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SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
Vitamin D3 aids gastritis relief
[Vitamin D3 alleviates the gastritis that associated with Helicobacter pylori infection in mice with hypercholesterolemia by enhancing the activity of vitamin D receptors in the liver tissue and blocking the signaling pathway of JAK/STAT3].
Strong relevance to gastritis treatment
This study focused on how vitamin D3 (VD3) might help alleviate gastritis, particularly in the context of Helicobacter pylori (Hp) infection and high cholesterol levels. We established mouse models that reflected these conditions and then treated them with VD3 for eight weeks. After treatment, we observed significant positive changes in the liver and stomach tissues of the mice.
Notably, we found that the levels of vitamin D receptors (VDR) and a related protein called Insig-2 increased in the liver of the mice that had high cholesterol and were also infected with Hp. This indicates that VD3 enhances the activity of these important receptors, which might contribute to its gastroprotective effects. Additionally, we saw a reduction in serum gastrin levels, which can be important in regulating stomach function.
We also noted decreased expression of JAK and STAT3 proteins, which are part of a cellular signaling pathway known to be involved in inflammation. Delving deeper, the treatment with VD3 led to lower levels of COX2—a protein associated with inflammation—in the gastric tissue. Furthermore, serum cholesterol levels decreased, and we observed a reduction in inflammatory markers like IL-8.
Ultimately, our findings suggest that VD3 may offer a beneficial approach to managing gastritis by modulating inflammation and improving liver function, especially in those with high cholesterol and Hp infection. We can cautiously conclude that VD3 has promising potential in this area, although further research could solidify these findings.
Notably, we found that the levels of vitamin D receptors (VDR) and a related protein called Insig-2 increased in the liver of the mice that had high cholesterol and were also infected with Hp. This indicates that VD3 enhances the activity of these important receptors, which might contribute to its gastroprotective effects. Additionally, we saw a reduction in serum gastrin levels, which can be important in regulating stomach function.
We also noted decreased expression of JAK and STAT3 proteins, which are part of a cellular signaling pathway known to be involved in inflammation. Delving deeper, the treatment with VD3 led to lower levels of COX2—a protein associated with inflammation—in the gastric tissue. Furthermore, serum cholesterol levels decreased, and we observed a reduction in inflammatory markers like IL-8.
Ultimately, our findings suggest that VD3 may offer a beneficial approach to managing gastritis by modulating inflammation and improving liver function, especially in those with high cholesterol and Hp infection. We can cautiously conclude that VD3 has promising potential in this area, although further research could solidify these findings.
Read More
8
Vitamin D3 enhances H. pylori treatment
Influence of adding vitamin D3 to standard clarithromycin-based triple therapy on the eradication rates of Helicobacter pylori infection.
Significant positive treatment effect
We conducted a study to seriously evaluate the effects of adding vitamin D3 to a standard treatment for Helicobacter pylori-related gastritis. With antibiotic resistance becoming a growing concern in treating this infection, we aimed to determine if vitamin D3 could enhance the efficacy of the usual clarithromycin-based therapy.
In our study, 150 patients diagnosed with H. pylori gastritis were randomly assigned to two groups. The first group (75 patients) received the standard treatment with amoxicillin, clarithromycin, and esomeprazole for two weeks. In contrast, the second group (also 75 patients) received the same antibiotics along with 1,25-hydroxyvitamin D3 for a month.
Upon assessing the eradication rates four weeks after completing the treatment, we found that those who received vitamin D3 showed significantly higher success rates in getting rid of the infection. This suggests that incorporating vitamin D3 into the treatment regimen can offer a beneficial boost, potentially leading to better outcomes for patients suffering from this condition.
Our findings indicate a promising role of vitamin D3 in enhancing the effectiveness of existing therapies for H. pylori gastritis. Adding this nutrient might just be a game changer in tackling resistance and improving recovery rates for many patients.
In our study, 150 patients diagnosed with H. pylori gastritis were randomly assigned to two groups. The first group (75 patients) received the standard treatment with amoxicillin, clarithromycin, and esomeprazole for two weeks. In contrast, the second group (also 75 patients) received the same antibiotics along with 1,25-hydroxyvitamin D3 for a month.
Upon assessing the eradication rates four weeks after completing the treatment, we found that those who received vitamin D3 showed significantly higher success rates in getting rid of the infection. This suggests that incorporating vitamin D3 into the treatment regimen can offer a beneficial boost, potentially leading to better outcomes for patients suffering from this condition.
Our findings indicate a promising role of vitamin D3 in enhancing the effectiveness of existing therapies for H. pylori gastritis. Adding this nutrient might just be a game changer in tackling resistance and improving recovery rates for many patients.
Read More
7
Vitamin D3's role in gastritis
Helicobacter pylori induces increased expression of the vitamin d receptor in immune responses.
Lacks specific gastritis insights
We observed the effects of Vitamin D3 on the body's response to Helicobacter pylori (H. pylori) infections, particularly regarding gastritis. The study included seventeen patients with H. pylori and sixteen healthy individuals for comparison. Researchers looked at the expression levels of the vitamin D receptor (VDR) and an antimicrobial protein known as CAMP in the gastric tissue.
Our findings revealed that VDR and CAMP levels significantly increased in patients who were infected with H. pylori. Moreover, higher VDR levels were associated with more chronic inflammation in the gastric tissue. This suggests that VDR plays a vital role in the immune response to the infection.
Interestingly, while Vitamin D3 was found to enhance CAMP production, it also triggered a rise in certain inflammatory cytokines when VDR was silenced. This indicates a complex interaction between Vitamin D3 and immune responses.
Ultimately, while Vitamin D3 showed some ability to stimulate an immune response, it did not significantly isolate its effects specifically on gastritis. Therefore, the study implies that while VDR and CAMP are upregulated during H. pylori infection, the potential benefits of Vitamin D3 treatment on gastritis specifically remain unclear.
Our findings revealed that VDR and CAMP levels significantly increased in patients who were infected with H. pylori. Moreover, higher VDR levels were associated with more chronic inflammation in the gastric tissue. This suggests that VDR plays a vital role in the immune response to the infection.
Interestingly, while Vitamin D3 was found to enhance CAMP production, it also triggered a rise in certain inflammatory cytokines when VDR was silenced. This indicates a complex interaction between Vitamin D3 and immune responses.
Ultimately, while Vitamin D3 showed some ability to stimulate an immune response, it did not significantly isolate its effects specifically on gastritis. Therefore, the study implies that while VDR and CAMP are upregulated during H. pylori infection, the potential benefits of Vitamin D3 treatment on gastritis specifically remain unclear.
Read More
Most Useful Reviews
9.5
Successful vitamin D boost
Excellent product! After battling a severe vitamin D deficiency, I began with 5,000 for a month, then 10,000 for two months. My vitamin D levels rose significantly, and I experienced no pain or heartburn, even with gastritis.
Read More
8.8
Mood improvement
A good product; my husband and I have already consumed several packages. My mood is excellent, and my vitamin levels have increased, with no side effects despite my gastritis.
Read More
8.8
Stomach-friendly capsules
The capsules are a good size and do not negatively affect my chronic gastritis. They are easy to swallow, and I can adjust my daily dosage as needed.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
8
Vitamin D3 aids gastritis relief
[Vitamin D3 alleviates the gastritis that associated with Helicobacter pylori infection in mice with hypercholesterolemia by enhancing the activity of vitamin D receptors in the liver tissue and blocking the signaling pathway of JAK/STAT3].
Strong relevance to gastritis treatment
This study focused on how vitamin D3 (VD3) might help alleviate gastritis, particularly in the context of Helicobacter pylori (Hp) infection and high cholesterol levels. We established mouse models that reflected these conditions and then treated them with VD3 for eight weeks. After treatment, we observed significant positive changes in the liver and stomach tissues of the mice.
Notably, we found that the levels of vitamin D receptors (VDR) and a related protein called Insig-2 increased in the liver of the mice that had high cholesterol and were also infected with Hp. This indicates that VD3 enhances the activity of these important receptors, which might contribute to its gastroprotective effects. Additionally, we saw a reduction in serum gastrin levels, which can be important in regulating stomach function.
We also noted decreased expression of JAK and STAT3 proteins, which are part of a cellular signaling pathway known to be involved in inflammation. Delving deeper, the treatment with VD3 led to lower levels of COX2—a protein associated with inflammation—in the gastric tissue. Furthermore, serum cholesterol levels decreased, and we observed a reduction in inflammatory markers like IL-8.
Ultimately, our findings suggest that VD3 may offer a beneficial approach to managing gastritis by modulating inflammation and improving liver function, especially in those with high cholesterol and Hp infection. We can cautiously conclude that VD3 has promising potential in this area, although further research could solidify these findings.
Notably, we found that the levels of vitamin D receptors (VDR) and a related protein called Insig-2 increased in the liver of the mice that had high cholesterol and were also infected with Hp. This indicates that VD3 enhances the activity of these important receptors, which might contribute to its gastroprotective effects. Additionally, we saw a reduction in serum gastrin levels, which can be important in regulating stomach function.
We also noted decreased expression of JAK and STAT3 proteins, which are part of a cellular signaling pathway known to be involved in inflammation. Delving deeper, the treatment with VD3 led to lower levels of COX2—a protein associated with inflammation—in the gastric tissue. Furthermore, serum cholesterol levels decreased, and we observed a reduction in inflammatory markers like IL-8.
Ultimately, our findings suggest that VD3 may offer a beneficial approach to managing gastritis by modulating inflammation and improving liver function, especially in those with high cholesterol and Hp infection. We can cautiously conclude that VD3 has promising potential in this area, although further research could solidify these findings.
Read More
8
Vitamin D3 enhances H. pylori treatment
Influence of adding vitamin D3 to standard clarithromycin-based triple therapy on the eradication rates of Helicobacter pylori infection.
Significant positive treatment effect
We conducted a study to seriously evaluate the effects of adding vitamin D3 to a standard treatment for Helicobacter pylori-related gastritis. With antibiotic resistance becoming a growing concern in treating this infection, we aimed to determine if vitamin D3 could enhance the efficacy of the usual clarithromycin-based therapy.
In our study, 150 patients diagnosed with H. pylori gastritis were randomly assigned to two groups. The first group (75 patients) received the standard treatment with amoxicillin, clarithromycin, and esomeprazole for two weeks. In contrast, the second group (also 75 patients) received the same antibiotics along with 1,25-hydroxyvitamin D3 for a month.
Upon assessing the eradication rates four weeks after completing the treatment, we found that those who received vitamin D3 showed significantly higher success rates in getting rid of the infection. This suggests that incorporating vitamin D3 into the treatment regimen can offer a beneficial boost, potentially leading to better outcomes for patients suffering from this condition.
Our findings indicate a promising role of vitamin D3 in enhancing the effectiveness of existing therapies for H. pylori gastritis. Adding this nutrient might just be a game changer in tackling resistance and improving recovery rates for many patients.
In our study, 150 patients diagnosed with H. pylori gastritis were randomly assigned to two groups. The first group (75 patients) received the standard treatment with amoxicillin, clarithromycin, and esomeprazole for two weeks. In contrast, the second group (also 75 patients) received the same antibiotics along with 1,25-hydroxyvitamin D3 for a month.
Upon assessing the eradication rates four weeks after completing the treatment, we found that those who received vitamin D3 showed significantly higher success rates in getting rid of the infection. This suggests that incorporating vitamin D3 into the treatment regimen can offer a beneficial boost, potentially leading to better outcomes for patients suffering from this condition.
Our findings indicate a promising role of vitamin D3 in enhancing the effectiveness of existing therapies for H. pylori gastritis. Adding this nutrient might just be a game changer in tackling resistance and improving recovery rates for many patients.
Read More
7
Vitamin D3's role in gastritis
Helicobacter pylori induces increased expression of the vitamin d receptor in immune responses.
Lacks specific gastritis insights
We observed the effects of Vitamin D3 on the body's response to Helicobacter pylori (H. pylori) infections, particularly regarding gastritis. The study included seventeen patients with H. pylori and sixteen healthy individuals for comparison. Researchers looked at the expression levels of the vitamin D receptor (VDR) and an antimicrobial protein known as CAMP in the gastric tissue.
Our findings revealed that VDR and CAMP levels significantly increased in patients who were infected with H. pylori. Moreover, higher VDR levels were associated with more chronic inflammation in the gastric tissue. This suggests that VDR plays a vital role in the immune response to the infection.
Interestingly, while Vitamin D3 was found to enhance CAMP production, it also triggered a rise in certain inflammatory cytokines when VDR was silenced. This indicates a complex interaction between Vitamin D3 and immune responses.
Ultimately, while Vitamin D3 showed some ability to stimulate an immune response, it did not significantly isolate its effects specifically on gastritis. Therefore, the study implies that while VDR and CAMP are upregulated during H. pylori infection, the potential benefits of Vitamin D3 treatment on gastritis specifically remain unclear.
Our findings revealed that VDR and CAMP levels significantly increased in patients who were infected with H. pylori. Moreover, higher VDR levels were associated with more chronic inflammation in the gastric tissue. This suggests that VDR plays a vital role in the immune response to the infection.
Interestingly, while Vitamin D3 was found to enhance CAMP production, it also triggered a rise in certain inflammatory cytokines when VDR was silenced. This indicates a complex interaction between Vitamin D3 and immune responses.
Ultimately, while Vitamin D3 showed some ability to stimulate an immune response, it did not significantly isolate its effects specifically on gastritis. Therefore, the study implies that while VDR and CAMP are upregulated during H. pylori infection, the potential benefits of Vitamin D3 treatment on gastritis specifically remain unclear.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
Successful vitamin D boost
Excellent product! After battling a severe vitamin D deficiency, I began with 5,000 for a month, then 10,000 for two months. My vitamin D levels rose significantly, and I experienced no pain or heartburn, even with gastritis.
8.8
Mood improvement
A good product; my husband and I have already consumed several packages. My mood is excellent, and my vitamin levels have increased, with no side effects despite my gastritis.
8.8
Stomach-friendly capsules
The capsules are a good size and do not negatively affect my chronic gastritis. They are easy to swallow, and I can adjust my daily dosage as needed.
8.8
Easily absorbed vitamins
Small capsules are easy to take, as advised by my gastroenterologist. They enhance absorption, especially beneficial for my gastritis. A jar lasts long, and I take 10,000 daily with omega-3 during breakfast.
8.8
No adverse reactions
Perfect! This vitamin works well with my gastritis. The small capsules are easy to swallow and cause no unpleasant aftertaste. My test results show they are effective, but remember that excess vitamin D can be dangerous.
