Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 13 Reviews
8.2
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We investigated the potential of cyanocobalamin, or Vitamin B12, as a treatment for skin inflammation using a cutting-edge transdermal delivery system. The research focused on microneedle patches that effectively deliver this antioxidant form of Vitamin B12 into the skin.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Read More
7
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Read More
9
We examined how a combined probiotic treatment affects children with food allergies. The study included 92 kids with both skin and gastrointestinal symptoms. Those who took the probiotic showed a significant drop in their allergy symptoms over 21 days, including a decrease in inflammation markers.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Read More
Most Useful Reviews
9
Budget-friendly relief
1 people found this helpful
Salvation for allergy sufferers. Most individuals are allergic to synthetic forms of group B. Methylcolbamine in this form is a true lifesaver. The tablets are small and sweet, best dissolved under the tongue. They are quite affordable compared to the Russian pharmaceutical market. I take them for three months with breaks and consider the company's B complex as well. For those with a persistent lack of time for proper nutrition—Salvation for allergies!
Read More
9
Increased vitamin levels
I highly recommend this methyl form as it increased my vitamin levels in the blood without causing allergies.
Read More
9
Quality packaging
It's effective; the packaging is excellent, and it does not cause allergies.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
- All Researches
9
We examined how a combined probiotic treatment affects children with food allergies. The study included 92 kids with both skin and gastrointestinal symptoms. Those who took the probiotic showed a significant drop in their allergy symptoms over 21 days, including a decrease in inflammation markers.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Read More
8
We investigated the potential of cyanocobalamin, or Vitamin B12, as a treatment for skin inflammation using a cutting-edge transdermal delivery system. The research focused on microneedle patches that effectively deliver this antioxidant form of Vitamin B12 into the skin.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Our findings highlighted reduced inflammation and damage in skin models, indicated by decreased cytokine levels and less oxidative stress. This approach may present a new, cost-effective method to enhance skin care for patients dealing with chronic inflammatory conditions.
However, it's important to note that while the results are promising, further studies are needed for broader applications.
Read More
7
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Budget-friendly relief
1 people found this helpful
Salvation for allergy sufferers. Most individuals are allergic to synthetic forms of group B. Methylcolbamine in this form is a true lifesaver. The tablets are small and sweet, best dissolved under the tongue. They are quite affordable compared to the Russian pharmaceutical market. I take them for three months with breaks and consider the company's B complex as well. For those with a persistent lack of time for proper nutrition—Salvation for allergies!
Read More
9
Increased vitamin levels
I highly recommend this methyl form as it increased my vitamin levels in the blood without causing allergies.
Read More
9
Quality packaging
It's effective; the packaging is excellent, and it does not cause allergies.
Read More
9
Recommended product
Excellent product, no allergies experienced! I highly recommend it due to its great quality.
Read More
9
No side effects
This brand is very impressive. I recommend it as it does not cause allergies or stomach issues.
Read More
Frequently Asked Questions
9
Improved wellbeing
Super! An excellent quality product with perfectly selected ingredients. I experienced no allergies or negative reactions. The large package lasts long, and I noticed improvements in bowel function and metabolism after a week. My nervous system functions better now, and I feel less anxious.
9
Budget-friendly relief
1 people found this helpful
Salvation for allergy sufferers. Most individuals are allergic to synthetic forms of group B. Methylcolbamine in this form is a true lifesaver. The tablets are small and sweet, best dissolved under the tongue. They are quite affordable compared to the Russian pharmaceutical market. I take them for three months with breaks and consider the company's B complex as well. For those with a persistent lack of time for proper nutrition—Salvation for allergies!
9
Increased vitamin levels
I highly recommend this methyl form as it increased my vitamin levels in the blood without causing allergies.
9
No side effects
This brand is very impressive. I recommend it as it does not cause allergies or stomach issues.
0
Energy boost
It relieves fatigue effectively. I wake up to two children demanding food and feel drained. This pill works wonders as if I consumed an energy drink within five minutes of taking it. However, be cautious if you have allergies to mould; my son reacts allergically to similar vitamins.
9
No allergies
Vitamin B12, in a well-absorbed form, does not lead to allergies.
9
Positive effect
Great verified manufacturer, had no allergies, and experienced a positive effect when taking it with food.
9
Pleasant taste
This B12 supplement is good, with the right dosage and pleasant taste. There are no side effects or allergies.
9
We examined how a combined probiotic treatment affects children with food allergies. The study included 92 kids with both skin and gastrointestinal symptoms. Those who took the probiotic showed a significant drop in their allergy symptoms over 21 days, including a decrease in inflammation markers.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
Specifically, children in the main group had improved skin and gut symptoms, along with notable reductions in IgE levels compared to those who didn’t receive the treatment. While symptoms increased slightly after the treatment stopped, they remained less severe than before, demonstrating the potential benefits of B12 in managing allergies.
7
We explored a group of 29 patients who were referred to three allergy centers in the UK due to suspected vitamin B12 hypersensitivity (VB12H). Over the period from 2014 to 2022, these patients underwent various tests, including skin prick tests and drug provocation tests. The aim was to understand how vitamin B12 treatment relates to allergies and to develop a reliable method for assessing hypersensitivity.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
Among the patients, 62% displayed immediate hypersensitivity reactions, with some experiencing severe anaphylaxis to vitamin B12 forms. Interestingly, we found that some patients who were sensitized to a specific type of vitamin B12 could tolerate another form. This indicates that not all vitamin B12 treatments may cause problems for everyone. However, confirmed cases of VB12H are considered to be quite rare.
Overall, while we identified individual cases where vitamin B12 treatment provoked allergic responses, the evidence suggests that vitamin B12 hypersensitivity is uncommon. This nuances the discussions around vitamin B12 treatment face since adverse reactions are not widespread. Our proposed evaluation protocol includes skin testing and considerations for allergies to related substances, such as polyethylene glycol.
Therefore, while there is an observable connection between vitamin B12 and allergic reactions in a small subset of individuals, the study indicates that treatment for vitamin B12 deficiency remains generally safe for most individuals.
References
- Guillot AJ, MartĂnez-Navarrete M, Giner RM, Recio MC, Santos HA, et al. Cyanocobalamin-loaded dissolving microneedles diminish skin inflammation in vivo. J Control Release. 2024;375:537. 10.1016/j.jconrel.2024.09.032
- Vorobieva OA, Shih EV, Drozdov VN, Shikh NV. [The results of the use of a combined probiotic ( and spp. Đ’B-12) in children with gastrointestinal and skin manifestations of food allergy]. Vopr Pitan. 2023;92:79. 10.33029/0042-8833-2023-92-3-79-86
- El Rhermoul FZ, Mustafa A, Wagner A, Nakonechna A, Kayode OS, et al. Vitamin B Hypersensitivity: A Retrospective Multicenter Study. J Allergy Clin Immunol Pract. 2024;12:699. 10.1016/j.jaip.2023.10.037
