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SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.3
USERS' SCORE
Good
Based on 10 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
Vitamin D3 improves ulcer healing
Improved Healing of Diabetic Foot Ulcers After High-dose Vitamin D: A Randomized Double-blinded Clinical Trial.
Study focuses on vitamin D3 impact
We set out to explore how different doses of vitamin D3, specifically Cholecalciferol, impact the healing of chronic diabetic foot ulcers. Our study included patients with diabetes who had one or more foot ulcers present for longer than six weeks. We assigned participants at random to receive either a high dose of 170 micrograms or a low dose of 20 micrograms daily. Throughout the experiment, both patients and assessors were kept unaware of who was receiving which treatment to ensure unbiased results.
Over our 48-week follow-up period, we observed that the high-dose vitamin D3 treatment yielded significantly better healing outcomes. Among the patients receiving the high dose, 70% of their ulcers healed, while only 35% of those on the low dose showed healing. The median ulcer reduction in the high-dose group was impressive, showing complete healing in many cases, while those on the low dose saw a more modest reduction.
In conclusion, our findings suggest that high-dose vitamin D3 can play a crucial role in promoting the healing of chronic diabetic foot ulcers. By effectively boosting healing rates, this treatment could provide an important avenue for improving health outcomes in patients suffering from these persistent wounds.
Over our 48-week follow-up period, we observed that the high-dose vitamin D3 treatment yielded significantly better healing outcomes. Among the patients receiving the high dose, 70% of their ulcers healed, while only 35% of those on the low dose showed healing. The median ulcer reduction in the high-dose group was impressive, showing complete healing in many cases, while those on the low dose saw a more modest reduction.
In conclusion, our findings suggest that high-dose vitamin D3 can play a crucial role in promoting the healing of chronic diabetic foot ulcers. By effectively boosting healing rates, this treatment could provide an important avenue for improving health outcomes in patients suffering from these persistent wounds.
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9
Vitamin D3 mitigates gastric injury
Vitamin D3 mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-κB/MMP-9 signaling pathway.
Focused study on aspirin ulcers
We explored the effects of Vitamin D3 on stomach ulcers caused by aspirin, focusing specifically on how it influences certain molecules in the stomach lining. In our study, we divided 24 rats into four groups: a control group, a group receiving Vitamin D3 without any gastric injury, a group with aspirin-induced gastric injuries, and a group treated with Vitamin D3 after such injuries occurred.
Our findings were quite promising. Vitamin D3 seemed to play a protective role against the damage caused by aspirin. It significantly increased levels of important protective molecules like E-Cadherin, GKN1 (a type of gastrokine), and mucin 5AC. These molecules are essential for maintaining the integrity of the stomach lining, helping to mitigate the effects of oxidative stress and inflammation often seen in gastric injuries.
Furthermore, Vitamin D3 treatment helped improve both the structure and function of gastric tissue. By reducing inflammation pathways, particularly those involving NLRP3 and NF-κB, Vitamin D3 demonstrated its potential as a protective agent in the context of aspirin-induced gastric injury.
Our findings were quite promising. Vitamin D3 seemed to play a protective role against the damage caused by aspirin. It significantly increased levels of important protective molecules like E-Cadherin, GKN1 (a type of gastrokine), and mucin 5AC. These molecules are essential for maintaining the integrity of the stomach lining, helping to mitigate the effects of oxidative stress and inflammation often seen in gastric injuries.
Furthermore, Vitamin D3 treatment helped improve both the structure and function of gastric tissue. By reducing inflammation pathways, particularly those involving NLRP3 and NF-κB, Vitamin D3 demonstrated its potential as a protective agent in the context of aspirin-induced gastric injury.
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8
Vitamin D3 alleviates ulcerative colitis
1,25(OH) D alleviates DSS-induced ulcerative colitis via inhibiting NLRP3 inflammasome activation.
High relevance to ulcerative colitis
We explored how vitamin D3, specifically 1,25-dihydroxyvitamin D3, can impact ulcerative colitis, a condition characterized by inflammation in the colon. Our research focused on its ability to halt the activation of the NLRP3 inflammasome, a key player in driving inflammation.
Our findings showed that vitamin D3 works through the vitamin D receptor, effectively blocking the activation of caspase-1 and the inflammatory cytokine IL-1β. Furthermore, we discovered that it prevents the assembly of a protein complex known as ASC, which is crucial for NLRP3 activation.
Additionally, vitamin D3 inhibited the binding of NLRP3 to NEK7, further curbing this inflammatory response. Another interesting aspect is that it impacts autophagy, which contributes to the inhibition of the NLRP3 inflammasome as well.
Not only did vitamin D3 show promise in preventing the condition, but it also offered therapeutic benefits in an experimental model of ulcerative colitis. This indicates that vitamin D3 could be a useful option in managing autoimmune diseases and conditions driven by NLRP3 inflammasome activation.
Our findings showed that vitamin D3 works through the vitamin D receptor, effectively blocking the activation of caspase-1 and the inflammatory cytokine IL-1β. Furthermore, we discovered that it prevents the assembly of a protein complex known as ASC, which is crucial for NLRP3 activation.
Additionally, vitamin D3 inhibited the binding of NLRP3 to NEK7, further curbing this inflammatory response. Another interesting aspect is that it impacts autophagy, which contributes to the inhibition of the NLRP3 inflammasome as well.
Not only did vitamin D3 show promise in preventing the condition, but it also offered therapeutic benefits in an experimental model of ulcerative colitis. This indicates that vitamin D3 could be a useful option in managing autoimmune diseases and conditions driven by NLRP3 inflammasome activation.
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Most Useful Reviews
9.5
Quick recovery
The Vitamin D3 helped heal my mouth ulcer swiftly.
Read More
9.5
Supports immunity
My doctor prescribed 5000ME of Vitamin D3 for suspected coronavirus. I typically take 2000ME regularly. Vitamin D3 is vital for the immune system and helps with calcium metabolism. It prevents respiratory infections and supports recovery from various ailments, including ulcers. Always consult a doctor before dosing.
Read More
9.5
Faster healing
I love this product! Our family uses it for prevention. I've noticed that my facial skin has improved, and my prior mouth ulcers heal significantly quicker and with less pain when I take Vitamin D. There has also been an unexpected improvement in my cervical erosion.
Read More
Most Recommended Products for Ulcer
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.3
9
Vitamin D3 mitigates gastric injury
Vitamin D3 mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-κB/MMP-9 signaling pathway.
Focused study on aspirin ulcers
We explored the effects of Vitamin D3 on stomach ulcers caused by aspirin, focusing specifically on how it influences certain molecules in the stomach lining. In our study, we divided 24 rats into four groups: a control group, a group receiving Vitamin D3 without any gastric injury, a group with aspirin-induced gastric injuries, and a group treated with Vitamin D3 after such injuries occurred.
Our findings were quite promising. Vitamin D3 seemed to play a protective role against the damage caused by aspirin. It significantly increased levels of important protective molecules like E-Cadherin, GKN1 (a type of gastrokine), and mucin 5AC. These molecules are essential for maintaining the integrity of the stomach lining, helping to mitigate the effects of oxidative stress and inflammation often seen in gastric injuries.
Furthermore, Vitamin D3 treatment helped improve both the structure and function of gastric tissue. By reducing inflammation pathways, particularly those involving NLRP3 and NF-κB, Vitamin D3 demonstrated its potential as a protective agent in the context of aspirin-induced gastric injury.
Our findings were quite promising. Vitamin D3 seemed to play a protective role against the damage caused by aspirin. It significantly increased levels of important protective molecules like E-Cadherin, GKN1 (a type of gastrokine), and mucin 5AC. These molecules are essential for maintaining the integrity of the stomach lining, helping to mitigate the effects of oxidative stress and inflammation often seen in gastric injuries.
Furthermore, Vitamin D3 treatment helped improve both the structure and function of gastric tissue. By reducing inflammation pathways, particularly those involving NLRP3 and NF-κB, Vitamin D3 demonstrated its potential as a protective agent in the context of aspirin-induced gastric injury.
Read More
9
Vitamin D3 enhances colitis treatment
Co-administration of 1,25-dihydroxyvitamin D3 and infliximab improves colitis in mice by modulating Treg differentiation.
Limited standalone effectiveness observed
We conducted an investigation into how vitamin D3 (VitD3) works in conjunction with infliximab (IFX) to improve conditions in a mouse model of ulcerative colitis (UC). Our study revealed that this combination therapy not only alleviates symptoms but also helps reduce harmful intestinal inflammation.
Utilizing a model for colitis induced by dextran sulfate sodium, we evaluated the effectiveness of co-administering VitD3 with different doses of IFX. The results were impressive: when IFX was paired with VitD3, it resulted in better clinical outcomes and less intestinal inflammation compared to IFX alone.
Specifically, we saw improvements in clinical signs and pathology, along with a reduction in inflammatory markers. Notably, the combination therapy also enhanced the differentiation of regulatory T cells (Tregs) and increased levels of IL-10, both of which play critical roles in managing inflammation. Our findings suggest that this complementary approach could be a promising alternative for patients who cannot tolerate standard treatments.
Utilizing a model for colitis induced by dextran sulfate sodium, we evaluated the effectiveness of co-administering VitD3 with different doses of IFX. The results were impressive: when IFX was paired with VitD3, it resulted in better clinical outcomes and less intestinal inflammation compared to IFX alone.
Specifically, we saw improvements in clinical signs and pathology, along with a reduction in inflammatory markers. Notably, the combination therapy also enhanced the differentiation of regulatory T cells (Tregs) and increased levels of IL-10, both of which play critical roles in managing inflammation. Our findings suggest that this complementary approach could be a promising alternative for patients who cannot tolerate standard treatments.
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9
Co-delivery improves colitis treatment
An efficient co-delivery system based on multilayer structural nanoparticles for programmed sequential release of resveratrol and vitamin D3 to combat dextran sodium sulfate-induced colitis in mice.
Moderate relevance due to combination
We investigated how the combination of resveratrol and vitamin D3 could help manage symptoms of ulcerative colitis in mice, especially in the context of a specially designed delivery system. Through the use of multilayer structural nanoparticles, we were able to efficiently encapsulate both compounds to enhance their stability and effectiveness.
In our evaluation, we observed that these nanoparticles successfully released vitamin D3 and resveratrol in a controlled manner, particularly in simulated intestinal environments. This sequential release means that the components are delivered in a timed fashion to potentially maximize their benefits.
Not only did we find that this system improved the symptoms of colitis—like weight loss and inflammation—but it also seemed to support the overall health of the colon tissue. The study's results indicated a significant reduction in inflammation markers and oxidative stress in the mice treated with this co-delivery of vitamins.
While we initially aimed to assess the standalone benefit of vitamin D3, it was challenging to isolate its effects because of the dual approach. Thus, while we can assert that the combination helped alleviate symptoms, more research would be necessary to fully understand the specific role that vitamin D3 plays in this treatment.
In our evaluation, we observed that these nanoparticles successfully released vitamin D3 and resveratrol in a controlled manner, particularly in simulated intestinal environments. This sequential release means that the components are delivered in a timed fashion to potentially maximize their benefits.
Not only did we find that this system improved the symptoms of colitis—like weight loss and inflammation—but it also seemed to support the overall health of the colon tissue. The study's results indicated a significant reduction in inflammation markers and oxidative stress in the mice treated with this co-delivery of vitamins.
While we initially aimed to assess the standalone benefit of vitamin D3, it was challenging to isolate its effects because of the dual approach. Thus, while we can assert that the combination helped alleviate symptoms, more research would be necessary to fully understand the specific role that vitamin D3 plays in this treatment.
Read More
9
Vitamin D3 alleviates UC inflammation
Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway.
8/10 - Significant study findings
We conducted a thorough investigation into how vitamin D3 affects inflammation in ulcerative colitis (UC). Our study involved both UC patients and a specialized mouse model to explore the anti-inflammatory properties of 1,25-dihydroxyvitamin D (the active form of vitamin D).
Through various techniques, including RNA sequencing and chromatin assays, we unearthed a significant finding: vitamin D3 can inhibit the activation of an inflammatory protein known as NLRP6. It turns out that vitamin D3 does this by binding to specific sites in the NLRP6 gene, ultimately reducing inflammation associated with UC.
Importantly, we observed that vitamin D3 showed both preventive and therapeutic benefits in our UC mouse model, indicating its potential as a treatment option for managing symptoms of this condition. This exciting discovery not only sheds light on a new mechanism for vitamin D3's action but also points to its promise for clinical applications in inflammation-related diseases.
Through various techniques, including RNA sequencing and chromatin assays, we unearthed a significant finding: vitamin D3 can inhibit the activation of an inflammatory protein known as NLRP6. It turns out that vitamin D3 does this by binding to specific sites in the NLRP6 gene, ultimately reducing inflammation associated with UC.
Importantly, we observed that vitamin D3 showed both preventive and therapeutic benefits in our UC mouse model, indicating its potential as a treatment option for managing symptoms of this condition. This exciting discovery not only sheds light on a new mechanism for vitamin D3's action but also points to its promise for clinical applications in inflammation-related diseases.
Read More
9
Vitamin D3 lowers ulcerative colitis inflammation
Vitamin D Reduces the Helper T Cells 17 (Th17) Differentiation in Patients with Ulcerative Colitis by Targeting Long Non-coding RNA (lncRNA) OIP5-AS1/miR-26a-5p/IL-6 Axis.
Moderate relevance to vitamin D effects
We investigated how vitamin D3 affects ulcerative colitis (UC) by examining its influence on immune responses. The study involved measuring serum levels of vitamin D, along with Interferon-γ (IFN-γ) and Interleukin (IL)-17 in patients with UC.
We found that patients with UC had lower vitamin D levels, which were negatively correlated with IL-17, a key player in inflammation. When we treated immune cells with calcitriol, the active form of vitamin D, we observed a decrease in a long non-coding RNA known as OIP5-AS1. This lncRNA interacts with microRNA (miR)-26a-5p and plays a significant role in regulating inflammation.
Our findings suggest that vitamin D3 may help reduce Th17 cell differentiation and IL-6 expression, indicating potential therapeutic benefits in managing UC. In experiments involving mice, calcitriol showed promise in alleviating colitis symptoms through its action on the OIP5-AS1 pathway.
We found that patients with UC had lower vitamin D levels, which were negatively correlated with IL-17, a key player in inflammation. When we treated immune cells with calcitriol, the active form of vitamin D, we observed a decrease in a long non-coding RNA known as OIP5-AS1. This lncRNA interacts with microRNA (miR)-26a-5p and plays a significant role in regulating inflammation.
Our findings suggest that vitamin D3 may help reduce Th17 cell differentiation and IL-6 expression, indicating potential therapeutic benefits in managing UC. In experiments involving mice, calcitriol showed promise in alleviating colitis symptoms through its action on the OIP5-AS1 pathway.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.6
9.5
Quick recovery
The Vitamin D3 helped heal my mouth ulcer swiftly.
9.5
Supports immunity
My doctor prescribed 5000ME of Vitamin D3 for suspected coronavirus. I typically take 2000ME regularly. Vitamin D3 is vital for the immune system and helps with calcium metabolism. It prevents respiratory infections and supports recovery from various ailments, including ulcers. Always consult a doctor before dosing.
Read More
9.5
Faster healing
I love this product! Our family uses it for prevention. I've noticed that my facial skin has improved, and my prior mouth ulcers heal significantly quicker and with less pain when I take Vitamin D. There has also been an unexpected improvement in my cervical erosion.
9.5
Mandatory element
During the pandemic, I consider Vitamin D essential. After completing my course, my leg ulcers disappeared.
8.8
Natural antibiotic
The quality is excellent, and its benefits include aiding throat issues and colds, acting as a natural antibiotic. The pleasant smell enhances its appeal, and it's suitable for both adults and children. It has effectively supported my immunity and aids in healing ulcers. The dosage is appropriate and the effects are impressive.
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