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SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
USERS' SCORE
Good
Based on 18 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D3 improves eczema symptoms
Assessment of the Effectiveness of Vitamin Supplement in Treating Eczema: A Systematic Review and Meta-Analysis.
High relevance to the research
We explored the potential benefits of vitamin D3 as a treatment for eczema, a condition that has been increasingly prevalent in recent years. By examining several randomized controlled trials, we were able to focus on how effective vitamin D3 might be in alleviating the symptoms of eczema, as measured by established severity indexes.
Our analysis included ten studies, with eight of them providing sufficient data for a quantitative comparison. In comparing the vitamin D3 group to control groups, we observed a significant reduction in eczema severity, evidenced by lower scores on the SCORAD and EASI scales. Specifically, participants taking vitamin D3 had a mean difference of -5.96, indicating a meaningful improvement in their symptoms.
This evidence suggests that incorporating vitamin D3 into eczema management could be beneficial. We believe this finding is important as it highlights a potential therapeutic avenue for eczema sufferers looking for effective solutions.
Our analysis included ten studies, with eight of them providing sufficient data for a quantitative comparison. In comparing the vitamin D3 group to control groups, we observed a significant reduction in eczema severity, evidenced by lower scores on the SCORAD and EASI scales. Specifically, participants taking vitamin D3 had a mean difference of -5.96, indicating a meaningful improvement in their symptoms.
This evidence suggests that incorporating vitamin D3 into eczema management could be beneficial. We believe this finding is important as it highlights a potential therapeutic avenue for eczema sufferers looking for effective solutions.
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8
Vitamin D3 improves winter eczema
Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children.
Direct evaluation of vitamin D3 effect
We explored the impact of vitamin D3 supplementation on winter-related atopic dermatitis (eczema) in children. Our study involved a randomized, double-blind, placebo-controlled trial conducted in Ulaanbaatar, Mongolia, where kids aged 2 to 17 years were given either vitamin D3 or a placebo for one month.
We found that children who received vitamin D3 experienced a significant improvement in their eczema symptoms. Specifically, those taking vitamin D3 saw a notable reduction in their Eczema Area and Severity Index (EASI) score compared to those on placebo, with a difference that was both clinically and statistically significant.
Importantly, kids in the vitamin D3 group also received education on skincare and emollients, ensuring a comprehensive approach to managing their condition. No adverse effects were reported in either the vitamin D3 or placebo groups, highlighting its safety.
Overall, our findings suggest that vitamin D3 is a promising treatment for alleviating winter-related eczema in children, particularly in regions where vitamin D deficiency is prevalent during the colder months.
We found that children who received vitamin D3 experienced a significant improvement in their eczema symptoms. Specifically, those taking vitamin D3 saw a notable reduction in their Eczema Area and Severity Index (EASI) score compared to those on placebo, with a difference that was both clinically and statistically significant.
Importantly, kids in the vitamin D3 group also received education on skincare and emollients, ensuring a comprehensive approach to managing their condition. No adverse effects were reported in either the vitamin D3 or placebo groups, highlighting its safety.
Overall, our findings suggest that vitamin D3 is a promising treatment for alleviating winter-related eczema in children, particularly in regions where vitamin D deficiency is prevalent during the colder months.
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3
Vitamin D3 lacks eczema benefits
Increased food allergy and vitamin D: randomized, double-blind, placebo-controlled trial.
Highly relevant to food allergy context.
We conducted a rigorous study to investigate whether vitamin D3 supplementation for mothers during breastfeeding could help improve infantile eczema and reduce the risk of allergic disorders later on. Our study included 164 mothers of infants displaying facial eczema, who were randomly assigned to receive either vitamin D3 supplements or a placebo for six weeks. The aim was to observe the impact of vitamin D3 on eczema severity and other related allergies over time.
After six weeks, we assessed the infants' eczema severity at the 3-month check-up using a standard scoring system. Unfortunately, our findings indicated that vitamin D3 supplementation did not significantly improve eczema symptoms compared to the placebo group. In fact, we discovered a worrying trend: infants whose mothers took vitamin D3 were at an increased risk for developing food allergies by the age of two. The difference was notable, with a higher incidence of food allergies among those receiving the vitamin D3 compared to the placebo.
In conclusion, while the intent was to find a beneficial effect of vitamin D3 on eczema, our study revealed no significant benefits in managing eczema severity, alongside an increased risk for food allergies. Given that some participants were lost to follow-up, further research is definitely needed to explore these results more thoroughly.
After six weeks, we assessed the infants' eczema severity at the 3-month check-up using a standard scoring system. Unfortunately, our findings indicated that vitamin D3 supplementation did not significantly improve eczema symptoms compared to the placebo group. In fact, we discovered a worrying trend: infants whose mothers took vitamin D3 were at an increased risk for developing food allergies by the age of two. The difference was notable, with a higher incidence of food allergies among those receiving the vitamin D3 compared to the placebo.
In conclusion, while the intent was to find a beneficial effect of vitamin D3 on eczema, our study revealed no significant benefits in managing eczema severity, alongside an increased risk for food allergies. Given that some participants were lost to follow-up, further research is definitely needed to explore these results more thoroughly.
Read More
Most Useful Reviews
9.5
Cleared up eczema
I discovered I had a Vitamin D deficiency in June 2009. I opted for D-3 instead of the prescribed D-2 megadoses. After nearly three months of taking these tiny, easy-to-swallow pills, I felt significantly better. My energy returned, and my eczema improved. I often forgot to take them with meals, yet they remained effective. I highly recommend these vitamins and iHerb, especially for the amazing price!
Read More
9.5
Eczema improvement
I initially took two tablets a day but now take one, which works perfectly for my eczema. I feel energised, experience better mornings, and my skin is now smooth and soft, especially my hands, which had suffered for three years. I'm truly grateful for this improvement!
Read More
9.5
Eczema reduction
I struggle with swallowing pills, but these small ones are easy to take. I take them for immune support and bone health. After a month, my sensitive skin and eczema improved significantly; I didn't experience the usual heat rashes this summer. I'm happy with the results!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
9
Vitamin D3 relates to eczema severity
Changes and clinical significance of serum vitamin A, 25-(OH)D3, TG2, IL-4 and IL-13 levels in children with eczema.
Important but limited findings
We explored the effects of vitamin D3 levels on children suffering from eczema in a study involving 159 pediatric patients. The children were grouped based on the severity of their eczema, allowing us to see how varying levels of vitamin A, vitamin D3, and certain inflammatory markers changed with the severity of the condition.
Our findings revealed that as the severity of eczema increased, the levels of vitamin A and 25-(OH)D3 decreased. Meanwhile, we noticed a rise in inflammatory markers such as TG2, IL-4, and IL-13. Interestingly, we found a strong negative correlation between the levels of vitamin A and 25-(OH)D3 and the eczema severity scores, indicating that lower vitamin D levels were associated with more severe eczema symptoms.
After three months of treatment, children across all severity groups showed significant improvement in their vitamin A and D3 levels, along with changes in the inflammatory markers. Notably, 25-(OH)D3 demonstrated the best accuracy in diagnosing the severity of eczema compared to the other markers examined. This suggests that monitoring vitamin D3 could be quite valuable for assessing and managing eczema in children.
Overall, our study indicates that vitamin D3 plays a significant role in the severity of eczema symptoms, reinforcing the importance of maintaining healthy vitamin D levels for children suffering from this condition.
Our findings revealed that as the severity of eczema increased, the levels of vitamin A and 25-(OH)D3 decreased. Meanwhile, we noticed a rise in inflammatory markers such as TG2, IL-4, and IL-13. Interestingly, we found a strong negative correlation between the levels of vitamin A and 25-(OH)D3 and the eczema severity scores, indicating that lower vitamin D levels were associated with more severe eczema symptoms.
After three months of treatment, children across all severity groups showed significant improvement in their vitamin A and D3 levels, along with changes in the inflammatory markers. Notably, 25-(OH)D3 demonstrated the best accuracy in diagnosing the severity of eczema compared to the other markers examined. This suggests that monitoring vitamin D3 could be quite valuable for assessing and managing eczema in children.
Overall, our study indicates that vitamin D3 plays a significant role in the severity of eczema symptoms, reinforcing the importance of maintaining healthy vitamin D levels for children suffering from this condition.
Read More
9
Vitamin D3 aids children's eczema treatment
Oral vitamin D modulates the epidermal expression of the vitamin D receptor and cathelicidin in children with atopic dermatitis.
Direct correlation with outcomes
We investigated the impact of vitamin D3 supplementation on eczema severity in children. Over six weeks, a group of 22 children with moderate to severe atopic dermatitis took oral vitamin D3 weekly. We measured changes in their skin's expression of important proteins and how their eczema was doing overall.
The results were quite promising. After the treatment, not only did the children's vitamin D levels increase, but there was also a noticeable decrease in eczema severity as measured by the SCORAD index. Our findings revealed that both the vitamin D receptor and a skin defense protein called Cathelicidin saw significant increases—especially in areas affected by eczema. However, we found that levels of Thymic Stromal Lymphopoietin (another important skin factor) did not change after the treatment.
Overall, this study suggests that oral vitamin D3 can play a beneficial role in managing eczema in children, helping improve their skin health alongside enhancing important skin functions. This gives us new insights into how vitamin D3 might serve as a supportive treatment option.
The results were quite promising. After the treatment, not only did the children's vitamin D levels increase, but there was also a noticeable decrease in eczema severity as measured by the SCORAD index. Our findings revealed that both the vitamin D receptor and a skin defense protein called Cathelicidin saw significant increases—especially in areas affected by eczema. However, we found that levels of Thymic Stromal Lymphopoietin (another important skin factor) did not change after the treatment.
Overall, this study suggests that oral vitamin D3 can play a beneficial role in managing eczema in children, helping improve their skin health alongside enhancing important skin functions. This gives us new insights into how vitamin D3 might serve as a supportive treatment option.
Read More
9
Vitamin D3 reduces eczema risk
Maternal antenatal vitamin D supplementation and offspring risk of atopic eczema in the first 4 years of life: evidence from a randomized controlled trial.
High relevance due to direct investigation
We investigated how maternal supplementation with vitamin D3 during pregnancy influences the risk of developing atopic eczema in children. Our research was part of the UK Maternal Vitamin D Osteoporosis Study (MAVIDOS), a well-designed, double-blind, randomized placebo-controlled trial. Pregnant women in the study were assigned to take either 1000 IU of cholecalciferol (vitamin D3) or a placebo from around 14 weeks of gestation until delivery.
We tracked the prevalence of atopic eczema in their children at ages 12, 24, and 48 months, using recognized criteria for diagnosis. Our findings suggest that maternal cholecalciferol supplementation plays a beneficial role, as we noted a potential protective effect against the development of infantile atopic eczema. This effect might be due to increased levels of vitamin D3 in breast milk, which may help bolster the child’s immune system.
These results add valuable information to the conversation about how prenatal interventions can influence childhood health, particularly in relation to skin conditions like eczema.
We tracked the prevalence of atopic eczema in their children at ages 12, 24, and 48 months, using recognized criteria for diagnosis. Our findings suggest that maternal cholecalciferol supplementation plays a beneficial role, as we noted a potential protective effect against the development of infantile atopic eczema. This effect might be due to increased levels of vitamin D3 in breast milk, which may help bolster the child’s immune system.
These results add valuable information to the conversation about how prenatal interventions can influence childhood health, particularly in relation to skin conditions like eczema.
Read More
9
Vitamin D boosts levels, not symptoms
Serum 25-hydroxyvitamin D levels in patients with atopic eczema and the influence of narrowband ultraviolet B phototherapy.
Investigated vitamin D's effects
We examined how vitamin D3 levels affect atopic dermatitis, commonly known as eczema, particularly in patients undergoing narrowband ultraviolet B (nbUVB) therapy. This study involved 38 patients divided by gender and severity of their dermatitis, and tracked changes in both their vitamin D levels and their eczema severity before and after treatment.
Following the nbUVB therapy, we noted a remarkable increase in the median serum vitamin D levels—from 45 nmol/l before treatment to 169 nmol/l after treatment. Alongside this boost in vitamin D levels, we also observed a noteworthy reduction in eczema severity, with the average score dropping significantly.
However, our findings did not show a clear connection between the increase in vitamin D levels and the improvement in eczema severity. This suggests that while patients with eczema may benefit from increased vitamin D due to treatments like nbUVB, the direct relationship between vitamin D levels and eczema severity isn't confirmed by our study.
Overall, while patients with atopic dermatitis may be at risk of vitamin D deficiency, our results imply that simply increasing vitamin D levels might not guarantee improvements in eczema severity.
Following the nbUVB therapy, we noted a remarkable increase in the median serum vitamin D levels—from 45 nmol/l before treatment to 169 nmol/l after treatment. Alongside this boost in vitamin D levels, we also observed a noteworthy reduction in eczema severity, with the average score dropping significantly.
However, our findings did not show a clear connection between the increase in vitamin D levels and the improvement in eczema severity. This suggests that while patients with eczema may benefit from increased vitamin D due to treatments like nbUVB, the direct relationship between vitamin D levels and eczema severity isn't confirmed by our study.
Overall, while patients with atopic dermatitis may be at risk of vitamin D deficiency, our results imply that simply increasing vitamin D levels might not guarantee improvements in eczema severity.
Read More
8
Vitamin D's potential for eczema prevention
Prenatal and child vitamin D levels and allergy and asthma in childhood.
Significant findings on eczema risk
We explored the relationship between vitamin D levels and eczema in children by analyzing data from a Spanish birth cohort. The study involved measuring the vitamin D levels of both mothers and their children, which included a significant number of participants – 2,525 pregnant women and 803 children.
Our findings revealed that about 19% of mothers and 24% of children had low levels of vitamin D, which could contribute to various health issues, including eczema. Encouragingly, we found that higher levels of vitamin D in children at the age of 4 were linked to a lower risk of developing atopic eczema as they grew older.
Specifically, for each increase of 5 ng/ml in children's vitamin D levels, the odds of eczema decreased. While there was also a suggestion that both maternal and child vitamin D levels might help reduce the prevalence of late-onset wheezing, these results require further investigation to confirm any potential benefits.
Overall, this study indicates that maintaining adequate vitamin D levels, particularly during early childhood, may be beneficial for reducing the risk of eczema, suggesting a possible area for further research and public health recommendations.
Our findings revealed that about 19% of mothers and 24% of children had low levels of vitamin D, which could contribute to various health issues, including eczema. Encouragingly, we found that higher levels of vitamin D in children at the age of 4 were linked to a lower risk of developing atopic eczema as they grew older.
Specifically, for each increase of 5 ng/ml in children's vitamin D levels, the odds of eczema decreased. While there was also a suggestion that both maternal and child vitamin D levels might help reduce the prevalence of late-onset wheezing, these results require further investigation to confirm any potential benefits.
Overall, this study indicates that maintaining adequate vitamin D levels, particularly during early childhood, may be beneficial for reducing the risk of eczema, suggesting a possible area for further research and public health recommendations.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.5
9.5
Cleared up eczema
I discovered I had a Vitamin D deficiency in June 2009. I opted for D-3 instead of the prescribed D-2 megadoses. After nearly three months of taking these tiny, easy-to-swallow pills, I felt significantly better. My energy returned, and my eczema improved. I often forgot to take them with meals, yet they remained effective. I highly recommend these vitamins and iHerb, especially for the amazing price!
Read More
9.5
Eczema improvement
I initially took two tablets a day but now take one, which works perfectly for my eczema. I feel energised, experience better mornings, and my skin is now smooth and soft, especially my hands, which had suffered for three years. I'm truly grateful for this improvement!
9.5
Eczema reduction
I struggle with swallowing pills, but these small ones are easy to take. I take them for immune support and bone health. After a month, my sensitive skin and eczema improved significantly; I didn't experience the usual heat rashes this summer. I'm happy with the results!
9.5
Diminished eczema spots
I ordered these for my sister, who has eczema. She loves the results; her spots are fading. The 5000 IU dosage works well for her, and she insists on having a steady supply. It's essential to maintain the dosage to avoid deficiencies.
9.5
Eczema relief
Our entire family takes this regularly; it forms the foundation of our health. With normal vitamin D levels, we feel protected from conditions like cancer and diabetes. My eczema has completely cleared up due to its high doses.
