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SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 17 Reviews
8.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D3 improves asthma control
Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials.
High relevance for study topic
We explored the effectiveness of vitamin D3 in reducing asthma exacerbations among children through a systematic review and meta-analysis of randomized controlled trials. In our investigation, we analyzed data from ten studies, which included a total of 1,243 children with asthma. Among these, 631 received vitamin D3 supplementation while 612 were given a placebo.
Our pooled analysis revealed promising results: vitamin D3 supplementation significantly reduced the overall number of asthma exacerbations. Specifically, we found a risk ratio of 0.62, indicating a notable decrease in attacks. Notably, a subgroup analysis showed that children receiving the standard daily dose of vitamin D experienced an even more significant improvement, with a risk ratio of 0.41.
Overall, we concluded that vitamin D3 supplementation holds the potential to lower asthma exacerbations in children. This is particularly encouraging as it also correlates with improved lung function, measured through FEV1. Hence, vitamin D3 could be a valuable addition to asthma management for young patients.
Our pooled analysis revealed promising results: vitamin D3 supplementation significantly reduced the overall number of asthma exacerbations. Specifically, we found a risk ratio of 0.62, indicating a notable decrease in attacks. Notably, a subgroup analysis showed that children receiving the standard daily dose of vitamin D experienced an even more significant improvement, with a risk ratio of 0.41.
Overall, we concluded that vitamin D3 supplementation holds the potential to lower asthma exacerbations in children. This is particularly encouraging as it also correlates with improved lung function, measured through FEV1. Hence, vitamin D3 could be a valuable addition to asthma management for young patients.
Read More
5
Vitamin D3 may aid asthma
A 12-week double-blind randomised controlled trial investigating the effect of dietary supplementation with 125 g/d vitamin D in adults with asthma.
Direct investigation of asthma treatment
We conducted a robust study to understand how vitamin D3 supplementation affects adults with asthma. Over 12 weeks, we closely monitored 32 participants with mild to moderate asthma. They were randomly assigned to receive either a daily supplement of 125 µg of vitamin D or a placebo, which allowed us to measure the real impact of vitamin D on lung function and asthma symptoms.
Our findings showed a slight improvement in lung function among those who received vitamin D compared to those on the placebo. Specifically, there was a modest increase in the ratio of forced expiratory volume (FEV) to forced vital capacity (FVC), indicating better lung mechanics. However, we didn’t observe any significant changes in asthma control scores or the inflammatory markers we measured.
It's worth noting that we found a meaningful association between initial vitamin D levels and markers of inflammation, suggesting that those with lower vitamin D might benefit more from supplementation. Overall, while vitamin D3 might not be a miracle solution, our results indicate it could be a helpful addition to current asthma management strategies, especially for those with low vitamin D levels.
Our findings showed a slight improvement in lung function among those who received vitamin D compared to those on the placebo. Specifically, there was a modest increase in the ratio of forced expiratory volume (FEV) to forced vital capacity (FVC), indicating better lung mechanics. However, we didn’t observe any significant changes in asthma control scores or the inflammatory markers we measured.
It's worth noting that we found a meaningful association between initial vitamin D levels and markers of inflammation, suggesting that those with lower vitamin D might benefit more from supplementation. Overall, while vitamin D3 might not be a miracle solution, our results indicate it could be a helpful addition to current asthma management strategies, especially for those with low vitamin D levels.
Read More
9
Vitamin D3 improves asthma symptoms
Vitamin D resolved human and experimental asthma via B lymphocyte-induced maturation protein 1 in T cells and innate lymphoid cells.
Direct effects on asthma management
We aimed to understand how vitamin D3 supplementation might affect asthma, particularly focusing on children and adults who struggle with this condition. By analyzing various groups and a controlled murine model, we investigated the immunomodulatory effects of vitamin D3 and discovered encouraging results.
Our findings indicated that individuals receiving vitamin D3 showed milder asthma symptoms and a decreased reliance on steroid medications. Notably, children and adults alike experienced better control over their asthma. Furthermore, we observed that vitamin D3 levels correlated with an increased expression of a protein called Blimp-1, which plays a vital role in immune response regulation.
In our animal studies, mice supplemented with vitamin D3 exhibited relief from asthma traits, including lower serum IgE levels and reduced airway mucus. Additionally, these mice showed enhanced production of the anti-inflammatory protein IL-10. The results suggest that vitamin D3 promotes a shift from pro-inflammatory states to anti-inflammatory responses, particularly through mechanisms involving Blimp-1 in lung cells.
Overall, we found that vitamin D3 not only eases asthma symptoms for humans but also improves immunity in experimental models. This positions vitamin D3 as a potential adjunctive treatment for managing asthma more effectively.
Our findings indicated that individuals receiving vitamin D3 showed milder asthma symptoms and a decreased reliance on steroid medications. Notably, children and adults alike experienced better control over their asthma. Furthermore, we observed that vitamin D3 levels correlated with an increased expression of a protein called Blimp-1, which plays a vital role in immune response regulation.
In our animal studies, mice supplemented with vitamin D3 exhibited relief from asthma traits, including lower serum IgE levels and reduced airway mucus. Additionally, these mice showed enhanced production of the anti-inflammatory protein IL-10. The results suggest that vitamin D3 promotes a shift from pro-inflammatory states to anti-inflammatory responses, particularly through mechanisms involving Blimp-1 in lung cells.
Overall, we found that vitamin D3 not only eases asthma symptoms for humans but also improves immunity in experimental models. This positions vitamin D3 as a potential adjunctive treatment for managing asthma more effectively.
Read More
Most Useful Reviews
9.5
No more asthma attacks
!!!! REAL D3 BLOOD TEST RESULTS HERE !!!!. New test results for my Vitamin D3 25-hydroxy levels arrived. I was taking 40,000 IU of a different brand to reach my optimal level (85 ng/mL), but was still too low (43 ng/mL). With this brand of D3, I only need 15,000 IU to achieve the desired level. Under my doctor's supervision, I've discovered that Casein protein in milk products and my low D3 levels were causing my late-onset asthma, especially during exercise and allergies. Since seeing a sports medicine doctor, I have not experienced asthma attacks and have remained healthy for over a year. The advantages of Vitamin D3 alongside the identification of Casein as a trigger have significantly improved my quality of life, from alleviating knee pain to enhancing sleep quality and my outlook.
Read More
9.5
Cough relief
I found this supplement effective for my coughing and asthma. After using many inhalers with little success, I discovered that vitamin D could help. Within two days of starting this product, I noticed a significant reduction in my cough. For three years now, I haven't had a cold. I'm grateful for this supplement, which I can't find in Japan, and to the doctor whose article helped me.
Read More
9.5
Asthma improvement
After my doctor suggested vitamin D for my cough asthma, I decided to give it a try. A month later, I got the flu but have not experienced asthma since. I believe in its effectiveness and continue to take NOW vitamin D regularly.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
9
Combined effects on asthma treatment
A systematic pharmacological strategy-based to decode the synergistic mechanism of 7,4'-dihydroxyflavone in combination with vitamin D3 against asthma.
Moderate relevance due to limitations
We explored how vitamin D3 can play a role in asthma treatment, particularly when combined with 7,4'-dihydroxyflavone (74DHF). Our study took a systems pharmacology approach, which means we looked at how these two compounds might work together at a molecular level to combat asthma.
Through our analysis, we identified 47 overlapping targets, 20 core targets, and key pathways associated with asthma relief. We observed that this combination could help reduce inflammatory responses in immune cells and counteract changes in bronchial epithelial cells that contribute to asthma severity.
Although the potential benefits of vitamin D3 combined with 74DHF are promising, we must emphasize that the specific isolated effects of vitamin D3 alone were not assessed, making it challenging to determine its individual contribution. Nonetheless, this study highlights an innovative strategy for developing combination therapies in asthma management.
Through our analysis, we identified 47 overlapping targets, 20 core targets, and key pathways associated with asthma relief. We observed that this combination could help reduce inflammatory responses in immune cells and counteract changes in bronchial epithelial cells that contribute to asthma severity.
Although the potential benefits of vitamin D3 combined with 74DHF are promising, we must emphasize that the specific isolated effects of vitamin D3 alone were not assessed, making it challenging to determine its individual contribution. Nonetheless, this study highlights an innovative strategy for developing combination therapies in asthma management.
Read More
9
Vitamin D boosts asthma control
Vitamin D Oral Replacement in Children With Obesity Related Asthma: VDORA1 Randomized Clinical Trial.
Study highlights vitamin D importance
We aimed to uncover the right dosage of vitamin D that helps children with obesity-related asthma achieve healthy vitamin D levels. This was addressed through a two-part clinical trial involving children and adolescents with asthma and obesity.
In the first part of the study, we evaluated four different oral vitamin D regimens over 16 weeks. This helped us determine a safe dose that would elevate serum vitamin D levels to at least 40 ng/mL. Remarkably, while no participants receiving standard care reached the target level, a significant 50-72.7% of those taking our tested vitamin D doses did meet the goal.
The second part compared our chosen vitamin D replacement dose—which consisted of a 50,000 IU loading dose followed by 8,000 IU daily—to standard care over another 16-week period. This time, an impressive 78.6% of the children on the replacement dose achieved the desired vitamin D levels, while none of the standard care group did.
Throughout the study, we noted that the vitamin D treatment was safe, with no serious adverse events reported. This research opens up new insights into effectively treating vitamin D deficiencies in children struggling with both asthma and obesity, emphasizing the substantial role vitamin D may play in their overall health.
In the first part of the study, we evaluated four different oral vitamin D regimens over 16 weeks. This helped us determine a safe dose that would elevate serum vitamin D levels to at least 40 ng/mL. Remarkably, while no participants receiving standard care reached the target level, a significant 50-72.7% of those taking our tested vitamin D doses did meet the goal.
The second part compared our chosen vitamin D replacement dose—which consisted of a 50,000 IU loading dose followed by 8,000 IU daily—to standard care over another 16-week period. This time, an impressive 78.6% of the children on the replacement dose achieved the desired vitamin D levels, while none of the standard care group did.
Throughout the study, we noted that the vitamin D treatment was safe, with no serious adverse events reported. This research opens up new insights into effectively treating vitamin D deficiencies in children struggling with both asthma and obesity, emphasizing the substantial role vitamin D may play in their overall health.
Read More
9
Vitamin D3 improves asthma symptoms
Vitamin D resolved human and experimental asthma via B lymphocyte-induced maturation protein 1 in T cells and innate lymphoid cells.
Direct effects on asthma management
We aimed to understand how vitamin D3 supplementation might affect asthma, particularly focusing on children and adults who struggle with this condition. By analyzing various groups and a controlled murine model, we investigated the immunomodulatory effects of vitamin D3 and discovered encouraging results.
Our findings indicated that individuals receiving vitamin D3 showed milder asthma symptoms and a decreased reliance on steroid medications. Notably, children and adults alike experienced better control over their asthma. Furthermore, we observed that vitamin D3 levels correlated with an increased expression of a protein called Blimp-1, which plays a vital role in immune response regulation.
In our animal studies, mice supplemented with vitamin D3 exhibited relief from asthma traits, including lower serum IgE levels and reduced airway mucus. Additionally, these mice showed enhanced production of the anti-inflammatory protein IL-10. The results suggest that vitamin D3 promotes a shift from pro-inflammatory states to anti-inflammatory responses, particularly through mechanisms involving Blimp-1 in lung cells.
Overall, we found that vitamin D3 not only eases asthma symptoms for humans but also improves immunity in experimental models. This positions vitamin D3 as a potential adjunctive treatment for managing asthma more effectively.
Our findings indicated that individuals receiving vitamin D3 showed milder asthma symptoms and a decreased reliance on steroid medications. Notably, children and adults alike experienced better control over their asthma. Furthermore, we observed that vitamin D3 levels correlated with an increased expression of a protein called Blimp-1, which plays a vital role in immune response regulation.
In our animal studies, mice supplemented with vitamin D3 exhibited relief from asthma traits, including lower serum IgE levels and reduced airway mucus. Additionally, these mice showed enhanced production of the anti-inflammatory protein IL-10. The results suggest that vitamin D3 promotes a shift from pro-inflammatory states to anti-inflammatory responses, particularly through mechanisms involving Blimp-1 in lung cells.
Overall, we found that vitamin D3 not only eases asthma symptoms for humans but also improves immunity in experimental models. This positions vitamin D3 as a potential adjunctive treatment for managing asthma more effectively.
Read More
8
Vitamin D3 improves asthma symptoms
Evaluation the Effect of Supplements Containing Vitamin D and Trace Elements in Patients with Moderate to Severe Asthma.
Relevant but not solely focused on vitamin D3.
We explored the effects of vitamin D3 along with other supplements like folic acid, selenium, zinc, and copper on patients suffering from moderate to severe asthma. In our study, we involved 70 participants over the age of six and divided them into two groups. One group received a daily syrup containing these supplements, while the other was given vitamin D3 drops for two months, alongside their routine asthma treatment.
After the treatment, we observed a noticeable improvement in lung function, asthma control, and overall quality of life in both groups. While the data showed a significant enhancement in these areas, we didn’t find substantial changes in cytokine levels, which are markers of inflammation. Interestingly, levels of selenium and folic acid at the start were linked to the severity of asthma symptoms, and after treatment, vitamin D levels positively influenced lung function.
Alongside these findings, we noted a reduction in oxidative stress in both groups, with the vitamin D group showing slightly better results. Overall, our study indicates that supplements, especially vitamin D, can help boost clinical outcomes and quality of life for those with asthma, making them a beneficial addition to conventional treatments.
After the treatment, we observed a noticeable improvement in lung function, asthma control, and overall quality of life in both groups. While the data showed a significant enhancement in these areas, we didn’t find substantial changes in cytokine levels, which are markers of inflammation. Interestingly, levels of selenium and folic acid at the start were linked to the severity of asthma symptoms, and after treatment, vitamin D levels positively influenced lung function.
Alongside these findings, we noted a reduction in oxidative stress in both groups, with the vitamin D group showing slightly better results. Overall, our study indicates that supplements, especially vitamin D, can help boost clinical outcomes and quality of life for those with asthma, making them a beneficial addition to conventional treatments.
Read More
8
Vitamin D3 improves asthma control
Vitamin D supplementation decrease asthma exacerbations in children: a systematic review and meta-analysis of randomized controlled trials.
High relevance for study topic
We explored the effectiveness of vitamin D3 in reducing asthma exacerbations among children through a systematic review and meta-analysis of randomized controlled trials. In our investigation, we analyzed data from ten studies, which included a total of 1,243 children with asthma. Among these, 631 received vitamin D3 supplementation while 612 were given a placebo.
Our pooled analysis revealed promising results: vitamin D3 supplementation significantly reduced the overall number of asthma exacerbations. Specifically, we found a risk ratio of 0.62, indicating a notable decrease in attacks. Notably, a subgroup analysis showed that children receiving the standard daily dose of vitamin D experienced an even more significant improvement, with a risk ratio of 0.41.
Overall, we concluded that vitamin D3 supplementation holds the potential to lower asthma exacerbations in children. This is particularly encouraging as it also correlates with improved lung function, measured through FEV1. Hence, vitamin D3 could be a valuable addition to asthma management for young patients.
Our pooled analysis revealed promising results: vitamin D3 supplementation significantly reduced the overall number of asthma exacerbations. Specifically, we found a risk ratio of 0.62, indicating a notable decrease in attacks. Notably, a subgroup analysis showed that children receiving the standard daily dose of vitamin D experienced an even more significant improvement, with a risk ratio of 0.41.
Overall, we concluded that vitamin D3 supplementation holds the potential to lower asthma exacerbations in children. This is particularly encouraging as it also correlates with improved lung function, measured through FEV1. Hence, vitamin D3 could be a valuable addition to asthma management for young patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 17 Reviews
8.8
9.5
Cough relief
I found this supplement effective for my coughing and asthma. After using many inhalers with little success, I discovered that vitamin D could help. Within two days of starting this product, I noticed a significant reduction in my cough. For three years now, I haven't had a cold. I'm grateful for this supplement, which I can't find in Japan, and to the doctor whose article helped me.
Read More
9.5
Asthma improvement
After my doctor suggested vitamin D for my cough asthma, I decided to give it a try. A month later, I got the flu but have not experienced asthma since. I believe in its effectiveness and continue to take NOW vitamin D regularly.
9.5
No more asthma attacks
!!!! REAL D3 BLOOD TEST RESULTS HERE !!!!. New test results for my Vitamin D3 25-hydroxy levels arrived. I was taking 40,000 IU of a different brand to reach my optimal level (85 ng/mL), but was still too low (43 ng/mL). With this brand of D3, I only need 15,000 IU to achieve the desired level. Under my doctor's supervision, I've discovered that Casein protein in milk products and my low D3 levels were causing my late-onset asthma, especially during exercise and allergies. Since seeing a sports medicine doctor, I have not experienced asthma attacks and have remained healthy for over a year. The advantages of Vitamin D3 alongside the identification of Casein as a trigger have significantly improved my quality of life, from alleviating knee pain to enhancing sleep quality and my outlook.
Read More
8.8
Supports asthma treatment
I highly recommend vitamin D! It plays a vital role in various processes, including reducing asthma symptoms. It's especially beneficial for those living in areas with limited sunlight, like Siberia.
8.8
Asthma alleviation
Great value for a supplement that's easy to take! These small soft gels have alleviated my asthma and allergies, and I've noticed I catch fewer colds. I plan to keep taking them.
