Last update
10/4/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.3
USERS' SCORE
Moderately Good
Based on 74 Reviews
7.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
We explored how Vitamin D3 impacts autoimmune thyroiditis, a specific autoimmune disorder. In this study, researchers established a mouse model of experimental autoimmune thyroiditis (EAT) to see how Vitamin D3 could influence this condition. After eight weeks of treatment, they assessed thyroid health and immune response through various methods, including staining tissues and measuring hormone levels.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Our observations revealed that administering Vitamin D3 helped reduce damage to the thyroid and decreased the presence of inflammatory cells within the thyroid. This treatment also led to lower levels of thyroid hormones and autoimmune antibodies in the blood, highlighting its positive effect on thyroid function. Additionally, Vitamin D3 appeared to promote the regulatory T cell (Treg) subset while decreasing the levels of Th17 cells, which are often involved in autoimmune processes.
Mechanistically, the study found that Vitamin D3 triggered specific pathways that influence Treg cell activity and survival. Notably, it activated a signaling pathway involving YAP and JAK/STAT, which are crucial for immune cell regulation. These findings suggest that Vitamin D3 could play a significant role in balancing immune responses in autoimmune thyroiditis, making it a promising candidate for further research and potential treatment strategies.
Read More
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
9
We aimed to understand how vitamin D3, specifically its active form 1,25(OH)D, affects autoimmune hepatitis (AIH), a complex autoimmune disease that causes liver damage. Researchers focused on the role of a special type of immune cell known as dendritic cells (DCs), which are influenced by vitamin D3 to promote a more balanced immune response.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Read More
Most Useful Reviews
9
Enhanced well-being
264 people found this helpful
My analysis confirmed that this product effectively raises vitamin D levels. I have noticed a significant improvement in my immune system, with only mild ARVI symptoms over three years. My energy and overall activity have increased as well. With 120 capsules per pack, it's long-lasting and convenient to take with breakfast.
Read More
9
Knowledgeable recommendations
235 people found this helpful
Vitamin D3 is often deficient in our population and is vital for health. If you have an autoimmune disorder or gut issues, consider starting with lower doses. It aids in improving tissue health, but if you're malnourished, it may cause dizziness. It's crucial to combine vitamin D with magnesium and vitamin K2. This product effectively increased my vitamin D levels.
Read More
9
Strengthened immune response
235 people found this helpful
Taking one capsule daily has significantly improved my immune system, helping me avoid colds and viruses. Since using vitamin D3 regularly, my entire family has remained healthy, including myself despite having an autoimmune disorder, Hashimoto's thyroiditis.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.3
- All Researches
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
9
We explored an intriguing instance of IgG4-related disease (IgG4-RD) manifesting as Mikulicz syndrome in an 85-year-old male patient. This condition usually involves significant systemic symptoms, yet our patient exhibited primarily local manifestations, specifically bilateral dacryoadenitis and orbital pseudotumor, without major organ complications.
Interestingly, despite normal serum IgG4 levels, which were below 135 mg/dL, the clinical and imaging findings strongly suggested the diagnosis of IgG4-RD. This scenario underscores the importance of undertaking a biopsy for accurate diagnosis. Histopathological examination revealed notable signs, such as a dense lymphoplasmacytic infiltrate and storiform fibrosis, with a considerable percentage of IgG4-positive cells, ultimately confirming our diagnosis.
We observed that treatment with prednisone, alongside azathioprine for long-term control, was effective. To mitigate the risk of glucocorticoid-induced osteoporosis, we added calcium and vitamin D3 supplementation. Remarkably, the patient showed significant clinical improvement within just 24 hours, with resolution of orbital and glandular symptoms over the following year. There was a complete recovery of vision and no relapses, with only minor dry eye as a long-term concern.
This case demonstrates the necessity of considering IgG4-RD even when serum IgG4 levels are normal and highlights the role of histopathology in diagnosis. Furthermore, it showcases the effectiveness of corticosteroids as a first-line treatment in managing this condition.
Interestingly, despite normal serum IgG4 levels, which were below 135 mg/dL, the clinical and imaging findings strongly suggested the diagnosis of IgG4-RD. This scenario underscores the importance of undertaking a biopsy for accurate diagnosis. Histopathological examination revealed notable signs, such as a dense lymphoplasmacytic infiltrate and storiform fibrosis, with a considerable percentage of IgG4-positive cells, ultimately confirming our diagnosis.
We observed that treatment with prednisone, alongside azathioprine for long-term control, was effective. To mitigate the risk of glucocorticoid-induced osteoporosis, we added calcium and vitamin D3 supplementation. Remarkably, the patient showed significant clinical improvement within just 24 hours, with resolution of orbital and glandular symptoms over the following year. There was a complete recovery of vision and no relapses, with only minor dry eye as a long-term concern.
This case demonstrates the necessity of considering IgG4-RD even when serum IgG4 levels are normal and highlights the role of histopathology in diagnosis. Furthermore, it showcases the effectiveness of corticosteroids as a first-line treatment in managing this condition.
Read More
9
We aimed to understand how vitamin D3, specifically its active form 1,25(OH)D, affects autoimmune hepatitis (AIH), a complex autoimmune disease that causes liver damage. Researchers focused on the role of a special type of immune cell known as dendritic cells (DCs), which are influenced by vitamin D3 to promote a more balanced immune response.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Through our investigation using a mouse model, we observed that injecting these vitamin D3-modulated dendritic cells, which overexpress a molecule called PD-L1, significantly lessened liver injury and severity of autoimmune hepatitis. This treatment appeared to correct the imbalance between two types of T cells: regulatory T cells (TFR) and follicular helper T cells (TFH).
By increasing the TFR population and restoring their balance with TFH cells, vitamin D3 treatment helped regulate this immune response. Additionally, the infusion boosted the production of anti-inflammatory substances while decreasing those linked to inflammation, suggesting a potential new avenue for treating autoimmune hepatitis. Overall, these findings indicate that vitamin D3-modulated dendritic cells could be a promising strategy for managing autoimmune conditions like AIH.
Read More
9
We investigated the effects of Vitamin D modulation on autoimmune prostatitis using a mouse model. In this study, we focused on how changes in gut microbiota influence the immune response, specifically looking at how vitamin D can help shift macrophage polarization—key players in the immune system—from a pro-inflammatory state (M1) to a more healing state (M2).
We observed that treatment with Eriocalyxin B (EriB), known for its anti-inflammatory properties, significantly reduced prostate inflammation in these mice. Our findings indicate that EriB not only altered the gut microbiome but also enhanced the absorption of vitamin D, contributing to a shift in macrophage phenotype. This suggests that the immune state of macrophages, altered through gut bacteria and vitamin D levels, plays a crucial role in managing autoimmune prostatitis.
Notably, fecal transplantation from EriB-treated mice resulted in a marked reduction in inflammatory markers and further supported the macrophage polarization effect. This is the first time we connected gut microbiota and vitamin D as pivotal factors in the treatment of autoimmune disorders like chronic prostatitis, highlighting a new therapeutic pathway. Overall, our research emphasizes the importance of vitamin D in modulating autoimmune responses through gut health.
We observed that treatment with Eriocalyxin B (EriB), known for its anti-inflammatory properties, significantly reduced prostate inflammation in these mice. Our findings indicate that EriB not only altered the gut microbiome but also enhanced the absorption of vitamin D, contributing to a shift in macrophage phenotype. This suggests that the immune state of macrophages, altered through gut bacteria and vitamin D levels, plays a crucial role in managing autoimmune prostatitis.
Notably, fecal transplantation from EriB-treated mice resulted in a marked reduction in inflammatory markers and further supported the macrophage polarization effect. This is the first time we connected gut microbiota and vitamin D as pivotal factors in the treatment of autoimmune disorders like chronic prostatitis, highlighting a new therapeutic pathway. Overall, our research emphasizes the importance of vitamin D in modulating autoimmune responses through gut health.
Read More
9
We observed a fascinating interplay between vitamin D3 and immune responses in patients with multiple sclerosis (MS), an autoimmune disorder that leads to significant neurological damage. Our focus was on a type of immune cell called tolerogenic dendritic cells (tolDCs), which help maintain a balance in the immune system. In our study, we used monocytes from both healthy donors and treatment-naive MS patients to assess how these cells behaved under different conditions.
Our findings revealed that tolDCs derived from MS patients had reduced tolerogenic properties when compared to their healthy counterparts. To our surprise, we found that direct activation of the aryl hydrocarbon receptor (AhR), a key player in immune regulation, could restore the tolerogenic features of MS patient-derived tolDCs. Furthermore, when we combined this approach with a treatment known as dimethyl fumarate (DMF), the results were even more promising.
The combination therapy of DMF and vitamin D3-tolDCs not only improved the tolerogenic effects but also showed better results in an experimental model of MS than using either treatment alone. This suggests that we may have a novel and effective strategy for enhancing immune tolerance in autoimmune diseases like MS.
Overall, our research indicates that vitamin D3, when used alongside DMF, could offer a new pathway for treatment, potentially minimizing the need for broader immunosuppression. This discovery opens up exciting possibilities for better management of autoimmune conditions in the future.
Our findings revealed that tolDCs derived from MS patients had reduced tolerogenic properties when compared to their healthy counterparts. To our surprise, we found that direct activation of the aryl hydrocarbon receptor (AhR), a key player in immune regulation, could restore the tolerogenic features of MS patient-derived tolDCs. Furthermore, when we combined this approach with a treatment known as dimethyl fumarate (DMF), the results were even more promising.
The combination therapy of DMF and vitamin D3-tolDCs not only improved the tolerogenic effects but also showed better results in an experimental model of MS than using either treatment alone. This suggests that we may have a novel and effective strategy for enhancing immune tolerance in autoimmune diseases like MS.
Overall, our research indicates that vitamin D3, when used alongside DMF, could offer a new pathway for treatment, potentially minimizing the need for broader immunosuppression. This discovery opens up exciting possibilities for better management of autoimmune conditions in the future.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 74 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Enhanced well-being
264 people found this helpful
My analysis confirmed that this product effectively raises vitamin D levels. I have noticed a significant improvement in my immune system, with only mild ARVI symptoms over three years. My energy and overall activity have increased as well. With 120 capsules per pack, it's long-lasting and convenient to take with breakfast.
Read More
9
Knowledgeable recommendations
235 people found this helpful
Vitamin D3 is often deficient in our population and is vital for health. If you have an autoimmune disorder or gut issues, consider starting with lower doses. It aids in improving tissue health, but if you're malnourished, it may cause dizziness. It's crucial to combine vitamin D with magnesium and vitamin K2. This product effectively increased my vitamin D levels.
Read More
9
Strengthened immune response
235 people found this helpful
Taking one capsule daily has significantly improved my immune system, helping me avoid colds and viruses. Since using vitamin D3 regularly, my entire family has remained healthy, including myself despite having an autoimmune disorder, Hashimoto's thyroiditis.
Read More
9
Family immunity boost
205 people found this helpful
We all know vitamin D is essential for immunity. After selecting this brand, we have all been healthier and noticed improvements in hair and nails. My daughter’s level increased significantly after two months. It's crucial to continue taking it to maintain vitamin D levels.
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9
No side effects
199 people found this helpful
I chose oil-based capsules from Russian pharmacies but faced stomach issues. Switching to these capsules proved beneficial; they contain 5000 IU, and my vitamin D levels normalised. I feel much better now, with no uncomfortable side effects.
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Frequently Asked Questions
9
Vitamin D improvement
163 people found this helpful
After discovering my vitamin D levels were very low, I chose this product from a trusted company. I began taking it and a month later, my vitamin D increased according to my follow-up test. I'm continuing with the treatment.
9
Improved health
103 people found this helpful
I was diagnosed with a vitamin D deficiency and refused my doctor's suggestion of high doses of D-2, opting instead for D-3. I took one pill daily for three months, resulting in my D levels rising significantly. I feel much better; my low energy, skin issues, and mood have stabilised. Even forgetting to take it with meals didn’t hinder its effectiveness. This tiny pill has been a fantastic addition to my health regime, and I recommend it to everyone.
7.5
Increased energy
478 people found this helpful
I took one capsule every two days, without a prescription, alongside Omega 3, vitamin C, folic acid, and iron. My energy levels improved significantly, allowing me to awaken without an alarm. I lost weight without dieting, and my appetite stabilised. The impact of vitamin D was profound, and the cost of the vitamins was unexpectedly affordable. I noticed these positive changes after about a week.
9
Treats autoimmune disorder
7 people found this helpful
Vitamin D significantly improved my brothers' health. My older brother had urticaria due to an overactive immune response, and my younger brother was frequently tired, suffering from an autoimmune disorder linked to low vitamin D levels. Moderate doses are more effective over time than high doses over short periods. For optimal absorption, it’s better taken with a fatty meal.
9
Enhanced well-being
264 people found this helpful
My analysis confirmed that this product effectively raises vitamin D levels. I have noticed a significant improvement in my immune system, with only mild ARVI symptoms over three years. My energy and overall activity have increased as well. With 120 capsules per pack, it's long-lasting and convenient to take with breakfast.
9
Increased energy levels
4 people found this helpful
This vitamin D is fantastic! My levels rose from 29.6 to 56 after a month. I felt more energetic, and the lethargy I had is gone. It's crucial to monitor levels before and during treatment due to the risk of overdose affecting autoimmune disorders. I plan to continue taking it.
9
Strengthened immune response
235 people found this helpful
Taking one capsule daily has significantly improved my immune system, helping me avoid colds and viruses. Since using vitamin D3 regularly, my entire family has remained healthy, including myself despite having an autoimmune disorder, Hashimoto's thyroiditis.
9
Improved skin condition
35 people found this helpful
I take this vitamin daily; it’s perfect for my eczema. After reducing my dosage, I feel invigorated with more energy and improved mornings. My skin has become soft and smooth for the first time in years, especially my hands that had been plagued by eczema. This is truly a miracle! Don't hesitate to order it.
9
Knowledgeable recommendations
235 people found this helpful
Vitamin D3 is often deficient in our population and is vital for health. If you have an autoimmune disorder or gut issues, consider starting with lower doses. It aids in improving tissue health, but if you're malnourished, it may cause dizziness. It's crucial to combine vitamin D with magnesium and vitamin K2. This product effectively increased my vitamin D levels.
9.5
Effective for family
66 people found this helpful
My go-to vitamin! My family regularly takes vitamin D, excluding summer. I try different brands but have reordered this one several times. My D levels are maintained around 70 units, based on blood tests. I recommend the 5000 IU maintenance dosage, as it works well for me.
9
Improved D level
55 people found this helpful
This is not my first time using this! Prior to treatment, my vitamin D level was low. My doctor recommended 5000 IU daily in winter and every other day in summer. Tests showed an increase to 84 ng/ml. For those with autoimmune disorders, maintaining vitamin D is crucial.
7.5
Consistent D3 usage
153 people found this helpful
Due to my autoimmune disorder (Hashimoto's disease), I must regularly take vitamin D3 in high doses.
9.5
Vitamin D3 aids autoimmune thyroiditis
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
7
Vitamin D's role in muscle health
We explored the connection between vitamin D levels and muscle health in patients with idiopathic inflammatory myopathies (IIM), a type of autoimmune disorder. The study included 46 IIM patients and 67 healthy individuals, assessing both groups to understand how vitamin D and its receptor (VDR) relate to disease symptoms, physical fitness, and lipid metabolism.
Through muscle biopsies and blood tests, we measured the vitamin D levels and gene expressions related to its metabolism. We found that lower levels of biologically active vitamin D in IIM patients suggest their bodies may not be effectively processing this vital nutrient. Moreover, regular exercise seemed to improve vitamin D levels, VDR expression, and linked muscle function with overall health outcomes for these patients.
Our findings emphasize the importance of vitamin D in managing muscle health and its potential role in enhancing physical fitness among individuals with autoimmune conditions. While the study presents promising insights, it is clear that ongoing research is needed to fully understand the relationship between vitamin D, muscle function, and autoimmune disorders.
Through muscle biopsies and blood tests, we measured the vitamin D levels and gene expressions related to its metabolism. We found that lower levels of biologically active vitamin D in IIM patients suggest their bodies may not be effectively processing this vital nutrient. Moreover, regular exercise seemed to improve vitamin D levels, VDR expression, and linked muscle function with overall health outcomes for these patients.
Our findings emphasize the importance of vitamin D in managing muscle health and its potential role in enhancing physical fitness among individuals with autoimmune conditions. While the study presents promising insights, it is clear that ongoing research is needed to fully understand the relationship between vitamin D, muscle function, and autoimmune disorders.
8
We explored the connection between vitamin D levels and the management of Graves' disease, an autoimmune disorder characterized by overactive thyroid function. Through our research with 171 patients, we aimed to see if pre-treatment levels of 25-hydroxyvitamin D could influence the reduction of thyrotropin receptor antibodies (TRAB) during treatment.
Our study divided patients into three groups based on their vitamin D levels: less than 20 ng/mL, between 20-29 ng/mL, and 30 ng/mL or more. The findings were quite revealing. We observed that patients with vitamin D levels ranging from 20 to 29 ng/mL experienced significantly higher rates of TRAB remission and negative conversion compared to the other groups during follow-ups at 6, 12, and 24 months.
This suggests that maintaining vitamin D within this specific range can be beneficial for patients newly diagnosed with Graves' disease as they undergo antithyroid treatment. However, we noted that vitamin D levels did not seem to affect the normalization of free triiodothyronine and free thyroxine levels over time.
In summary, our findings emphasize the potential role of adequate vitamin D levels in supporting immune regulation and therapeutic outcomes in autoimmune disorders, particularly Graves' disease.
Our study divided patients into three groups based on their vitamin D levels: less than 20 ng/mL, between 20-29 ng/mL, and 30 ng/mL or more. The findings were quite revealing. We observed that patients with vitamin D levels ranging from 20 to 29 ng/mL experienced significantly higher rates of TRAB remission and negative conversion compared to the other groups during follow-ups at 6, 12, and 24 months.
This suggests that maintaining vitamin D within this specific range can be beneficial for patients newly diagnosed with Graves' disease as they undergo antithyroid treatment. However, we noted that vitamin D levels did not seem to affect the normalization of free triiodothyronine and free thyroxine levels over time.
In summary, our findings emphasize the potential role of adequate vitamin D levels in supporting immune regulation and therapeutic outcomes in autoimmune disorders, particularly Graves' disease.
4
We set out to discover how effective vitamin D is in treating autoimmune disorders, specifically in patients with Hashimoto's thyroiditis (HT). Our analysis involved looking at several studies examining various dietary supplements, including selenium and vitamin D, to see how they impact thyroid autoantibody levels and overall thyroid function.
Within the studies we reviewed, vitamin D did not seem to significantly reduce thyroid autoantibody levels like other supplements. In particular, we noted that treatments involving vitamin D, whether alone or in combination with other nutrients, did not show a meaningful effect on reducing thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of significant benefit suggests that while vitamin D is often included in treatment plans for autoimmune disorders, it may not play a critical role in alleviating the symptoms or autoimmunity associated with HT. Therefore, it might be wise for those seeking supplemental help to consider other options, particularly selenium, which showed more promising results.
Within the studies we reviewed, vitamin D did not seem to significantly reduce thyroid autoantibody levels like other supplements. In particular, we noted that treatments involving vitamin D, whether alone or in combination with other nutrients, did not show a meaningful effect on reducing thyroid peroxidase autoantibodies (TPOAb) or thyroglobulin autoantibodies (TgAb).
This lack of significant benefit suggests that while vitamin D is often included in treatment plans for autoimmune disorders, it may not play a critical role in alleviating the symptoms or autoimmunity associated with HT. Therefore, it might be wise for those seeking supplemental help to consider other options, particularly selenium, which showed more promising results.
4
We embarked on a study to investigate whether oral calcifediol (25-hydroxyvitamin D3) could improve clinical outcomes in patients with multiple sclerosis (MS). Our research was designed as a randomized, double-blind trial, including two groups of participants: one receiving calcifediol and the other cholecalciferol, both at a daily dosage of 50 µg.
At the conclusion of our trial, we observed a marked difference in serum vitamin D levels between the two groups. The calcifediol group achieved significantly higher concentrations of vitamin D, suggesting it is more effective in quickly raising vitamin D levels in MS patients compared to cholecalciferol.
However, we must report that despite these increased vitamin D levels, neither treatment group showed significant improvements in other important clinical measures such as MS relapses, disability progression, or overall quality of life. Both groups indeed indicated some improvements in cognitive function, but the major clinical outcomes remained largely unchanged.
Overall, our findings suggest that while calcifediol is better at increasing vitamin D levels, it did not lead to substantial improvements in the management of multiple sclerosis. Thus, further investigation may be needed to understand the broader implications of vitamin D treatment in autoimmune disorders like MS.
At the conclusion of our trial, we observed a marked difference in serum vitamin D levels between the two groups. The calcifediol group achieved significantly higher concentrations of vitamin D, suggesting it is more effective in quickly raising vitamin D levels in MS patients compared to cholecalciferol.
However, we must report that despite these increased vitamin D levels, neither treatment group showed significant improvements in other important clinical measures such as MS relapses, disability progression, or overall quality of life. Both groups indeed indicated some improvements in cognitive function, but the major clinical outcomes remained largely unchanged.
Overall, our findings suggest that while calcifediol is better at increasing vitamin D levels, it did not lead to substantial improvements in the management of multiple sclerosis. Thus, further investigation may be needed to understand the broader implications of vitamin D treatment in autoimmune disorders like MS.
References
- Vernerová L, Vokurková M, Laiferová NA, Nemec M, Špiritović M, et al. Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis. Arthritis Res Ther. 2025;27:48. 10.1186/s13075-025-03516-9
- Wang CM, Chen YJ, Yang BC, Yang JW, Wang W, et al. Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets. Front Immunol. 2025;16:1528707. 10.3389/fimmu.2025.1528707
- Chen X, Zhang Y, Lin L, Chen Y, Shen X, et al. A beneficial levels of 25-hydroxyvitamin D for a decrease in thyrotropin receptor antibody (TRAB) in patients with Graves' disease: a real-world study. BMC Endocr Disord. 2025;25:14. 10.1186/s12902-024-01823-x
- Rafati A, Ramezani R, Esmaeili Gouvarchin Ghaleh H, Bahrami S, Alvanegh AG, et al. Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice. Transplant Proc. 2025;57:355. 10.1016/j.transproceed.2024.12.020
- Casas R, Tompa A, Åkesson K, Teixeira PF, Lindqvist A, et al. Redosing with Intralymphatic GAD-Alum in the Treatment of Type 1 Diabetes: The DIAGNODE-B Pilot Trial. Int J Mol Sci. 2025;26. 10.3390/ijms26010374
- Rasheed A, Khan G. Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis. Front Immunol. 2024;15:1503808. 10.3389/fimmu.2024.1503808
- Wu R, Li Y, Peng H, Yang Z, Wang Y, et al. Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025;24:e16740. 10.1111/jocd.16740
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. 10.1007/s10067-024-07285-9
- Peng B, Wang W, Gu Q, Wang P, Teng W, et al. Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis. Front Endocrinol (Lausanne). 2024;15:1445878. 10.3389/fendo.2024.1445878
- Balshi A, Leuenberger G, Dempsey J, Baber U, Sloane JA. Glucagon-like peptide-1 agonist safety and efficacy in a multiple sclerosis cohort. Mult Scler Relat Disord. 2025;93:106229. 10.1016/j.msard.2024.106229
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