' 
![]()
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
Vitamin D3 alleviates angina symptoms
Vitamin D replacement therapy in patients with cardiac syndrome X.
Direct effects of vitamin D3
We aimed to understand how vitamin D3 treatment might help reduce angina and exercise-related ischemia in patients suffering from cardiac syndrome X and low vitamin D levels.
In our study, we treated patients with a course of vitamin D3 injections, delivered intramuscularly every other week for two months. We monitored the number of angina episodes per day as well as various measures of exercise capacity before and after the treatment.
By the end of the two-month protocol, we observed a striking increase in serum vitamin D levels to within a normal range. Most importantly, patients reported a significant reduction in angina frequency. We also noted improvements in exercise duration, work capacity, and a reduction in ST-segment depression during stress tests, which suggests a decrease in ischemia.
These findings support the idea that vitamin D3 replacement can dramatically improve the symptoms experienced by patients suffering from angina linked to cardiac syndrome X.
In our study, we treated patients with a course of vitamin D3 injections, delivered intramuscularly every other week for two months. We monitored the number of angina episodes per day as well as various measures of exercise capacity before and after the treatment.
By the end of the two-month protocol, we observed a striking increase in serum vitamin D levels to within a normal range. Most importantly, patients reported a significant reduction in angina frequency. We also noted improvements in exercise duration, work capacity, and a reduction in ST-segment depression during stress tests, which suggests a decrease in ischemia.
These findings support the idea that vitamin D3 replacement can dramatically improve the symptoms experienced by patients suffering from angina linked to cardiac syndrome X.
Read More
8
Vitamin D linked to angina risk
Association of Vitamin D Deficiency with Chronic Stable Angina: A Case Control Study.
High relevance to vitamin D effects
We conducted a case-control study involving patients with chronic stable angina and matched controls to investigate the potential connection between vitamin D deficiency and this heart condition. Our goal was to understand if low levels of vitamin D could be a manageable risk factor for those experiencing angina.
During the study, we observed that a significant portion of the patients with chronic stable angina—about 78.6%—were classified as having severe vitamin D deficiency. In contrast, only 7.1% of the control group showed similar deficiency levels. This striking difference led us to conclude that vitamin D levels might play an important role in the onset of chronic stable angina.
Moreover, we found that each increase in vitamin D level by one ng/ml decreased the likelihood of having chronic stable angina significantly. This suggests that maintaining adequate vitamin D levels could be vital for heart health, particularly for those at risk of angina.
Overall, our findings highlight an important association between vitamin D deficiency and chronic stable angina, indicating that addressing vitamin D levels may offer a new avenue for prevention and management of this condition.
During the study, we observed that a significant portion of the patients with chronic stable angina—about 78.6%—were classified as having severe vitamin D deficiency. In contrast, only 7.1% of the control group showed similar deficiency levels. This striking difference led us to conclude that vitamin D levels might play an important role in the onset of chronic stable angina.
Moreover, we found that each increase in vitamin D level by one ng/ml decreased the likelihood of having chronic stable angina significantly. This suggests that maintaining adequate vitamin D levels could be vital for heart health, particularly for those at risk of angina.
Overall, our findings highlight an important association between vitamin D deficiency and chronic stable angina, indicating that addressing vitamin D levels may offer a new avenue for prevention and management of this condition.
Read More
8
Vitamin D3 improves vascular function
Effect of vitamin D therapy on endothelial function in ischemic heart disease female patients with vitamin D deficiency or insufficiency: A primary report.
Indirectly relates to angina treatment
We aimed to understand how vitamin D3 therapy affects patients with ischemic heart disease (IHD) who also experience angina and have low levels of vitamin D. Our study involved female patients in Isfahan, Iran, who were either recovering from a recent percutaneous coronary intervention or suffering from stable angina. They were given two doses of vitamin D3 injections, each containing 300,000 IU, spaced a month apart.
After the treatment, we measured changes in their endothelial function by looking at flow-mediated dilatation (FMD), a key indicator of vascular health. We observed that overall endothelial function improved significantly, with the diameter of the brachial artery expanding and FMD increasing from about 2% to nearly 5%. However, even with these enhancements, we found no direct correlation between the improved endothelial function and the serum levels of vitamin D3.
It’s important to note that while we did see improvements in endothelial function, these changes do not specifically guarantee relief from angina symptoms. This means that further research would be necessary to fully explore the relationship between vitamin D3 therapy and angina relief in patients suffering from IHD.
After the treatment, we measured changes in their endothelial function by looking at flow-mediated dilatation (FMD), a key indicator of vascular health. We observed that overall endothelial function improved significantly, with the diameter of the brachial artery expanding and FMD increasing from about 2% to nearly 5%. However, even with these enhancements, we found no direct correlation between the improved endothelial function and the serum levels of vitamin D3.
It’s important to note that while we did see improvements in endothelial function, these changes do not specifically guarantee relief from angina symptoms. This means that further research would be necessary to fully explore the relationship between vitamin D3 therapy and angina relief in patients suffering from IHD.
Read More
Most Useful Reviews
9.5
Angina improvement
I started taking 5,000 IU of Vitamin D daily after years on lower doses. My wife's 15-year battle with night sweats and depression has ended, and her energy has returned. For my angina, which lasted five years, it has also vanished in the last month. We think the higher dose of Vitamin D is responsible. We previously found only temporary relief.
Read More
8.8
Angina relief
I only take it during autumn and winter, and I've noticed a decrease in my angina. There is significant evidence supporting its benefits for the immune system and its ability to synthesise antibacterial peptides. I generally take 3 (5000) capsules weekly in winter, and I prefer Vitamin D3 as it is better absorbed.
Read More
8.8
Angina reduction
I take Vitamin D in autumn and winter, noticing a reduction in my angina during this time. It is essential for immune support, and I rely on it almost constantly. In winter, I consume 3 (5000) capsules weekly, favouring D3 for its superior absorption.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
9
Vitamin D3 alleviates angina symptoms
Vitamin D replacement therapy in patients with cardiac syndrome X.
Direct effects of vitamin D3
We aimed to understand how vitamin D3 treatment might help reduce angina and exercise-related ischemia in patients suffering from cardiac syndrome X and low vitamin D levels.
In our study, we treated patients with a course of vitamin D3 injections, delivered intramuscularly every other week for two months. We monitored the number of angina episodes per day as well as various measures of exercise capacity before and after the treatment.
By the end of the two-month protocol, we observed a striking increase in serum vitamin D levels to within a normal range. Most importantly, patients reported a significant reduction in angina frequency. We also noted improvements in exercise duration, work capacity, and a reduction in ST-segment depression during stress tests, which suggests a decrease in ischemia.
These findings support the idea that vitamin D3 replacement can dramatically improve the symptoms experienced by patients suffering from angina linked to cardiac syndrome X.
In our study, we treated patients with a course of vitamin D3 injections, delivered intramuscularly every other week for two months. We monitored the number of angina episodes per day as well as various measures of exercise capacity before and after the treatment.
By the end of the two-month protocol, we observed a striking increase in serum vitamin D levels to within a normal range. Most importantly, patients reported a significant reduction in angina frequency. We also noted improvements in exercise duration, work capacity, and a reduction in ST-segment depression during stress tests, which suggests a decrease in ischemia.
These findings support the idea that vitamin D3 replacement can dramatically improve the symptoms experienced by patients suffering from angina linked to cardiac syndrome X.
Read More
8
Vitamin D linked to angina risk
Association of Vitamin D Deficiency with Chronic Stable Angina: A Case Control Study.
High relevance to vitamin D effects
We conducted a case-control study involving patients with chronic stable angina and matched controls to investigate the potential connection between vitamin D deficiency and this heart condition. Our goal was to understand if low levels of vitamin D could be a manageable risk factor for those experiencing angina.
During the study, we observed that a significant portion of the patients with chronic stable angina—about 78.6%—were classified as having severe vitamin D deficiency. In contrast, only 7.1% of the control group showed similar deficiency levels. This striking difference led us to conclude that vitamin D levels might play an important role in the onset of chronic stable angina.
Moreover, we found that each increase in vitamin D level by one ng/ml decreased the likelihood of having chronic stable angina significantly. This suggests that maintaining adequate vitamin D levels could be vital for heart health, particularly for those at risk of angina.
Overall, our findings highlight an important association between vitamin D deficiency and chronic stable angina, indicating that addressing vitamin D levels may offer a new avenue for prevention and management of this condition.
During the study, we observed that a significant portion of the patients with chronic stable angina—about 78.6%—were classified as having severe vitamin D deficiency. In contrast, only 7.1% of the control group showed similar deficiency levels. This striking difference led us to conclude that vitamin D levels might play an important role in the onset of chronic stable angina.
Moreover, we found that each increase in vitamin D level by one ng/ml decreased the likelihood of having chronic stable angina significantly. This suggests that maintaining adequate vitamin D levels could be vital for heart health, particularly for those at risk of angina.
Overall, our findings highlight an important association between vitamin D deficiency and chronic stable angina, indicating that addressing vitamin D levels may offer a new avenue for prevention and management of this condition.
Read More
8
Vitamin D3 improves vascular function
Effect of vitamin D therapy on endothelial function in ischemic heart disease female patients with vitamin D deficiency or insufficiency: A primary report.
Indirectly relates to angina treatment
We aimed to understand how vitamin D3 therapy affects patients with ischemic heart disease (IHD) who also experience angina and have low levels of vitamin D. Our study involved female patients in Isfahan, Iran, who were either recovering from a recent percutaneous coronary intervention or suffering from stable angina. They were given two doses of vitamin D3 injections, each containing 300,000 IU, spaced a month apart.
After the treatment, we measured changes in their endothelial function by looking at flow-mediated dilatation (FMD), a key indicator of vascular health. We observed that overall endothelial function improved significantly, with the diameter of the brachial artery expanding and FMD increasing from about 2% to nearly 5%. However, even with these enhancements, we found no direct correlation between the improved endothelial function and the serum levels of vitamin D3.
It’s important to note that while we did see improvements in endothelial function, these changes do not specifically guarantee relief from angina symptoms. This means that further research would be necessary to fully explore the relationship between vitamin D3 therapy and angina relief in patients suffering from IHD.
After the treatment, we measured changes in their endothelial function by looking at flow-mediated dilatation (FMD), a key indicator of vascular health. We observed that overall endothelial function improved significantly, with the diameter of the brachial artery expanding and FMD increasing from about 2% to nearly 5%. However, even with these enhancements, we found no direct correlation between the improved endothelial function and the serum levels of vitamin D3.
It’s important to note that while we did see improvements in endothelial function, these changes do not specifically guarantee relief from angina symptoms. This means that further research would be necessary to fully explore the relationship between vitamin D3 therapy and angina relief in patients suffering from IHD.
Read More
8
Calcium-D3 safe in heart treatments
[Interaction of calcium drug and vitamin D3 with some medicines used in coronary heart disease therapy].
Study highlights interactions with drugs
We studied the effects of vitamin D3, combined with calcium, on patients suffering from chronic coronary heart disease, particularly those experiencing angina. Our research involved 130 patients divided into two groups: one receiving standard treatment and the other receiving calcium-D3 alongside their regular medications.
Both groups showed a positive shift, particularly in the reduction of angina severity and the need for nitroglycerin. Importantly, we observed no negative impact from calcium-D3 on the severity of coronary heart disease. However, some side effects were noted, particularly in those taking furosemide and hydrochlorothiazide, leading to adjustments in their medication.
Overall, this study indicates that while the addition of calcium-D3 did not harm treatment outcomes for angina, it also highlights that we cannot definitively attribute improvements solely to vitamin D3. Instead, it appears to be safely included as part of a broader treatment strategy without undermining the effectiveness of existing therapies.
Both groups showed a positive shift, particularly in the reduction of angina severity and the need for nitroglycerin. Importantly, we observed no negative impact from calcium-D3 on the severity of coronary heart disease. However, some side effects were noted, particularly in those taking furosemide and hydrochlorothiazide, leading to adjustments in their medication.
Overall, this study indicates that while the addition of calcium-D3 did not harm treatment outcomes for angina, it also highlights that we cannot definitively attribute improvements solely to vitamin D3. Instead, it appears to be safely included as part of a broader treatment strategy without undermining the effectiveness of existing therapies.
Read More
7
Vitamin D3 improves heart health
[Effect of vitamin D correction on insulin resistance in patients with coronary heart disease and metabolic syndrome].
Significant connection to angina
We explored the relationship between vitamin D levels and insulin resistance in 135 patients suffering from ischemic heart disease, particularly those experiencing stable angina. The study revealed that a staggering 91.9% of these patients had low vitamin D levels, a condition known as hypovitaminosis D.
Over a period of six months, all patients received a daily supplement of 2000 IU of cholecalciferol, which is a form of vitamin D. After this treatment, we observed promising effects on patients with coronary artery diseases, particularly in terms of improving vitamin D levels.
Our findings suggest that treating vitamin D deficiency may be beneficial for individuals who have both coronary heart disease and metabolic syndrome. For these patients, we recommend a sustained approach to treating hypovitaminosis D, as it appears to positively influence their overall health.
Over a period of six months, all patients received a daily supplement of 2000 IU of cholecalciferol, which is a form of vitamin D. After this treatment, we observed promising effects on patients with coronary artery diseases, particularly in terms of improving vitamin D levels.
Our findings suggest that treating vitamin D deficiency may be beneficial for individuals who have both coronary heart disease and metabolic syndrome. For these patients, we recommend a sustained approach to treating hypovitaminosis D, as it appears to positively influence their overall health.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Angina improvement
I started taking 5,000 IU of Vitamin D daily after years on lower doses. My wife's 15-year battle with night sweats and depression has ended, and her energy has returned. For my angina, which lasted five years, it has also vanished in the last month. We think the higher dose of Vitamin D is responsible. We previously found only temporary relief.
Read More
8.8
Angina relief
I only take it during autumn and winter, and I've noticed a decrease in my angina. There is significant evidence supporting its benefits for the immune system and its ability to synthesise antibacterial peptides. I generally take 3 (5000) capsules weekly in winter, and I prefer Vitamin D3 as it is better absorbed.
Read More
8.8
Angina reduction
I take Vitamin D in autumn and winter, noticing a reduction in my angina during this time. It is essential for immune support, and I rely on it almost constantly. In winter, I consume 3 (5000) capsules weekly, favouring D3 for its superior absorption.
8.8
Angina management
I take this drug in courses after experiencing angina flare-ups, and it helps maintain my thyroid health. I am very satisfied with its effectiveness.
