Overview
SCIENTIFIC SCORE
Questionable
Based on 24 Researches
6.9
USERS' SCORE
Good
Based on 18 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
We focused on understanding the impact of vitamin D supplementation on atopic dermatitis, commonly known as eczema, in both children and adults. This systematic review analyzed data from eleven randomized controlled trials (RCTs), involving a total of 686 participants.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Read More
8
We explored the potential benefits of vitamin D3 as a treatment for eczema, a condition that has been increasingly prevalent in recent years. By examining several randomized controlled trials, we were able to focus on how effective vitamin D3 might be in alleviating the symptoms of eczema, as measured by established severity indexes.
Our analysis included ten studies, with eight of them providing sufficient data for a quantitative comparison. In comparing the vitamin D3 group to control groups, we observed a significant reduction in eczema severity, evidenced by lower scores on the SCORAD and EASI scales. Specifically, participants taking vitamin D3 had a mean difference of -5.96, indicating a meaningful improvement in their symptoms.
This evidence suggests that incorporating vitamin D3 into eczema management could be beneficial. We believe this finding is important as it highlights a potential therapeutic avenue for eczema sufferers looking for effective solutions.
Our analysis included ten studies, with eight of them providing sufficient data for a quantitative comparison. In comparing the vitamin D3 group to control groups, we observed a significant reduction in eczema severity, evidenced by lower scores on the SCORAD and EASI scales. Specifically, participants taking vitamin D3 had a mean difference of -5.96, indicating a meaningful improvement in their symptoms.
This evidence suggests that incorporating vitamin D3 into eczema management could be beneficial. We believe this finding is important as it highlights a potential therapeutic avenue for eczema sufferers looking for effective solutions.
Read More
8
We explored the impact of vitamin D3 supplementation on winter-related atopic dermatitis (eczema) in children. Our study involved a randomized, double-blind, placebo-controlled trial conducted in Ulaanbaatar, Mongolia, where kids aged 2 to 17 years were given either vitamin D3 or a placebo for one month.
We found that children who received vitamin D3 experienced a significant improvement in their eczema symptoms. Specifically, those taking vitamin D3 saw a notable reduction in their Eczema Area and Severity Index (EASI) score compared to those on placebo, with a difference that was both clinically and statistically significant.
Importantly, kids in the vitamin D3 group also received education on skincare and emollients, ensuring a comprehensive approach to managing their condition. No adverse effects were reported in either the vitamin D3 or placebo groups, highlighting its safety.
Overall, our findings suggest that vitamin D3 is a promising treatment for alleviating winter-related eczema in children, particularly in regions where vitamin D deficiency is prevalent during the colder months.
We found that children who received vitamin D3 experienced a significant improvement in their eczema symptoms. Specifically, those taking vitamin D3 saw a notable reduction in their Eczema Area and Severity Index (EASI) score compared to those on placebo, with a difference that was both clinically and statistically significant.
Importantly, kids in the vitamin D3 group also received education on skincare and emollients, ensuring a comprehensive approach to managing their condition. No adverse effects were reported in either the vitamin D3 or placebo groups, highlighting its safety.
Overall, our findings suggest that vitamin D3 is a promising treatment for alleviating winter-related eczema in children, particularly in regions where vitamin D deficiency is prevalent during the colder months.
Read More
Most Useful Reviews
9
Cleared up eczema
103 people found this helpful
I discovered I had a Vitamin D deficiency in June 2009. I opted for D-3 instead of the prescribed D-2 megadoses. After nearly three months of taking these tiny, easy-to-swallow pills, I felt significantly better. My energy returned, and my eczema improved. I often forgot to take them with meals, yet they remained effective. I highly recommend these vitamins and iHerb, especially for the amazing price!
Read More
9
Eczema improvement
35 people found this helpful
I initially took two tablets a day but now take one, which works perfectly for my eczema. I feel energised, experience better mornings, and my skin is now smooth and soft, especially my hands, which had suffered for three years. I'm truly grateful for this improvement!
Read More
9
Eczema reduction
7 people found this helpful
I struggle with swallowing pills, but these small ones are easy to take. I take them for immune support and bone health. After a month, my sensitive skin and eczema improved significantly; I didn't experience the usual heat rashes this summer. I'm happy with the results!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 24 Researches
6.9
- All Researches
9
We examined how vitamin D3 levels affect atopic dermatitis, commonly known as eczema, particularly in patients undergoing narrowband ultraviolet B (nbUVB) therapy. This study involved 38 patients divided by gender and severity of their dermatitis, and tracked changes in both their vitamin D levels and their eczema severity before and after treatment.
Following the nbUVB therapy, we noted a remarkable increase in the median serum vitamin D levels—from 45 nmol/l before treatment to 169 nmol/l after treatment. Alongside this boost in vitamin D levels, we also observed a noteworthy reduction in eczema severity, with the average score dropping significantly.
However, our findings did not show a clear connection between the increase in vitamin D levels and the improvement in eczema severity. This suggests that while patients with eczema may benefit from increased vitamin D due to treatments like nbUVB, the direct relationship between vitamin D levels and eczema severity isn't confirmed by our study.
Overall, while patients with atopic dermatitis may be at risk of vitamin D deficiency, our results imply that simply increasing vitamin D levels might not guarantee improvements in eczema severity.
Following the nbUVB therapy, we noted a remarkable increase in the median serum vitamin D levels—from 45 nmol/l before treatment to 169 nmol/l after treatment. Alongside this boost in vitamin D levels, we also observed a noteworthy reduction in eczema severity, with the average score dropping significantly.
However, our findings did not show a clear connection between the increase in vitamin D levels and the improvement in eczema severity. This suggests that while patients with eczema may benefit from increased vitamin D due to treatments like nbUVB, the direct relationship between vitamin D levels and eczema severity isn't confirmed by our study.
Overall, while patients with atopic dermatitis may be at risk of vitamin D deficiency, our results imply that simply increasing vitamin D levels might not guarantee improvements in eczema severity.
Read More
8
We investigated the levels of vitamin D and other related factors in children suffering from eczema to better understand their relationship with the severity of this condition. Our analysis included 159 children, categorized by the severity of their eczema symptoms into mild, moderate, and severe groups.
Over the course of the study, we observed that as eczema severity increased, serum levels of vitamin A and 25-(OH)D3 (a form of vitamin D) tended to decrease. Conversely, levels of tissue transglutaminase (TG2), interleukin-4 (IL-4), and interleukin-13 (IL-13), which are markers of inflammation, increased. Significant correlations emerged showing that lower levels of vitamin A and 25-(OH)D3 were linked to higher SCORAD scores (a measure of eczema severity), while increases in TG2, IL-4, and IL-13 levels paralleled worsening symptoms.
Importantly, vitamin D levels had the highest accuracy for assessing eczema severity compared to the other markers studied. After treatment over three months, we noted improvements in the levels of all measured indicators, suggesting that addressing these serum factors could have a positive impact on managing eczema symptoms.
Our findings indicate that monitoring vitamin D levels, along with other serum indicators, might offer valuable insights for clinicians in evaluating and treating eczema in children.
Over the course of the study, we observed that as eczema severity increased, serum levels of vitamin A and 25-(OH)D3 (a form of vitamin D) tended to decrease. Conversely, levels of tissue transglutaminase (TG2), interleukin-4 (IL-4), and interleukin-13 (IL-13), which are markers of inflammation, increased. Significant correlations emerged showing that lower levels of vitamin A and 25-(OH)D3 were linked to higher SCORAD scores (a measure of eczema severity), while increases in TG2, IL-4, and IL-13 levels paralleled worsening symptoms.
Importantly, vitamin D levels had the highest accuracy for assessing eczema severity compared to the other markers studied. After treatment over three months, we noted improvements in the levels of all measured indicators, suggesting that addressing these serum factors could have a positive impact on managing eczema symptoms.
Our findings indicate that monitoring vitamin D levels, along with other serum indicators, might offer valuable insights for clinicians in evaluating and treating eczema in children.
Read More
8
We focused on understanding the impact of vitamin D supplementation on atopic dermatitis, commonly known as eczema, in both children and adults. This systematic review analyzed data from eleven randomized controlled trials (RCTs), involving a total of 686 participants.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Read More
8
Maternal vitamin D influences infant eczema
We examined the relationship between maternal vitamin D levels during early pregnancy and the occurrence of atopic dermatitis (AD), commonly known as eczema, in infants. Our study involved 4,051 woman-infant pairs, focusing on those with singleton pregnancies. We looked closely at the vitamin D levels of mothers in their first trimester and analyzed how these levels, along with vitamin D supplementation during pregnancy, influenced the likelihood of infants developing AD.
The results showed that infants born to mothers with low vitamin D levels faced a significantly higher risk of developing eczema. Specifically, mothers with vitamin D deficiency had a 77% increased risk of their infants developing AD. Interestingly, this heightened risk was mostly observed in naturally conceived pregnancies, while those conceived through assisted reproductive techniques didn't show the same association.
Additionally, we found that mothers who took vitamin D or multivitamin supplements during pregnancy had a lower risk of having infants with AD. This suggests that adequate vitamin D intake may play a protective role against eczema in infants. Our findings underscore the importance of monitoring vitamin D levels in expectant mothers, as doing so could help reduce the risk of eczema in their future children.
The results showed that infants born to mothers with low vitamin D levels faced a significantly higher risk of developing eczema. Specifically, mothers with vitamin D deficiency had a 77% increased risk of their infants developing AD. Interestingly, this heightened risk was mostly observed in naturally conceived pregnancies, while those conceived through assisted reproductive techniques didn't show the same association.
Additionally, we found that mothers who took vitamin D or multivitamin supplements during pregnancy had a lower risk of having infants with AD. This suggests that adequate vitamin D intake may play a protective role against eczema in infants. Our findings underscore the importance of monitoring vitamin D levels in expectant mothers, as doing so could help reduce the risk of eczema in their future children.
Read More
We explored the effectiveness of dietary interventions, particularly vitamin D, in treating eczema symptoms in children without food allergies. Our systematic review included several randomized controlled trials (RCTs) that assessed various treatments. Among these, vitamin D was analyzed alongside other therapies like probiotics and evening primrose oil.
The findings revealed an overall trend suggesting that probiotics, especially when combined with prebiotics, could lead to a notable reduction in eczema symptoms as measured by standard scoring systems. However, the evidence specifically highlighting vitamin D's role in alleviating eczema was limited. This indicates that while some dietary approaches show promise, the impact of vitamin D alone remains less clear.
Thus, we recognize the need for more focused research that can specifically examine the effects of vitamin D on eczema, ideally isolating it from other dietary factors. Well-structured studies are essential to deepen our understanding and develop effective treatment strategies for managing eczema in children.
The findings revealed an overall trend suggesting that probiotics, especially when combined with prebiotics, could lead to a notable reduction in eczema symptoms as measured by standard scoring systems. However, the evidence specifically highlighting vitamin D's role in alleviating eczema was limited. This indicates that while some dietary approaches show promise, the impact of vitamin D alone remains less clear.
Thus, we recognize the need for more focused research that can specifically examine the effects of vitamin D on eczema, ideally isolating it from other dietary factors. Well-structured studies are essential to deepen our understanding and develop effective treatment strategies for managing eczema in children.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cleared up eczema
103 people found this helpful
I discovered I had a Vitamin D deficiency in June 2009. I opted for D-3 instead of the prescribed D-2 megadoses. After nearly three months of taking these tiny, easy-to-swallow pills, I felt significantly better. My energy returned, and my eczema improved. I often forgot to take them with meals, yet they remained effective. I highly recommend these vitamins and iHerb, especially for the amazing price!
Read More
9
Eczema improvement
35 people found this helpful
I initially took two tablets a day but now take one, which works perfectly for my eczema. I feel energised, experience better mornings, and my skin is now smooth and soft, especially my hands, which had suffered for three years. I'm truly grateful for this improvement!
Read More
9
Eczema reduction
7 people found this helpful
I struggle with swallowing pills, but these small ones are easy to take. I take them for immune support and bone health. After a month, my sensitive skin and eczema improved significantly; I didn't experience the usual heat rashes this summer. I'm happy with the results!
Read More
9
Diminished eczema spots
I ordered these for my sister, who has eczema. She loves the results; her spots are fading. The 5000 IU dosage works well for her, and she insists on having a steady supply. It's essential to maintain the dosage to avoid deficiencies.
Read More
9
Eczema relief
Our entire family takes this regularly; it forms the foundation of our health. With normal vitamin D levels, we feel protected from conditions like cancer and diabetes. My eczema has completely cleared up due to its high doses.
Read More
Frequently Asked Questions
9
Cleared up eczema
103 people found this helpful
I discovered I had a Vitamin D deficiency in June 2009. I opted for D-3 instead of the prescribed D-2 megadoses. After nearly three months of taking these tiny, easy-to-swallow pills, I felt significantly better. My energy returned, and my eczema improved. I often forgot to take them with meals, yet they remained effective. I highly recommend these vitamins and iHerb, especially for the amazing price!
9
Eczema reduction
7 people found this helpful
I struggle with swallowing pills, but these small ones are easy to take. I take them for immune support and bone health. After a month, my sensitive skin and eczema improved significantly; I didn't experience the usual heat rashes this summer. I'm happy with the results!
7.5
Improved skin condition
10 people found this helpful
I took one tablet daily to boost my immunity, especially for my eczema. When the eczema worsened, I opted for two tablets and saw immediate improvement in my skin condition. I believe it supports my immunity during pollen season as well.
9
Eczema improvement
35 people found this helpful
I initially took two tablets a day but now take one, which works perfectly for my eczema. I feel energised, experience better mornings, and my skin is now smooth and soft, especially my hands, which had suffered for three years. I'm truly grateful for this improvement!
0
Eczema worsening
While vitamin D boosts immunity, it may exacerbate my eczema. After just two days of taking it, my facial eczema flared up. I had been advised to take it with vitamin K and magnesium, but now I have concerns about using it due to the outbreak.
7.5
Eczema management
2 people found this helpful
During the cold season, I took vitamin D for skin diseases like eczema. This dosage has optimally helped me, especially after recovering from COVID. I noticed a significant improvement in my condition after incorporating vitamins D, C, and Zinc. My family enjoys them too, as they are easy to take.
6
Eczema reduction
Vitamin D3 helps moderate immunity. I take it alongside vitamins C and E, biotin, and zinc. I've noticed my allergic reactions are milder and the duration of eczema has shortened.
9
Diminished eczema spots
I ordered these for my sister, who has eczema. She loves the results; her spots are fading. The 5000 IU dosage works well for her, and she insists on having a steady supply. It's essential to maintain the dosage to avoid deficiencies.
7.5
Improved skin health
I've been using this vitamin for a long time, especially during illness, when I double the dosage. It lasts three months and has significantly improved my skin, particularly where I had wounds resembling eczema.
References
- Li Y, Wang Z, Li X, Ma K, Shi Z. Changes and clinical significance of serum vitamin A, 25-(OH)D3, TG2, IL-4 and IL-13 levels in children with eczema. Arch Dermatol Res. 2025;317:375. doi:10.1007/s00403-025-03887-8
- Nielsen AY, Høj S, Thomsen SF, Meteran H. Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis. Nutrients. 2024;16. doi:10.3390/nu16234128
- Zhang Q, Yang D, Shen Q, Li W, Li R, et al. Correlation of Maternal Vitamin D Status in Early Pregnancy and Vitamin D Supplementation during Pregnancy with Atopic Dermatitis in Infants: A Prospective Birth Cohort Study. Nutrients. 2024;16. doi:10.3390/nu16132168
- McCarthy RL, Tawfik SS, Theocharopoulos I, Atkar R, McDonald B, et al. Vitamin D deficiency and atopic dermatitis severity in a Bangladeshi population living in East London: A cross-sectional study. Skin Health Dis. 2024;4:e358. doi:10.1002/ski2.358
- Vassilopoulou E, Comotti A, Douladiris N, Konstantinou GΝ, Zuberbier T, et al. A systematic review and meta-analysis of nutritional and dietary interventions in randomized controlled trials for skin symptoms in children with atopic dermatitis and without food allergy: An EAACI task force report. Allergy. 2024;79:1708. doi:10.1111/all.16160
- Zeng R, Lodge CJ, Koplin JJ, Lopez DJ, Erbas B, et al. Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age. Nutrients. 2024;16. doi:10.3390/nu16091303
- Ding YJ, Li XN, Xiao Z, Li CY, Jia LH. Low vitamin D during pregnancy is associated with infantile eczema by up-regulation of PI3K/AKT/mTOR signaling pathway and affecting FOXP3 expression: A bidirectional cohort study. J Nutr Biochem. 2024;124:109516. doi:10.1016/j.jnutbio.2023.109516
- Ziyab AH, Al-Taiar A, Al-Sabah R, Shaban L, Almousa Z, et al. Sex and obesity status modify the association between vitamin D and eczema among adolescents. Pediatr Res. 2023;94:1235. doi:10.1038/s41390-023-02641-y
- Zeng R, Li Y, Shen S, Qiu X, Chang CL, et al. Is antenatal or early-life vitamin D associated with eczema or food allergy in childhood? A systematic review. Clin Exp Allergy. 2023;53:511. doi:10.1111/cea.14281
- Cabalín C, Pérez-Mateluna G, Iturriaga C, Camargo CA, Borzutzky A. Oral vitamin D modulates the epidermal expression of the vitamin D receptor and cathelicidin in children with atopic dermatitis. Arch Dermatol Res. 2023;315:761. doi:10.1007/s00403-022-02416-1
- Li Q, Zhou Q, Zhang G, Tian X, Li Y, et al. Vitamin D Supplementation and Allergic Diseases during Childhood: A Systematic Review and Meta-Analysis. Nutrients. 2022;14. doi:10.3390/nu14193947
- Sangüesa J, Sunyer J, Garcia-Esteban R, Abellan A, Esplugues A, et al. Prenatal and child vitamin D levels and allergy and asthma in childhood. Pediatr Res. 2023;93:1745. doi:10.1038/s41390-022-02256-9
- El-Heis S, D'Angelo S, Curtis EM, Healy E, Moon RJ, et al. Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life: evidence from a randomized controlled trial. Br J Dermatol. 2022;187:659. doi:10.1111/bjd.21721
- Mansour NO, Mohamed AA, Hussein M, Eldemiry E, Daifalla A, et al. The impact of vitamin D supplementation as an adjuvant therapy on clinical outcomes in patients with severe atopic dermatitis: A randomized controlled trial. Pharmacol Res Perspect. 2020;8:e00679. doi:10.1002/prp2.679
- Aldaghi M, Tehrani H, Karrabi M, Abadi FS, Sahebkar M. The effect of multistrain synbiotic and vitamin D3 supplements on the severity of atopic dermatitis among infants under 1 year of age: a double-blind, randomized clinical trial study. J Dermatolog Treat. 2022;33:812. doi:10.1080/09546634.2020.1782319
- Zhu Z, Yang Z, Wang C, Liu H. Assessment of the Effectiveness of Vitamin Supplement in Treating Eczema: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2019;2019:6956034. doi:10.1155/2019/6956034
- Stanley Xavier A, Selvarajan S, Chandrasekar L, Kamalanathan S. Effect of Cholecalciferol Supplementation on Treatment Response and IL-10 Level in Vitamin D Deficient Dermatitis Patients: A Randomized Double-Blind Placebo-Controlled Trial. J Diet Suppl. 2020;17:415. doi:10.1080/19390211.2019.1619009
- Dani SU. A curious association of chronic homeopathic arsenic ingestion with nonspecific symptoms in a Swiss teenager. Swiss Med Wkly. 2019;149:w20071. doi:10.4414/smw.2019.20071
- Rose RF, Williams C, Oliphant T, Browne F, Turner D, et al. Serum 25-hydroxyvitamin D levels in patients with atopic eczema and the influence of narrowband ultraviolet B phototherapy. Photodermatol Photoimmunol Photomed. 2014;30:287.
- Camargo CA, Ganmaa D, Sidbury R, Erdenedelger Kh, Radnaakhand N, et al. Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children. J Allergy Clin Immunol. 2014;134:831. doi:10.1016/j.jaci.2014.08.002
- Norizoe C, Akiyama N, Segawa T, Tachimoto H, Mezawa H, et al. Increased food allergy and vitamin D: randomized, double-blind, placebo-controlled trial. Pediatr Int. 2014;56:6. doi:10.1111/ped.12207
- Hata TR, Audish D, Kotol P, Coda A, Kabigting F, et al. A randomized controlled double-blind investigation of the effects of vitamin D dietary supplementation in subjects with atopic dermatitis. J Eur Acad Dermatol Venereol. 2014;28:781. doi:10.1111/jdv.12176
- Jones AP, Palmer D, Zhang G, Prescott SL. Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy. Pediatrics. 2012;130:e1128. doi:10.1542/peds.2012-1172
- Mallbris L, Carlén L, Wei T, Heilborn J, Nilsson MF, et al. Injury downregulates the expression of the human cathelicidin protein hCAP18/LL-37 in atopic dermatitis. Exp Dermatol. 2010;19:442. doi:10.1111/j.1600-0625.2009.00918.x
