Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin D2 (as Ergocalciferol)
25 mcg (1,000 IU)
125%
Top Medical Research Studies
8
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
Read More
7
Vitamin D effects on asthma explored
We explored the role of vitamin D, specifically calcitriol, in managing allergic eosinophilic asthma and how it interacts with a key molecule, CD46, in T cells. Our research involved stimulating CD4 T cells from patients and healthy donors with specific antibodies and measuring the production of two important immune signals: IFN-γ and IL-10.
Our findings suggest that lower levels of CD46 on activated CD4 T cells are linked to a more favorable Th1 cell response to calcitriol. This means that individuals with certain profiles might benefit more from vitamin D supplementation, potentially reducing inflammation associated with their asthma.
However, we need further validation of these results in clinical settings. If proven effective, this stratification could pave the way for personalized treatments for people with allergic conditions and possibly other diseases influenced by immune responses.
Our findings suggest that lower levels of CD46 on activated CD4 T cells are linked to a more favorable Th1 cell response to calcitriol. This means that individuals with certain profiles might benefit more from vitamin D supplementation, potentially reducing inflammation associated with their asthma.
However, we need further validation of these results in clinical settings. If proven effective, this stratification could pave the way for personalized treatments for people with allergic conditions and possibly other diseases influenced by immune responses.
Read More
8
We explored the role of vitamin D2 in managing symptoms of chronic spontaneous urticaria (CSU), a persistent skin condition that can be quite bothersome. In our study, we included 60 patients with CSU and 40 healthy individuals for comparison.
Participants underwent vitamin D testing, and those with low levels were given a high-dose vitamin D2 supplement along with antihistamines for six weeks. Our findings revealed that a significant number of CSU patients had low vitamin D levels, which were notably lower than those in the control group.
After the six-week treatment period, we observed considerable improvements in both allergy symptoms and overall quality of life among those taking vitamin D2. Specifically, many reported feeling better and experiencing fewer urticaria symptoms. This suggests that vitamin D2 could play a beneficial role in managing allergies, especially in those with existing deficiencies.
However, it's important to note that vitamin D2 was administered alongside antihistamines, so we can't pinpoint its effect without considering the medications’ impacts. Overall, our study offers promising insights into how vitamin D2 might support individuals dealing with allergic conditions like CSU.
Participants underwent vitamin D testing, and those with low levels were given a high-dose vitamin D2 supplement along with antihistamines for six weeks. Our findings revealed that a significant number of CSU patients had low vitamin D levels, which were notably lower than those in the control group.
After the six-week treatment period, we observed considerable improvements in both allergy symptoms and overall quality of life among those taking vitamin D2. Specifically, many reported feeling better and experiencing fewer urticaria symptoms. This suggests that vitamin D2 could play a beneficial role in managing allergies, especially in those with existing deficiencies.
However, it's important to note that vitamin D2 was administered alongside antihistamines, so we can't pinpoint its effect without considering the medications’ impacts. Overall, our study offers promising insights into how vitamin D2 might support individuals dealing with allergic conditions like CSU.
Read More
Most Useful Reviews
9
Boosted immunity
I ordered this supplement for my son, who has a D deficiency and allergies to D3, along with low immunity. It has excellent ingredients and is a high-quality product.
Read More
7.5
Overall wellness improved
Excellent product! The ingredients are well chosen, and I experienced no allergies or negative reactions. The large packaging lasts a long time. I noticed improvements in my bowel function and metabolism within a week. My nervous system feels better, and I am less anxious. I'm impressed with the vitamin's effectiveness.
Read More
6
Teeth health improved
3 people found this helpful
I suffered from allergies while taking only D3. I've realised it's fine to take D2 as a precaution. This supplement is crucial if you have dental issues since calcium loss can lead to problems. If your teeth are sparser than in your youth, you should consider D, K2, magnesium, and calcium.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
- All Researches
9
We explored the effects of vitamin D in combination with fluticasone propionate on allergy-related symptoms in children with bronchial asthma. In this study, we grouped participants into two treatment plans: one group received only fluticasone, while the other group received both fluticasone and vitamin D. By comparing their progress, we noted various health improvements related to asthma control.
The findings highlighted that the children who received the combination therapy experienced quicker relief from asthma symptoms, such as wheezing and shortness of breath. Their overall lung function also improved, as seen in measures like forced vital capacity and peak expiratory flow. Moreover, the kids taking vitamin D showed better immune responses, indicated by increased levels of specific immunoglobulins and lymphocytes important for fighting off infections.
We also observed significant improvements in well-being and quality of life for those in the combination group. However, it's essential to note that while vitamin D appears to offer additional benefits when taken alongside traditional asthma treatments, the study did not focus solely on vitamin D's effects. Overall, the data suggest that vitamin D could play a positive role in managing allergies associated with asthma, but further research is needed to isolate its effects conclusively.
The findings highlighted that the children who received the combination therapy experienced quicker relief from asthma symptoms, such as wheezing and shortness of breath. Their overall lung function also improved, as seen in measures like forced vital capacity and peak expiratory flow. Moreover, the kids taking vitamin D showed better immune responses, indicated by increased levels of specific immunoglobulins and lymphocytes important for fighting off infections.
We also observed significant improvements in well-being and quality of life for those in the combination group. However, it's essential to note that while vitamin D appears to offer additional benefits when taken alongside traditional asthma treatments, the study did not focus solely on vitamin D's effects. Overall, the data suggest that vitamin D could play a positive role in managing allergies associated with asthma, but further research is needed to isolate its effects conclusively.
Read More
9
Vitamin D metabolites aid pulmonary health
We explored the impact of vitamin D metabolites on respiratory health, particularly in the context of hypersensitivity pneumonitis (HP). Our study focused on C57BL/6J mice that were placed on a diet severely lacking in vitamin D to induce deficiency. These mice were then exposed to an antigen linked to HP while inhaling either 25(OH)-vitamin D3 or 1,25(OH)2-vitamin D3.
Over the course of the experiment, we observed significant changes in the respiratory function of vitamin D-deficient mice. The metabolites of vitamin D we tested seemed to counteract many adverse effects associated with vitamin D deficiency. Inhalations of these compounds not only improved respiratory functions but also reduced inflammation and fibrosis that was exacerbated by the HP-causing antigen.
This research suggests that inhaling vitamin D metabolites may restore normal levels of active vitamin D in the lungs of deficient mice, providing a promising avenue for further exploration into how vitamin D may help manage respiratory conditions related to allergies and hypersensitivity.
Over the course of the experiment, we observed significant changes in the respiratory function of vitamin D-deficient mice. The metabolites of vitamin D we tested seemed to counteract many adverse effects associated with vitamin D deficiency. Inhalations of these compounds not only improved respiratory functions but also reduced inflammation and fibrosis that was exacerbated by the HP-causing antigen.
This research suggests that inhaling vitamin D metabolites may restore normal levels of active vitamin D in the lungs of deficient mice, providing a promising avenue for further exploration into how vitamin D may help manage respiratory conditions related to allergies and hypersensitivity.
Read More
8
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
Read More
8
We conducted an extensive review of multiple studies to understand how vitamin D might influence atopic dermatitis (AD), a skin condition that impacts many people, particularly children. Our focus was on randomized controlled trials that compared vitamin D supplementation with a placebo group.
After analyzing data from eleven studies involving a total of 686 participants, we found compelling evidence that vitamin D supplementation can significantly reduce the severity of AD. Participants who received vitamin D showed a marked improvement compared to those who did not, with a notable decrease in their disease severity scores.
It's important to highlight that while our findings are promising, we also recognize the need for larger and longer-term studies to confirm these results. By understanding the role of vitamin D, we can better explore potential treatments for managing allergy-related conditions like atopic dermatitis.
After analyzing data from eleven studies involving a total of 686 participants, we found compelling evidence that vitamin D supplementation can significantly reduce the severity of AD. Participants who received vitamin D showed a marked improvement compared to those who did not, with a notable decrease in their disease severity scores.
It's important to highlight that while our findings are promising, we also recognize the need for larger and longer-term studies to confirm these results. By understanding the role of vitamin D, we can better explore potential treatments for managing allergy-related conditions like atopic dermatitis.
Read More
8
We explored the effects of vitamin D2 on patients suffering from chronic spontaneous urticaria (CSU), a condition that can cause frustrating and uncomfortable allergic reactions. In a well-structured study, we evaluated 60 CSU patients alongside 40 healthy individuals to understand the relationship between vitamin D levels and allergy symptoms. Throughout the research, we measured serotonin 25-hydroxy vitamin D (25(OH)D) levels at the start and after six weeks of treatment.
The findings revealed that a significant number of CSU patients had low vitamin D levels, particularly those with 25(OH)D concentrations below 30 ng/ml. Notably, after receiving vitamin D2 supplements along with antihistamine medications for six weeks, the majority of patients reported substantial improvements in their allergy symptoms and quality of life. This improvement was assessed using standardized tools that measure urticaria severity and impact on daily living.
Overall, our study suggests that vitamin D2 can be beneficial for individuals struggling with CSU by alleviating symptoms and enhancing overall well-being. While the combination of vitamin D2 and antihistamines complicates attributing the effects solely to vitamin D2, the results are promising for those seeking relief from allergic reactions.
The findings revealed that a significant number of CSU patients had low vitamin D levels, particularly those with 25(OH)D concentrations below 30 ng/ml. Notably, after receiving vitamin D2 supplements along with antihistamine medications for six weeks, the majority of patients reported substantial improvements in their allergy symptoms and quality of life. This improvement was assessed using standardized tools that measure urticaria severity and impact on daily living.
Overall, our study suggests that vitamin D2 can be beneficial for individuals struggling with CSU by alleviating symptoms and enhancing overall well-being. While the combination of vitamin D2 and antihistamines complicates attributing the effects solely to vitamin D2, the results are promising for those seeking relief from allergic reactions.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Boosted immunity
I ordered this supplement for my son, who has a D deficiency and allergies to D3, along with low immunity. It has excellent ingredients and is a high-quality product.
Read More
7.5
Overall wellness improved
Excellent product! The ingredients are well chosen, and I experienced no allergies or negative reactions. The large packaging lasts a long time. I noticed improvements in my bowel function and metabolism within a week. My nervous system feels better, and I am less anxious. I'm impressed with the vitamin's effectiveness.
Read More
6
Teeth health improved
3 people found this helpful
I suffered from allergies while taking only D3. I've realised it's fine to take D2 as a precaution. This supplement is crucial if you have dental issues since calcium loss can lead to problems. If your teeth are sparser than in your youth, you should consider D, K2, magnesium, and calcium.
Read More
Frequently Asked Questions
7.5
Overall wellness improved
Excellent product! The ingredients are well chosen, and I experienced no allergies or negative reactions. The large packaging lasts a long time. I noticed improvements in my bowel function and metabolism within a week. My nervous system feels better, and I am less anxious. I'm impressed with the vitamin's effectiveness.
6
Teeth health improved
3 people found this helpful
I suffered from allergies while taking only D3. I've realised it's fine to take D2 as a precaution. This supplement is crucial if you have dental issues since calcium loss can lead to problems. If your teeth are sparser than in your youth, you should consider D, K2, magnesium, and calcium.
9
Boosted immunity
I ordered this supplement for my son, who has a D deficiency and allergies to D3, along with low immunity. It has excellent ingredients and is a high-quality product.
5
We examined the role of vitamin D supplementation in managing allergic rhinitis through a systematic review and meta-analysis. By reviewing randomized controlled trials focused on patients with allergic rhinitis, we aimed to determine the effectiveness of vitamin D in alleviating symptoms.
Our findings indicate that vitamin D may help reduce allergic rhinitis symptoms compared to placebos; however, the improvement was not statistically significant. We also discovered considerable variation among the studies we analyzed, pointing toward the complexities of measuring vitamin D's effects.
Interestingly, factors like the proportion of female participants and the use of corticosteroids impacted how patients responded to vitamin D. Specifically, vitamin D supplementation that was not paired with corticosteroids showed a more substantial impact on relieving symptoms.
While vitamin D appears to offer some benefits for allergic rhinitis, the overall effect may depend on individual circumstances, including gender and medication use. Thus, it's essential to consider these aspects when evaluating treatment options for allergies.
Our findings indicate that vitamin D may help reduce allergic rhinitis symptoms compared to placebos; however, the improvement was not statistically significant. We also discovered considerable variation among the studies we analyzed, pointing toward the complexities of measuring vitamin D's effects.
Interestingly, factors like the proportion of female participants and the use of corticosteroids impacted how patients responded to vitamin D. Specifically, vitamin D supplementation that was not paired with corticosteroids showed a more substantial impact on relieving symptoms.
While vitamin D appears to offer some benefits for allergic rhinitis, the overall effect may depend on individual circumstances, including gender and medication use. Thus, it's essential to consider these aspects when evaluating treatment options for allergies.
8
We explored the effects of vitamin D2 on patients suffering from chronic spontaneous urticaria (CSU), a condition that can cause frustrating and uncomfortable allergic reactions. In a well-structured study, we evaluated 60 CSU patients alongside 40 healthy individuals to understand the relationship between vitamin D levels and allergy symptoms. Throughout the research, we measured serotonin 25-hydroxy vitamin D (25(OH)D) levels at the start and after six weeks of treatment.
The findings revealed that a significant number of CSU patients had low vitamin D levels, particularly those with 25(OH)D concentrations below 30 ng/ml. Notably, after receiving vitamin D2 supplements along with antihistamine medications for six weeks, the majority of patients reported substantial improvements in their allergy symptoms and quality of life. This improvement was assessed using standardized tools that measure urticaria severity and impact on daily living.
Overall, our study suggests that vitamin D2 can be beneficial for individuals struggling with CSU by alleviating symptoms and enhancing overall well-being. While the combination of vitamin D2 and antihistamines complicates attributing the effects solely to vitamin D2, the results are promising for those seeking relief from allergic reactions.
The findings revealed that a significant number of CSU patients had low vitamin D levels, particularly those with 25(OH)D concentrations below 30 ng/ml. Notably, after receiving vitamin D2 supplements along with antihistamine medications for six weeks, the majority of patients reported substantial improvements in their allergy symptoms and quality of life. This improvement was assessed using standardized tools that measure urticaria severity and impact on daily living.
Overall, our study suggests that vitamin D2 can be beneficial for individuals struggling with CSU by alleviating symptoms and enhancing overall well-being. While the combination of vitamin D2 and antihistamines complicates attributing the effects solely to vitamin D2, the results are promising for those seeking relief from allergic reactions.
8
We explored the role of vitamin D2 in managing symptoms of chronic spontaneous urticaria (CSU), a persistent skin condition that can be quite bothersome. In our study, we included 60 patients with CSU and 40 healthy individuals for comparison.
Participants underwent vitamin D testing, and those with low levels were given a high-dose vitamin D2 supplement along with antihistamines for six weeks. Our findings revealed that a significant number of CSU patients had low vitamin D levels, which were notably lower than those in the control group.
After the six-week treatment period, we observed considerable improvements in both allergy symptoms and overall quality of life among those taking vitamin D2. Specifically, many reported feeling better and experiencing fewer urticaria symptoms. This suggests that vitamin D2 could play a beneficial role in managing allergies, especially in those with existing deficiencies.
However, it's important to note that vitamin D2 was administered alongside antihistamines, so we can't pinpoint its effect without considering the medications’ impacts. Overall, our study offers promising insights into how vitamin D2 might support individuals dealing with allergic conditions like CSU.
Participants underwent vitamin D testing, and those with low levels were given a high-dose vitamin D2 supplement along with antihistamines for six weeks. Our findings revealed that a significant number of CSU patients had low vitamin D levels, which were notably lower than those in the control group.
After the six-week treatment period, we observed considerable improvements in both allergy symptoms and overall quality of life among those taking vitamin D2. Specifically, many reported feeling better and experiencing fewer urticaria symptoms. This suggests that vitamin D2 could play a beneficial role in managing allergies, especially in those with existing deficiencies.
However, it's important to note that vitamin D2 was administered alongside antihistamines, so we can't pinpoint its effect without considering the medications’ impacts. Overall, our study offers promising insights into how vitamin D2 might support individuals dealing with allergic conditions like CSU.
7
Vitamin D's role in allergies explored
We set out to examine the relationship between vitamin D levels and atopic dermatitis (AD), a common chronic inflammatory condition in children that involves skin sensitivity and allergies. In our study, we evaluated blood samples from 51 children with AD and compared their vitamin D levels and other immune markers to those of 20 healthy kids.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
Our results indicated that children with AD had notably higher levels of interleukin-33 (IL-33) and immunoglobulin E (IgE) compared to healthy peers. We noted a significant correlation between IL-33 and vitamin D levels among the participants with AD. This finding hints at a possible connection between vitamin D and allergic responses, with vitamin D potentially playing a role in modulating inflammation in conditions like AD.
However, it's essential to highlight that while our study uncovered these associations, we cannot conclusively state that vitamin D treatment directly benefits allergy reduction, as the complexities of allergies involve multiple factors. The significance of our findings lies in their potential implications for understanding how vitamin D interacts with immune responses in allergic conditions, paving the way for future research in this area.
References
- Kawada K, Sato C, Ishida T, Nagao Y, Yamamoto T, et al. Vitamin D Supplementation and Allergic Rhinitis: A Systematic Review and Meta-Analysis. Medicina (Kaunas). 2025;61. doi:10.3390/medicina61020355
- Molatefi R, Fouladi N, Asghariazar V, Samemaleki S, Golizadeh M, et al. The evaluation of the serum levels of vitamin D and interleukin-33 in children with atopic dermatitis and its association with diseases severity. Arch Dermatol Res. 2025;317:182. doi:10.1007/s00403-024-03709-3
- Akbulut O, Köksal BT, Aydın B, Oznacar T, Haberal A, et al. Does vitamin D deficiency predispose to allergic proctocolitis?. Nutrition. 2025;131:112659. doi:10.1016/j.nut.2024.112659
- Nielsen AY, Høj S, Thomsen SF, Meteran H. Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis. Nutrients. 2024;16. doi:10.3390/nu16234128
- Wu D, Wang J, Wei Y, Zhang X, Hou Z. Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy. Physiol Res. 2024;73:841.
- Lemieszek MK, Chojnacki M, Paśnik I, Gawryś W, Wilczyńska A, et al. Beneficial Impact of Inhaled 25(OH)-Vitamin D3 and 1,25(OH)2-Vitamin D3 on Pulmonary Response in the Murine Model of Hypersensitivity Pneumonitis. Int J Mol Sci. 2024;25. doi:10.3390/ijms251910289
- Stichova J, Slanina P, Chovancova Z, Baros J, Litzman M, et al. Low CD46 expression on activated CD4 T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donors. Front Allergy. 2024;5:1462579. doi:10.3389/falgy.2024.1462579
- Petrarca C, Clemente E, Amato V, Gatta A, Cortese S, et al. Vitamin D3 improves the effects of low dose Der p 2 allergoid treatment in Der p 2 sensitized BALB/c mice. Clin Mol Allergy. 2016;14:7. doi:10.1186/s12948-016-0044-1
- Boonpiyathad T, Pradubpongsa P, Sangasapaviriya A. Vitamin D supplements improve urticaria symptoms and quality of life in chronic spontaneous urticaria patients: A prospective case-control study. Dermatoendocrinol. 2016;8:e983685. doi:10.4161/derm.29727
- Boonpiyathad T, Pradubpongsa P, Sangasapaviriya A. Vitamin d supplements improve urticaria symptoms and quality of life in chronic spontaneous urticaria patients: a prospective case-control study. Dermatoendocrinol. 2014;6:e29727. doi:10.4161/derm.29727
