 45 and 74, across three clinics in Japan.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
Participants were divided into two groups, with one receiving a daily dose of 10 μg of vitamin D3, while the other took a placebo for 16 weeks. Our findings highlighted that those who took vitamin D3 experienced a reduction in the duration of their upper respiratory symptoms, as well as a decrease in severity and improvement in their quality of life during illness.
Overall, our results indicate that supplementing with vitamin D3 might be a proactive step in handling the discomforts associated with common colds. This simple addition to one's daily routine could lead to a notably better experience when facing URTIs, providing a hopeful outlook for those looking for relief from their symptoms.
9.5
Boosted immunity
Most Useful Review
After regularly taking vitamin D3, both my child and I have practically stopped suffering from the common cold. My daughter consistently broke kindergarten attendance records and rarely fell ill during the winter months. I've noticed I feel more energetic too. When I stop taking the supplement, my thoracic spine often aches, but it improves as soon as I resume the vitamin D3. I'm very pleased with the results.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.8
9
Vitamin D3 aids migraine relief
Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial.
Most Relevant Research
We conducted a rigorous study to explore how vitamin D3 supplementation might influence headaches in people suffering from migraines. By utilizing a well-structured, placebo-controlled, double-blind design, we included 80 participants with episodic migraines, assigning them either a daily dose of vitamin D3 or a placebo for 12 weeks.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
After the study, we observed significant improvements in those receiving vitamin D3. Participants reported fewer headache days each month, shorter headache durations, and less severe pain overall. They also used fewer pain relievers compared to those on placebo, showcasing the potential benefit of vitamin D3 in managing migraine symptoms.
Our findings suggest that vitamin D3 not only aids in reducing headache frequency but may also play a role in addressing inflammation, as evidenced by reduced levels of certain inflammatory markers in the blood. This highlights its possible therapeutic value for migraine sufferers, indicating that a daily dose could make a meaningful difference in their lives.
10
Headache relief
Most Useful Review
Excellent! I really liked this vitamin D. I had tried various types before, but none suited me. I constantly suffered from severe headaches and insomnia. Since taking this vitamin D, I feel great. I take three tablets a day, and they taste nice. I'm hopeful that my test results will improve after completing the course.
Acne details
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.7
USERS' SCORE
Good
Based on 5 Reviews
8.7
8
Vitamin D analogs reduce acne effectively
Identification of a unique subset of 2-methylene-19-nor analogs of vitamin D with comedolytic activity in the rhino mouse.
Most Relevant Research
We explored the effects of vitamin D and its analogs on acne, primarily focusing on their ability to reduce the size of comedones (or acne lesions) in a rhino mouse model. This study evaluated the active form of vitamin D, known as 1,25-dihydroxyvitamin D(3), along with several modified analogs.
All analogs tested, including the natural hormone, increased the thickness of skin. However, only a particular group of analogs without a full side chain and 25-hydroxyl group were effective in actually reducing comedone size. Notably, this reduction in acne did not negatively impact serum calcium levels, which is a common concern with vitamin D treatments.
Interestingly, while all compounds featuring a side chain of 2 to 5 carbons worked similarly in terms of comedolytic activity, longer chains tended to increase calcemic risk. Moreover, our findings indicated that increasing the epidermal thickness required a lower dose compared to what was needed for comedolysis. This identifies a distinct set of vitamin D analogs that can help manage acne without the side effects of hypercalcemia.
Overall, we highlighted how certain vitamin D analogs can combat acne effectively while minimizing potential risks related to calcium levels.
All analogs tested, including the natural hormone, increased the thickness of skin. However, only a particular group of analogs without a full side chain and 25-hydroxyl group were effective in actually reducing comedone size. Notably, this reduction in acne did not negatively impact serum calcium levels, which is a common concern with vitamin D treatments.
Interestingly, while all compounds featuring a side chain of 2 to 5 carbons worked similarly in terms of comedolytic activity, longer chains tended to increase calcemic risk. Moreover, our findings indicated that increasing the epidermal thickness required a lower dose compared to what was needed for comedolysis. This identifies a distinct set of vitamin D analogs that can help manage acne without the side effects of hypercalcemia.
Overall, we highlighted how certain vitamin D analogs can combat acne effectively while minimizing potential risks related to calcium levels.
9.5
Improved acne situation
Most Useful Review
Excellent vitamins! My skin has improved significantly, with much less acne and a better mood. Teeth issues have also diminished. This is precisely the result I expected when ordering. I highly recommend this wonderful vitamin, especially if you spend a lot of time indoors away from the sun.
Anemia details
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.4
USERS' SCORE
Good
Based on 3 Reviews
8.7
7
Vitamin D3's role in anemia
Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: Protocol for an 8-week, parallel group, double-blind randomized controlled trial.
Most Relevant Research
We conducted a study to see how vitamin D3 might help improve iron levels in women of childbearing age who had marginally low iron stores. Our approach involved a carefully designed 8-week randomized controlled trial, where 120 women aged between 19 and 40 were divided into two groups. One group received fruit juice fortified with 4000 IU of vitamin D3 daily, while the other had a placebo juice.
Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.
Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.
As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.
Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.
Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.
As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.
9.5
Strengthened immunity
Most Useful Review
I give vitamin D to my children from birth, and they rarely fall ill. I provide both my eldest, who is 5 years old, and the youngest, who is 2.5 years old, with one tablet after breakfast. Vitamin D3 fortifies the immune system and aids in the development of a newborn's nervous system. It also enhances iron absorption, as rickets and anemia in children are often linked.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 7 Reviews
8.7
9
CYP11A1, Autism Symptoms, Vitamin D3
Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention.
Most Relevant Research
We explored how overexpression of the CYP11A1 enzyme in the placenta can impact offspring and potentially lead to autism-like behaviors, particularly focusing on anxiety. Using a specialized murine model, we looked closely at how this genetic change affected social interactions and anxiety levels in the mice.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
Our findings highlighted a significant increase in anxiety-related behaviors, which we measured through various tests like the open field and elevated plus maze assessments. Interestingly, we observed that supplementing with vitamin D3 led to noticeable improvements in these anxiety behaviors, suggesting a protective role for vitamin D3 against the adverse effects caused by altered hormone levels from the Cyp11a1 overexpression.
Additionally, we found that vitamin D3 treatment not only helped in behavioral aspects but also corrected underlying neuroinflammatory responses—specifically the activation of microglia in the brain. This suggests that addressing vitamin D levels during pregnancy could be a potential strategy to mitigate these changes and improve outcomes for offspring at risk of autism spectrum disorders.
9.5
Reduced anxiety
Most Useful Review
This was a great supplement; it helped alleviate my anxiety. I highly recommend it to everyone.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 14 Reviews
8.7
9.5
Strong immunity boost
Most Useful Review
This Vitamin D-3 is essential for bone health and immune support. After testing, my son’s levels rose significantly, improving his immunity and energy. He now enjoys taking the tasty tablets daily.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5
USERS' SCORE
Good
Based on 10 Reviews
8.7
2
Vitamin D3 ineffective for CFS
Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial.
Most Relevant Research
We conducted a thorough investigation into whether high-dose intermittent vitamin D3 could alleviate symptoms of chronic fatigue syndrome (CFS) and improve vascular health. This double-blind, randomized placebo-controlled trial involved patients meeting established criteria for CFS. Participants received either 100,000 units of vitamin D3 or a placebo every two months for six months.
Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.
In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.
Over the course of the study, we measured key outcomes such as arterial stiffness, blood pressure, cholesterol levels, and fatigue levels through various tests. Surprisingly, our findings showed that vitamin D3 treatment did not lead to any significant improvements in these areas. We observed only a slight increase in vitamin D levels in the treatment group, but this did not translate into better vascular health or reduced fatigue.
In conclusion, we honestly found that high-dose vitamin D3 did not offer any notable benefits for patients struggling with chronic fatigue syndrome. This study highlights the complexities of treating CFS and suggests that vitamin D3 may not be the solution some had hoped for.
9.5
Increased energy
Most Useful Review
I take two vitamin D capsules a day, and I've noticed a surge in energy and less fatigue. I also take magnesium alongside it.
Cold Sores details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Anxiety improvement
Most Useful Review
I have been taking it regularly, and my levels have improved remarkably—from 22 to 70! My cold sores have reduced significantly, and I’ve not caught a cold since. My insomnia has slightly improved too.
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.7
9
Vitamin D3 lowers cholesterol levels
Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity.
Most Relevant Research
We investigated how vitamin D3 supplements impact cholesterol levels in pediatric patients suffering from obesity. The study involved 723 children over two years, with 283 receiving vitamin D3 and 440 on a placebo.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
After closely examining the children’s cholesterol, triglycerides, and glucose levels, we found a strong relationship between these factors and their vitamin D3 levels. Following the supplementation, the group taking vitamin D3 experienced some notable improvements.
Specifically, we saw significant decreases in total cholesterol, HDL cholesterol, and triglycerides in the vitamin D3 group when compared to those who received the placebo. This indicates that vitamin D3 could play a beneficial role in managing high cholesterol and improving overall metabolic health in children coping with obesity.
Our findings suggest that vitamin D3 is a valuable addition to strategies aimed at improving lipid levels and encouraging healthy lifestyles in young patients struggling with excessive weight. Overall, supplementing with vitamin D3 appears to offer an effective approach to tackling high cholesterol in this at-risk population.
9.5
High-quality bud
Most Useful Review
Very high quality bud at a great price, and it works well!
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.7
8.3
Cramps improvement
Most Useful Review
I bought this for my mother due to her calcium deficiency and night leg cramps. The doctor recommended calcium and magnesium. This product has a great composition, and since she started using it, the results have been evident. Plus, it has a pleasant vanilla flavour.
Liver Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.7
9
Vitamin D3 aids liver health
Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial.
Most Relevant Research
We aimed to explore how vitamin D3 supplementation affects liver disease, specifically in patients with cirrhosis. In a thorough double-blind, randomized controlled trial involving 60 participants, we offered patients either a weekly dose of 50,000 IU of vitamin D or a placebo for 12 weeks. Our goal was to assess various health indicators, including serum vitamin D levels, blood glucose measures, and liver function tests.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
After the 12-week period, we observed significant changes among those taking vitamin D. The serum levels of 25-hydroxy-vitamin-D3 increased substantially, alongside notable improvements in fasting blood glucose and insulin resistance, measured by HOMA-IR. These results suggest that vitamin D3 could play a beneficial role in managing certain metabolic aspects of liver disease in cirrhosis patients.
Overall, our study highlights the potential of vitamin D3 supplementation as a simple yet effective strategy to improve specific health parameters in people living with cirrhosis, paving the way for further exploration in this important area of research.
9.5
Effective vitamin D
Most Useful Review
While it doesn't taste great, this supplement is effective. My 11-year-old, who has long-standing health issues, experienced improved vitamin D levels from 19 to 106 after six months. He has liver disease and doesn't absorb fat-soluble vitamins well, but this product has not affected his liver parameters. We tried other supplements, but none had such an effect. I continue to use this regularly.
Menopause details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Good
Based on 7 Reviews
8.7
7
Vitamin D3 in menopause management
Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats.
Most Relevant Research
In this study, we explored how vitamin D3, among other supplements, affects metabolic health during menopause. The research utilized a group of ovariectomized female rats, which serve as a model for menopausal conditions in women. These rats were divided into several groups, including a control group and various groups that received different treatments, including vitamin D3.
The findings indicated that administering vitamin D3, along with boric acid, magnesium, and extra virgin olive oil, led to notable improvements in metabolic parameters. We observed benefits in areas such as inflammation and oxidative stress, which are crucial for managing health during menopause. However, while vitamin D3 showed positive effects, the study highlighted that the combination of all supplements had a more significant impact than vitamin D3 alone.
Ultimately, while vitamin D3 contributes positively to metabolic health in menopause, the full extent of its isolated benefits remains unclear without further studies. Thus, we recognize the need for additional research to fully understand how effective vitamin D3 can be independently in this context.
The findings indicated that administering vitamin D3, along with boric acid, magnesium, and extra virgin olive oil, led to notable improvements in metabolic parameters. We observed benefits in areas such as inflammation and oxidative stress, which are crucial for managing health during menopause. However, while vitamin D3 showed positive effects, the study highlighted that the combination of all supplements had a more significant impact than vitamin D3 alone.
Ultimately, while vitamin D3 contributes positively to metabolic health in menopause, the full extent of its isolated benefits remains unclear without further studies. Thus, we recognize the need for additional research to fully understand how effective vitamin D3 can be independently in this context.
9.5
Boosts immunity
Most Useful Review
This is perhaps the best Vitamin D I have ever tasted. The ingredients and quality are outstanding. I take four tablets daily; they are truly delicious! This dosage effectively boosts immunity, and at my age, pre-menopause, it’s vital for my bone density and mental health.
Osteoporosis details
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.4
USERS' SCORE
Good
Based on 11 Reviews
8.7
9
Vitamin D derivatives enhance bone health
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Most Relevant Research
We looked into the potential effects of vitamin D3, particularly its derivatives, on osteoporosis. Recent research highlights how modifications to the A-ring of 1α,25-dihydroxyvitamin D can enhance its binding to the vitamin D receptor. This change not only boosts the vitamin's effectiveness but also helps it resist breakdown in the body, making it stay active for longer periods.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
One standout example is a derivative known as AH-1, which demonstrated significant benefits for bone health in an osteoporosis model using ovariectomized rats. When given at a low dosage, AH-1 outperformed natural vitamin D, suggesting a promising path for improving osteoporosis treatment.
We also noted that while traditional vitamin D has its benefits, these newly developed analogs could lead to treatments that target osteoporosis more effectively, providing options without the side effects commonly associated with vitamin D therapy. This research emphasizes the importance of vitamin D derivatives as we seek better solutions for managing bone health.
9.5
Immune system support
Most Useful Review
This product is excellent! Vitamin D plays a key role in calcium-phosphorus metabolism, helping to absorb calcium from the intestines. Insufficient vitamin D can lower blood calcium levels, leading to osteoporosis and fractures. It’s also vital for immune health, reducing the risk of autoimmune diseases.
Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.7
8
Vitamin D3 aids cold recovery
Intake of 25-Hydroxyvitamin D3 Reduces Duration and Severity of Upper Respiratory Tract Infection: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Comparison Study.
Most Relevant Research
We explored how 25-hydroxyvitamin D3 (25OHD), a form of vitamin D, influences upper respiratory tract infections (URTIs), commonly known as colds. In a carefully designed clinical study, we followed 428 participants aged 45 to 74 over a 16-week period. They were randomly assigned to receive either 10 μg of 25OHD daily or a placebo, all while maintaining a double-blind setup to ensure accurate results.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
Our findings revealed that those who took 25OHD had reduced duration and severity of their cold symptoms. Participants reported improvements in their overall quality of life during the bouts of URTI. By tracking the health of the participants through surveys designed to measure cold symptoms, we gathered valuable data that indicates vitamin D3 could play a helpful role in managing colds.
This suggests that incorporating vitamin D3 into our diets may be beneficial when we catch a cold, potentially leading to a quicker recovery. It’s a promising avenue for anyone looking to ease the discomfort and duration of these frustrating infections.
10
Prevents colds effectively
Most Useful Review
NOW FOODS VITAMIN D IS ESSENTIAL FOR COLD SUFFERERS. My item arrived promptly, and the seller was professional in addressing my queries. Since I began taking these vitamin D tablets, I have not experienced a cold. I genuinely enjoy the taste of the tablets and would recommend them to my family and friends who are suffering from colds.
Arthritis details
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin D3's role in OA prevention
1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice.
Most Relevant Research
We explored the link between vitamin D3 and knee osteoarthritis (OA) by examining both young and older mice. Our findings revealed that a deficiency in vitamin D3, specifically the active form known as 1,25(OH)D, significantly sped up the development of age-related OA. This included issues such as cartilage damage and increased chondrocyte senescence.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
8.8
Improved immunity
Most Useful Review
This vitamin D product is excellent! It plays a vital role in calcium-phosphorus metabolism and helps absorb calcium from the intestines. A deficiency can lead to osteoporosis and influence immune function. Adequate vitamin D levels can reduce the risk of autoimmune diseases, including rheumatoid arthritis, highlighting its importance for health.
Chest Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.6
8
Calcium and vitamin D3 treatment effective
ECG changes in a 25-year-old woman with hypocalcemia due to hypoparathyroidism. Hypocalcemia mimicking acute myocardial infarction.
Most Relevant Research
We explored the case of a 25-year-old woman who experienced chest pain and ECG changes typically associated with a heart attack. After undergoing cardiac catheterization, doctors found her coronary arteries to be normal but noted impaired left ventricular performance.
Further tests revealed she had primary hypoparathyroidism leading to low calcium levels, or hypocalcemia. To address this, she was treated with calcium and vitamin D3 supplements, which significantly improved her condition and alleviated her symptoms.
Although she eventually remained symptom-free, some ECG repolarization disturbances persisted. This case provides important insights into how low calcium levels can mimic acute myocardial infarction and highlights the effective role of vitamin D3 and calcium in alleviating related chest pain.
Further tests revealed she had primary hypoparathyroidism leading to low calcium levels, or hypocalcemia. To address this, she was treated with calcium and vitamin D3 supplements, which significantly improved her condition and alleviated her symptoms.
Although she eventually remained symptom-free, some ECG repolarization disturbances persisted. This case provides important insights into how low calcium levels can mimic acute myocardial infarction and highlights the effective role of vitamin D3 and calcium in alleviating related chest pain.
9.5
Reduced joint pain
Most Useful Review
My joints have stopped crunching and the pain has significantly decreased. After suffering from various pains, I was relieved to find no underlying issues upon testing. By three months of taking the supplement, I've hardly any pain, except for some remaining discomfort in my shoulder joint.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.9
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin D treatment reduces BPPV
Reduction of recurrence rate of benign paroxysmal positional vertigo by treatment of severe vitamin D deficiency.
Most Relevant Research
We sought to understand the impact of severe vitamin D deficiency on benign paroxysmal positional vertigo (BPPV), a common cause of dizziness. Previous studies showed a connection between low vitamin D levels and both the onset and recurrence of BPPV, but none had conclusively demonstrated that addressing this deficiency could lessen the recurrence of symptoms.
To examine this further, we included patients diagnosed with unilateral, idiopathic posterior canal BPPV and severe vitamin D deficiency, indicated by levels of 25-hydroxyvitamin D3 at or below 10 ng/ml. After thorough evaluations including hearing tests and balance assessments, we prescribed vitamin D therapy to our participants.
Over the following months, we monitored the changes in their vitamin D levels and followed up with them for 18 months to observe any recurrence of dizziness. Our findings revealed that patients who showed an improvement in their vitamin D levels experienced a significant reduction in the recurrence of BPPV symptoms.
This suggests that by addressing vitamin D deficiency, we can potentially offer a more effective approach to managing BPPV—lessening those troublesome dizzy spells that can really impact quality of life.
To examine this further, we included patients diagnosed with unilateral, idiopathic posterior canal BPPV and severe vitamin D deficiency, indicated by levels of 25-hydroxyvitamin D3 at or below 10 ng/ml. After thorough evaluations including hearing tests and balance assessments, we prescribed vitamin D therapy to our participants.
Over the following months, we monitored the changes in their vitamin D levels and followed up with them for 18 months to observe any recurrence of dizziness. Our findings revealed that patients who showed an improvement in their vitamin D levels experienced a significant reduction in the recurrence of BPPV symptoms.
This suggests that by addressing vitamin D deficiency, we can potentially offer a more effective approach to managing BPPV—lessening those troublesome dizzy spells that can really impact quality of life.
9.5
Dizziness relieved
Most Useful Review
Taking 1000 IU of vitamin D for two weeks showed some small improvements. The dizziness vanished, and I experienced less pronounced weakness. My sleep quality improved, and I felt more energised. Afterward, my dosage was raised to 5000 IU and then to 10,000 IU, resulting in significantly better energy levels, less fatigue, and improved immunity as well as hair quality.
Hypothyroidism details
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.7
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin D3 reduces thyroid autoimmunity
A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis.
Most Relevant Research
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
9.5
Fatigue alleviated
Most Useful Review
Vitamin D3 needs no introduction; all doctors recommend it due to its vital role in many bodily functions. I've bought it endlessly for my family and myself. This brand's quality is exceptional, lasting six months. With rheumatoid arthritis and hypothyroidism, I find it crucial. It helps with calcium and phosphorus absorption. Since taking it, my fatigue, gum inflammation, and weakness have significantly improved.
Knee Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.6
1
Vitamin D3 shows no benefit
Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial.
Most Relevant Research
We conducted a thorough investigation into the effects of vitamin D3 supplementation on knee pain and cartilage volume in people suffering from knee osteoarthritis, particularly those with low vitamin D levels. This study took place in Tasmania and Victoria, Australia, and was designed as a multicenter, randomized, double-blind, placebo-controlled clinical trial.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
Over a span of two years, we divided participants into two groups: one received a monthly dose of oral vitamin D3 (50,000 IU), while the other group received a placebo. Our main focus was to evaluate any changes in tibial cartilage volume, measured through MRI, as well as the participants' knee pain levels as indicated by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score.
The results showed that, compared to the placebo group, those who received vitamin D3 experienced no significant differences in either tibial cartilage volume or reported knee pain over the two years. This indicates that vitamin D3 supplementation does not provide meaningful benefits for reducing tibial cartilage loss or improving knee pain in patients with symptomatic knee osteoarthritis.
9.5
Reduced knee pain
Most Useful Review
The most important thing is that my joints have stopped crunching and they hurt less. After getting tested, I discovered there was no underlying issue for my sensations. Now, after nearly three months of taking the dietary supplement, I’m delighted to find that I hardly feel any pain. My shoulder still aches, but my knee pain and discomfort in my fingers have significantly decreased.
Multiple Sclerosis details
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.6
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin D3 alleviates MS symptoms
Immunoregulatory Effect of Calcitriol on Experimental Autoimmune Encephalomyelitis (EAE) Mice.
Most Relevant Research
We investigated the influence of calcitriol, the active form of vitamin D, on experimental autoimmune encephalomyelitis (EAE), an animal model akin to multiple sclerosis. Our study involved twenty-eight mice divided into four groups, allowing us to compare outcomes between those with and without EAE, as well as those receiving calcitriol treatment.
We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.
Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.
We found that, in mice with EAE, inflammation indicators such as interleukin-17 (IL-17) significantly increased, while transforming growth factor beta (TGF-β) levels decreased compared to healthy controls. Upon treating the EAE group with calcitriol, we observed a reversal of these changes, suggesting a substantial immunomodulatory effect, which eased symptoms typically associated with EAE.
Notably, we also noticed that calcitriol enhanced gene expression for interleukin-9 (IL-9) in both healthy and EAE mice. Overall, our findings support the notion that calcitriol holds promise as a potential treatment to alleviate the symptoms of multiple sclerosis through its anti-inflammatory properties.
8.8
Prevention and treatment
Most Useful Review
Vitamin D is crucial for treating and preventing various diseases, including multiple sclerosis, diabetes, and respiratory infections. It plays an essential role in supporting the immune system and overall health in older patients.
Nausea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
No nausea reported
Most Useful Review
I took a small dosage for my child, and she takes it without experiencing nausea or allergies.
Obesity details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin D reduces triglycerides effectively
Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials.
Most Relevant Research
We explored the effects of vitamin D supplementation on lipid profiles in overweight and obese women. Our investigation included data from various randomized controlled trials (RCTs) that specifically examined how vitamin D might influence cholesterol and triglyceride levels in this population.
Our analysis revealed that vitamin D had a significant impact on lowering triglycerides and total cholesterol levels. We found reductions of about 6.13 mg/dL for triglycerides and 4.45 mg/dL for total cholesterol. Additionally, there was a noteworthy increase in HDL cholesterol, the “good” cholesterol, by an average of 1.54 mg/dL.
Interestingly, we noticed that those with higher baseline triglyceride levels saw even greater benefits, particularly with a significant reduction in triglycerides when vitamin D was supplemented for 26 weeks or less. However, it’s important to mention that vitamin D supplementation did not have a significant effect on LDL cholesterol levels in this group.
Overall, our findings suggest that vitamin D can be an effective option for managing certain aspects of lipid profiles in overweight or obese women, particularly in addressing high triglycerides.
Our analysis revealed that vitamin D had a significant impact on lowering triglycerides and total cholesterol levels. We found reductions of about 6.13 mg/dL for triglycerides and 4.45 mg/dL for total cholesterol. Additionally, there was a noteworthy increase in HDL cholesterol, the “good” cholesterol, by an average of 1.54 mg/dL.
Interestingly, we noticed that those with higher baseline triglyceride levels saw even greater benefits, particularly with a significant reduction in triglycerides when vitamin D was supplemented for 26 weeks or less. However, it’s important to mention that vitamin D supplementation did not have a significant effect on LDL cholesterol levels in this group.
Overall, our findings suggest that vitamin D can be an effective option for managing certain aspects of lipid profiles in overweight or obese women, particularly in addressing high triglycerides.
9.5
Prevents obesity
Most Useful Review
Excellent dosage for my 10-year-old daughter, who chews them with enjoyment. Vitamin D is essential for immunity; without it, obesity and frequent colds are likely. Previously, I used to fall ill three times each winter, but now, despite her whole class getting sick, she remains healthy. I'm delighted with this vitamin and will purchase more. The brand is impressive too!
Psoriasis details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.6
9.5
Vitamin D3 ethosomes for psoriasis
Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
Most Relevant Research
We aimed to explore the effectiveness of a special gel infused with vitamin D3, known as an ethosome, in managing psoriasis. This inflammatory skin condition is driven by an overactive immune response, and vitamin D3 plays a crucial role in the growth and development of skin cells called keratinocytes, making it a promising treatment option.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
9.5
Hormonal balance
Most Useful Review
I've been diabetic for nearly 30 years and became interested in vitamin D after learning about its crucial role in calcium metabolism and gene regulation. A deficiency can lead to various issues, including psoriasis. Surprisingly, vitamin D shortages are common even in sunny regions. It's clear walking and sunlight are vital, but supplementation may be necessary to address these health concerns.
Asthma details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8.5
8
Vitamin D3 improves asthma control
Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials.
Most Relevant Research
We explored the effectiveness of vitamin D3 in reducing asthma exacerbations among children through a systematic review and meta-analysis of randomized controlled trials. In our investigation, we analyzed data from ten studies, which included a total of 1,243 children with asthma. Among these, 631 received vitamin D3 supplementation while 612 were given a placebo.
Our pooled analysis revealed promising results: vitamin D3 supplementation significantly reduced the overall number of asthma exacerbations. Specifically, we found a risk ratio of 0.62, indicating a notable decrease in attacks. Notably, a subgroup analysis showed that children receiving the standard daily dose of vitamin D experienced an even more significant improvement, with a risk ratio of 0.41.
Overall, we concluded that vitamin D3 supplementation holds the potential to lower asthma exacerbations in children. This is particularly encouraging as it also correlates with improved lung function, measured through FEV1. Hence, vitamin D3 could be a valuable addition to asthma management for young patients.
Our pooled analysis revealed promising results: vitamin D3 supplementation significantly reduced the overall number of asthma exacerbations. Specifically, we found a risk ratio of 0.62, indicating a notable decrease in attacks. Notably, a subgroup analysis showed that children receiving the standard daily dose of vitamin D experienced an even more significant improvement, with a risk ratio of 0.41.
Overall, we concluded that vitamin D3 supplementation holds the potential to lower asthma exacerbations in children. This is particularly encouraging as it also correlates with improved lung function, measured through FEV1. Hence, vitamin D3 could be a valuable addition to asthma management for young patients.
8.8
Game changer for asthma
Most Useful Review
The best! This supplement was transformative for my daughter, who has experienced asthma flares. Her rheumatologist suggested high dosing as a potential remedy for her fevers. I’ve bought 13 bottles in two years because our entire family uses it, and I always keep two backups in case it goes out of stock.
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
USERS' SCORE
Good
Based on 7 Reviews
8.5
8
Vitamin D3 offers anti-cancer benefits
Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.
Most Relevant Research
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
8
Improved symptoms
Most Useful Review
I consumed these for two months, bringing my vitamin D level from 22 to 70. The improvement was unexpected, especially as my cold frequency decreased and my symptoms of anxiety and health anxiety improved. I also noticed better sleep.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
USERS' SCORE
Good
Based on 9 Reviews
8.5
9
Vitamin D3 improves depressive symptoms
Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial.
Most Relevant Research
We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
8.8
Reduces depression
Most Useful Review
The most useful purchase. If you live in Ukraine or Russia, this supplement is essential from October to April. It replenishes the deficiency of vitamin D, alleviates depression, and even improves skin appearance. I definitely recommend it.
Insomnia details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 8 Reviews
8.5
8
Vitamin D3 improves adolescent insomnia
High-dose Vitamin D Supplementation and Improvement in Cognitive Abilities, Insomnia, and Daytime Sleepiness in Adolescent Girls.
Most Relevant Research
We studied how high-dose vitamin D3 supplementation might affect insomnia in adolescent girls. Over nine weeks, 940 participants received a weekly dose of 50,000 IU of vitamin D3 while we tracked changes in their sleep patterns.
Interestingly, we observed a notable reduction in insomnia rates after the treatment. The number of girls reporting insomnia dropped from 15.0% to 11.3%, indicating that this vitamin can potentially improve sleep quality.
We also noticed a slight decrease in daytime sleepiness, with cases falling from 15.6% to 14.7%. Furthermore, those experiencing both insomnia and sleepiness saw a decline from 8.0% to 6.1%.
These findings suggest that high-dose vitamin D can play a significant role in alleviating sleep issues among adolescent girls. However, further studies are needed to see if these effects are consistent across diverse age and gender groups.
Interestingly, we observed a notable reduction in insomnia rates after the treatment. The number of girls reporting insomnia dropped from 15.0% to 11.3%, indicating that this vitamin can potentially improve sleep quality.
We also noticed a slight decrease in daytime sleepiness, with cases falling from 15.6% to 14.7%. Furthermore, those experiencing both insomnia and sleepiness saw a decline from 8.0% to 6.1%.
These findings suggest that high-dose vitamin D can play a significant role in alleviating sleep issues among adolescent girls. However, further studies are needed to see if these effects are consistent across diverse age and gender groups.
9.5
Resolved insomnia issues
Most Useful Review
Excellent! This vitamin D really suited me. Previously, I experienced severe headaches and insomnia with other brands. Now, I take three tablets daily, and I'm feeling much better. I'm optimistic it will improve my test scores after the full course.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.4
9
Vitamin D3 modulates autoimmune response
Vitamin D3 attenuates autoimmune thyroiditis by regulating Th17/Treg cell differentiation via YAP/JAK1/STAT1 axis.
Most Relevant Research
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
9
Improved skin condition
Most Useful Review
Excellent vitamins! My skin has improved, with much less acne, and my mood has lifted. My teeth no longer cause trouble. This is exactly the result I expected when ordering these vitamins. I highly recommend this wonderful product for anyone, especially if you spend a lot of time indoors from the sun, as it helps in treating an autoimmune disorder.
Cardiovascular Disease details
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
6.5
USERS' SCORE
Good
Based on 2 Reviews
8.4
8
Vitamin D improves heart disease factors
The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.
Most Relevant Research
We conducted a double-blind, randomized clinical trial to see how treating vitamin D deficiency could influence heart health, particularly in patients with ischemic heart disease (IHD). In our study, 44 IHD patients aged 40 to 65 were treated with either vitamin D or a placebo to assess changes in their lipid profiles and C-reactive protein (CRP) levels.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
Our findings revealed that participants who received vitamin D supplementation showed notable improvements. Specifically, we observed higher levels of high-density lipoprotein cholesterol (HDL-C)—often referred to as the "good" cholesterol—and lower triglyceride levels among those treated with vitamin D. Interestingly, the increase in HDL-C and improvement in triglyceride levels underscore vitamin D’s potential role in enhancing lipid profiles in patients struggling with heart disease.
We also noted that vitamin D treatment didn’t significantly impact CRP levels, which are typically used as a marker for inflammation and heart disease risk. This suggests that while vitamin D might help improve certain lipids, its effects on other markers of heart disease need further investigation.
Overall, our study highlights the potential benefits of vitamin D supplementation as a tool to manage heart disease risk factors, offering a promising option for healthcare professionals working with patients suffering from IHD.
8.3
Improves mood
Most Useful Review
This vitamin D3, from a well-known brand, is truly effective. I take it in the morning after meals, and I've noticed an improvement in my mood and energy levels, which has been beneficial for my depression. It helps regulate blood pressure and heart rate while supporting the immune and cardiovascular systems.
Hypertension details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
Calcitriol reduces age-related hypertension
Calcitriol reverses age-related hypertension via downregulating renal AP1/ATR pathway through regulating mitochondrial function.
Most Relevant Research
We explored the role of calcitriol, the active form of vitamin D, in addressing age-related hypertension. The study involved young and aged male mice, where we administered calcitriol daily for eight weeks. Our goal was to determine if this vitamin could effectively lower high blood pressure that often comes with aging.
Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.
Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.
Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.
Throughout the research, we measured blood pressure and examined various biological markers in the kidneys. What we discovered was quite promising. Aged mice exhibited increased blood pressure and impaired sodium excretion, both linked to changes in certain kidney pathways. After treatment with calcitriol, these mice showed significant reductions in blood pressure and improvements in sodium handling.
Mechanistically, calcitriol appeared to enhance mitochondrial function and alter the behavior of specific proteins related to blood pressure regulation. By promoting healthier kidney function and reducing harmful signaling pathways, calcitriol seems to offer a viable strategy for tackling hypertension as we age.
Overall, our findings suggest that calcitriol could be a valuable addition to our approaches in managing age-related hypertension, reaffirming the importance of vitamin D for our health as we get older.
8.8
Disease prevention
Most Useful Review
Vitamin D is crucial in both treating and preventing several diseases, including hypertension, diabetes, multiple sclerosis, and COVID-19.
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.4
USERS' SCORE
Good
Based on 15 Reviews
8
8
Vitamin D3 impacts allergy severity
Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis.
Most Relevant Research
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
9.5
Pleasant without allergies
Most Useful Review
Excellent vitamins! My child enjoys them as they taste sweet and pleasant. I haven't noticed any side effects or allergies.
