Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.4
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9.5
We examined how vitamin D supplementation could help improve symptoms for those suffering from irritable bowel syndrome (IBS). This systematic review pulled together findings from four randomized, placebo-controlled trials, with a total of 335 participants, to determine the effectiveness of vitamin D on various IBS measures.
Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.
Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.
Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.
Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.
Read More
9
We aimed to find out how vitamin D supplementation might help those suffering from irritable bowel syndrome (IBS). To do this, we conducted a thorough review of nine randomized controlled trials that included a total of 780 participants.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
Read More
9
We aimed to understand how vitamin D3 supplementation might help adolescents suffering from irritable bowel syndrome (IBS), especially those who are deficient in vitamin D. Our study involved 112 adolescents diagnosed with IBS, who were split into two groups based on their age and gender.
One group received a daily dose of 2000 IU of oral vitamin D for six months, while the other group received a placebo. To evaluate the impact of the treatment, we assessed vitamin D levels and used various IBS scoring systems before and after the six-month period.
The results were promising for the vitamin D group. We observed significant improvements in both the IBS Severity Scoring System (IBS-SSS) and the quality of life related to IBS (IBS-QoL), with improvements noted at a high level of statistical significance. Additionally, the serum vitamin D levels in the treatment group doubled, which correlates with the improvements in IBS.
Interestingly, the placebo group did not show significant changes in their serum vitamin D levels. Throughout the study, we found that vitamin D supplementation was well tolerated, with no adverse effects reported.
In conclusion, our findings suggest that vitamin D3 supplementation can be quite beneficial for adolescents with IBS and vitamin D deficiency, helping to improve their symptoms and overall quality of life.
One group received a daily dose of 2000 IU of oral vitamin D for six months, while the other group received a placebo. To evaluate the impact of the treatment, we assessed vitamin D levels and used various IBS scoring systems before and after the six-month period.
The results were promising for the vitamin D group. We observed significant improvements in both the IBS Severity Scoring System (IBS-SSS) and the quality of life related to IBS (IBS-QoL), with improvements noted at a high level of statistical significance. Additionally, the serum vitamin D levels in the treatment group doubled, which correlates with the improvements in IBS.
Interestingly, the placebo group did not show significant changes in their serum vitamin D levels. Throughout the study, we found that vitamin D supplementation was well tolerated, with no adverse effects reported.
In conclusion, our findings suggest that vitamin D3 supplementation can be quite beneficial for adolescents with IBS and vitamin D deficiency, helping to improve their symptoms and overall quality of life.
Read More
Most Useful Reviews
7.5
Vitamin benefits noted
I highly recommend continuing vitamin intake, particularly for those with irritable bowel syndrome, as absorption can be poor. This vitamin D supplement from a reputable company offers essential support for gut health, which we often struggle to maintain.
Read More
9
Enhanced psychological state
10 people found this helpful
Since taking this supplement, I feel much better. It positively affects my mood and helps my bones absorb calcium, which is beneficial for those of us with irritable bowel syndrome. It's fat-soluble, so it's best taken with high-fat foods.
Read More
7.5
Quick vitamin D increase
1 people found this helpful
This supplement is ideal for those with a diagnosed vitamin D deficiency. It's well tolerated and aids in increasing vitamin D levels quickly. I’ve experienced relief from chronic fatigue syndrome, and it’s crucial for individuals with irritable bowel syndrome to monitor their levels.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.4
- All Researches
9.5
We examined how vitamin D supplementation could help improve symptoms for those suffering from irritable bowel syndrome (IBS). This systematic review pulled together findings from four randomized, placebo-controlled trials, with a total of 335 participants, to determine the effectiveness of vitamin D on various IBS measures.
Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.
Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.
Participants with IBS often struggle with symptoms like pain and discomfort, and vitamin D deficiency has been frequently noted in these individuals. Our research indicated that taking vitamin D could lead to significant improvements in IBS severity compared to a placebo. The results showed that those receiving vitamin D reported notable changes in their IBS severity scores and quality of life scores after the supplementation.
Specifically, after taking vitamin D, participants fared much better in terms of symptom relief than those who received a placebo. While we found some variability in the overall effects on the total score of IBS, the positive outcomes in severity and quality of life were compelling. Overall, our findings suggest that vitamin D supplementation presents a promising option for managing IBS symptoms.
Read More
9
We aimed to find out how vitamin D supplementation might help those suffering from irritable bowel syndrome (IBS). To do this, we conducted a thorough review of nine randomized controlled trials that included a total of 780 participants.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
Our findings showed that vitamin D supplementation significantly improved IBS symptoms and overall quality of life. Specifically, we observed a notable reduction in symptom severity scores and increased satisfaction with life among those taking vitamin D compared to those who did not. Additionally, we confirmed an increase in the levels of serum 25(OH)D, which is crucial for overall health.
Importantly, we also found that the risks of any adverse events while taking vitamin D were low. The results suggest that vitamin D could be a promising option for managing IBS effectively and safely.
Read More
9
We conducted a study to understand how probiotic 35624 affects irritable bowel syndrome (IBS) in children and adolescents aged 8 to 18. This real-world study, carried out in Chile, involved 64 young participants over a span of 12 weeks, during which we closely monitored their gastrointestinal symptoms.
Throughout the study, participants showed significant improvements in various IBS symptoms measured by specific scoring systems. By week 6 and again at week 12, we saw strong positive changes with 98.3% of them experiencing improvements in three or more IBS domains. This shift was impressive, as the severity of their IBS symptoms moved from moderate or severe to mild or in remission.
Interestingly, the study also looked into vitamin D levels, as vitamin D deficiency is prevalent among children in Latin America. However, we found that low baseline serum vitamin D levels did not correlate with the severity of IBS symptoms or the response to the probiotic treatment. While the improvements were promising, they did not last after a two-week washout period, highlighting the need for more research to understand these effects fully, particularly regarding vitamin D's influence.
Throughout the study, participants showed significant improvements in various IBS symptoms measured by specific scoring systems. By week 6 and again at week 12, we saw strong positive changes with 98.3% of them experiencing improvements in three or more IBS domains. This shift was impressive, as the severity of their IBS symptoms moved from moderate or severe to mild or in remission.
Interestingly, the study also looked into vitamin D levels, as vitamin D deficiency is prevalent among children in Latin America. However, we found that low baseline serum vitamin D levels did not correlate with the severity of IBS symptoms or the response to the probiotic treatment. While the improvements were promising, they did not last after a two-week washout period, highlighting the need for more research to understand these effects fully, particularly regarding vitamin D's influence.
Read More
9
We investigated the impacts of a combination treatment involving probiotics and vitamin D on individuals with irritable bowel syndrome (IBS), specifically those experiencing diarrhea-predominant IBS (IBS-D) or mixed bowel movements (IBS-M). The study involved 246 adults followed by private gastroenterologists, who were given a daily dose of probiotics along with vitamin D over a period of 42 days.
At the end of this timeframe, we found that a significant number of patients—about 62.9%—reported improvements in their symptoms. In fact, there was a notable decrease in the IBS Severity Scoring System scores. This improvement also correlated with enhancements in overall quality of life related to IBS, as well as reductions in anxiety and depression symptoms.
Our findings align with earlier randomized clinical trials, reinforcing the notion that the probiotic and vitamin D combination can be beneficial. While we recognize that this study consolidates the evidence of such a combination rather than isolating the effects of vitamin D alone, the results suggest that including vitamin D in treatment plans may indeed foster better mental and gut health for those suffering from IBS.
At the end of this timeframe, we found that a significant number of patients—about 62.9%—reported improvements in their symptoms. In fact, there was a notable decrease in the IBS Severity Scoring System scores. This improvement also correlated with enhancements in overall quality of life related to IBS, as well as reductions in anxiety and depression symptoms.
Our findings align with earlier randomized clinical trials, reinforcing the notion that the probiotic and vitamin D combination can be beneficial. While we recognize that this study consolidates the evidence of such a combination rather than isolating the effects of vitamin D alone, the results suggest that including vitamin D in treatment plans may indeed foster better mental and gut health for those suffering from IBS.
Read More
9
We aimed to understand how vitamin D treatment affects individuals with irritable bowel syndrome (IBS) who didn’t have any identifiable stressors contributing to their symptoms. For this study, we provided vitamin D supplements to patients over a three-month period. Of the patients, 97 had their vitamin D levels checked again, showing sufficient improvement, while 14 were lost to follow-up.
Our approach suggested that intramuscular injections were the best form of treatment, but interestingly, we found that 34 of the participants opted for oral supplements. Those taking oral vitamin D displayed a lesser increase in serum vitamin D levels compared to those receiving injections.
The results were promising: over half, specifically 56.7%, reported complete relief from their IBS symptoms after vitamin D replacement. Additionally, 36.1% experienced significant improvement, and 6.2% noted moderate relief. The study also highlighted that even though many found relief, we need to consider the 14 individuals lost to follow-up when interpreting the overall effectiveness.
Our approach suggested that intramuscular injections were the best form of treatment, but interestingly, we found that 34 of the participants opted for oral supplements. Those taking oral vitamin D displayed a lesser increase in serum vitamin D levels compared to those receiving injections.
The results were promising: over half, specifically 56.7%, reported complete relief from their IBS symptoms after vitamin D replacement. Additionally, 36.1% experienced significant improvement, and 6.2% noted moderate relief. The study also highlighted that even though many found relief, we need to consider the 14 individuals lost to follow-up when interpreting the overall effectiveness.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Vitamin benefits noted
I highly recommend continuing vitamin intake, particularly for those with irritable bowel syndrome, as absorption can be poor. This vitamin D supplement from a reputable company offers essential support for gut health, which we often struggle to maintain.
Read More
9
Enhanced psychological state
10 people found this helpful
Since taking this supplement, I feel much better. It positively affects my mood and helps my bones absorb calcium, which is beneficial for those of us with irritable bowel syndrome. It's fat-soluble, so it's best taken with high-fat foods.
Read More
7.5
Quick vitamin D increase
1 people found this helpful
This supplement is ideal for those with a diagnosed vitamin D deficiency. It's well tolerated and aids in increasing vitamin D levels quickly. I’ve experienced relief from chronic fatigue syndrome, and it’s crucial for individuals with irritable bowel syndrome to monitor their levels.
Read More
6
Mood improvement noted
1 people found this helpful
I’ve realised that vitamin D supports calcium exchange and even influences hair growth. Its deficiency often leads to issues like depression and muscle weakness. Given the pandemic, having adequate vitamin D is vital, especially for those with irritable bowel syndrome.
Read More
6
Supports immunity
1 people found this helpful
Vitamin D plays a crucial role in calcium metabolism and immune function. With many having low levels since the pandemic, it’s logical to supplement, particularly for managing irritable bowel syndrome. I appreciate the 5000 IU dosage for easy prevention.
Read More
Frequently Asked Questions
9
Bowel movements improved
1 people found this helpful
I started taking this supplement upon a friend's recommendation, and it significantly improved my bowel movements. I'm happy to address my vitamin deficiency with it. The capsules are reasonably priced and easy to consume, although they tend to stick together in heat.
9
Enhanced psychological state
10 people found this helpful
Since taking this supplement, I feel much better. It positively affects my mood and helps my bones absorb calcium, which is beneficial for those of us with irritable bowel syndrome. It's fat-soluble, so it's best taken with high-fat foods.
7.5
Vitamin benefits noted
I highly recommend continuing vitamin intake, particularly for those with irritable bowel syndrome, as absorption can be poor. This vitamin D supplement from a reputable company offers essential support for gut health, which we often struggle to maintain.
7.5
Quick vitamin D increase
1 people found this helpful
This supplement is ideal for those with a diagnosed vitamin D deficiency. It's well tolerated and aids in increasing vitamin D levels quickly. I’ve experienced relief from chronic fatigue syndrome, and it’s crucial for individuals with irritable bowel syndrome to monitor their levels.
0
Not suitable for all
Unfortunately, this supplement didn't suit me due to poor fat absorption after my bile removal. It upset my stomach after each dose. However, my wife uses it without issues, proving it can help others manage irritable bowel syndrome effectively.
6
Supports immunity
1 people found this helpful
Vitamin D plays a crucial role in calcium metabolism and immune function. With many having low levels since the pandemic, it’s logical to supplement, particularly for managing irritable bowel syndrome. I appreciate the 5000 IU dosage for easy prevention.
9
We aimed to understand how vitamin D treatment affects individuals with irritable bowel syndrome (IBS) who didn’t have any identifiable stressors contributing to their symptoms. For this study, we provided vitamin D supplements to patients over a three-month period. Of the patients, 97 had their vitamin D levels checked again, showing sufficient improvement, while 14 were lost to follow-up.
Our approach suggested that intramuscular injections were the best form of treatment, but interestingly, we found that 34 of the participants opted for oral supplements. Those taking oral vitamin D displayed a lesser increase in serum vitamin D levels compared to those receiving injections.
The results were promising: over half, specifically 56.7%, reported complete relief from their IBS symptoms after vitamin D replacement. Additionally, 36.1% experienced significant improvement, and 6.2% noted moderate relief. The study also highlighted that even though many found relief, we need to consider the 14 individuals lost to follow-up when interpreting the overall effectiveness.
Our approach suggested that intramuscular injections were the best form of treatment, but interestingly, we found that 34 of the participants opted for oral supplements. Those taking oral vitamin D displayed a lesser increase in serum vitamin D levels compared to those receiving injections.
The results were promising: over half, specifically 56.7%, reported complete relief from their IBS symptoms after vitamin D replacement. Additionally, 36.1% experienced significant improvement, and 6.2% noted moderate relief. The study also highlighted that even though many found relief, we need to consider the 14 individuals lost to follow-up when interpreting the overall effectiveness.
4
We explored the connection between vitamin D and irritable bowel syndrome (IBS) by analyzing data from twelve clinical trials that included 1331 IBS patients. Our goal was to see how vitamin D levels might relate to IBS symptoms and whether vitamin D supplementation can make a difference.
The findings revealed something interesting: patients with IBS tend to have lower levels of vitamin D in their blood. While vitamin D supplementation did show an improvement in the quality of life for these patients, it did not significantly affect the overall severity of their IBS symptoms.
This indicates that while vitamin D deficiency is linked to IBS and supplementation can enhance daily living, it may not directly relieve the main symptoms that trouble patients. Therefore, vitamin D could be a valuable part of the conversation around managing IBS, but it should not be seen as a standalone treatment for symptom relief.
The findings revealed something interesting: patients with IBS tend to have lower levels of vitamin D in their blood. While vitamin D supplementation did show an improvement in the quality of life for these patients, it did not significantly affect the overall severity of their IBS symptoms.
This indicates that while vitamin D deficiency is linked to IBS and supplementation can enhance daily living, it may not directly relieve the main symptoms that trouble patients. Therefore, vitamin D could be a valuable part of the conversation around managing IBS, but it should not be seen as a standalone treatment for symptom relief.
7
Vitamin D may enhance IBS outcomes
We sought to understand whether vitamin D intake and status could help alleviate symptoms and improve the quality of life for adults suffering from irritable bowel syndrome (IBS). Our investigation involved a systematic review and meta-analysis of various studies, including clinical trials and observational studies that looked at vitamin D's effects on IBS-related outcomes.
After analyzing the data, we found moderate evidence suggesting that vitamin D supplementation can enhance serum vitamin D levels in adults with IBS. Notably, those individuals who began with low or deficient vitamin D status experienced improvements in their quality of life following supplementation. However, it is important to highlight that while these findings indicate potential benefits, the overall impact of vitamin D on symptom severity in IBS is still being explored, and results can vary among individuals.
In summary, vitamin D supplementation could be a promising avenue for those with IBS, particularly for those with a deficiency. It's an exciting area of research that could lead to better health outcomes for many.
After analyzing the data, we found moderate evidence suggesting that vitamin D supplementation can enhance serum vitamin D levels in adults with IBS. Notably, those individuals who began with low or deficient vitamin D status experienced improvements in their quality of life following supplementation. However, it is important to highlight that while these findings indicate potential benefits, the overall impact of vitamin D on symptom severity in IBS is still being explored, and results can vary among individuals.
In summary, vitamin D supplementation could be a promising avenue for those with IBS, particularly for those with a deficiency. It's an exciting area of research that could lead to better health outcomes for many.
1
We conducted a robust study to understand if vitamin D3 supplementation could alleviate symptoms of irritable bowel syndrome (IBS). In this randomized, double-blind, placebo-controlled trial, we recruited 135 participants from the community during winter months, giving them either a daily dose of 3,000 IU of vitamin D or a placebo for 12 weeks.
Our main focus was to see if there was any change in the severity of IBS symptoms among the participants. While we observed a significant increase in vitamin D levels in those receiving the supplement compared to the placebo group, this did not translate into any notable change in IBS symptoms or quality of life improvements. The differences we noted were not statistically significant, indicating that vitamin D3 supplementation does not provide benefits for managing IBS.
Overall, our findings suggest that vitamin D should not be recommended as a treatment for IBS symptoms despite the prevalence of vitamin D insufficiency in the general population. It highlights the importance of considering general health reasons for vitamin D screening and supplementation, but not specifically for IBS management.
Our main focus was to see if there was any change in the severity of IBS symptoms among the participants. While we observed a significant increase in vitamin D levels in those receiving the supplement compared to the placebo group, this did not translate into any notable change in IBS symptoms or quality of life improvements. The differences we noted were not statistically significant, indicating that vitamin D3 supplementation does not provide benefits for managing IBS.
Overall, our findings suggest that vitamin D should not be recommended as a treatment for IBS symptoms despite the prevalence of vitamin D insufficiency in the general population. It highlights the importance of considering general health reasons for vitamin D screening and supplementation, but not specifically for IBS management.
References
- Qi S, Zhao M, Sun Y, Boro S, Arora B, et al. Impact of vitamin D supplementation on symptom severity and quality of life in patients with irritable bowel syndrome: A meta-analysis. Adv Clin Exp Med. 2025. doi:10.17219/acem/191463
- Cara KC, Taylor SF, Alhmly HF, Wallace TC. The effects of vitamin D intake and status on symptom severity and quality-of-life in adults with irritable bowel syndrome (IBS): a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2024. doi:10.1080/10408398.2024.2400603
- Cruchet Muñoz S, Verbeke Palma S, Lera Marqués L, Espinosa Pizarro MN, Malig Mechasqui J, et al. Effects of 35624 in Children and Adolescents with Irritable Bowel Syndrome. Nutrients. 2024;16. doi:10.3390/nu16121967
- Jouët P, Altman C, Bruley DES Varannes S, Juhel C, Henri F. Probiotics plus vitamin D in irritable bowel syndrome: a prospective multicentric non-interventional study. Minerva Gastroenterol (Torino). 2024;70:332. doi:10.23736/S2724-5985.24.03581-2
- Uberti F, Trotta F, Cavalli R, Galla R, Caldera F, et al. Enhancing Vitamin D3 Efficacy: Insights from Complexation with Cyclodextrin Nanosponges and Its Impact on Gut-Brain Axes in Physiology and IBS Syndrome. Int J Mol Sci. 2024;25. doi:10.3390/ijms25042189
- Xu S, Luo Q, He J, Chen X, Li S, et al. Causal associations of 25-hydroxyvitamin D with functional gastrointestinal disorders: a two-sample Mendelian randomization study. Genes Nutr. 2023;18:14. doi:10.1186/s12263-023-00734-1
- Kesavan C, Das A, Goyal P, Jackson CS, Strong DD, et al. Vitamin D Deficiency (VDD) and Benefits of Supplementation in Veterans with IBS-D. Diagnostics (Basel). 2023;13. doi:10.3390/diagnostics13172807
- Yan C, Hu C, Chen X, Jia X, Zhu Z, et al. Vitamin D improves irritable bowel syndrome symptoms: A meta-analysis. Heliyon. 2023;9:e16437. doi:10.1016/j.heliyon.2023.e16437
- Yu XL, Wu QQ, He LP, Zheng YF. Role of in vitamin D in irritable bowel syndrome. World J Clin Cases. 2023;11:2677. doi:10.12998/wjcc.v11.i12.2677
- Alvi H, Ali G, Iqbal S, Ahsan MN, Siddiqui MA, et al. Role of 25-hydroxyvitamin D in irritable bowel syndrome patients. J Family Med Prim Care. 2022;11:7975. doi:10.4103/jfmpc.jfmpc_1336_22
- Abdelmalak MFL, Abdelrahim DS, George Michael TMA, Abdel-Maksoud OM, Labib JMW. Vitamin D and lactoferrin attenuate stress-induced colitis in Wistar rats via enhancing AMPK expression with inhibiting mTOR-STAT3 signaling and modulating autophagy. Cell Biochem Funct. 2023;41:211. doi:10.1002/cbf.3774
- Grozić A, Coker K, Dussik CM, Sabir MS, Sabir Z, et al. Identification of putative transcriptomic biomarkers in irritable bowel syndrome (IBS): Differential gene expression and regulation of TPH1 and SERT by vitamin D. PLoS One. 2022;17:e0275683. doi:10.1371/journal.pone.0275683
- Abuelazm M, Muhammad S, Gamal M, Labieb F, Amin MA, et al. The Effect of Vitamin D Supplementation on the Severity of Symptoms and the Quality of Life in Irritable Bowel Syndrome Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2022;14. doi:10.3390/nu14132618
- Bin Y, Kang L, Lili Y. Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: a systematic review and meta-analysis. Nutr Hosp. 2022;39:1144. doi:10.20960/nh.04044
- Huang H, Lu L, Chen Y, Zeng Y, Xu C. The efficacy of vitamin D supplementation for irritable bowel syndrome: a systematic review with meta-analysis. Nutr J. 2022;21:24. doi:10.1186/s12937-022-00777-x
- Chong RIH, Yaow CYL, Loh CYL, Teoh SE, Masuda Y, et al. Vitamin D supplementation for irritable bowel syndrome: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2022;37:993. doi:10.1111/jgh.15852
- Williams CE, Williams EA, Corfe BM. Vitamin D supplementation in people with IBS has no effect on symptom severity and quality of life: results of a randomised controlled trial. Eur J Nutr. 2022;61:299. doi:10.1007/s00394-021-02633-w
- Khalighi Sikaroudi M, Mokhtare M, Shidfar F, Janani L, Faghihi Kashani A, et al. Effects of vitamin D3 supplementation on clinical symptoms, quality of life, serum serotonin (5-hydroxytryptamine), 5-hydroxy-indole acetic acid, and ratio of 5-HIAA/5-HT in patients with diarrhea-predominant irritable bowel syndrome: A randomized clinical trial. EXCLI J. 2020;19:652. doi:10.17179/excli2020-2247
- Khalighi Sikaroudi M, Mokhtare M, Janani L, Faghihi Kashani AH, Masoodi M, et al. Vitamin D3 Supplementation in Diarrhea-Predominant Irritable Bowel Syndrome Patients: The Effects on Symptoms Improvement, Serum Corticotropin-Releasing Hormone, and Interleukin-6 - A Randomized Clinical Trial. Complement Med Res. 2020;27:302. doi:10.1159/000506149
- Jalili M, Vahedi H, Poustchi H, Hekmatdoost A. Soy isoflavones and cholecalciferol reduce inflammation, and gut permeability, without any effect on antioxidant capacity in irritable bowel syndrome: A randomized clinical trial. Clin Nutr ESPEN. 2019;34:50. doi:10.1016/j.clnesp.2019.09.003
- Abbasnezhad A, Amani R, Hasanvand A, Yousefi Rad E, Alipour M, et al. Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome. J Am Coll Nutr. 2019;38:327. doi:10.1080/07315724.2018.1510349
- Amani R, Abbasnezhad A, Hajiani E, Cheraghian B, Abdoli Z, et al. Vitamin D3 Induced Decrease in IL-17 and Malondialdehyde, and Increase in IL-10 and Total Antioxidant Capacity Levels in Patients with Irritable Bowel Syndrome. Iran J Immunol. 2018;15:186. doi:10.22034/IJI.2018.39388
- El Amrousy D, Hassan S, El Ashry H, Yousef M, Hodeib H. Vitamin D supplementation in adolescents with irritable bowel syndrome: Is it useful? A randomized controlled trial. Saudi J Gastroenterol. 2018;24:109. doi:10.4103/sjg.SJG_438_17
- Abbasnezhad A, Amani R, Hajiani E, Alavinejad P, Cheraghian B, et al. Effect of vitamin D on gastrointestinal symptoms and health-related quality of life in irritable bowel syndrome patients: a randomized double-blind clinical trial. Neurogastroenterol Motil. 2016;28:1533. doi:10.1111/nmo.12851
- Sprake EF, Grant VA, Corfe BM. Vitamin D3 as a novel treatment for irritable bowel syndrome: single case leads to critical analysis of patient-centred data. BMJ Case Rep. 2012;2012. doi:10.1136/bcr-2012-007223
