Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 19 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
We explored how a specific genetic variant associated with vitamin D might influence the occurrence of cold sores, also known as Herpes Simplex Labialis (HSL). Our research involved nearly 1,800 participants from the TwinsUK registry, with a focus on a group of 595 that completed both blood tests and questionnaires regarding their cold sore experiences.
From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.
However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.
Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.
From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.
However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.
Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.
Read More
Most Useful Reviews
9
No colds anymore
6 people found this helpful
This is the best vitamin D3! My three-year-old takes it easily and has not caught a cold or developed cold sores since. It's crucial for our health during troubling times. My purchases from iHerb always arrive promptly in Brazil.
Read More
9
Strong immunity boost
3 people found this helpful
After taking a high dosage of vitamin D every other day for two months, my condition improved remarkably, and I haven’t had a cold or cold sores for nearly a year.
Read More
7.5
Cold sore reduction
3 people found this helpful
I take vitamin D regularly and find it effective. While some may doubt the brand's quality, I've had good results, especially with cold sores and rapid recovery during colds.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We explored how a specific genetic variant associated with vitamin D might influence the occurrence of cold sores, also known as Herpes Simplex Labialis (HSL). Our research involved nearly 1,800 participants from the TwinsUK registry, with a focus on a group of 595 that completed both blood tests and questionnaires regarding their cold sore experiences.
From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.
However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.
Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.
From the participants surveyed, 235 reported having experienced cold sores at least once, and out of these, 160 indicated that they had recurrent episodes. While we investigated several genetic variants, including three commonly discussed in relation to cold sores, we found no significant links between these particular SNPs and the occurrence or recurrence of cold sores.
However, our analysis did reveal a noteworthy association with a genetic variation in the Vitamin D Receptor (VDR) gene. This variant was significantly correlated with both the history of cold sore outbreaks and their frequency. While this suggests a potential relationship between vitamin D-related genetics and cold sore experiences, it does not mean that vitamin D treatment has a proven direct effect on reducing these occurrences.
Overall, our findings provide an intriguing glimpse into the genetic factors that may play a role in cold sore reactivation, especially as it pertains to the VDR gene. Yet, since we didn't explore the direct effects of vitamin D supplementation, more research would be needed to conclusively determine how vitamin D treatment might influence cold sore frequency.
Read More
User Reviews
USERS' SCORE
Good
Based on 19 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
No colds anymore
6 people found this helpful
This is the best vitamin D3! My three-year-old takes it easily and has not caught a cold or developed cold sores since. It's crucial for our health during troubling times. My purchases from iHerb always arrive promptly in Brazil.
Read More
9
Strong immunity boost
3 people found this helpful
After taking a high dosage of vitamin D every other day for two months, my condition improved remarkably, and I haven’t had a cold or cold sores for nearly a year.
Read More
7.5
Cold sore reduction
3 people found this helpful
I take vitamin D regularly and find it effective. While some may doubt the brand's quality, I've had good results, especially with cold sores and rapid recovery during colds.
Read More
9
Prevents cold sores
1 people found this helpful
This D3 has been excellent! Since taking it this winter, I haven’t caught a cold. I sometimes take it daily when it's very cold outside. I highly recommend it.
Read More
9
Cold sore relief
1 people found this helpful
A must-have! We’ve been taking this vitamin as a family for months on our doctor’s advice. Despite the winter cold, we haven’t caught any colds, and we feel both physically and mentally energetic. I combine it with omega-3 and other vitamins. Score 5!
Read More
Frequently Asked Questions
7.5
Supports cold sores
1 people found this helpful
I ordered this supplement during a period of constant colds and a lack of energy. Within two weeks, I felt better—less fatigue. I believe my vitamin D was low due to poor nutrition. I took one capsule daily and now I take one every other day.
9
Strong immunity boost
3 people found this helpful
After taking a high dosage of vitamin D every other day for two months, my condition improved remarkably, and I haven’t had a cold or cold sores for nearly a year.
9
Cold sores improved
1 people found this helpful
My doctor recommended this for immunity and cold sores. After the course, my cold sores disappeared. I'm thrilled! When I feel a cold coming, I double the dose, and it helps me recover swiftly.
9
Cold sore relief
1 people found this helpful
A must-have! We’ve been taking this vitamin as a family for months on our doctor’s advice. Despite the winter cold, we haven’t caught any colds, and we feel both physically and mentally energetic. I combine it with omega-3 and other vitamins. Score 5!
9
No more cold sores
487 people found this helpful
Taking vitamin D has significantly improved my health. I no longer experience joint pain or fatigue, and headaches have disappeared. My nails and hair are stronger. I haven't caught a cold since taking it, which was common for me before.
7.5
Eases cold symptoms
1 people found this helpful
I've suffered from hay fever and other cold symptoms for years. Since I started taking this supplement, my itching and stuffy nose have improved significantly, and I seem less susceptible to colds.
6
Effective for cold sores
2 people found this helpful
Proven effectiveness! After taking a domestic vitamin D drops prescribed by my doctor, I found no improvement in my vitamin levels. I switched to Now's supplement and noticed a significant increase. It aids in immune support and helps with cold sores. I recommend taking D3 with K2 and including fats in your diet for proper absorption.
7.5
Cold sore improvement
33 people found this helpful
I had very low vitamin D levels, causing muscle pain and fatigue, alongside frequent colds and cold sores. After starting supplementation, I'm noticing improvements in these symptoms.
9
Improved cold sore immunity
1 people found this helpful
I had never checked my vitamin D levels before, but after a severe injury, I discovered it was very low. I began taking 2000 to 4000 IU and saw improvement. After two months, my levels rose significantly, and I no longer get constant colds. Vitamin D3 is crucial for immunity!
References
- Santamaria P, Bowyer RCE, Nibali L. Associations between host genetic variants and Herpes Simplex Labialis in the TwinsUK cohort. Arch Oral Biol. 2023;145:105587. doi:10.1016/j.archoralbio.2022.105587
