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Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin D2 (as Ergocalciferol)
25 mcg (1,000 IU)
125%
The product is found useful for the following medical conditions
Common Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 8 Reviews
8.7
8
Vitamin D reduces cold severity
Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.
Most Relevant Research
We explored the connection between vitamin D levels and the frequency of upper respiratory tract infections (URTI) in physically active individuals throughout different seasons. In our research, we observed over 1,600 military recruits during their basic training, noting that only 21% were vitamin D sufficient during winter. Alarmingly, those who had sufficient vitamin D levels were found to be 40% less likely to experience URTIs compared to their deficient counterparts, suggesting that maintaining adequate vitamin D may be crucial for better respiratory health during demanding training periods.
Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.
Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.
Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
10
Family immunity
Most Useful Review
I order this dosage for summer, but during the rest of the year, I take 2000 IU from the same brand. The significant result is that my family hasn't caught a common cold or any illness for 2 years, even through challenges like the recent pandemic.
Leg Cramps details
SCIENTIFIC SCORE
Very Likely Ineffective
Based on 2 Researches
2
USERS' SCORE
Good
Based on 3 Reviews
8.7
4
We assessed the impact of vitamin D on leg cramps experienced during pregnancy, referring to data from various studies. One of the key findings was that vitamin D treatment showed little to no difference when it came to reducing the frequency of leg cramps.
In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.
Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.
In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.
Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.
9.5
Excellent results
Most Useful Review
The quality is exceptional; I had a deficiency which caused my bones in my arms and legs to ache. I noticed the results immediately and found the size comfortable.
Osteoporosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
USERS' SCORE
Good
Based on 8 Reviews
8.7
9
Doxercalciferol improves bone health
Doxercalciferol Alleviates Bone Deteriorations and Cartilage Degeneration in Aging Mice.
Most Relevant Research
We sought to understand how doxercalciferol, a form of vitamin D2, affects bone health in aging mice, particularly in relation to osteoporosis. Through a series of experiments, we investigated its potential benefits in preventing bone loss, a common issue as animals age.
Our findings revealed that aging mice exhibited increased urine calcium excretion, decreased bone calcium content, and a reduction in biomechanical strength. However, upon administering doxercalciferol, we observed significant effects; especially, it lowered serum parathyroid hormone (PTH) levels which are commonly elevated in aging.
Additionally, our analysis through specific staining techniques confirmed that doxercalciferol helped protect against bone loss and supported cartilage regeneration. We also noted that the treatment enhanced the activity of bone-building cells while inhibiting the activity of cells that break down bone.
Overall, these results suggest that doxercalciferol could be an effective treatment for aging-related osteoporosis by enhancing bone health and improving overall quality of life.
Our findings revealed that aging mice exhibited increased urine calcium excretion, decreased bone calcium content, and a reduction in biomechanical strength. However, upon administering doxercalciferol, we observed significant effects; especially, it lowered serum parathyroid hormone (PTH) levels which are commonly elevated in aging.
Additionally, our analysis through specific staining techniques confirmed that doxercalciferol helped protect against bone loss and supported cartilage regeneration. We also noted that the treatment enhanced the activity of bone-building cells while inhibiting the activity of cells that break down bone.
Overall, these results suggest that doxercalciferol could be an effective treatment for aging-related osteoporosis by enhancing bone health and improving overall quality of life.
9.5
Effective alternative found
Most Useful Review
Much better and less hazardous than taking Fosamax! My husband takes this for his osteoporosis, and it works well. He switched from Fosamax due to side effects to a more natural method, which has proven successful without side effects.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Vitamin D3 aids autoimmune thyroiditis
Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.
Most Relevant Research
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
9.5
Prevention success
Most Useful Review
Excellent D3! I take this dosage during summer, and for the rest of the year, I have 2000 IU from the same manufacturer. Over two years, my family hasn't caught any colds, and we were asymptomatic even during the pandemic. This supplement has been essential in managing our immune health, particularly in relation to autoimmune disorders.
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.9
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin D reduces headache risk
New evidence that vitamin D prevents headache: a bidirectional two-sample Mendelian randomization analysis.
Most Relevant Research
We explored the potential connection between vitamin D levels and headaches through a thorough investigation using two-sample Mendelian randomization analysis. Our goal was to determine if there’s a causal relationship between high vitamin D levels and the risk of experiencing headaches.
Our findings revealed that higher levels of vitamin D are linked to a lower risk of headaches. Specifically, we found that vitamin D may have a preventive effect, reducing the likelihood of headaches occurring. However, we also observed that there is no evidence to suggest that headaches cause changes in vitamin D levels.
This means while supplementing vitamin D may help keep headaches at bay, headaches themselves do not appear to affect vitamin D levels. This information contributes valuable insights into how maintaining sufficient vitamin D could play a role in headache management.
Our findings revealed that higher levels of vitamin D are linked to a lower risk of headaches. Specifically, we found that vitamin D may have a preventive effect, reducing the likelihood of headaches occurring. However, we also observed that there is no evidence to suggest that headaches cause changes in vitamin D levels.
This means while supplementing vitamin D may help keep headaches at bay, headaches themselves do not appear to affect vitamin D levels. This information contributes valuable insights into how maintaining sufficient vitamin D could play a role in headache management.
9.5
No headaches experienced
Most Useful Review
Perfect! I have struggled to take any form of Vitamin D without suffering from massive headaches for nearly 20 years. Finally, I read about someone similar who switched to D2, and it worked. I'm eagerly awaiting my blood work to show an increase in Vitamin D for the first time in years, but for now, I am taking six capsules a day without any headaches!
Liver Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Vitamin D improves liver health
Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial.
Most Relevant Research
We explored the effects of vitamin D supplementation in patients with liver cirrhosis—a progressive disease that often manifests alongside vitamin D deficiency. In a carefully designed study, we involved sixty patients who participated in a double-blind, randomized controlled trial. Each patient received either a weekly dose of 50,000 IU of vitamin D or a placebo over 12 weeks.
Throughout the study, we assessed key health markers before and after supplementation, including liver function tests, lipid profiles, and glycaemic indices such as fasting blood glucose and insulin resistance. By the end of the trial, our findings indicated that vitamin D supplementation significantly improved fasting blood glucose levels and insulin resistance in the participants.
Specifically, we observed noteworthy increases in serum 25-hydroxy-vitamin D levels and reductions in fasting blood glucose and insulin resistance indicators. These results suggest that vitamin D might be an important player in improving metabolic health for those suffering from liver cirrhosis.
Throughout the study, we assessed key health markers before and after supplementation, including liver function tests, lipid profiles, and glycaemic indices such as fasting blood glucose and insulin resistance. By the end of the trial, our findings indicated that vitamin D supplementation significantly improved fasting blood glucose levels and insulin resistance in the participants.
Specifically, we observed noteworthy increases in serum 25-hydroxy-vitamin D levels and reductions in fasting blood glucose and insulin resistance indicators. These results suggest that vitamin D might be an important player in improving metabolic health for those suffering from liver cirrhosis.
9.5
Essential for immunity
Most Useful Review
This is a crucial vitamin for our body. I bought it for my brother as it was prescribed by his doctor. I intended to purchase it again, but it’s now unavailable. This vitamin is vital for immunity, especially if one suffers from liver disease.
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.5
8
Vitamin D deficiency linked to allergies
Does vitamin D deficiency predispose to allergic proctocolitis?
Most Relevant Research
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
9.5
Boosted immunity
Most Useful Review
I ordered this supplement for my son, who has a D deficiency and allergies to D3, along with low immunity. It has excellent ingredients and is a high-quality product.
Back Pain details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.7
USERS' SCORE
Good
Based on 3 Reviews
8.5
9.5
Vitamin D aids back pain recovery
An Unusual Mimic of Axial Spondyloarthritis: A Case Report.
Most Relevant Research
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
8.3
Returned shoulder pain
Most Useful Review
It came back again and it's worse. Initially, my shoulder pain disappeared in days. However, after forgetting to take it for one day, the pain returned, and it's worse now.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7
USERS' SCORE
Good
Based on 10 Reviews
8.5
9
Vitamin D supports depression management
Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial.
Most Relevant Research
We conducted a double-blind, randomized, placebo-controlled trial to explore how cholecalciferol, a form of vitamin D, influences depressive symptoms in individuals suffering from type 2 diabetes mellitus (T2DM). This clinical study lasted for 12 weeks and involved participants who were either given a daily dose of 4000 IU of cholecalciferol or a placebo.
Throughout the study, we measured various factors, including the participants’ depression levels using the Beck Depression Inventory-II, as well as important biological markers like C-peptide, serotonin, and neurotrophin-3.
Our findings showed a significant reduction in depression scores among those taking cholecalciferol compared to the placebo group. Additionally, we observed a notable increase in C-peptide levels, which may indicate some metabolic benefits, although no significant changes were found in serotonin and neurotrophin-3 levels.
Ultimately, while cholecalciferol appears to alleviate mild to moderate depressive symptoms in T2DM patients through improved C-peptide levels, its impact on serotonin and neurotrophin-3 remains unclear. This highlights vitamin D as a potentially helpful option for managing depression alongside diabetes.
Throughout the study, we measured various factors, including the participants’ depression levels using the Beck Depression Inventory-II, as well as important biological markers like C-peptide, serotonin, and neurotrophin-3.
Our findings showed a significant reduction in depression scores among those taking cholecalciferol compared to the placebo group. Additionally, we observed a notable increase in C-peptide levels, which may indicate some metabolic benefits, although no significant changes were found in serotonin and neurotrophin-3 levels.
Ultimately, while cholecalciferol appears to alleviate mild to moderate depressive symptoms in T2DM patients through improved C-peptide levels, its impact on serotonin and neurotrophin-3 remains unclear. This highlights vitamin D as a potentially helpful option for managing depression alongside diabetes.
9.5
Essential winter item
Most Useful Review
In a country with minimal sunlight, vitamin D is crucial for me in winter. Since starting it in November, I haven't faced any physical or mental issues, suggesting it's effective.
Knee Pain details
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
Vitamin D3 shows promise for knee OA
The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis.
Most Relevant Research
We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
9.5
No leg pain
Most Useful Review
Another great product from Now. The capsules are small and easy to swallow. They appear to be effective as I’ve not experienced leg pain, which I usually get when I don’t have enough Vitamin D, since taking them.
Rash details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
8.8
Skin quality improvement
Most Useful Review
I truly appreciate the Vitamin D3 from this brand. It has a commendable composition with natural ingredients, making it a great health ally. This vitamin effectively compensates for the lack of sunlight, thereby fortifying my immune system. I have noticed that after a few weeks of use, my skin quality has improved significantly—there are fewer rashes, and my complexion is more even. I took it alongside Omega and vitamin C, so I’m not sure which contributed most to the improvement; however, I genuinely appreciate the benefits of these vitamins.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
5.8
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.8
0
Vitamin D3 ineffective for CFS relief
Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial.
Most Relevant Research
We conducted a study to see if high-dose vitamin D3 could improve vascular health and reduce fatigue in individuals suffering from chronic fatigue syndrome (CFS). This was a well-structured trial involving 50 participants, all of whom met specific diagnostic criteria for CFS. Participants were divided into two groups: one received 100,000 units of vitamin D3 every two months, while the other received a placebo over a period of six months.
Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.
In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.
In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
9.5
Enhanced energy
Most Useful Review
An inexpensive vitamin D that helps maintain blood levels, suitable for children. I noticed having more energy and less fatigue, and waking up was easier. It significantly bolstered my immunity against chronic fatigue syndrome.
