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SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
2
No significant benefit from vitamin D3
Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial.
High relevance to diarrhea prevention
We conducted a thorough investigation into how vitamin D3 supplementation affects diarrhea in young children. The study involved 3,046 infants aged 1 to 11 months living in high-risk areas of Kabul, Afghanistan. They were randomly assigned to receive either six doses of vitamin D3 or a placebo over 18 months.
Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.
However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.
Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.
Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.
Our analysis measured instances of diarrhea, defined as having three or more loose stools in a single day. We focused on comparing the time to the first diarrhea episode and the risk of recurring episodes between both groups.
However, the results were quite clear: vitamin D3 supplementation did not lead to any significant reduction in the time before the first episode of diarrhea or in the likelihood of having recurrent diarrhea. The differences observed between the vitamin D3 group and the placebo group were not meaningful.
Despite our expectations, this study suggests that vitamin D3 supplementation doesn't provide the preventive benefits we were hoping for when it comes to diarrhea in this population. We recommend against using similar supplementation under comparable circumstances without further research.
Additional studies in other settings might help in understanding if vitamin D3 could play a beneficial role in preventing diarrhea elsewhere.
Read More
9
TX527 improves IBD-related diarrhea
The vitamin D analog TX527 ameliorates disease symptoms in a chemically induced model of inflammatory bowel disease.
Strong focus on diarrhea treatment
We examined how the vitamin D analog TX527 affects diarrhea in a model of inflammatory bowel disease (IBD) induced by dextran sodium sulfate (DSS). In our study, we observed that TX527 significantly improved disease symptoms by reducing both bleeding and diarrhea.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Read More
7
Vitamin D3 mitigates diarrhea effects
Vitamin D in Acute Campylobacteriosis-Results From an Intervention Study Applying a Clinical Induced Enterocolitis Model.
Highly relevant to vitamin D3 effects
We investigated whether vitamin D3, specifically in the form of synthetic 25-OH-cholecalciferol, could help reduce diarrhea during an acute campylobacter infection. Using a controlled study involving IL-10 mice, we treated one group with vitamin D3 four days before they were infected with the bacteria, while another group received a placebo.
Our findings revealed that while vitamin D3 did not significantly lower the levels of gastrointestinal pathogens, it did lead to fewer instances of diarrhea among the treated mice compared to those receiving the placebo. Additionally, we observed that the vitamin D3 treatment seemed to help protect the mice's intestinal health; it reduced the inflammation and improved cell regeneration in the colonic area.
Interestingly, vitamin D3 also contributed to a lower immune response in the infected mice. There were fewer immune cells and lower levels of inflammatory mediators when compared to the placebo group. Perhaps most importantly, the application of vitamin D3 resulted in a reduced risk of the bacteria spreading from the inflamed intestines to other parts of the body, such as the kidneys and spleen, and helped maintain a healthier intestinal barrier.
In summary, our study suggests that taking synthetic vitamin D3 can have beneficial effects during acute campylobacteriosis, particularly in managing diarrhea and preserving gut health.
Our findings revealed that while vitamin D3 did not significantly lower the levels of gastrointestinal pathogens, it did lead to fewer instances of diarrhea among the treated mice compared to those receiving the placebo. Additionally, we observed that the vitamin D3 treatment seemed to help protect the mice's intestinal health; it reduced the inflammation and improved cell regeneration in the colonic area.
Interestingly, vitamin D3 also contributed to a lower immune response in the infected mice. There were fewer immune cells and lower levels of inflammatory mediators when compared to the placebo group. Perhaps most importantly, the application of vitamin D3 resulted in a reduced risk of the bacteria spreading from the inflamed intestines to other parts of the body, such as the kidneys and spleen, and helped maintain a healthier intestinal barrier.
In summary, our study suggests that taking synthetic vitamin D3 can have beneficial effects during acute campylobacteriosis, particularly in managing diarrhea and preserving gut health.
Read More
Most Useful Reviews
0
Discontinued use
I began taking Vitamin D at 10,000 IU daily as prescribed, but it caused abdominal pain and diarrhoea. I switched to vitamin D with added vitamin K, and those issues resolved.
Read More
9.5
Improved condition
Excellent! I took this vitamin as I have a deficiency. My doctor mentioned that this type of diarrhoea is beneficial. I've started taking the vitamin, and I find the capsule easy to swallow, which I appreciate.
Read More
2.5
Heart issues
This particular brand of D3 is popular but didn't work for me. After just two doses, I experienced a rapid heartbeat and sleep disturbances, along with diarrhoea. I thought it might be the vitamin, so I stopped, but when I tried it again, the same issues returned.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
9
Vitamin D3 mitigates diarrhea effects
Dietary 25-Hydroxyvitamin D Supplementation Alleviates Porcine Epidemic Diarrhea Virus Infection by Improving Intestinal Structure and Immune Response in Weaned Pigs.
Significant but complex findings
We conducted a study to see how supplementing weaned pigs with 25-hydroxyvitamin D (25(OH)D) could help ease diarrhea linked to porcine epidemic diarrhea virus (PEDV) infection. Forty-two pigs were divided into six groups and fed different amounts of vitamin D3 for 26 days. On day 22, we introduced the virus to all but one control group, which only received saline.
Our findings were quite striking. We noted that pig weight gain significantly dropped due to the PEDV infection, which also led to severe diarrhea. This infection negatively impacted the pigs' gut health by reducing villous height and increasing crypt depth—a clear indicator of intestinal distress. However, in the group supplemented with the highest level of vitamin D3 (155.5 μg), we observed considerable improvements. Their intestinal damage was significantly less than that of the control group exposed to PEDV.
Furthermore, the vitamin D3 supplementation helped lower the presence of inflammatory markers in the pigs’ systems, suggesting that this vitamin plays a role in modulating the immune response. Overall, our results indicate that adding 25(OH)D to pig diets can be beneficial in reducing diarrhea and supporting gut health in the face of PEDV infection.
Our findings were quite striking. We noted that pig weight gain significantly dropped due to the PEDV infection, which also led to severe diarrhea. This infection negatively impacted the pigs' gut health by reducing villous height and increasing crypt depth—a clear indicator of intestinal distress. However, in the group supplemented with the highest level of vitamin D3 (155.5 μg), we observed considerable improvements. Their intestinal damage was significantly less than that of the control group exposed to PEDV.
Furthermore, the vitamin D3 supplementation helped lower the presence of inflammatory markers in the pigs’ systems, suggesting that this vitamin plays a role in modulating the immune response. Overall, our results indicate that adding 25(OH)D to pig diets can be beneficial in reducing diarrhea and supporting gut health in the face of PEDV infection.
Read More
9
TX527 improves IBD-related diarrhea
The vitamin D analog TX527 ameliorates disease symptoms in a chemically induced model of inflammatory bowel disease.
Strong focus on diarrhea treatment
We examined how the vitamin D analog TX527 affects diarrhea in a model of inflammatory bowel disease (IBD) induced by dextran sodium sulfate (DSS). In our study, we observed that TX527 significantly improved disease symptoms by reducing both bleeding and diarrhea.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Notably, this analog also enhanced colon length, indicating a positive effect on the health of the intestines. Histological analysis revealed that TX527 helped protect mucosal integrity and reduced immune cell infiltration, which are key factors in IBD.
Furthermore, we found that TX527 led to a decrease in levels of several inflammatory cytokines like IL-1, IL-6, IFN-γ, and TNF-α in the colonic tissue. This suggests that the treatment not only alleviates the symptoms but also targets the underlying inflammation associated with diarrhea in IBD.
In conclusion, our findings highlight the potential of TX527 as a therapeutic option for managing diarrhea in inflammatory bowel disease.
Read More
8
Vitamin D3 aids piglet health
Capsaicin and 1,25-Dihydroxyvitamin D Glycoside: Effects on the Reproductive Performance of Hyper-Prolific Sows.
Effectiveness of vitamin D3 treatment
We evaluated the effects of vitamin D3, specifically 1,25-dihydroxyvitamin D3, on the reproductive performance of sows and the health of their piglets, focusing on incidences of diarrhea. In our study, we assessed two experiments involving 320 sows divided into different dietary treatments, including control groups without vitamin D3 or capsaicin (CAP).
The results indicated that sows supplemented with vitamin D3 showed a reduction in diarrhea cases among their piglets compared to those in the control group. In fact, the use of these dietary additives, including CAP, seemed to enhance the overall health of the piglets, which we found particularly important for litter growth.
While it is worth noting that vitamin D3 was combined with capsaicin in the treatment groups, making it challenging to delineate the effects of vitamin D3 alone, our findings directly suggest that including vitamin D3 in sow diets positively contributes to piglet health by lowering the incidence of diarrhea.
The results indicated that sows supplemented with vitamin D3 showed a reduction in diarrhea cases among their piglets compared to those in the control group. In fact, the use of these dietary additives, including CAP, seemed to enhance the overall health of the piglets, which we found particularly important for litter growth.
While it is worth noting that vitamin D3 was combined with capsaicin in the treatment groups, making it challenging to delineate the effects of vitamin D3 alone, our findings directly suggest that including vitamin D3 in sow diets positively contributes to piglet health by lowering the incidence of diarrhea.
Read More
8
Vitamin D's effect on diarrhea unclear
Vitamin D and carbamazepine protect against infection in mice by restoring macrophage lysosome acidification.
Study explores immunity, not diarrhea
We explored how Vitamin D, alongside carbamazepine, affects the body’s defense against Clostridioides difficile infection (CDI), a leading cause of severe diarrhea in hospitals. The study examined how Clostridial toxin B (TcdB) impacts macrophage function, which plays a crucial role in our immune response. In particular, researchers looked at whether TcdB reduces the acidity of lysosomes within macrophages, leading to increased inflammation and tissue damage.
Our findings shed light on how restoring lysosomal function with Vitamin D and carbamazepine could help combat this inflammation and damage. We noticed that both treatments were able to mitigate TcdB-induced dysfunction in mice, thereby reducing inflammation and histological harm.
However, it is important to note that while the study provides evidence for the protective role of Vitamin D and carbamazepine in the context of CDI, it does not isolate the effects of Vitamin D alone on diarrhea. This makes it difficult to determine whether Vitamin D3 by itself has a direct impact on reducing diarrhea. Overall, we observed promising results regarding immunity enhancement, but the specific effects on diarrhea require further investigation.
Our findings shed light on how restoring lysosomal function with Vitamin D and carbamazepine could help combat this inflammation and damage. We noticed that both treatments were able to mitigate TcdB-induced dysfunction in mice, thereby reducing inflammation and histological harm.
However, it is important to note that while the study provides evidence for the protective role of Vitamin D and carbamazepine in the context of CDI, it does not isolate the effects of Vitamin D alone on diarrhea. This makes it difficult to determine whether Vitamin D3 by itself has a direct impact on reducing diarrhea. Overall, we observed promising results regarding immunity enhancement, but the specific effects on diarrhea require further investigation.
Read More
8
Vitamin D3 aids viral infection response
1,25-Dihydroxyvitamin D inhibits porcine epidemic diarrhea virus replication by regulating cell cycle resumption in IPEC-J2 porcine epithelial cells.
Indirect relation to diarrhea effects
We investigated how vitamin D3, specifically 1,25-dihydroxyvitamin D, interacts with porcine epidemic diarrhea virus (PEDV), which is known to cause severe gastrointestinal issues in pigs, including diarrhea. Our focus was to see if vitamin D3 could help in reducing PEDV replication, thereby mitigating its effects on the animals' health.
Through our research, we found that vitamin D3 supplementation diminished PEDV-induced cell damage and apoptosis in pig intestinal epithelial cells. Notably, we observed significant reductions in PEDV gene and protein levels in these cells after treatment with vitamin D3. These findings indicate a potential antiviral effect that warrants further investigation in the context of diarrhea management.
The study also revealed that vitamin D3 appears to help cells move past a phase that the virus exploits to replicate. This movement out of the G0/G1 phase was supported by the treatment of vitamin D3, marking an intriguing potential pathway for enhancing healing from PEDV-related conditions.
While we focused on viral context rather than general diarrhea treatments, the findings suggest that vitamin D3 might play a supportive role against viral infections that cause gastrointestinal distress, such as PEDV. Though more work is needed to see these effects in broader contexts, our study lays an important foundation for further exploration into vitamin D's benefits in viral infections.
Through our research, we found that vitamin D3 supplementation diminished PEDV-induced cell damage and apoptosis in pig intestinal epithelial cells. Notably, we observed significant reductions in PEDV gene and protein levels in these cells after treatment with vitamin D3. These findings indicate a potential antiviral effect that warrants further investigation in the context of diarrhea management.
The study also revealed that vitamin D3 appears to help cells move past a phase that the virus exploits to replicate. This movement out of the G0/G1 phase was supported by the treatment of vitamin D3, marking an intriguing potential pathway for enhancing healing from PEDV-related conditions.
While we focused on viral context rather than general diarrhea treatments, the findings suggest that vitamin D3 might play a supportive role against viral infections that cause gastrointestinal distress, such as PEDV. Though more work is needed to see these effects in broader contexts, our study lays an important foundation for further exploration into vitamin D's benefits in viral infections.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.5
9.5
Improved condition
Excellent! I took this vitamin as I have a deficiency. My doctor mentioned that this type of diarrhoea is beneficial. I've started taking the vitamin, and I find the capsule easy to swallow, which I appreciate.
7.5
No side effects
I took this vitamin at a dosage of 5000 IU during autumn and winter. The jar lasted a while, and while I didn’t take special tests, my health significantly improved. There were no noticeable side effects, although my digestive system usually reacts poorly to various drugs, often causing diarrhoea.
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2.5
Stopped taking
These vitamins did not suit me. I experienced diarrhoea after starting them, so I stopped taking them and gave them to my brother, who had no issues.
2.5
Heart issues
This particular brand of D3 is popular but didn't work for me. After just two doses, I experienced a rapid heartbeat and sleep disturbances, along with diarrhoea. I thought it might be the vitamin, so I stopped, but when I tried it again, the same issues returned.
0
Discontinued use
I began taking Vitamin D at 10,000 IU daily as prescribed, but it caused abdominal pain and diarrhoea. I switched to vitamin D with added vitamin K, and those issues resolved.
