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SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8
USERS' SCORE
Good
Based on 19 Reviews
8.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
Vitamin D3's role in OA prevention
1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice.
Strong relevance to vitamin D3 and OA
We explored the link between vitamin D3 and knee osteoarthritis (OA) by examining both young and older mice. Our findings revealed that a deficiency in vitamin D3, specifically the active form known as 1,25(OH)D, significantly sped up the development of age-related OA. This included issues such as cartilage damage and increased chondrocyte senescence.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
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8
Vitamin D3 mitigates arthritis symptoms
1,25-Dihydroxyvitamin D regulates macrophage activation through FBP1/PKR and ameliorates arthritis in TNF-transgenic mice.
Study highly relevant to arthritis
We explored the impact of 1,25-Dihydroxyvitamin D, commonly known as vitamin D3, on rheumatoid arthritis (RA) and macrophage activity. Our research reveals that vitamin D3 can significantly suppress the activation of a particular type of immune cell known as M1 macrophages, which are often linked to inflammation and RA.
Specifically, vitamin D3 appears to reduce the expression of inflammatory markers like IL-6 and CXCL10 in the macrophages of RA patients. Through experiments with THP-1 cells—lab-induced macrophages— vitamin D3 was found to boost the expression of fructose-1,6-bisphosphatase 1 (FBP1), a protein that helps control immune responses by interacting with another protein called PKR.
Importantly, treatment with vitamin D3 not only diminished M1 macrophage activity but also led to improvements in arthritis symptoms in mice genetically predisposed to develop RA. This suggests that vitamin D3 could play a beneficial role in regulating macrophage function and alleviating the clinical signs of arthritis.
Overall, we are encouraged by these findings, as they provide a clearer understanding of how vitamin D3 can support the immune system and potentially aid individuals suffering from arthritis.
Specifically, vitamin D3 appears to reduce the expression of inflammatory markers like IL-6 and CXCL10 in the macrophages of RA patients. Through experiments with THP-1 cells—lab-induced macrophages— vitamin D3 was found to boost the expression of fructose-1,6-bisphosphatase 1 (FBP1), a protein that helps control immune responses by interacting with another protein called PKR.
Importantly, treatment with vitamin D3 not only diminished M1 macrophage activity but also led to improvements in arthritis symptoms in mice genetically predisposed to develop RA. This suggests that vitamin D3 could play a beneficial role in regulating macrophage function and alleviating the clinical signs of arthritis.
Overall, we are encouraged by these findings, as they provide a clearer understanding of how vitamin D3 can support the immune system and potentially aid individuals suffering from arthritis.
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8
Vitamin D3 aids knee OA symptoms
The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis.
Direct focus on vitamin D3
We investigated how vitamin D3 supplementation affects symptoms in patients dealing with knee osteoarthritis (OA). This was an open-label clinical trial conducted over three months, where participants received 4000 IU of vitamin D3 daily. We measured clinical responses at the beginning and after three months using specific assessment tools.
Our findings were promising, as we saw a notable drop in pain levels and improvements in stiffness and physical function based on patient reports. Out of the 80 patients who completed the study, an impressive 86.7% showed a positive response to treatment, indicating that vitamin D3 could play a beneficial role in managing OA symptoms.
Interestingly, while vitamin D3 supplementation raised serum levels of certain inflammatory markers, specifically IL-33, it also led to significant reductions in other pro-inflammatory cytokines like TNF-α and IL-17. No adverse effects were reported during the trial, underscoring the safety profile of vitamin D3.
In conclusion, our results suggest that vitamin D3 is a promising option for easing symptoms in knee OA, and further research is warranted to explore the implications of altered inflammatory markers in the disease process.
Our findings were promising, as we saw a notable drop in pain levels and improvements in stiffness and physical function based on patient reports. Out of the 80 patients who completed the study, an impressive 86.7% showed a positive response to treatment, indicating that vitamin D3 could play a beneficial role in managing OA symptoms.
Interestingly, while vitamin D3 supplementation raised serum levels of certain inflammatory markers, specifically IL-33, it also led to significant reductions in other pro-inflammatory cytokines like TNF-α and IL-17. No adverse effects were reported during the trial, underscoring the safety profile of vitamin D3.
In conclusion, our results suggest that vitamin D3 is a promising option for easing symptoms in knee OA, and further research is warranted to explore the implications of altered inflammatory markers in the disease process.
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Most Useful Reviews
9.5
Improved arthritis symptoms
This is a superb product that has substantially improved my health and well-being. My mood has enhanced, and I no longer require medication for my arthritis. It's also been incredibly helpful during severe colds or flu.
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8.8
Noticeable arthritis relief
Excellent! Arthritis is very palpable.
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9.5
Family arthritis solution
We continuously purchase Vitamin D for the whole family. It has significantly improved my mum's vitamin D levels from 13 to 120, alleviating her leg pain due to arthritis. I recommend it for everyone.
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Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8
9
Vitamin D3 may improve fatigue
The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.
Scientifically relevant vitamin D effects.
We conducted an insightful study to explore how vitamin D3 supplementation might affect rheumatoid arthritis (RA) symptoms, particularly focusing on disease activity and fatigue. This research involved a total of 68 RA patients who were monitored over a period of 12 weeks.
Our participants were divided into two groups. One group received a weekly dose of 50,000 IU of vitamin D3 alongside their conventional arthritis medications. The other group continued with their standard treatment regimen without any vitamin D3.
As we evaluated the outcomes, we found that the group receiving vitamin D3 exhibited significant improvements. Specifically, they showed enhanced levels of vitamin D and reported lower fatigue, as measured by the FACIT-F score. While both groups initially presented similar health characteristics, those on vitamin D3 achieved a normal range in fatigue levels compared to the continued struggle within the other group.
Interestingly, we observed a positive correlation between higher vitamin D levels and improved fatigue scores, indicating that vitamin D3 could indeed play a beneficial role in managing symptoms associated with rheumatoid arthritis. However, disease activity scores did not show a strong significant correlation with vitamin D levels, suggesting that more research may be necessary to understand this relationship fully.
Our participants were divided into two groups. One group received a weekly dose of 50,000 IU of vitamin D3 alongside their conventional arthritis medications. The other group continued with their standard treatment regimen without any vitamin D3.
As we evaluated the outcomes, we found that the group receiving vitamin D3 exhibited significant improvements. Specifically, they showed enhanced levels of vitamin D and reported lower fatigue, as measured by the FACIT-F score. While both groups initially presented similar health characteristics, those on vitamin D3 achieved a normal range in fatigue levels compared to the continued struggle within the other group.
Interestingly, we observed a positive correlation between higher vitamin D levels and improved fatigue scores, indicating that vitamin D3 could indeed play a beneficial role in managing symptoms associated with rheumatoid arthritis. However, disease activity scores did not show a strong significant correlation with vitamin D levels, suggesting that more research may be necessary to understand this relationship fully.
Read More
9
Vitamin D3's role in OA prevention
1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice.
Strong relevance to vitamin D3 and OA
We explored the link between vitamin D3 and knee osteoarthritis (OA) by examining both young and older mice. Our findings revealed that a deficiency in vitamin D3, specifically the active form known as 1,25(OH)D, significantly sped up the development of age-related OA. This included issues such as cartilage damage and increased chondrocyte senescence.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
When we supplemented with vitamin D3, we were pleased to see a reversal of these negative changes in OA phenotypes among the test mice. It not only improved cartilage health but also countered oxidative stress and cell aging associated with OA.
Our research highlights the important role of vitamin D3 in maintaining joint health and its potential to help prevent or slow down the onset of OA through mechanisms involving Sirt1, a gene linked to aging and cellular health. This suggests that ensuring sufficient levels of vitamin D3 could be a useful strategy for those at risk of developing arthritis.
Read More
8
Calcitriol impacts immune response in RA
Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice.
Study focused on calcitriol in MSCs
We explored the effects of calcitriol, the active form of vitamin D3, on mesenchymal stem cells (MSCs) and their potential to influence rheumatoid arthritis (RA) in a mouse model. Using a well-structured study design, we induced RA in BALB/c mice and divided them into three groups: one group received untreated MSCs, another received calcitriol-treated MSCs, while the third group received no treatment at all. After the treatment, we assessed various immune responses and inflammatory mediators.
Our findings revealed that the calcitriol-treated MSCs significantly outperformed untreated MSCs in regulating immune responses. Specifically, we noted improvements in the function of innate immune cells, particularly splenocytes. These cells showed enhanced regulatory abilities, which led to a decrease in pro-inflammatory cytokines like IL-17 and an increase in anti-inflammatory cytokines such as IL-4 and IL-10. This suggests that calcitriol may play a crucial role in modulating the immune response in RA.
However, while the study shows encouraging results for calcitriol-treated MSCs in reducing inflammation, it’s important to note that this research is still in the early stages and primarily conducted in a controlled laboratory environment. Further studies are needed to determine how these findings translate to human treatment outcomes.
Our findings revealed that the calcitriol-treated MSCs significantly outperformed untreated MSCs in regulating immune responses. Specifically, we noted improvements in the function of innate immune cells, particularly splenocytes. These cells showed enhanced regulatory abilities, which led to a decrease in pro-inflammatory cytokines like IL-17 and an increase in anti-inflammatory cytokines such as IL-4 and IL-10. This suggests that calcitriol may play a crucial role in modulating the immune response in RA.
However, while the study shows encouraging results for calcitriol-treated MSCs in reducing inflammation, it’s important to note that this research is still in the early stages and primarily conducted in a controlled laboratory environment. Further studies are needed to determine how these findings translate to human treatment outcomes.
Read More
8
Vitamin D3 mitigates arthritis damage
1,25(OH)D induces chondrocyte autophagy and reduces the loss of proteoglycans in osteoarthritis through inhibiting the NF-κB pathway.
Study directly examines vitamin D
We investigated the effects of vitamin D3 on arthritis, particularly focusing on its potential to influence the NF-κB pathway, a key player in the development of osteoarthritis (OA). Our findings revealed that vitamin D3 significantly protects against OA symptoms by stabilizing NF-κB, an important transcription factor involved in inflammation.
Through a series of experiments, including analysis of protein levels and gene expression in both living models and isolated cells, we observed that vitamin D3 helps to inhibit the phosphorylation and nuclear translocation of NF-κB. This means that vitamin D3 could effectively prevent this factor from entering the nucleus of chondrocytes—cells crucial for cartilage health—where it could drive damaging inflammatory processes.
We also found that vitamin D3 promotes a process called autophagy in chondrocytes. This process helps maintain cellular health by clearing out damaged components. Our study reinforced the idea that vitamin D3 not only acts through the vitamin D receptor but also significantly impacts the AMPK/mTOR signaling pathway, further supporting its role in managing arthritis.
Overall, our research underscores the beneficial effects of vitamin D3 on arthritis, suggesting that enhancing vitamin D levels might be a valuable strategy in OA treatment.
Through a series of experiments, including analysis of protein levels and gene expression in both living models and isolated cells, we observed that vitamin D3 helps to inhibit the phosphorylation and nuclear translocation of NF-κB. This means that vitamin D3 could effectively prevent this factor from entering the nucleus of chondrocytes—cells crucial for cartilage health—where it could drive damaging inflammatory processes.
We also found that vitamin D3 promotes a process called autophagy in chondrocytes. This process helps maintain cellular health by clearing out damaged components. Our study reinforced the idea that vitamin D3 not only acts through the vitamin D receptor but also significantly impacts the AMPK/mTOR signaling pathway, further supporting its role in managing arthritis.
Overall, our research underscores the beneficial effects of vitamin D3 on arthritis, suggesting that enhancing vitamin D levels might be a valuable strategy in OA treatment.
Read More
8
Vitamin D deficiency linked to osteoarthritis
Relationship between serum vitamin D levels and the prevalence of knee osteoarthritis: A retrospective study on 3424 subjects.
Relevant study on vitamin D levels
We examined the link between vitamin D levels and knee osteoarthritis in a large group of 3,424 individuals, mostly women. Our focus was on understanding how vitamin D, particularly in its form known as 25-hydroxyvitamin D3, might impact the occurrence and severity of knee osteoarthritis.
The results highlighted a striking finding: nearly half of the participants had knee osteoarthritis, and those affected showed significantly lower vitamin D levels. We found a notable correlation between vitamin D deficiency and the likelihood of developing knee osteoarthritis, particularly among women under 65.
Our analysis suggests that maintaining healthy vitamin D levels could be beneficial in preventing knee osteoarthritis, especially for younger women. However, this study serves primarily to highlight the prevalence of vitamin D deficiency among individuals with knee osteoarthritis rather than establishing vitamin D supplementation as a treatment solution.
The results highlighted a striking finding: nearly half of the participants had knee osteoarthritis, and those affected showed significantly lower vitamin D levels. We found a notable correlation between vitamin D deficiency and the likelihood of developing knee osteoarthritis, particularly among women under 65.
Our analysis suggests that maintaining healthy vitamin D levels could be beneficial in preventing knee osteoarthritis, especially for younger women. However, this study serves primarily to highlight the prevalence of vitamin D deficiency among individuals with knee osteoarthritis rather than establishing vitamin D supplementation as a treatment solution.
Read More
User Reviews
USERS' SCORE
Good
Based on 19 Reviews
8.8
9.5
Improved arthritis symptoms
This is a superb product that has substantially improved my health and well-being. My mood has enhanced, and I no longer require medication for my arthritis. It's also been incredibly helpful during severe colds or flu.
9.5
Family arthritis solution
We continuously purchase Vitamin D for the whole family. It has significantly improved my mum's vitamin D levels from 13 to 120, alleviating her leg pain due to arthritis. I recommend it for everyone.
9.5
Effective for autoimmune diseases
I highly value this product! My family and I take 5,000 IU regularly. I monitor my vitamin D due to rheumatoid arthritis and have found Now Foods to offer the best price-quality ratio.
9.5
Improves joint pain
After testing my vitamin D levels at "14" (with 30 being normal), I tried a pharmacy remedy for three months, which raised it to only "17". After switching to this vitamin at two capsules a month, my condition improved remarkably—drowsiness and joint pain vanished, and my level rose to "70". It’s essential in treating autoimmune arthritis. Highly recommend!
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9
Strengthens immune system
Vitamin D strengthens the immune system, so I get sick less frequently in summer. It aids in calcium absorption, promoting bone mineralisation and preventing osteoporosis. It also protects against hypertension and autoimmune diseases, including rheumatoid arthritis. Additionally, it optimises brain function, improves memory, and slows the ageing process, reducing hair loss.
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