Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.1
USERS' SCORE
Medium or Average
Based on 24 Reviews
6.2
Supplement Facts
Serving Size:   1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%

Top Medical Research Studies

We set out to evaluate what effect vitamin D3 supplementation might have on patients suffering from mild obstructive sleep apnea syndrome (OSAS). In this study, 19 adult men who were diagnosed with mild OSAS and had low vitamin D levels participated over an 8-week period. Each week, they took a sizable dose of 50,000 IU of vitamin D3 while undergoing various health assessments. We measured important factors like blood glucose, lipid profiles, and inflammation markers, along with repeated sleep monitoring through polysomnography.

By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.

Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.
Read More
We aimed to explore the connection between Vitamin D levels and excessive daytime sleepiness in patients diagnosed with obstructive sleep apnea (OSA). In this study, we analyzed serum Vitamin D levels in a group of newly diagnosed OSA patients, dividing them into two categories: those who experienced excessive daytime sleepiness (EDS) and those who did not.

Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.

Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
Read More
We explored the connection between vitamin D levels and obstructive sleep apnea (OSA) severity in a group of 262 adults who were diagnosed with OSA through polysomnography (a type of sleep study). Our aim was to understand if vitamin D deficiency could influence the severity of sleep apnea symptoms, particularly given the growing evidence linking these two health issues.

In our findings, we observed that 63% of participants had low vitamin D levels, which were associated with increased severity of OSA. The results showed a negative correlation between vitamin D levels and key sleep parameters, meaning that lower vitamin D was linked to worse apnea-hypopnea indices, which measure the frequency of breathing interruptions.

Notably, when we adjusted for various factors like age, sex, and body mass index, our analysis revealed that individuals with higher vitamin D levels had lower chances of experiencing severe OSA. Conversely, those with vitamin D deficiency were nearly three times more likely to have severe symptoms, particularly in individuals over 50 or those categorized as obese.

This study suggests that maintaining adequate vitamin D levels might be important in managing OSA severity. However, it’s essential to note that we did not specifically examine the effects of vitamin D treatment, so more research is needed to determine whether increasing vitamin D can effectively improve sleep apnea outcomes.

Overall, our work highlights the potential role of vitamin D as a modifiable factor in the complex management of obstructive sleep apnea and its symptoms.
Read More

Most Useful Reviews

9
Improved sleep quality
130 people found this helpful
I found melatonin and niacin from iHerb effective for my severe sleep apnea, allowing me to withdraw from strong benzo medication. After starting vitamin D, my sleep quality markedly improved, and I could sleep through the night without frequent awakenings. Despite my daily sun exposure, I now realise the significant role of vitamin D in stabilising my mental health and enhancing sleep.
Read More
9
Restored sleep
8 people found this helpful
After experiencing early awakenings due to menopause, I decided to try this supplement. Within days, I could sleep peacefully through the night. I feel more energised now and am unsure if the supplement is solely responsible, but I’m certainly happier.
Read More
7.5
Regular periods
8 people found this helpful
After two weeks on this, I noticed increased activity, comfortable sleep, regular monthly periods, and significant weight loss. It has made a positive difference.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.1
  • All Researches
We embarked on an intriguing study to see how an eight-week weight loss and lifestyle intervention could influence vitamin D levels in men suffering from obstructive sleep apnea (OSA). Our group of 89 men was split into two; one group received usual care, while the second group engaged in the lifestyle program alongside their standard treatment.

After this intervention, we observed some promising results regarding vitamin D levels. Specifically, the intervention group showed a significant increase in serum 25-hydroxyvitamin D (25(OH)D) levels, with improvements noted at both the end of the 8 weeks and six months later. Indeed, their vitamin D deficiency was potentially resolved.

Moreover, we found that these higher vitamin D levels correlated with better sleep quality, as evidenced by increased sleep efficiency and improvements in several sleep metrics, such as the apnea-hypopnea index (AHI) and oxygen desaturation index. Additionally, body composition measurements, including fat mass, also showed positive changes.

In conclusion, our findings suggest that a coordinated approach combining weight loss and lifestyle changes can be beneficial not just for vitamin D status, but also for overall health aspects related to obstructive sleep apnea.
Read More
We set out to evaluate what effect vitamin D3 supplementation might have on patients suffering from mild obstructive sleep apnea syndrome (OSAS). In this study, 19 adult men who were diagnosed with mild OSAS and had low vitamin D levels participated over an 8-week period. Each week, they took a sizable dose of 50,000 IU of vitamin D3 while undergoing various health assessments. We measured important factors like blood glucose, lipid profiles, and inflammation markers, along with repeated sleep monitoring through polysomnography.

By the end of the study, we observed a significant increase in participants' vitamin D levels, which jumped from an average of 19.5 to 41.8 ng/mL—an indication that the supplementation was effective. Along with this rise in vitamin D, we also noted improvements in fasting blood glucose and total cholesterol levels, as well as a decrease in key inflammation markers. Most encouragingly, the frequency of obstructive apneas and other related sleep disturbances significantly decreased.

Based on these findings, it seems that vitamin D supplementation can play a beneficial role in improving the prognosis for those with mild OSAS. It's exciting to consider how something as simple as a vitamin could lead to better sleep health for individuals struggling with sleep apnea.
Read More
We embarked on a large-scale study to understand how vitamin D influences obstructive sleep apnea (OSA), especially in those who are obese. Analyzing data from nearly 445,000 participants from the UK Biobank, we focused on individuals who had no previous diagnosis of OSA. The key outcome was the development of new cases of OSA over an average follow-up of 12 years.

What we found was intriguing: higher serum levels of 25-hydroxyvitamin D, the main form of vitamin D in the bloodstream, were associated with a reduced risk of developing new-onset OSA, particularly in participants struggling with obesity. Those with both a body mass index (BMI) of 25 or higher and waist circumference measurements of 90 cm or more showed a significant inverse relationship. This suggests that those with these characteristics might benefit more from maintaining higher vitamin D levels.

The results indicate that while vitamin D supplementation on its own wasn't tested, our findings certainly highlight its potential role in preventing OSA, particularly in at-risk populations. It's a reminder of the importance of monitoring and maintaining adequate vitamin D levels, especially for those dealing with obesity.
Read More
8
Vitamin D linked to sleep apnea severity
We aimed to explore the connection between serum vitamin D levels and the severity of obstructive sleep apnea syndrome (OSAS), particularly in patients also dealing with metabolic syndrome, known as Syndrome Z. Our study involved 270 individuals diagnosed with both conditions. We gathered important data on various aspects, including demographics, sleep patterns, and laboratory results.

From our findings, we observed that a significant number of participants had varying degrees of OSAS severity. Notably, there was a clear trend showing that as the severity of OSAS increased, vitamin D levels decreased. After accounting for various factors, we found a strong association between lower serum 25(OH)D3 levels and greater OSAS severity.

This suggests that monitoring vitamin D levels in patients with the dual challenges of metabolic syndrome and sleep apnea could be vital. While our study highlights an association, we noted it does not directly address the effectiveness of vitamin D3 treatment for improving sleep apnea. Therefore, further research is needed to determine whether boosting vitamin D levels can positively impact sleep apnea symptoms.
Read More
7
We conducted a study aimed at understanding how vitamin D3 might influence obstructive sleep apnea (OSA), particularly in hypertensive, obese patients. The research carefully examined the potential benefits of combining vitamin D3 with a medication called Dapagliflozin, a type of SGLT-2 inhibitor known for its additional cardiovascular advantages.

Over 16 weeks, participants were divided into four groups: those receiving Dapagliflozin, those receiving vitamin D3, those receiving both treatments, and a control group that received no treatment. We looked at a range of health parameters, including weight, blood sugar levels, and quality of life scores, to assess the overall impact of these treatments.

Our findings revealed positive outcomes from using vitamin D3 alongside SGLT-2 inhibitors, suggesting that this combination therapy could help improve cardiac and metabolic health, as well as quality of life in patients struggling with OSA. However, we acknowledged the need for further studies to isolate the specific effects of vitamin D on sleep apnea independently from the benefits provided by the medication.
Read More

User Reviews

USERS' SCORE
Medium or Average
Based on 24 Reviews
6.2
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Improved sleep quality
130 people found this helpful
I found melatonin and niacin from iHerb effective for my severe sleep apnea, allowing me to withdraw from strong benzo medication. After starting vitamin D, my sleep quality markedly improved, and I could sleep through the night without frequent awakenings. Despite my daily sun exposure, I now realise the significant role of vitamin D in stabilising my mental health and enhancing sleep.
Read More
9
Restored sleep
8 people found this helpful
After experiencing early awakenings due to menopause, I decided to try this supplement. Within days, I could sleep peacefully through the night. I feel more energised now and am unsure if the supplement is solely responsible, but I’m certainly happier.
Read More
7.5
Regular periods
8 people found this helpful
After two weeks on this, I noticed increased activity, comfortable sleep, regular monthly periods, and significant weight loss. It has made a positive difference.
Read More
7.5
Better sleep
2 people found this helpful
I bought this sunscreen to avoid sunburn, suspecting I might be deficient in Vitamin D. After a few months of use, I’ve not caught a cold and have noticed improved sleep. I previously struggled to sleep even with music, but now I can fall asleep easily.
Read More
9
Better night rest
1 people found this helpful
After starting this supplement, both my husband and I have slept soundly. Previously, I would struggle to fall asleep, but now I experience a noticeable improvement in my sleeping patterns. My husband, who used to snore frequently, also sleeps better.
Read More

Frequently Asked Questions

7.5
Effective for sleep
I ordered it because I heard it was effective for sleep apnea. I definitely notice a difference compared to before.
9
Mood enhancement
1 people found this helpful
After a month of taking this vitamin, both my husband and I have seen significant mood improvements. He noticed a change within two weeks, with better mornings and sleep quality. My nails also grew stronger, as my overall health and condition improved markedly after introducing vitamin D.
7.5
Increased energy
1 people found this helpful
After increasing my vitamin D3 dosage to 10,000 IU, my sleep improved significantly. I felt more energetic and found it easier to wake up. I highly recommend trying it, as it has worked well for me.
6
Vital for health
1 people found this helpful
Living in an area with limited sunlight, I’ve realised vitamin D3 is crucial for my health. For six months, I’ve taken the recommended daily dose of 5000 IU and have noticed significant improvements in my sleep and general wellbeing, combating the lethargy I previously felt.
9
Improved sleep quality
130 people found this helpful
I found melatonin and niacin from iHerb effective for my severe sleep apnea, allowing me to withdraw from strong benzo medication. After starting vitamin D, my sleep quality markedly improved, and I could sleep through the night without frequent awakenings. Despite my daily sun exposure, I now realise the significant role of vitamin D in stabilising my mental health and enhancing sleep.
6
Customised dosage
1 people found this helpful
I discovered a vitamin D3 deficiency after experiencing ongoing fatigue. Initially taking one pill daily did not help, so I increased it to four. This adjustment led to significant improvement in my energy levels and sleep patterns, but everyone's dosage needs may vary.
0
Stopped sleeping
1 people found this helpful
I started taking this vitamin and completely ceased sleeping. I had to stop taking it, although the dosage seemed good.
9
Normalised sleep
1 people found this helpful
I took this alongside other supplements, and I believe it helped normalise my Vitamin D levels, allowing me to fall asleep at a reasonable hour. I used to go to bed at 4-5 am and wake up feeling exhausted, but after a few weeks, I began to sleep better.
9
Sleep quality improved
1 people found this helpful
After purchasing 5,000 IU, I realised some had low content, so I opted for 2,000 and 1,000 IU. I don’t open the 5,000 due to concerns of an overdose, but since starting the 2,000 and 1,000, my sleep quality has improved. I’ll continue with the 1,000 IU, especially as I’m pregnant.
We explored the connection between vitamin D levels and obstructive sleep apnea (OSA) severity in a group of 262 adults who were diagnosed with OSA through polysomnography (a type of sleep study). Our aim was to understand if vitamin D deficiency could influence the severity of sleep apnea symptoms, particularly given the growing evidence linking these two health issues.

In our findings, we observed that 63% of participants had low vitamin D levels, which were associated with increased severity of OSA. The results showed a negative correlation between vitamin D levels and key sleep parameters, meaning that lower vitamin D was linked to worse apnea-hypopnea indices, which measure the frequency of breathing interruptions.

Notably, when we adjusted for various factors like age, sex, and body mass index, our analysis revealed that individuals with higher vitamin D levels had lower chances of experiencing severe OSA. Conversely, those with vitamin D deficiency were nearly three times more likely to have severe symptoms, particularly in individuals over 50 or those categorized as obese.

This study suggests that maintaining adequate vitamin D levels might be important in managing OSA severity. However, it’s essential to note that we did not specifically examine the effects of vitamin D treatment, so more research is needed to determine whether increasing vitamin D can effectively improve sleep apnea outcomes.

Overall, our work highlights the potential role of vitamin D as a modifiable factor in the complex management of obstructive sleep apnea and its symptoms.
We aimed to explore the connection between Vitamin D levels and excessive daytime sleepiness in patients diagnosed with obstructive sleep apnea (OSA). In this study, we analyzed serum Vitamin D levels in a group of newly diagnosed OSA patients, dividing them into two categories: those who experienced excessive daytime sleepiness (EDS) and those who did not.

Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.

Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
4
Vitamin D3 enhances metabolic health
We conducted a pilot study to see how vitamin D3 supplementation impacts individuals with obstructive sleep apnea (OSA). Our double-blind, randomized, placebo-controlled trial involved 19 Caucasian adults with OSA, some of whom were already using continuous positive airways pressure (CPAP) therapy.

Over a 15-week period, participants took either 4,000 IU of vitamin D3 or a placebo. We assessed various outcomes, including drowsiness, quality of life, fatigue levels, and cognitive function. While we observed a significant increase in vitamin D levels among those who received the supplement, we found that it did not improve symptoms related to sleepiness, quality of life, or cognitive performance.

Interestingly, we did notice a decrease in certain metabolic markers, suggesting that vitamin D3 may play a role in improving metabolic health among OSA patients. Overall, while vitamin D3 showed promise in enhancing metabolic parameters, it didn’t seem to alleviate the primary symptoms of OSA. Our findings pave the way for larger studies to further explore these effects.

References

  1. Loh HH, Tay SP, Koa AJ, Yong MC, Said A, et al. Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients. J Transl Med. 2025;23:296. 10.1186/s12967-025-06312-w
  2. Vázquez-Lorente H, Herrera-Quintana L, Ruiz JR, Amaro-Gahete FJ, Carneiro-Barrera A. Impact of weight loss and lifestyle intervention on vitamin D in men with obstructive sleep apnea: The INTERAPNEA trial. Sleep Med. 2025;128:37. 10.1016/j.sleep.2025.01.011
  3. Archontogeorgis K, Economou NT, Bargiotas P, Nena E, Voulgaris A, et al. Sleepiness and Vitamin D Levels in Patients with Obstructive Sleep Apnea. Healthcare (Basel). 2024;12. 10.3390/healthcare12060698
  4. Yao N, Ma C, Dou R, Shen C, Yuan Y, et al. Exploring the link between vitamin D deficiency and obstructive sleep apnea: A comprehensive review. J Sleep Res. 2024;33:e14166. 10.1111/jsr.14166
  5. Kechribari I, Kontogianni MD, Georgoulis M, Lamprou K, Perraki E, et al. Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea. Life (Basel). 2024;14. 10.3390/life14020275
  6. Zhang Y, Zhang Y, Ye Z, Zhou C, Yang S, et al. Relationship of serum 25-hydroxyvitamin D, obesity with new-onset obstructive sleep apnea. Int J Obes (Lond). 2024;48:218. 10.1038/s41366-023-01402-5
  7. Locci C, Ruiu A, Saderi L, Sotgiu G, Bassu S, et al. Relationships between 25-Hydroxyvitamin D Levels and Obstructive Sleep Apnea Severity in Children: An Observational Study. J Clin Med. 2023;12. 10.3390/jcm12031242
  8. Kilavuz A, Celikhisar H, Dasdemir Ilkhan G. The Association of Serum 25(OH) Vitamin D Level with Severity of Obstructive Sleep Apnea Syndrome in Patients with Syndrome Z (the Interaction of Obstructive Sleep Apnea with Metabolic Syndrome). Metab Syndr Relat Disord. 2021;19:549. 10.1089/met.2021.0066
  9. Ayyıldız F, Yıldıran H, Afandiyeva N, Gülbahar Ö, Köktürk O. The effects of vitamin D supplemantation on prognosis in patients with mild obstructive sleep apnea syndrome. Turk J Med Sci. 2021;51:2524. 10.3906/sag-2101-83
  10. Kerley CP, Hutchinson K, Bramham J, McGowan A, Faul J, et al. Vitamin D Improves Selected Metabolic Parameters but Not Neuropsychological or Quality of Life Indices in OSA: A Pilot Study. J Clin Sleep Med. 2017;13:19. 10.5664/jcsm.6378
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