Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin D2 (as Ergocalciferol)
25 mcg (1,000 IU)
125%
Top Medical Research Studies
8
We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Read More
8
We investigated the role of vitamin D3 in managing post-operative knee pain in patients undergoing unicompartmental knee arthroplasty (UKA). Our study involved 240 patients divided into three groups. One group received vitamin D3 supplements before surgery, another group received them afterward, and the last group had normal vitamin D levels from the start.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
Read More
8
We explored the relationship between 25-hydroxy vitamin D levels and knee osteoarthritis (KOA) by conducting a thorough analysis of eight randomized controlled trials (RCTs). This involved looking at nearly 3,100 patients and examining factors such as tibial cartilage volume, joint space width, synovial fluid volume, and patients' self-reported pain and function scores.
Our findings showed that vitamin D supplementation significantly improved certain aspects of knee health. Specifically, we observed notable reductions in pain levels and improvements in joint function, as measured by the WOMAC scale. Interestingly, while vitamin D helped with the overall discomfort and functionality of those suffering from knee issues, it did not significantly affect stiffness or some other knee-related measurements, like changes in joint space.
Given these results, it seems clear that for patients struggling with knee pain and dysfunction, vitamin D could be a valuable addition to their treatment regimen. However, it’s also worth noting that the most pronounced benefits appeared with dosages exceeding 2,000 IU daily, suggesting that dosage plays an important role in effectiveness.
Our findings showed that vitamin D supplementation significantly improved certain aspects of knee health. Specifically, we observed notable reductions in pain levels and improvements in joint function, as measured by the WOMAC scale. Interestingly, while vitamin D helped with the overall discomfort and functionality of those suffering from knee issues, it did not significantly affect stiffness or some other knee-related measurements, like changes in joint space.
Given these results, it seems clear that for patients struggling with knee pain and dysfunction, vitamin D could be a valuable addition to their treatment regimen. However, it’s also worth noting that the most pronounced benefits appeared with dosages exceeding 2,000 IU daily, suggesting that dosage plays an important role in effectiveness.
Read More
Most Useful Reviews
9
No leg pain
Another great product from Now. The capsules are small and easy to swallow. They appear to be effective as I’ve not experienced leg pain, which I usually get when I don’t have enough Vitamin D, since taking them.
Read More
7.5
Resolved elbow pain
I'm very pleased with these vitamins. They have effectively helped me address my knee pain and elbow issues that I had been struggling with for a long time.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.8
- All Researches
9
We focused on the effects of vitamin D (VITD) in reducing knee pain linked to osteoarthritis (OA) using a study conducted on Wistar rats. The rats were induced with OA through a combination of surgical methods known as ACLT (anterior cruciate ligament transection) along with medial meniscectomy. This allowed us to closely observe the direct impact of VITD on pain levels and cartilage health.
Our investigations revealed that VITD not only alleviated pain but also minimized cartilage destruction. We measured pain severity through various tests, examined knee structure through histopathological studies, and analyzed different biological markers including inflammatory cytokines and matrix metalloproteinases (MMPs), which are linked to cartilage degradation.
The results were quite promising. Not only did VITD show a significant reduction in pain, but it also decreased inflammation and the destruction of chondrocytes, or cartilage cells. These benefits appear to stem from VITD's ability to lower the expression of MMPs, which are known contributors to cartilage breakdown in OA.
Overall, our findings strongly suggest that adding vitamin D to treatment regimens could be beneficial for those suffering from knee pain related to osteoarthritis, making it a potential ally in managing this common joint condition.
Our investigations revealed that VITD not only alleviated pain but also minimized cartilage destruction. We measured pain severity through various tests, examined knee structure through histopathological studies, and analyzed different biological markers including inflammatory cytokines and matrix metalloproteinases (MMPs), which are linked to cartilage degradation.
The results were quite promising. Not only did VITD show a significant reduction in pain, but it also decreased inflammation and the destruction of chondrocytes, or cartilage cells. These benefits appear to stem from VITD's ability to lower the expression of MMPs, which are known contributors to cartilage breakdown in OA.
Overall, our findings strongly suggest that adding vitamin D to treatment regimens could be beneficial for those suffering from knee pain related to osteoarthritis, making it a potential ally in managing this common joint condition.
Read More
8
We investigated the role of vitamin D3 in managing post-operative knee pain in patients undergoing unicompartmental knee arthroplasty (UKA). Our study involved 240 patients divided into three groups. One group received vitamin D3 supplements before surgery, another group received them afterward, and the last group had normal vitamin D levels from the start.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
Read More
8
We explored how Vitamin D affects knee pain in those suffering from knee osteoarthritis (KOA), a prevalent condition that significantly impacts the elderly. Using data from the Osteoarthritis Initiative, our analysis included 524 participants and focused on the relationship between serum Vitamin D levels and pain scores measured by the WOMAC scale.
Our findings indicated that higher levels of Vitamin D were linked to lower pain scores in men. This suggests that Vitamin D may be beneficial for male KOA patients. However, for women, we didn’t find any significant connection between Vitamin D levels and their pain scores.
We noticed a nonlinear relationship overall, which became less significant when we adjusted for other variables. This points to the possibility that Vitamin D could serve as a targeted treatment strategy for reducing knee pain in men, though it seems less effective for women. These exciting results highlight the need for further studies to verify if Vitamin D supplementation can indeed help alleviate KOA pain in male patients.
Our findings indicated that higher levels of Vitamin D were linked to lower pain scores in men. This suggests that Vitamin D may be beneficial for male KOA patients. However, for women, we didn’t find any significant connection between Vitamin D levels and their pain scores.
We noticed a nonlinear relationship overall, which became less significant when we adjusted for other variables. This points to the possibility that Vitamin D could serve as a targeted treatment strategy for reducing knee pain in men, though it seems less effective for women. These exciting results highlight the need for further studies to verify if Vitamin D supplementation can indeed help alleviate KOA pain in male patients.
Read More
8
Vitamin D aids knee pain relief
We explored how vitamin D supplementation impacts knee pain and other related factors in patients with knee osteoarthritis (KOA). A group of 165 KOA patients received 40,000 IU of vitamin D weekly for six months, and their treatment was compared against 25 healthy individuals.
Our findings revealed that patients with KOA had notably higher levels of an autophagosome protein, LC3A, compared to the healthy controls. After vitamin D supplementation, there was a significant reduction in serum LC3A levels, pointing toward an improvement in the autophagy process. This decrease in LC3A levels was also linked with a reduction in pain and better functional scores.
Additionally, we saw improvements in muscle strength and overall physical performance among those who received vitamin D. In essence, vitamin D not only helped lower inflammatory markers but also contributed to alleviating knee pain and enhancing mobility for KOA patients.
Overall, the evidence suggests that vitamin D can be an effective ally in managing knee pain and improving physical performance in individuals suffering from KOA.
Our findings revealed that patients with KOA had notably higher levels of an autophagosome protein, LC3A, compared to the healthy controls. After vitamin D supplementation, there was a significant reduction in serum LC3A levels, pointing toward an improvement in the autophagy process. This decrease in LC3A levels was also linked with a reduction in pain and better functional scores.
Additionally, we saw improvements in muscle strength and overall physical performance among those who received vitamin D. In essence, vitamin D not only helped lower inflammatory markers but also contributed to alleviating knee pain and enhancing mobility for KOA patients.
Overall, the evidence suggests that vitamin D can be an effective ally in managing knee pain and improving physical performance in individuals suffering from KOA.
Read More
8
We explored the relationship between 25-hydroxy vitamin D levels and knee osteoarthritis (KOA) by conducting a thorough analysis of eight randomized controlled trials (RCTs). This involved looking at nearly 3,100 patients and examining factors such as tibial cartilage volume, joint space width, synovial fluid volume, and patients' self-reported pain and function scores.
Our findings showed that vitamin D supplementation significantly improved certain aspects of knee health. Specifically, we observed notable reductions in pain levels and improvements in joint function, as measured by the WOMAC scale. Interestingly, while vitamin D helped with the overall discomfort and functionality of those suffering from knee issues, it did not significantly affect stiffness or some other knee-related measurements, like changes in joint space.
Given these results, it seems clear that for patients struggling with knee pain and dysfunction, vitamin D could be a valuable addition to their treatment regimen. However, it’s also worth noting that the most pronounced benefits appeared with dosages exceeding 2,000 IU daily, suggesting that dosage plays an important role in effectiveness.
Our findings showed that vitamin D supplementation significantly improved certain aspects of knee health. Specifically, we observed notable reductions in pain levels and improvements in joint function, as measured by the WOMAC scale. Interestingly, while vitamin D helped with the overall discomfort and functionality of those suffering from knee issues, it did not significantly affect stiffness or some other knee-related measurements, like changes in joint space.
Given these results, it seems clear that for patients struggling with knee pain and dysfunction, vitamin D could be a valuable addition to their treatment regimen. However, it’s also worth noting that the most pronounced benefits appeared with dosages exceeding 2,000 IU daily, suggesting that dosage plays an important role in effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
No leg pain
Another great product from Now. The capsules are small and easy to swallow. They appear to be effective as I’ve not experienced leg pain, which I usually get when I don’t have enough Vitamin D, since taking them.
Read More
7.5
Resolved elbow pain
I'm very pleased with these vitamins. They have effectively helped me address my knee pain and elbow issues that I had been struggling with for a long time.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Montemor CN, Fernandes MTP, Marquez AS, Bignardi PR, Poli RC, et al. Impact of Reduced Vitamin D Levels on Pain, Function, and Severity in Knee or Hip Osteoarthritis. Nutrients. 2025;17. doi:10.3390/nu17030447
- Mende LK, Kuthati Y, Wong CS. Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction. Nutrients. 2025;17. doi:10.3390/nu17020349
- Rajani AM, Mittal A, Kulkarni VU, Rajani KA, Rajani KA. Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty. Malays Orthop J. 2024;18:7. doi:10.5704/MOJ.2411.002
- Gottreich JR, Katz JN, Jones MH. Nonsurgical Knee Osteoarthritis Treatments for Reducing Inflammation as Measured on MRI Scans: A Systematic Review of Randomized Controlled Trials. Orthop J Sports Med. 2024;12:23259671241272667. doi:10.1177/23259671241272667
- Zuo A, Jia Q, Zhang M, Zhou X, Li T, et al. The association of vitamin D with knee osteoarthritis pain: an analysis from the Osteoarthritis Initiative database. Sci Rep. 2024;14:30176. doi:10.1038/s41598-024-81845-6
- Wang QW, Ong MT, Man GC, Yeung YM, He X, et al. The effectiveness of vitamin D supplementation in patients with end-stage knee osteoarthritis: Study protocol for a double-blinded, randomized controlled trial. PLoS One. 2024;19:e0309610. doi:10.1371/journal.pone.0309610
- Saengsiwaritt W, Jittikoon J, Chaikledkaew U, Tawonsawatruk T, Honsawek S, et al. Effect of vitamin D supplementation on circulating level of autophagosome protein LC3A, inflammation, and physical performance in knee osteoarthritis. Clin Transl Sci. 2023;16:2543. doi:10.1111/cts.13646
- Wang Z, Zhu Z, Pan F, Zheng S, Parameswaran V, et al. Long-term effects of vitamin D supplementation and maintaining sufficient vitamin D on knee osteoarthritis over 5 years. Arthritis Res Ther. 2023;25:178. doi:10.1186/s13075-023-03167-8
- Wang R, Wang ZM, Xiang SC, Jin ZK, Zhang JJ, et al. Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne). 2023;10:1200592. doi:10.3389/fmed.2023.1200592
- Busa P, Huang N, Kuthati Y, Wong CS. Vitamin D reduces pain and cartilage destruction in knee osteoarthritis animals through inhibiting the matrix metalloprotease (MMPs) expression. Heliyon. 2023;9:e15268. doi:10.1016/j.heliyon.2023.e15268
- Shen J, Lin X, Lin Y, Xiao J, Wu C, et al. Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency. Front Nutr. 2023;10:1026722. doi:10.3389/fnut.2023.1026722
- Divjak A, Jovanovic I, Matic A, Lucic AT, Gajovic N, et al. The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis. Immunol Res. 2023;71:442. doi:10.1007/s12026-022-09354-0
- Lin T, Peng S, Lu S, Fu S, Zeng D, et al. Prediction of knee pain improvement over two years for knee osteoarthritis using a dynamic nomogram based on MRI-derived radiomics: a proof-of-concept study. Osteoarthritis Cartilage. 2023;31:267. doi:10.1016/j.joca.2022.10.014
- Strath LJ, Hernandez PV, Nodarse CL, Johnson AJ, Edberg JD, et al. Clinical vitamin D levels are associated with insular volume and inferior temporal gyrus white matter surface area in community-dwelling individuals with knee pain. Front Neurosci. 2022;16:882322. doi:10.3389/fnins.2022.882322
- Jin X, Ding C, Hunter DJ, Gallego B. Effectiveness of vitamin D supplementation on knee osteoarthritis - A target trial emulation study using data from the Osteoarthritis Initiative cohort. Osteoarthritis Cartilage. 2022;30:1495. doi:10.1016/j.joca.2022.06.005
- Peng HM, Weng XS, Li Y, Feng B, Qian W, et al. Effect of alendronate sodium plus vitamin D tablets on knee joint structure and osteoarthritis pain: a multi-center, randomized, double-blind, placebo-controlled study protocol. BMC Musculoskelet Disord. 2022;23:584. doi:10.1186/s12891-022-05521-4
