' 
![]()
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.6
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
Vitamin D3 improves epilepsy outcomes
Therapeutic effect of acute and chronic use of different doses of vitamin D3 on seizure responses and cognitive impairments induced by pentylenetetrazole in immature male rats.
Highly relevant to epilepsy treatment
We aimed to understand how vitamin D3 affects seizures and cognitive problems related to epilepsy. In our study, we used sixty-six young male rats, dividing them into control and treatment groups. This allowed us to compare the outcomes of those treated with vitamin D3 against our control rats.
We observed that the rats with epilepsy showed notable issues with learning and memory, as their ability to retain information was impaired. Additionally, when exposed to pentylenetetrazole (a chemical that induces seizures), these rats experienced increased seizure duration and decreased latency before seizures. However, interestingly, when we administered vitamin D3, both acutely and chronically, these adverse effects were significantly improved.
Not only did vitamin D3 help reduce seizure severity, but it also positively influenced the levels of antioxidants and inflammatory markers in the hippocampus, a key brain area for learning and memory. Our findings suggest that vitamin D3 can indeed play a beneficial role in mitigating the cognitive and seizure-related challenges associated with epilepsy.
We observed that the rats with epilepsy showed notable issues with learning and memory, as their ability to retain information was impaired. Additionally, when exposed to pentylenetetrazole (a chemical that induces seizures), these rats experienced increased seizure duration and decreased latency before seizures. However, interestingly, when we administered vitamin D3, both acutely and chronically, these adverse effects were significantly improved.
Not only did vitamin D3 help reduce seizure severity, but it also positively influenced the levels of antioxidants and inflammatory markers in the hippocampus, a key brain area for learning and memory. Our findings suggest that vitamin D3 can indeed play a beneficial role in mitigating the cognitive and seizure-related challenges associated with epilepsy.
Read More
9
Vitamin D3 enhances levels in epilepsy
Vitamin D deficiency in a Portuguese epilepsy cohort: who is at risk and how to treat.
Significant correlation with epilepsy treatment
We explored the impact of vitamin D3 treatment on patients with epilepsy and identified the factors that contribute to vitamin D deficiency in this group. The study included 92 individuals, revealing that a striking 79.3% had either deficient or insufficient levels of vitamin D. Notably, those on enzyme-inducing antiepileptic drugs (EIAEDs) had lower vitamin D levels, likely due to reduced absorption facilitated by those medications.
To address this deficiency, we treated participants with a daily dose of 6,670 IU of cholecalciferol (vitamin D3) for eight weeks. After this period, we saw a remarkable 98.99% increase in the average vitamin D levels among the patients, demonstrating the treatment's effectiveness regardless of their EIAED use or weight status.
This study highlights that many adults with epilepsy struggle with low vitamin D levels, especially if they are on certain medications or have limited sun exposure. Overall, vitamin D3 supplementation appears beneficial, suggesting that clinicians might consider routine vitamin D assessments for patients with epilepsy, particularly those at higher risk of deficiency.
To address this deficiency, we treated participants with a daily dose of 6,670 IU of cholecalciferol (vitamin D3) for eight weeks. After this period, we saw a remarkable 98.99% increase in the average vitamin D levels among the patients, demonstrating the treatment's effectiveness regardless of their EIAED use or weight status.
This study highlights that many adults with epilepsy struggle with low vitamin D levels, especially if they are on certain medications or have limited sun exposure. Overall, vitamin D3 supplementation appears beneficial, suggesting that clinicians might consider routine vitamin D assessments for patients with epilepsy, particularly those at higher risk of deficiency.
Read More
9
Vitamin D3 supports AED treatment
Effect of high dose vitamin d supplementation on vitamin d nutrition status of pre-pubertal children on anti-epileptic drugs - A randomized controlled trial.
Relevant study on vitamin D3 use
We investigated the effects of high-dose vitamin D3 supplementation on the vitamin D status of pre-pubertal children just beginning treatment with anti-epileptic drugs (AEDs). Our randomized controlled trial included 83 children aged 5 to 10 years, who were divided into two groups. One group received a monthly dose of 60,000 IU of vitamin D3 alongside their AEDs, while the other group received only the AED treatment without any vitamin D3.
After six months, we measured various health indicators, including serum levels of vitamin D and other important minerals. Our findings reveal that taking vitamin D3 significantly helps maintain healthy vitamin D levels in children starting AEDs. For those who did not receive vitamin D3, we observed a decrease in their vitamin D levels, suggesting that supplementation is crucial for preventing deficiency.
Overall, our study underscores the importance of vitamin D3 in supporting the health of children on AED therapy and highlights the need for proactive health measures in this population.
After six months, we measured various health indicators, including serum levels of vitamin D and other important minerals. Our findings reveal that taking vitamin D3 significantly helps maintain healthy vitamin D levels in children starting AEDs. For those who did not receive vitamin D3, we observed a decrease in their vitamin D levels, suggesting that supplementation is crucial for preventing deficiency.
Overall, our study underscores the importance of vitamin D3 in supporting the health of children on AED therapy and highlights the need for proactive health measures in this population.
Read More
Most Useful Reviews
7.5
Critical for epilepsy
Vitamin D3 is essential; low levels can cause serious health problems, including epilepsy, strokes, and various cancers. Finding the right dosage varies by individual, but adults should consider 2000-5000 IU daily, while pregnant women may need 5,000 IU. It’s particularly important to supplement during months of limited sunlight to support overall health, especially for conditions like epilepsy.
Read More
8
Important for epilepsy
Vitamin D is crucial; it is actually a hormone that regulates over 3,000 genes. Its deficiency can lead to significant neurological issues, including detrimental effects on mental development and an increased risk of conditions such as epilepsy. To improve absorption, it's best taken with cofactors K2 and magnesium. Aiming for optimal levels of 70-100 ng/ml is recommended—important for brain health and mitigating risks of dementia and epilepsy.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.6
9
Vitamin D3 improves epilepsy outcomes
Therapeutic effect of acute and chronic use of different doses of vitamin D3 on seizure responses and cognitive impairments induced by pentylenetetrazole in immature male rats.
Highly relevant to epilepsy treatment
We aimed to understand how vitamin D3 affects seizures and cognitive problems related to epilepsy. In our study, we used sixty-six young male rats, dividing them into control and treatment groups. This allowed us to compare the outcomes of those treated with vitamin D3 against our control rats.
We observed that the rats with epilepsy showed notable issues with learning and memory, as their ability to retain information was impaired. Additionally, when exposed to pentylenetetrazole (a chemical that induces seizures), these rats experienced increased seizure duration and decreased latency before seizures. However, interestingly, when we administered vitamin D3, both acutely and chronically, these adverse effects were significantly improved.
Not only did vitamin D3 help reduce seizure severity, but it also positively influenced the levels of antioxidants and inflammatory markers in the hippocampus, a key brain area for learning and memory. Our findings suggest that vitamin D3 can indeed play a beneficial role in mitigating the cognitive and seizure-related challenges associated with epilepsy.
We observed that the rats with epilepsy showed notable issues with learning and memory, as their ability to retain information was impaired. Additionally, when exposed to pentylenetetrazole (a chemical that induces seizures), these rats experienced increased seizure duration and decreased latency before seizures. However, interestingly, when we administered vitamin D3, both acutely and chronically, these adverse effects were significantly improved.
Not only did vitamin D3 help reduce seizure severity, but it also positively influenced the levels of antioxidants and inflammatory markers in the hippocampus, a key brain area for learning and memory. Our findings suggest that vitamin D3 can indeed play a beneficial role in mitigating the cognitive and seizure-related challenges associated with epilepsy.
Read More
9
Vitamin D3 enhances levels in epilepsy
Vitamin D deficiency in a Portuguese epilepsy cohort: who is at risk and how to treat.
Significant correlation with epilepsy treatment
We explored the impact of vitamin D3 treatment on patients with epilepsy and identified the factors that contribute to vitamin D deficiency in this group. The study included 92 individuals, revealing that a striking 79.3% had either deficient or insufficient levels of vitamin D. Notably, those on enzyme-inducing antiepileptic drugs (EIAEDs) had lower vitamin D levels, likely due to reduced absorption facilitated by those medications.
To address this deficiency, we treated participants with a daily dose of 6,670 IU of cholecalciferol (vitamin D3) for eight weeks. After this period, we saw a remarkable 98.99% increase in the average vitamin D levels among the patients, demonstrating the treatment's effectiveness regardless of their EIAED use or weight status.
This study highlights that many adults with epilepsy struggle with low vitamin D levels, especially if they are on certain medications or have limited sun exposure. Overall, vitamin D3 supplementation appears beneficial, suggesting that clinicians might consider routine vitamin D assessments for patients with epilepsy, particularly those at higher risk of deficiency.
To address this deficiency, we treated participants with a daily dose of 6,670 IU of cholecalciferol (vitamin D3) for eight weeks. After this period, we saw a remarkable 98.99% increase in the average vitamin D levels among the patients, demonstrating the treatment's effectiveness regardless of their EIAED use or weight status.
This study highlights that many adults with epilepsy struggle with low vitamin D levels, especially if they are on certain medications or have limited sun exposure. Overall, vitamin D3 supplementation appears beneficial, suggesting that clinicians might consider routine vitamin D assessments for patients with epilepsy, particularly those at higher risk of deficiency.
Read More
9
Vitamin D3 supports AED treatment
Effect of high dose vitamin d supplementation on vitamin d nutrition status of pre-pubertal children on anti-epileptic drugs - A randomized controlled trial.
Relevant study on vitamin D3 use
We investigated the effects of high-dose vitamin D3 supplementation on the vitamin D status of pre-pubertal children just beginning treatment with anti-epileptic drugs (AEDs). Our randomized controlled trial included 83 children aged 5 to 10 years, who were divided into two groups. One group received a monthly dose of 60,000 IU of vitamin D3 alongside their AEDs, while the other group received only the AED treatment without any vitamin D3.
After six months, we measured various health indicators, including serum levels of vitamin D and other important minerals. Our findings reveal that taking vitamin D3 significantly helps maintain healthy vitamin D levels in children starting AEDs. For those who did not receive vitamin D3, we observed a decrease in their vitamin D levels, suggesting that supplementation is crucial for preventing deficiency.
Overall, our study underscores the importance of vitamin D3 in supporting the health of children on AED therapy and highlights the need for proactive health measures in this population.
After six months, we measured various health indicators, including serum levels of vitamin D and other important minerals. Our findings reveal that taking vitamin D3 significantly helps maintain healthy vitamin D levels in children starting AEDs. For those who did not receive vitamin D3, we observed a decrease in their vitamin D levels, suggesting that supplementation is crucial for preventing deficiency.
Overall, our study underscores the importance of vitamin D3 in supporting the health of children on AED therapy and highlights the need for proactive health measures in this population.
Read More
9
Vitamin D3 benefits ECG in epilepsy
The Benefit of Prescribing Vitamin D as Add on Therapy on the Electrocardiographic Changes in Epileptic Patients.
Significant findings on ECG changes
We aimed to explore the effects of vitamin D3 supplementation in young patients dealing with epilepsy, particularly looking at how it might influence their heart health. Our study included 121 children and adolescents under 18 years old with a history of generalized tonic-clonic seizures, dividing them into three groups—those without medication, those on antiepileptic drugs, and those on antiepileptic drugs supplemented with vitamin D3.
Through our investigations, we found that the patients receiving vitamin D3 alongside their medication showed notable improvements in their heart’s electrical activity, specifically in terms of specific measurements on their electrocardiograms (ECGs). For instance, those taking both antiepileptic drugs and vitamin D3 had reductions in certain parameters of their ECGs compared to those only on antiepileptic medications.
However, we also noted some concerning signs in the group solely on antiepileptic drugs, which included prolonged QT intervals in some patients. Our findings suggest that vitamin D3 may play a beneficial role in normalizing heart function in persons with epilepsy treated with medications, but further research is needed to fully understand its effects.
Through our investigations, we found that the patients receiving vitamin D3 alongside their medication showed notable improvements in their heart’s electrical activity, specifically in terms of specific measurements on their electrocardiograms (ECGs). For instance, those taking both antiepileptic drugs and vitamin D3 had reductions in certain parameters of their ECGs compared to those only on antiepileptic medications.
However, we also noted some concerning signs in the group solely on antiepileptic drugs, which included prolonged QT intervals in some patients. Our findings suggest that vitamin D3 may play a beneficial role in normalizing heart function in persons with epilepsy treated with medications, but further research is needed to fully understand its effects.
Read More
8
Vitamin D3 assists epilepsy treatment
Vitamin D3 Treatment Reduces Epileptic Neuronal Damage by Inhibiting Apoptosis and Increasing Vitamin D Receptor Expression in an Epileptic Model.
Moderate significance of study findings
We explored how vitamin D3 may provide benefits for individuals suffering from epilepsy. In a rigorous approach, Sprague-Dawley rats were treated with pentylenetetrazole to induce epilepsy. Subsequently, these subjects received various treatments, including sodium valproate, vitamin D3, or a combination of vitamin D3 with paricalcitol.
Our findings were quite promising, showing that vitamin D3 treatment improved certain aspects of epileptic behavior. Notably, there was an increase in the time before seizures began and a significant reduction in the severity of seizures as recorded on the seventh day following the onset of epilepsy. Moreover, we observed enhancements in cell structure and a decrease in neuronal damage, which suggests a neuroprotective effect of vitamin D3 against the harsh impacts of epilepsy.
Perhaps most importantly, we saw a reduction in the rate of neuronal cell death—also known as apoptosis. This protective effect seems to be tied to an increase in vitamin D receptor expression in treated subjects, which suggests a robust mechanism behind its efficacy. Although there were no significant changes in the calcium-sensing receptor levels among the groups, the increase in vitamin D receptors offers hope for its therapeutic usage. Overall, our study supports the idea that vitamin D3 might play a valuable role in the treatment of epilepsy by mitigating neuronal damage and enhancing recovery.
Our findings were quite promising, showing that vitamin D3 treatment improved certain aspects of epileptic behavior. Notably, there was an increase in the time before seizures began and a significant reduction in the severity of seizures as recorded on the seventh day following the onset of epilepsy. Moreover, we observed enhancements in cell structure and a decrease in neuronal damage, which suggests a neuroprotective effect of vitamin D3 against the harsh impacts of epilepsy.
Perhaps most importantly, we saw a reduction in the rate of neuronal cell death—also known as apoptosis. This protective effect seems to be tied to an increase in vitamin D receptor expression in treated subjects, which suggests a robust mechanism behind its efficacy. Although there were no significant changes in the calcium-sensing receptor levels among the groups, the increase in vitamin D receptors offers hope for its therapeutic usage. Overall, our study supports the idea that vitamin D3 might play a valuable role in the treatment of epilepsy by mitigating neuronal damage and enhancing recovery.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
8
Important for epilepsy
Vitamin D is crucial; it is actually a hormone that regulates over 3,000 genes. Its deficiency can lead to significant neurological issues, including detrimental effects on mental development and an increased risk of conditions such as epilepsy. To improve absorption, it's best taken with cofactors K2 and magnesium. Aiming for optimal levels of 70-100 ng/ml is recommended—important for brain health and mitigating risks of dementia and epilepsy.
Read More
7.5
Critical for epilepsy
Vitamin D3 is essential; low levels can cause serious health problems, including epilepsy, strokes, and various cancers. Finding the right dosage varies by individual, but adults should consider 2000-5000 IU daily, while pregnant women may need 5,000 IU. It’s particularly important to supplement during months of limited sunlight to support overall health, especially for conditions like epilepsy.
Read More
