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Over our 48-week follow-up period, we observed that the high-dose vitamin D3 treatment yielded significantly better healing outcomes. Among the patients receiving the high dose, 70% of their ulcers healed, while only 35% of those on the low dose showed healing. The median ulcer reduction in the high-dose group was impressive, showing complete healing in many cases, while those on the low dose saw a more modest reduction.
In conclusion, our findings suggest that high-dose vitamin D3 can play a crucial role in promoting the healing of chronic diabetic foot ulcers. By effectively boosting healing rates, this treatment could provide an important avenue for improving health outcomes in patients suffering from these persistent wounds.
Our findings were quite promising. We observed that Vitamin D3 supplementation led to significant improvements in the overall health of the gastric tissue. Notably, it enhanced the expression of vital proteins such as E-Cadherin and gastrokine 1 (GKN1), both critical for maintaining stomach lining integrity. Moreover, it reduced markers of inflammation and oxidative stress, suggesting a protective mechanism against ulcer formation.
The study points to Vitamin D3 as a potential ally in mitigating the damaging effects of aspirin on the gastric mucosa. By highlighting its ability to bolster the stomach's defenses, we bring attention to how simple dietary supplementation could serve as an effective strategy for those at risk of gastric ulcers.
Our findings suggest that vitamin D can significantly aid the healing of DFUs. Specifically, it appears to lower blood sugar levels while also reducing inflammation and oxidative stress, which are known to impede healing. Such outcomes provide a positive outlook for using vitamin D as part of the treatment strategy for DFUs.
With diabetes being a major health challenge and DFUs contributing to severe complications, our research offers valuable insights. By demonstrating how vitamin D supplementation can improve healing, we hope to support medical professionals in enhancing patient care practices.
Overall, this evidence potentially shifts how we approach the treatment of diabetic foot ulcers, making a case for incorporating vitamin D into therapeutic protocols to promote faster recovery.
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Our findings were quite promising. We observed that Vitamin D3 supplementation led to significant improvements in the overall health of the gastric tissue. Notably, it enhanced the expression of vital proteins such as E-Cadherin and gastrokine 1 (GKN1), both critical for maintaining stomach lining integrity. Moreover, it reduced markers of inflammation and oxidative stress, suggesting a protective mechanism against ulcer formation.
The study points to Vitamin D3 as a potential ally in mitigating the damaging effects of aspirin on the gastric mucosa. By highlighting its ability to bolster the stomach's defenses, we bring attention to how simple dietary supplementation could serve as an effective strategy for those at risk of gastric ulcers.
The case involved a 57-year-old woman with a history of recurring eye issues who experienced a burning sensation and pain in her right eye, leading to a diagnosis of HSV keratitis. Despite receiving standard treatments, she developed a perforated corneal ulcer. Following surgical intervention, including a specialized graft, we initiated oral vitamin D therapies to support healing and boost her immune response.
Remarkably, after starting these vitamin D treatments, we observed significant improvement. The patient's cornea began to thicken and heal nicely, without any signs of HSV recurrence during the treatment period. This outcome suggested that incorporating vitamin D could play a helpful role in managing such infections and promoting better recovery.
Our findings indicate that using vitamin D receptor ligands as adjunctive therapies might offer a promising avenue for treating severe corneal conditions and enhancing overall healing, reducing the need for more invasive procedures in the future.
Our findings suggest that vitamin D can significantly aid the healing of DFUs. Specifically, it appears to lower blood sugar levels while also reducing inflammation and oxidative stress, which are known to impede healing. Such outcomes provide a positive outlook for using vitamin D as part of the treatment strategy for DFUs.
With diabetes being a major health challenge and DFUs contributing to severe complications, our research offers valuable insights. By demonstrating how vitamin D supplementation can improve healing, we hope to support medical professionals in enhancing patient care practices.
Overall, this evidence potentially shifts how we approach the treatment of diabetic foot ulcers, making a case for incorporating vitamin D into therapeutic protocols to promote faster recovery.
To do this, we induced colitis in mice and then assessed their symptoms and conducted histopathological evaluations to determine the therapeutic effects of this combination therapy. The results revealed that when given together, VitD3 and IFX significantly reduced the severity of colitis, showcasing improvements in clinical signs and suppression of inflammation.
Additionally, we looked at how this combination affected regulatory T cells (Tregs), which play a crucial role in immune response. We observed that the combined therapy encouraged more effective Treg differentiation, leading to higher levels of anti-inflammatory markers in the system. Particularly in ulcerative colitis patients, we found that higher levels of serum vitamin D correlated positively with Treg levels, suggesting a beneficial relationship.
Thus, our study suggests that VitD3, in combination with IFX, offers a promising approach for managing ulcerative colitis, especially for patients who may have difficulty tolerating standard treatments.
Our findings were quite promising. Vitamin D3 seemed to play a protective role against the damage caused by aspirin. It significantly increased levels of important protective molecules like E-Cadherin, GKN1 (a type of gastrokine), and mucin 5AC. These molecules are essential for maintaining the integrity of the stomach lining, helping to mitigate the effects of oxidative stress and inflammation often seen in gastric injuries.
Furthermore, Vitamin D3 treatment helped improve both the structure and function of gastric tissue. By reducing inflammation pathways, particularly those involving NLRP3 and NF-κB, Vitamin D3 demonstrated its potential as a protective agent in the context of aspirin-induced gastric injury.
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Frequently Asked Questions
An ulcer is a sore that develops on the lining of the stomach, small intestine, or colon. It occurs when the digestive tract is damaged or inflamed, often due to an imbalance between stomach acid and the protective factors in the digestive system. The most common types of ulcers include peptic ulcers, which can be further categorized into gastric ulcers (located in the stomach) and duodenal ulcers (found in the first part of the small intestine). Symptoms may include burning stomach pain, bloating, and nausea, which can vary in intensity based on the severity of the condition.
Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.
In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.
Based on user reviews, the timeline for seeing results when taking Vitamin D supplements for ulcers can vary, but several users report experiencing improvements relatively quickly. For instance, one user mentioned that their mouth ulcer healed swiftly after starting Vitamin D3 (Read Review). Similarly, another user noted faster healing and less pain associated with their mouth ulcers while using the supplement (Read Review).
Overall, many reviewers indicated that Vitamin D could play a supportive role in healing ulcers and enhancing overall immune function, which indirectly suggests its effectiveness within a short period. However, it’s essential to consult a healthcare provider regarding proper dosage and individual responses, especially if you have pre-existing conditions or are dealing with severe health issues related to ulcers (Read Review).
Current scientific research suggests that Vitamin D may be beneficial in the context of specific ulcer-related conditions. One notable study examined the effects of Vitamin D3 on gastric ulcers induced by aspirin, indicating significant protective properties for the stomach lining. The study, which involved a controlled experiment with rats, demonstrated that Vitamin D3 not only improved the overall health of gastric tissue but also reduced inflammation and oxidative stress markers, reinforcing its potential as a protective agent against gastric injuries caused by common medications [9].
Moreover, another investigation linked vitamin D levels with ulcerative colitis, revealing that low vitamin D levels correlated with heightened disease severity. The research highlighted that individuals with lower vitamin D intake experienced more severe symptoms, and supplementation was shown to improve clinical outcomes in affected patients [18]. However, while findings support the potential of Vitamin D in managing ulcer-related issues, further studies are necessary to clarify its effectiveness across different types of ulcers and to better understand the mechanisms of action.
Users have reported various improvements in their symptoms after taking Vitamin D supplements, particularly regarding ulcers and overall immune health. For instance, one user noted that their mouth ulcer healed swiftly upon starting Vitamin D3, highlighting the potential for rapid recovery (Read Review). Another user shared their experience of quicker healing and reduced pain associated with mouth ulcers, along with additional benefits for skin conditions (Read Review).
Moreover, users indicated that Vitamin D plays a crucial role in supporting the immune system, which potentially mitigates the frequency and severity of ailments. One user mentioned a complete disappearance of their leg ulcers after consistent use (Read Review). However, individual results can vary significantly, so it is always advisable to consult a healthcare professional before beginning any supplement regimen, especially for those with underlying health conditions (Read Review).
Users have provided a variety of insights regarding the combination of Vitamin D supplements with other treatments for handling ulcers. Several reviewers highlight that Vitamin D not only promotes the healing of ulcers but also enhances the immune system, further supporting overall recovery from various ailments. For instance, one user observed that their mouth ulcers healed significantly quicker when taking Vitamin D alongside consistent immune support (Read Review). Another user emphasized how Vitamin D played a crucial role in their healing process after dealing with leg ulcers, noting these disappeared after regular use (Read Review).
Additionally, some users underscore the importance of consulting with healthcare professionals when combining supplements, especially for those with ulcers or chronic health issues. A user advised a cautious approach, mentioning that while Vitamin D can be beneficial, it is essential to consider its interaction with existing conditions (Read Review). Overall, the consensus suggests that Vitamin D can be an effective supporter when used appropriately, but always under the guidance of a healthcare provider to ensure safety and optimal results.
Users report varying doses for Vitamin D in the context of treating ulcers, with many emphasizing the importance of consulting a doctor for individual needs. One reviewer mentioned a common dosage of 5000 IU of Vitamin D3 prescribed for another condition, noting they typically take 2000 IU regularly for immune support and overall health, which has been beneficial in supporting recovery from ailments, including ulcers (Read Review). Another user observed that while they began taking Vitamin D, their previously problematic mouth ulcers healed significantly quicker and with less pain (Read Review).
Moreover, some users highlighted the absorption considerations when taking Vitamin D, particularly noting that it should be taken with fatty foods for better efficacy (Read Review). Ultimately, while individual reports vary, the general consensus points to the benefits of Vitamin D for ulcer recovery, suggesting that a daily intake between 2000 to 5000 IU might be common among users, although it’s crucial to tailor the dosage based on medical advice and personal health conditions.
Our findings were quite promising. Vitamin D3 seemed to play a protective role against the damage caused by aspirin. It significantly increased levels of important protective molecules like E-Cadherin, GKN1 (a type of gastrokine), and mucin 5AC. These molecules are essential for maintaining the integrity of the stomach lining, helping to mitigate the effects of oxidative stress and inflammation often seen in gastric injuries.
Furthermore, Vitamin D3 treatment helped improve both the structure and function of gastric tissue. By reducing inflammation pathways, particularly those involving NLRP3 and NF-κB, Vitamin D3 demonstrated its potential as a protective agent in the context of aspirin-induced gastric injury.
Our findings revealed that vitamin D levels were lower in ulcerative colitis patients compared to healthy controls. Moreover, those with vitamin D deficiency had significantly higher disease activity scores, indicating more severe symptoms. Additionally, the quality of life was notably poorer for individuals with low vitamin D levels.
This suggests that vitamin D may play an important role in managing ulcerative colitis symptoms. We observed that higher vitamin D levels were linked to reduced disease activity and improved health-related quality of life. Therefore, it seems that vitamin D could be beneficial for those navigating the challenges of ulcerative colitis.
References
- El-Sayed SF, Mahmoud SM, Samy W, Wahid RM, Talaat A, et al. Vitamin D3 mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-κB/MMP-9 signaling pathway. Tissue Cell. 2025;93:102724. doi:10.1016/j.tice.2025.102724
- Nemet V, Matić S, Zielsdorf SJ, Tolj I, Jelić Vuković M, et al. Calcifediol and paricalcitol as adjunctive therapies for HSV-1 keratitis and corneal perforation: A case report. Medicine (Baltimore). 2024;103:e40654. doi:10.1097/MD.0000000000040654
- Liu L, Zhang F, Jamali M, Guimarães NS, Radkhah N, et al. The role of vitamin D in diabetic foot ulcer; an umbrella review of meta-analyses. Front Nutr. 2024;11:1454779. doi:10.3389/fnut.2024.1454779
- Wu X, Zeng J, Ye X, Peng M, Lan Y, et al. Effects of vitamin D supplementation on diabetic foot ulcer healing: a meta-analysis. Postgrad Med J. 2025;101:100. doi:10.1093/postmj/qgae107
- Zhang H, Xiao Y, Wen Q, Zhang S, Li P, et al. Washed microbiota transplantation improved the level of serum vitamin D in ulcerative colitis. J Gastroenterol Hepatol. 2024;39:2394. doi:10.1111/jgh.16717
- Li Y, Guo Y, Geng C, Song S, Yang W, et al. Vitamin D/vitamin D receptor protects intestinal barrier against colitis by positively regulating Notch pathway. Front Pharmacol. 2024;15:1421577. doi:10.3389/fphar.2024.1421577
- Hu Y, Wang Y, Chen Y, Li C, Long Y, et al. Co-administration of 1,25-dihydroxyvitamin D3 and infliximab improves colitis in mice by modulating Treg differentiation. Iran J Basic Med Sci. 2024;27:1172. doi:10.22038/IJBMS.2024.74640.16209
- Shalaby R, Nawawy ME, Selim K, Bahaa S, Refai SE, et al. The role of vitamin D in amelioration of oral lichen planus and its effect on salivary and tissue IFN-γ level: a randomized clinical trial. BMC Oral Health. 2024;24:813. doi:10.1186/s12903-024-04239-0
- El-Sayed SF, Mahmoud SM, Samy W, Wahid RM, Talaat A, et al. Vitamin D3 mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-κB/MMP-9 signaling pathway. Tissue Cell. 2025;93:102724. doi:10.1016/j.tice.2025.102724
- Hu Y, Wang Y, Chen Y, Li C, Long Y, et al. Co-administration of 1,25-dihydroxyvitamin D3 and infliximab improves colitis in mice by modulating Treg differentiation. Iran J Basic Med Sci. 2024;27:1172. doi:10.22038/IJBMS.2024.74640.16209
- Wang L, Wei Z, Lv L, Xue C. An efficient co-delivery system based on multilayer structural nanoparticles for programmed sequential release of resveratrol and vitamin D3 to combat dextran sodium sulfate-induced colitis in mice. Int J Biol Macromol. 2024;254:127962. doi:10.1016/j.ijbiomac.2023.127962
- Siregar FD, Hidayat W. The Role of Vitamin D on the Wound Healing Process: A Case Series. Int Med Case Rep J. 2023;16:227. doi:10.2147/IMCRJ.S402005
- Gao H, Zhou H, Zhang Z, Gao J, Li J, et al. Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway. Front Immunol. 2023;14:1135930. doi:10.3389/fimmu.2023.1135930
- Zhu C, Fan M, Zhu J, Cao L, Duan X, et al. Vitamin D Reduces the Helper T Cells 17 (Th17) Differentiation in Patients with Ulcerative Colitis by Targeting Long Non-coding RNA (lncRNA) OIP5-AS1/miR-26a-5p/IL-6 Axis. Iran J Immunol. 2022;19:150. doi:10.22034/iji.2022.90562.2014
- Ma GL, Cao SG, Xia SL, Zhu HQ, Jiang Y. [A preliminary study on the improved efficacy of mesalazine combined with vitamin D in ulcerative colitis]. Zhonghua Nei Ke Za Zhi. 2022;61:785. doi:10.3760/cma.j.cn112138-20210903-00613
- MacLeod BG, Klarich CS, Wessman LL, Gaddis KJ, Konstantinov NK, et al. Fluorescent Imaging as a Component of Diagnosing Pyoderma Gangrenosum: A Case Report. Adv Skin Wound Care. 2022;35:1. doi:10.1097/01.ASW.0000820248.26138.bc
- Lu Y, Chen J, He X, Xu S, Chen YE, et al. Combined Administration of Vitamin D and Geniposide Is Less Effective than Single Use of Vitamin D or Geniposide in the Treatment of Ulcerative Colitis. Front Pharmacol. 2021;12:714065. doi:10.3389/fphar.2021.714065
- Dash KR, Panda C, Das HS, Mishra D, Behera SK, et al. Association of Vitamin D Level With Disease Severity and Quality of Life in Newly Diagnosed Patients of Ulcerative Colitis: A Cross-Sectional Analysis. Cureus. 2021;13:e16481. doi:10.7759/cureus.16481
- Halschou-Jensen PM, Sauer J, Bouchelouche P, Fabrin J, Brorson S, et al. Improved Healing of Diabetic Foot Ulcers After High-dose Vitamin D: A Randomized Double-blinded Clinical Trial. Int J Low Extrem Wounds. 2023;22:466. doi:10.1177/15347346211020268
- Qiu F, Zhang Z, Yang L, Li R, Ma Y. Combined effect of vitamin C and vitamin D on intestinal epithelial barrier by regulating Notch signaling pathway. Nutr Metab (Lond). 2021;18:49. doi:10.1186/s12986-021-00576-x
- Osikov MV, Simonyan EV, Boyko MS, Ogneva OI, Ilyinykh MA, et al. Effect of Vitamin D3 in Composition of Original Rectal Suppositories on Parameter of Protein Oxidative Modification in Large Intestine in Experimental Ulcerative Colitis. Bull Exp Biol Med. 2021;170:608. doi:10.1007/s10517-021-05116-4
- Domazetovic V, Iantomasi T, Bonanomi AG, Stio M. Vitamin D regulates claudin-2 and claudin-4 expression in active ulcerative colitis by p-Stat-6 and Smad-7 signaling. Int J Colorectal Dis. 2020;35:1231. doi:10.1007/s00384-020-03576-0
- Cao R, Ma Y, Li S, Shen D, Yang S, et al. 1,25(OH) D alleviates DSS-induced ulcerative colitis via inhibiting NLRP3 inflammasome activation. J Leukoc Biol. 2020;108:283. doi:10.1002/JLB.3MA0320-406RR
