Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.9
USERS' SCORE
Good
Based on 26 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Read More
8
Vitamin D's role in heart health
We explored the relationship between serum vitamin D levels and the risk of cardiovascular disease, as well as all-cause and cancer mortality. Using data from over 11,500 adults aged 40 and older, we wanted to understand whether having higher amounts of this nutrient in our blood could lead to better health outcomes.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Read More
8
We wanted to understand how vitamin D levels affect cardiovascular health, specifically among individuals with type 2 diabetes. Our study involved 1,378 hospitalized patients, examining their vitamin D status and its relationship with cardiovascular disease (CVD).
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
Read More
Most Useful Reviews
9
Immunity boost
235 people found this helpful
I take one capsule of vitamin D3 daily. It reliably supports my body’s immunity against various viral diseases. Over the years of regular intake, my family, including children, has not experienced any significant illness, only mild colds. As someone with thyroid disease, this supplement is essential for me as vitamin D deficiency is linked to autoimmune conditions such as Hashimoto's and even type 1 diabetes, enhancing my resistance to cardiovascular disease.
Read More
9
Vitamin D levels
55 people found this helpful
This is a great product! After taking it, my vitamin D levels increased from 27 ng/ml to 84 ng/ml. My doctor advised me to take 5000 units daily in winter and every other day in summer. My thyroid gland has been removed, so maintaining vitamin D is crucial for me. It aids calcium absorption and plays a significant role in preventing complications related to cardiovascular disease, while also enhancing immune response.
Read More
9
Essential health support
1 people found this helpful
Vitamin D helps maintain healthy bones and gums and supports cardiovascular function. I take my supplement in the morning with fatty foods. Many lack sufficient vitamin D, and higher doses are warranted. I appreciate this essential nutrient for overall health.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.9
- All Researches
9
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Read More
8
Our study delved into the potential benefits of vitamin D3 in improving cardiovascular health, particularly among hypertensive patients suffering from obesity and obstructive sleep apnea (OSA). We designed a randomized clinical trial where participants received either dapagliflozin (an SGLT-2 inhibitor), vitamin D3, a combination of both, or no treatment over a period of 16 weeks.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
Read More
8
Vitamin D benefits blood pressure management
We examined the role of vitamin D supplementation in managing hypertension, particularly its effects on cardiovascular health. After analyzing data from a systematic review and meta-analysis that included 24 relevant studies, we discovered that vitamin D has significant benefits for blood pressure.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
Read More
8
Vitamin D's role in heart health
We explored the relationship between serum vitamin D levels and the risk of cardiovascular disease, as well as all-cause and cancer mortality. Using data from over 11,500 adults aged 40 and older, we wanted to understand whether having higher amounts of this nutrient in our blood could lead to better health outcomes.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Read More
8
We wanted to understand how vitamin D levels affect cardiovascular health, specifically among individuals with type 2 diabetes. Our study involved 1,378 hospitalized patients, examining their vitamin D status and its relationship with cardiovascular disease (CVD).
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
Read More
User Reviews
USERS' SCORE
Good
Based on 26 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Immunity boost
235 people found this helpful
I take one capsule of vitamin D3 daily. It reliably supports my body’s immunity against various viral diseases. Over the years of regular intake, my family, including children, has not experienced any significant illness, only mild colds. As someone with thyroid disease, this supplement is essential for me as vitamin D deficiency is linked to autoimmune conditions such as Hashimoto's and even type 1 diabetes, enhancing my resistance to cardiovascular disease.
Read More
9
Vitamin D levels
55 people found this helpful
This is a great product! After taking it, my vitamin D levels increased from 27 ng/ml to 84 ng/ml. My doctor advised me to take 5000 units daily in winter and every other day in summer. My thyroid gland has been removed, so maintaining vitamin D is crucial for me. It aids calcium absorption and plays a significant role in preventing complications related to cardiovascular disease, while also enhancing immune response.
Read More
9
Essential health support
1 people found this helpful
Vitamin D helps maintain healthy bones and gums and supports cardiovascular function. I take my supplement in the morning with fatty foods. Many lack sufficient vitamin D, and higher doses are warranted. I appreciate this essential nutrient for overall health.
Read More
9
Pain relief
1 people found this helpful
After taking 5,000 IU of vitamin D for severe toothache, I noticed a significant reduction in pain within two days. It's crucial for addressing deficiencies that affect bones and teeth, and aids in protecting against cardiovascular disease.
Read More
9
Cancer protection
1 people found this helpful
Vitamin D is crucial for everyone as it helps protect against various cancers, including breast cancer in women, and reduces the risk of cardiovascular disease. Additionally, it supports heart health and lowers blood pressure, while aiding in diabetes prevention by stimulating insulin production and boosting immunity.
Read More
Frequently Asked Questions
7.5
Boosted energy levels
1 people found this helpful
I’ve experienced improved energy and mood since taking vitamin D3. It supports overall bodily functions, strengthens bones, and positively impacts cardiovascular health. After just four days of one capsule daily, I felt revitalised and noticed enhanced digestion. Vitamin D is crucial for everyone in our family.
9
Vitamin D levels
55 people found this helpful
This is a great product! After taking it, my vitamin D levels increased from 27 ng/ml to 84 ng/ml. My doctor advised me to take 5000 units daily in winter and every other day in summer. My thyroid gland has been removed, so maintaining vitamin D is crucial for me. It aids calcium absorption and plays a significant role in preventing complications related to cardiovascular disease, while also enhancing immune response.
9
Immunity boost
235 people found this helpful
I take one capsule of vitamin D3 daily. It reliably supports my body’s immunity against various viral diseases. Over the years of regular intake, my family, including children, has not experienced any significant illness, only mild colds. As someone with thyroid disease, this supplement is essential for me as vitamin D deficiency is linked to autoimmune conditions such as Hashimoto's and even type 1 diabetes, enhancing my resistance to cardiovascular disease.
9
Pain relief
1 people found this helpful
After taking 5,000 IU of vitamin D for severe toothache, I noticed a significant reduction in pain within two days. It's crucial for addressing deficiencies that affect bones and teeth, and aids in protecting against cardiovascular disease.
9
Essential health support
1 people found this helpful
Vitamin D helps maintain healthy bones and gums and supports cardiovascular function. I take my supplement in the morning with fatty foods. Many lack sufficient vitamin D, and higher doses are warranted. I appreciate this essential nutrient for overall health.
7
We examined how vitamin D levels, specifically 25-hydroxyvitamin D [25(OH)D], relate to the risk of cardiovascular disease and overall mortality in patients with gout. This study included data from 7,337 gout patients enrolled in the UK Biobank, following them for an average of 11.4 years. We looked closely at serum 25(OH)D measurements taken at the beginning of the study to draw connections between vitamin D levels and health outcomes.
Our findings suggested an interesting pattern. Patients with low 25(OH)D levels, specifically those below 45 nmol/L, had a higher risk of death from any cause compared to those with higher levels. In fact, those with levels of 45 nmol/L or more had about a 28% lower risk of dying from any cause. We also noted that increasing vitamin D levels above the deficiency threshold might help lower the risk of cardiovascular disease, with evidence suggesting that reaching at least 50 nmol/L is beneficial.
These results highlight the importance of maintaining adequate vitamin D levels for gout patients, as it appears to be linked to reduced mortality risk, particularly related to cardiovascular issues. This study adds to the growing conversation about vitamin D's role in heart health and suggest we may need to consider vitamin D supplementation in patient care strategies.
Our findings suggested an interesting pattern. Patients with low 25(OH)D levels, specifically those below 45 nmol/L, had a higher risk of death from any cause compared to those with higher levels. In fact, those with levels of 45 nmol/L or more had about a 28% lower risk of dying from any cause. We also noted that increasing vitamin D levels above the deficiency threshold might help lower the risk of cardiovascular disease, with evidence suggesting that reaching at least 50 nmol/L is beneficial.
These results highlight the importance of maintaining adequate vitamin D levels for gout patients, as it appears to be linked to reduced mortality risk, particularly related to cardiovascular issues. This study adds to the growing conversation about vitamin D's role in heart health and suggest we may need to consider vitamin D supplementation in patient care strategies.
8
Vitamin D benefits blood pressure management
We examined the role of vitamin D supplementation in managing hypertension, particularly its effects on cardiovascular health. After analyzing data from a systematic review and meta-analysis that included 24 relevant studies, we discovered that vitamin D has significant benefits for blood pressure.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
9
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
7
Vitamin D deficiency linked to ischemia
We explored the effects of vitamin D deficiency on the severity of coronary artery disease through a pilot study involving 200 patients at Namazi Hospital in Shiraz, Iran. Our goal was to understand how varying levels of vitamin D relate to heart health, particularly focusing on myocardial perfusion imaging.
During the study, we assessed patients' vitamin D levels and conducted myocardial perfusion imaging to analyze heart blood flow. We categorized the imaging results into different severity levels of ischemia, from normal to severe, using specific scoring systems. In our findings, we observed that patients with vitamin D levels below 10 ng/mL faced a notable increase in severe myocardial ischemia. This connection was statistically significant, suggesting that lower vitamin D is linked to poorer heart health.
Interestingly, while a substantial number of people with low vitamin D also exhibited severe ischemia, we did not find strong associations when looking at vitamin D levels with broader categories. This indicates that patients might not have higher risk for coronary artery disease solely due to abnormal vitamin D levels, except when the deficiency was considerably pronounced.
Overall, our study shows a compelling relationship between very low vitamin D levels and increased severity of ischemia, which could encourage healthcare providers to consider vitamin D levels when evaluating patients at risk for heart disease.
During the study, we assessed patients' vitamin D levels and conducted myocardial perfusion imaging to analyze heart blood flow. We categorized the imaging results into different severity levels of ischemia, from normal to severe, using specific scoring systems. In our findings, we observed that patients with vitamin D levels below 10 ng/mL faced a notable increase in severe myocardial ischemia. This connection was statistically significant, suggesting that lower vitamin D is linked to poorer heart health.
Interestingly, while a substantial number of people with low vitamin D also exhibited severe ischemia, we did not find strong associations when looking at vitamin D levels with broader categories. This indicates that patients might not have higher risk for coronary artery disease solely due to abnormal vitamin D levels, except when the deficiency was considerably pronounced.
Overall, our study shows a compelling relationship between very low vitamin D levels and increased severity of ischemia, which could encourage healthcare providers to consider vitamin D levels when evaluating patients at risk for heart disease.
References
- Vanreusel I, Hens W, Van Craenenbroeck EM, Paelinck BP, Segers VFM, et al. Vitamin D levels correlate with exercise capacity in adults with CHD. Cardiol Young. 2025. 10.1017/S1047951125000526
- Fang X, Zhang J, Zhang Z, Ye D. Association between Vitamin D and mortality risk in gout patients. J Public Health (Oxf). 2025. 10.1093/pubmed/fdaf010
- Loh HH, Tay SP, Koa AJ, Yong MC, Said A, et al. Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients. J Transl Med. 2025;23:296. 10.1186/s12967-025-06312-w
- Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. 10.1186/s12906-025-04809-x
- Checa-Ros A, Locascio A, Okojie OJ, Abellán-Galiana P, D'Marco L. Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study. BMC Nephrol. 2025;26:119. 10.1186/s12882-025-04041-2
- Liu C, Wongsonegoro H, Sheng T, Fan H, Zhang J. Associations between serum micronutrients and all-cause, cancer, and cardiovascular mortality in a national representative population: Mediated by inflammatory biomarkers. Redox Biol. 2025;81:103573. 10.1016/j.redox.2025.103573
- Zhang N, Wang Y, Li W, Wang Y, Zhang H, et al. Association between serum vitamin D level and cardiovascular disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study. Sci Rep. 2025;15:6454. 10.1038/s41598-025-90785-8
- Zhang X, Liu J, Han L, Luo G, Jiang P, et al. Vitamin D reduces VSMC foam cell formation and protects against AS progression. J Endocrinol. 2025;265. 10.1530/JOE-24-0056
- Haghighatafshar M, Shekasteband B, Firuzyar T, Etemadi Z, Farhoudi F, et al. The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study. Iran J Med Sci. 2025;50:31. 10.30476/ijms.2024.101112.3372
- Bulfone L, Vacca A, Brosolo G, Da Porto A, Bertin N, et al. Subclinical Carotid Disease Is Associated with Low Serum Vitamin D in Nondiabetic Middle-Aged Hypertensive Patients. Nutrients. 2025;17. 10.3390/nu17030480
- Li Q, Tong Y, Guo J, Liang X, Shao H, et al. Vitamin D Receptor Regulates Oxidative Stress and Apoptosis Via the HIF-1α/HO-1 Pathway in Cardiomyocytes. Cell Biochem Biophys. 2025. 10.1007/s12013-025-01681-x
- Astani A, Maroofi A, Hekmatimoghaddam S, Sarebanhassanabadi M, Safari F. Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts. Mol Biol Rep. 2024;52:96. 10.1007/s11033-024-10168-6
- Qi RQ, Chen YF, Cheng J, Song JW, Chen YH, et al. Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling. Mol Med. 2024;30:223. 10.1186/s10020-024-00997-3
- France-Ratcliffe M, Harrison SL, Verma LA, Abdul-Rahim AH, McCallum L, et al. Vitamin D and cardiovascular outcomes in multiple sclerosis. Mult Scler Relat Disord. 2024;92:106155. 10.1016/j.msard.2024.106155
- Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. 10.4103/abr.abr_380_23
- Pan YX, Fu YC, Chen H, Zhao MY. [Association of serum 25(OH)D with cardiovascular risk-related indicators: cross-sectional analysis of NHANES]. Zhonghua Yu Fang Yi Xue Za Zhi. 2024;58:1388. 10.3760/cma.j.cn112150-20240519-00403
