Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
USERS' SCORE
Good
Based on 12 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
We conducted a double-blind, randomized clinical trial to investigate how vitamin D3 supplementation affects Hashimoto's thyroiditis (HT) in female patients. Over three months, participants received either 50,000 IU of vitamin D3 or a placebo. Our focus was on measuring changes in serum cytokine levels and gene expression in CD4+ T cells, which play a critical role in the immune response associated with autoimmune diseases like HT.
Following vitamin D3 supplementation, we observed a significant increase in serum levels of 25-hydroxyvitamin D, while serum calcium levels also rose compared to where they started. However, when checking for changes related to immune response, we noted that supplementation led to a decrease in interleukin-17 (IL-17) levels, but this change didn't differ significantly from those in the placebo group.
On the other hand, the transforming growth factor-beta (TGFβ) gene expression rose significantly with vitamin D3 treatment, yet once again, we didn't see a noticeable difference between the two groups. Importantly, there was no marked effect on other key immune markers, such as interferon-gamma and IL-4 levels. Although we did see some increase in T-bet and GATA3 transcription factors, the overall impact of vitamin D3 on Hashimoto's thyroiditis in our study suggests limited benefits.
This trial sheds light on the complex relationship between vitamin D supplementation and autoimmune conditions like Hashimoto's thyroiditis. While vitamin D3 shows some promise, further long-term studies are essential to truly understand its role and effectiveness in managing HT.
Following vitamin D3 supplementation, we observed a significant increase in serum levels of 25-hydroxyvitamin D, while serum calcium levels also rose compared to where they started. However, when checking for changes related to immune response, we noted that supplementation led to a decrease in interleukin-17 (IL-17) levels, but this change didn't differ significantly from those in the placebo group.
On the other hand, the transforming growth factor-beta (TGFβ) gene expression rose significantly with vitamin D3 treatment, yet once again, we didn't see a noticeable difference between the two groups. Importantly, there was no marked effect on other key immune markers, such as interferon-gamma and IL-4 levels. Although we did see some increase in T-bet and GATA3 transcription factors, the overall impact of vitamin D3 on Hashimoto's thyroiditis in our study suggests limited benefits.
This trial sheds light on the complex relationship between vitamin D supplementation and autoimmune conditions like Hashimoto's thyroiditis. While vitamin D3 shows some promise, further long-term studies are essential to truly understand its role and effectiveness in managing HT.
Read More
9
Vitamin D3 may reduce thyroid damage
We explored the potential benefits of vitamin D3 in treating autoimmune thyroiditis, specifically focusing on Hashimoto's thyroiditis. In a controlled experiment, female NOD/ShiLtJ mice were subjected to a treatment regimen that included a specific dosage of vitamin D3 injected every other day for eight weeks.
Our observations revealed that vitamin D3 significantly reduced thyroid damage caused by the autoimmune response. Mice receiving this treatment showed a decrease in thyroid inflammation, with lower levels of thyroid autoantibodies in their serum. Additionally, vitamin D3 appeared to reverse the changes in immune cell profiles in the thyroid.
Specifically, the treatment helped inhibit the overactive pro-inflammatory T-cell subsets while promoting the function of anti-inflammatory cells. This modulation within the immune system suggests that vitamin D3 supplementation may serve as an effective approach to manage the symptoms and progression of Hashimoto's thyroiditis.
Our observations revealed that vitamin D3 significantly reduced thyroid damage caused by the autoimmune response. Mice receiving this treatment showed a decrease in thyroid inflammation, with lower levels of thyroid autoantibodies in their serum. Additionally, vitamin D3 appeared to reverse the changes in immune cell profiles in the thyroid.
Specifically, the treatment helped inhibit the overactive pro-inflammatory T-cell subsets while promoting the function of anti-inflammatory cells. This modulation within the immune system suggests that vitamin D3 supplementation may serve as an effective approach to manage the symptoms and progression of Hashimoto's thyroiditis.
Read More
9
We investigated the potential role of vitamin D3 in managing Hashimoto's thyroiditis, an autoimmune condition that affects the thyroid gland. Over the course of one year, we conducted a study with 100 participants, all diagnosed with Hashimoto's and suffering from vitamin D deficiency.
In our approach, half of the participants received cholecalciferol (vitamin D3) supplements, while the other half were given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase (anti-TPO) antibodies in both groups. Our results revealed a significant decrease in antibody levels among those who received vitamin D3—showing a 30.5% reduction compared to only 16.5% in the placebo group.
This suggests that vitamin D3 supplementation may have a beneficial effect in reducing autoimmune activity in patients with Hashimoto's thyroiditis. However, further studies with larger sample sizes are necessary to fully understand the long-term implications of vitamin D3 on thyroid health.
In our approach, half of the participants received cholecalciferol (vitamin D3) supplements, while the other half were given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase (anti-TPO) antibodies in both groups. Our results revealed a significant decrease in antibody levels among those who received vitamin D3—showing a 30.5% reduction compared to only 16.5% in the placebo group.
This suggests that vitamin D3 supplementation may have a beneficial effect in reducing autoimmune activity in patients with Hashimoto's thyroiditis. However, further studies with larger sample sizes are necessary to fully understand the long-term implications of vitamin D3 on thyroid health.
Read More
Most Useful Reviews
9
Strong immunity boost
235 people found this helpful
Taking one capsule a day significantly improves my immunity against various viral diseases. Over the years, my family, including children, has not experienced any major cold or illness. As someone with Hashimoto's thyroiditis, this supplement is essential for me due to its link with vitamin D deficiency.
Read More
9
Improved wellbeing
4 people found this helpful
Vitamin D is crucial for me as I have Hashimoto's. It helps in calcium absorption and is vital for my thyroid function, skin, hair, and nails. I take it daily, and it has made a notable difference.
Read More
9
Improved mood
After taking this vitamin D for the second time, I've noticed a significant boost in my mood despite my Hashimoto's thyroiditis. My hair loss has even stopped, and I will continue to share it with my adult children.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
- All Researches
9
Vitamin D3 may reduce thyroid damage
We explored the potential benefits of vitamin D3 in treating autoimmune thyroiditis, specifically focusing on Hashimoto's thyroiditis. In a controlled experiment, female NOD/ShiLtJ mice were subjected to a treatment regimen that included a specific dosage of vitamin D3 injected every other day for eight weeks.
Our observations revealed that vitamin D3 significantly reduced thyroid damage caused by the autoimmune response. Mice receiving this treatment showed a decrease in thyroid inflammation, with lower levels of thyroid autoantibodies in their serum. Additionally, vitamin D3 appeared to reverse the changes in immune cell profiles in the thyroid.
Specifically, the treatment helped inhibit the overactive pro-inflammatory T-cell subsets while promoting the function of anti-inflammatory cells. This modulation within the immune system suggests that vitamin D3 supplementation may serve as an effective approach to manage the symptoms and progression of Hashimoto's thyroiditis.
Our observations revealed that vitamin D3 significantly reduced thyroid damage caused by the autoimmune response. Mice receiving this treatment showed a decrease in thyroid inflammation, with lower levels of thyroid autoantibodies in their serum. Additionally, vitamin D3 appeared to reverse the changes in immune cell profiles in the thyroid.
Specifically, the treatment helped inhibit the overactive pro-inflammatory T-cell subsets while promoting the function of anti-inflammatory cells. This modulation within the immune system suggests that vitamin D3 supplementation may serve as an effective approach to manage the symptoms and progression of Hashimoto's thyroiditis.
Read More
9
We investigated the potential role of vitamin D3 in managing Hashimoto's thyroiditis, an autoimmune condition that affects the thyroid gland. Over the course of one year, we conducted a study with 100 participants, all diagnosed with Hashimoto's and suffering from vitamin D deficiency.
In our approach, half of the participants received cholecalciferol (vitamin D3) supplements, while the other half were given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase (anti-TPO) antibodies in both groups. Our results revealed a significant decrease in antibody levels among those who received vitamin D3—showing a 30.5% reduction compared to only 16.5% in the placebo group.
This suggests that vitamin D3 supplementation may have a beneficial effect in reducing autoimmune activity in patients with Hashimoto's thyroiditis. However, further studies with larger sample sizes are necessary to fully understand the long-term implications of vitamin D3 on thyroid health.
In our approach, half of the participants received cholecalciferol (vitamin D3) supplements, while the other half were given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase (anti-TPO) antibodies in both groups. Our results revealed a significant decrease in antibody levels among those who received vitamin D3—showing a 30.5% reduction compared to only 16.5% in the placebo group.
This suggests that vitamin D3 supplementation may have a beneficial effect in reducing autoimmune activity in patients with Hashimoto's thyroiditis. However, further studies with larger sample sizes are necessary to fully understand the long-term implications of vitamin D3 on thyroid health.
Read More
8
Our exploration into the connection between vitamin D3 and Hashimoto's thyroiditis (HT) revealed exciting insights. We focused on how vitamin D might help modulate the immune system, potentially reducing the risk of this autoimmune disease.
The study reviewed existing literature, which consistently shows that individuals with HT tend to have significantly lower vitamin D levels compared to healthy individuals. This suggests that vitamin D could play a crucial role in immune regulation.
We observed a positive outcome when patients with HT and vitamin D deficiency were supplemented with cholecalciferol, a form of vitamin D. Notably, their thyroid autoantibody levels—markers of the autoimmune response—dropped significantly after treatment. While these results are promising, they also highlight the need for more rigorous research.
We concur that further randomized, double-blind, placebo-controlled trials are necessary to deepen our understanding of vitamin D's benefits for those suffering from autoimmune thyroid diseases.
The study reviewed existing literature, which consistently shows that individuals with HT tend to have significantly lower vitamin D levels compared to healthy individuals. This suggests that vitamin D could play a crucial role in immune regulation.
We observed a positive outcome when patients with HT and vitamin D deficiency were supplemented with cholecalciferol, a form of vitamin D. Notably, their thyroid autoantibody levels—markers of the autoimmune response—dropped significantly after treatment. While these results are promising, they also highlight the need for more rigorous research.
We concur that further randomized, double-blind, placebo-controlled trials are necessary to deepen our understanding of vitamin D's benefits for those suffering from autoimmune thyroid diseases.
Read More
8
We explored the impact of vitamin D in combination with selenium and diabetes medications on patients with Hashimoto's thyroiditis and type 2 diabetes mellitus (T2DM). In this study, 150 patients received either standard treatment, which included a low-iodine diet and diabetes medications, or additional vitamin D and selenium.
Our findings revealed that the addition of vitamin D and selenium significantly improved thyroid function and helped regulate blood sugar and lipid levels. Markers like free T3, TSH, and free T4, as well as autoantibodies, showed notable changes after 3 and 6 months of treatment.
This suggests that vitamin D could play an important role for those managing T2DM alongside Hashimoto's thyroiditis. However, while we have observed positive results with combined treatments, it’s important to recognize that the isolated effect of vitamin D alone wasn’t determined in the study.
Our findings revealed that the addition of vitamin D and selenium significantly improved thyroid function and helped regulate blood sugar and lipid levels. Markers like free T3, TSH, and free T4, as well as autoantibodies, showed notable changes after 3 and 6 months of treatment.
This suggests that vitamin D could play an important role for those managing T2DM alongside Hashimoto's thyroiditis. However, while we have observed positive results with combined treatments, it’s important to recognize that the isolated effect of vitamin D alone wasn’t determined in the study.
Read More
8
We explored the effects of vitamin D supplementation on patients with Hashimoto's thyroiditis (HT), particularly focusing on the role of vitamin D3. Our analysis included a comprehensive review of randomized controlled trials that aimed to assess how vitamin D impacted thyroid function and autoantibody levels.
Through our meta-analysis of 12 studies involving 862 participants, we observed that vitamin D supplementation significantly reduced the presence of thyroid-related antibodies, known as TPO-Ab and TG-Ab. These findings suggest that vitamin D can positively influence immune responses in those with HT.
Additionally, we saw improvements in thyroid function as indicated by reduced levels of thyroid-stimulating hormone (TSH) and increased levels of free triiodothyronine (FT3) and free thyroxine (FT4). Notably, active forms of vitamin D, like calcitriol, appeared to perform better than other forms such as vitamin D2 or D3 in reducing antibody levels.
Our analysis also indicated that longer treatment durations, specifically over 12 weeks, led to more significant improvements. Overall, the data imply that incorporating vitamin D into the treatment plan for HT patients could be beneficial for both immune modulation and thyroid function enhancement.
Through our meta-analysis of 12 studies involving 862 participants, we observed that vitamin D supplementation significantly reduced the presence of thyroid-related antibodies, known as TPO-Ab and TG-Ab. These findings suggest that vitamin D can positively influence immune responses in those with HT.
Additionally, we saw improvements in thyroid function as indicated by reduced levels of thyroid-stimulating hormone (TSH) and increased levels of free triiodothyronine (FT3) and free thyroxine (FT4). Notably, active forms of vitamin D, like calcitriol, appeared to perform better than other forms such as vitamin D2 or D3 in reducing antibody levels.
Our analysis also indicated that longer treatment durations, specifically over 12 weeks, led to more significant improvements. Overall, the data imply that incorporating vitamin D into the treatment plan for HT patients could be beneficial for both immune modulation and thyroid function enhancement.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Strong immunity boost
235 people found this helpful
Taking one capsule a day significantly improves my immunity against various viral diseases. Over the years, my family, including children, has not experienced any major cold or illness. As someone with Hashimoto's thyroiditis, this supplement is essential for me due to its link with vitamin D deficiency.
Read More
9
Improved wellbeing
4 people found this helpful
Vitamin D is crucial for me as I have Hashimoto's. It helps in calcium absorption and is vital for my thyroid function, skin, hair, and nails. I take it daily, and it has made a notable difference.
Read More
9
Improved mood
After taking this vitamin D for the second time, I've noticed a significant boost in my mood despite my Hashimoto's thyroiditis. My hair loss has even stopped, and I will continue to share it with my adult children.
Read More
9
Very pleased
As a Hashimoto’s thyroiditis sufferer, I consistently require vitamin D. This supplement meets my needs perfectly.
Read More
7.5
Essential dietary supplement
153 people found this helpful
With my autoimmune condition, Hashimoto's, I need to take vitamin D3 often and in higher doses.
Read More
Frequently Asked Questions
9
Improved mood
After taking this vitamin D for the second time, I've noticed a significant boost in my mood despite my Hashimoto's thyroiditis. My hair loss has even stopped, and I will continue to share it with my adult children.
7.5
Increased energy levels
As someone with Hashimoto's and vitamin D deficiency, taking it is crucial. I feel more energetic since starting the supplement.
9
Improved wellbeing
4 people found this helpful
Vitamin D is crucial for me as I have Hashimoto's. It helps in calcium absorption and is vital for my thyroid function, skin, hair, and nails. I take it daily, and it has made a notable difference.
9
Strong immunity boost
235 people found this helpful
Taking one capsule a day significantly improves my immunity against various viral diseases. Over the years, my family, including children, has not experienced any major cold or illness. As someone with Hashimoto's thyroiditis, this supplement is essential for me due to its link with vitamin D deficiency.
7.5
Improved migraine frequency
3 people found this helpful
I've been taking numerous supplements and following a high-protein, good-fat, and low-simple-carbohydrate diet. While I'm unsure which specific change is responsible, I've noted significant improvement in my migraines, going from six days down to 2-3 days of pain. I’ve also started Armour thyroid due to my Hashimoto diagnosis.
7.5
Daily essential
I take this daily for my Hashimoto's condition. Consulting a doctor before increasing the vitamin D dosage is advisable.
7.5
Effective winter support
This high-quality vitamin D3 helps maintain my levels in winter, essential for my Hashimoto’s. My endocrinologist recommends it for immunity throughout the year. Sharing with my mother has been beneficial for both of us.
7.5
Supports immune system
Since my Hashimoto’s diagnosis, I started taking vitamin D3 to combat deficiencies. It aids my immune system and boosts my mood.
8
We explored the effects of vitamin D supplementation on patients with Hashimoto's thyroiditis (HT), particularly focusing on the role of vitamin D3. Our analysis included a comprehensive review of randomized controlled trials that aimed to assess how vitamin D impacted thyroid function and autoantibody levels.
Through our meta-analysis of 12 studies involving 862 participants, we observed that vitamin D supplementation significantly reduced the presence of thyroid-related antibodies, known as TPO-Ab and TG-Ab. These findings suggest that vitamin D can positively influence immune responses in those with HT.
Additionally, we saw improvements in thyroid function as indicated by reduced levels of thyroid-stimulating hormone (TSH) and increased levels of free triiodothyronine (FT3) and free thyroxine (FT4). Notably, active forms of vitamin D, like calcitriol, appeared to perform better than other forms such as vitamin D2 or D3 in reducing antibody levels.
Our analysis also indicated that longer treatment durations, specifically over 12 weeks, led to more significant improvements. Overall, the data imply that incorporating vitamin D into the treatment plan for HT patients could be beneficial for both immune modulation and thyroid function enhancement.
Through our meta-analysis of 12 studies involving 862 participants, we observed that vitamin D supplementation significantly reduced the presence of thyroid-related antibodies, known as TPO-Ab and TG-Ab. These findings suggest that vitamin D can positively influence immune responses in those with HT.
Additionally, we saw improvements in thyroid function as indicated by reduced levels of thyroid-stimulating hormone (TSH) and increased levels of free triiodothyronine (FT3) and free thyroxine (FT4). Notably, active forms of vitamin D, like calcitriol, appeared to perform better than other forms such as vitamin D2 or D3 in reducing antibody levels.
Our analysis also indicated that longer treatment durations, specifically over 12 weeks, led to more significant improvements. Overall, the data imply that incorporating vitamin D into the treatment plan for HT patients could be beneficial for both immune modulation and thyroid function enhancement.
8
We explored the potential benefits of vitamin D3 supplementation for people suffering from Hashimoto's thyroiditis, an autoimmune condition affecting the thyroid. This analysis compiled data from eight randomized controlled trials, involving a total of 652 participants, to see how effective vitamin D3 might be in reducing specific thyroid autoantibodies.
The results showed promising findings: vitamin D3 supplementation significantly lowered levels of thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TGAb). Specifically, the data pointed to a marked reduction in these autoantibodies when vitamin D3 was taken for more than three months. However, shorter supplementation periods—three months or less—did not yield the same positive results.
Overall, these findings suggest that vitamin D3 could be a valuable addition to the management of Hashimoto's thyroiditis by helping to curb high autoantibody levels, which are associated with the disease. As we consider this evidence, it highlights the importance of adequate vitamin D levels among individuals with autoimmune thyroid conditions.
The results showed promising findings: vitamin D3 supplementation significantly lowered levels of thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TGAb). Specifically, the data pointed to a marked reduction in these autoantibodies when vitamin D3 was taken for more than three months. However, shorter supplementation periods—three months or less—did not yield the same positive results.
Overall, these findings suggest that vitamin D3 could be a valuable addition to the management of Hashimoto's thyroiditis by helping to curb high autoantibody levels, which are associated with the disease. As we consider this evidence, it highlights the importance of adequate vitamin D levels among individuals with autoimmune thyroid conditions.
9
Vitamin D3 may reduce thyroid damage
We explored the potential benefits of vitamin D3 in treating autoimmune thyroiditis, specifically focusing on Hashimoto's thyroiditis. In a controlled experiment, female NOD/ShiLtJ mice were subjected to a treatment regimen that included a specific dosage of vitamin D3 injected every other day for eight weeks.
Our observations revealed that vitamin D3 significantly reduced thyroid damage caused by the autoimmune response. Mice receiving this treatment showed a decrease in thyroid inflammation, with lower levels of thyroid autoantibodies in their serum. Additionally, vitamin D3 appeared to reverse the changes in immune cell profiles in the thyroid.
Specifically, the treatment helped inhibit the overactive pro-inflammatory T-cell subsets while promoting the function of anti-inflammatory cells. This modulation within the immune system suggests that vitamin D3 supplementation may serve as an effective approach to manage the symptoms and progression of Hashimoto's thyroiditis.
Our observations revealed that vitamin D3 significantly reduced thyroid damage caused by the autoimmune response. Mice receiving this treatment showed a decrease in thyroid inflammation, with lower levels of thyroid autoantibodies in their serum. Additionally, vitamin D3 appeared to reverse the changes in immune cell profiles in the thyroid.
Specifically, the treatment helped inhibit the overactive pro-inflammatory T-cell subsets while promoting the function of anti-inflammatory cells. This modulation within the immune system suggests that vitamin D3 supplementation may serve as an effective approach to manage the symptoms and progression of Hashimoto's thyroiditis.
8
Our exploration into the connection between vitamin D3 and Hashimoto's thyroiditis (HT) revealed exciting insights. We focused on how vitamin D might help modulate the immune system, potentially reducing the risk of this autoimmune disease.
The study reviewed existing literature, which consistently shows that individuals with HT tend to have significantly lower vitamin D levels compared to healthy individuals. This suggests that vitamin D could play a crucial role in immune regulation.
We observed a positive outcome when patients with HT and vitamin D deficiency were supplemented with cholecalciferol, a form of vitamin D. Notably, their thyroid autoantibody levels—markers of the autoimmune response—dropped significantly after treatment. While these results are promising, they also highlight the need for more rigorous research.
We concur that further randomized, double-blind, placebo-controlled trials are necessary to deepen our understanding of vitamin D's benefits for those suffering from autoimmune thyroid diseases.
The study reviewed existing literature, which consistently shows that individuals with HT tend to have significantly lower vitamin D levels compared to healthy individuals. This suggests that vitamin D could play a crucial role in immune regulation.
We observed a positive outcome when patients with HT and vitamin D deficiency were supplemented with cholecalciferol, a form of vitamin D. Notably, their thyroid autoantibody levels—markers of the autoimmune response—dropped significantly after treatment. While these results are promising, they also highlight the need for more rigorous research.
We concur that further randomized, double-blind, placebo-controlled trials are necessary to deepen our understanding of vitamin D's benefits for those suffering from autoimmune thyroid diseases.
8
We explored the impact of vitamin D in combination with selenium and diabetes medications on patients with Hashimoto's thyroiditis and type 2 diabetes mellitus (T2DM). In this study, 150 patients received either standard treatment, which included a low-iodine diet and diabetes medications, or additional vitamin D and selenium.
Our findings revealed that the addition of vitamin D and selenium significantly improved thyroid function and helped regulate blood sugar and lipid levels. Markers like free T3, TSH, and free T4, as well as autoantibodies, showed notable changes after 3 and 6 months of treatment.
This suggests that vitamin D could play an important role for those managing T2DM alongside Hashimoto's thyroiditis. However, while we have observed positive results with combined treatments, it’s important to recognize that the isolated effect of vitamin D alone wasn’t determined in the study.
Our findings revealed that the addition of vitamin D and selenium significantly improved thyroid function and helped regulate blood sugar and lipid levels. Markers like free T3, TSH, and free T4, as well as autoantibodies, showed notable changes after 3 and 6 months of treatment.
This suggests that vitamin D could play an important role for those managing T2DM alongside Hashimoto's thyroiditis. However, while we have observed positive results with combined treatments, it’s important to recognize that the isolated effect of vitamin D alone wasn’t determined in the study.
9
We investigated the potential role of vitamin D3 in managing Hashimoto's thyroiditis, an autoimmune condition that affects the thyroid gland. Over the course of one year, we conducted a study with 100 participants, all diagnosed with Hashimoto's and suffering from vitamin D deficiency.
In our approach, half of the participants received cholecalciferol (vitamin D3) supplements, while the other half were given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase (anti-TPO) antibodies in both groups. Our results revealed a significant decrease in antibody levels among those who received vitamin D3—showing a 30.5% reduction compared to only 16.5% in the placebo group.
This suggests that vitamin D3 supplementation may have a beneficial effect in reducing autoimmune activity in patients with Hashimoto's thyroiditis. However, further studies with larger sample sizes are necessary to fully understand the long-term implications of vitamin D3 on thyroid health.
In our approach, half of the participants received cholecalciferol (vitamin D3) supplements, while the other half were given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase (anti-TPO) antibodies in both groups. Our results revealed a significant decrease in antibody levels among those who received vitamin D3—showing a 30.5% reduction compared to only 16.5% in the placebo group.
This suggests that vitamin D3 supplementation may have a beneficial effect in reducing autoimmune activity in patients with Hashimoto's thyroiditis. However, further studies with larger sample sizes are necessary to fully understand the long-term implications of vitamin D3 on thyroid health.
We conducted a double-blind, randomized clinical trial to investigate how vitamin D3 supplementation affects Hashimoto's thyroiditis (HT) in female patients. Over three months, participants received either 50,000 IU of vitamin D3 or a placebo. Our focus was on measuring changes in serum cytokine levels and gene expression in CD4+ T cells, which play a critical role in the immune response associated with autoimmune diseases like HT.
Following vitamin D3 supplementation, we observed a significant increase in serum levels of 25-hydroxyvitamin D, while serum calcium levels also rose compared to where they started. However, when checking for changes related to immune response, we noted that supplementation led to a decrease in interleukin-17 (IL-17) levels, but this change didn't differ significantly from those in the placebo group.
On the other hand, the transforming growth factor-beta (TGFβ) gene expression rose significantly with vitamin D3 treatment, yet once again, we didn't see a noticeable difference between the two groups. Importantly, there was no marked effect on other key immune markers, such as interferon-gamma and IL-4 levels. Although we did see some increase in T-bet and GATA3 transcription factors, the overall impact of vitamin D3 on Hashimoto's thyroiditis in our study suggests limited benefits.
This trial sheds light on the complex relationship between vitamin D supplementation and autoimmune conditions like Hashimoto's thyroiditis. While vitamin D3 shows some promise, further long-term studies are essential to truly understand its role and effectiveness in managing HT.
Following vitamin D3 supplementation, we observed a significant increase in serum levels of 25-hydroxyvitamin D, while serum calcium levels also rose compared to where they started. However, when checking for changes related to immune response, we noted that supplementation led to a decrease in interleukin-17 (IL-17) levels, but this change didn't differ significantly from those in the placebo group.
On the other hand, the transforming growth factor-beta (TGFβ) gene expression rose significantly with vitamin D3 treatment, yet once again, we didn't see a noticeable difference between the two groups. Importantly, there was no marked effect on other key immune markers, such as interferon-gamma and IL-4 levels. Although we did see some increase in T-bet and GATA3 transcription factors, the overall impact of vitamin D3 on Hashimoto's thyroiditis in our study suggests limited benefits.
This trial sheds light on the complex relationship between vitamin D supplementation and autoimmune conditions like Hashimoto's thyroiditis. While vitamin D3 shows some promise, further long-term studies are essential to truly understand its role and effectiveness in managing HT.
8
We investigated the impact of vitamin D treatment on individuals suffering from Hashimoto's thyroiditis, a condition that often leads to hypothyroidism. Our study involved 75 patients diagnosed with Hashimoto's thyroiditis and 43 healthy individuals for comparison.
Vitamin D deficiency was prevalent among our patients, with levels significantly lower than those in the control group. To address this, patients with low vitamin D were given a weekly dose of 50,000 units of vitamin D3 for eight weeks, following established guidelines.
After two months of treatment, we observed notable changes. There were marked reductions in thyroid autoantibodies among those treated, suggesting that vitamin D therapy could positively influence the disease's progression. Additionally, cholesterol levels improved, potentially lowering cardiovascular risks in these patients.
Overall, our findings suggest that treating vitamin D deficiency in individuals with Hashimoto's thyroiditis may help slow the advance of hypothyroidism and enhance overall health outcomes. We highlight the importance of monitoring and supplementing vitamin D levels in patients with this autoimmune condition.
Vitamin D deficiency was prevalent among our patients, with levels significantly lower than those in the control group. To address this, patients with low vitamin D were given a weekly dose of 50,000 units of vitamin D3 for eight weeks, following established guidelines.
After two months of treatment, we observed notable changes. There were marked reductions in thyroid autoantibodies among those treated, suggesting that vitamin D therapy could positively influence the disease's progression. Additionally, cholesterol levels improved, potentially lowering cardiovascular risks in these patients.
Overall, our findings suggest that treating vitamin D deficiency in individuals with Hashimoto's thyroiditis may help slow the advance of hypothyroidism and enhance overall health outcomes. We highlight the importance of monitoring and supplementing vitamin D levels in patients with this autoimmune condition.
References
- Wang CM, Chen YJ, Yang BC, Yang JW, Wang W, et al. Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets. Front Immunol. 2025;16:1528707. doi:10.3389/fimmu.2025.1528707
- Durá-Travé T, Gallinas-Victoriano F. Autoimmune Thyroiditis and Vitamin D. Int J Mol Sci. 2024;25. doi:10.3390/ijms25063154
- Feng F, Zhou B, Zhou CL, Huang P, Wang G, et al. Vitamin D, selenium, and antidiabetic drugs in the treatment of type 2 diabetes mellitus with Hashimoto's thyroiditis. World J Diabetes. 2024;15:209. doi:10.4239/wjd.v15.i2.209
- Chahardoli R, Robat-Jazi B, Azizi F, Amouzegar A, Khalili D, et al. Alterations in CD4 T Cell Cytokines Profile in Female Patients with Hashimoto's Thyroiditis Following Vitamin D Supplementation: A Double-blind, Randomized Clinical Trial. Endocr Metab Immune Disord Drug Targets. 2024;24:1454. doi:10.2174/0118715303273297231226153751
- Tang J, Shan S, Li F, Yun P. Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis. Medicine (Baltimore). 2023;102:e36759. doi:10.1097/MD.0000000000036759
- Bhakat B, Pal J, Das S, Charaborty SK, SircarMedical NR. A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis. J Assoc Physicians India. 2023;71:1.
- Robat-Jazi B, Mobini S, Chahardoli R, Mansouri F, Nodehi M, et al. The Impact of Vitamin D Supplementation on the IFNγ-IP10 Axis in Women with Hashimoto's Thyroiditis Treated with Levothyroxine: A Double-blind Randomized Placebo-controlled Trial. Iran J Allergy Asthma Immunol. 2022;21:407. doi:10.18502/ijaai.v21i4.10288
- Krysiak R, Kowalcze K, Okopień B. Gluten-free diet attenuates the impact of exogenous vitamin D on thyroid autoimmunity in young women with autoimmune thyroiditis: a pilot study. Scand J Clin Lab Invest. 2022;82:518. doi:10.1080/00365513.2022.2129434
- Zhang J, Chen Y, Li H, Li H. Effects of vitamin D on thyroid autoimmunity markers in Hashimoto's thyroiditis: systematic review and meta-analysis. J Int Med Res. 2021;49:3000605211060675. doi:10.1177/03000605211060675
- Krysiak R, Szkróbka W, Okopień B. Dehydroepiandrosterone potentiates the effect of vitamin D on thyroid autoimmunity in euthyroid women with autoimmune thyroiditis: A pilot study. Clin Exp Pharmacol Physiol. 2021;48:195. doi:10.1111/1440-1681.13410
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