Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.3
USERS' SCORE
Good
Based on 22 Reviews
8
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
9
We evaluated the effectiveness of intramuscular vitamin B12 in treating low back pain among 60 patients aged 18 to 65 with mechanical pain lasting at least six months.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
Read More
9
We explored the effects of vitamin B12 treatment on a patient experiencing severe back pain, along with other symptoms associated with subacute combined degeneration (SCD) from prolonged vitamin B12 deficiency. This case involved a 49-year-old man who faced a year of worsening weakness, pain, and gait abnormalities.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Read More
8
B vitamins improve back pain relief
We explored how B vitamins, when combined with a reduced dose of diclofenac, could enhance pain relief for patients suffering from acute lumbar pain. In a controlled study of 123 participants, those receiving both B vitamins and diclofenac experienced significantly better outcomes compared to those taking diclofenac alone. Remarkably, more patients in the combination therapy group achieved total pain relief sooner, highlighting the potential benefits of B vitamins in reducing the required dosage of NSAIDs while still providing effective pain management.
Read More
Most Useful Reviews
7.5
Pain relief
26 people found this helpful
Hebaden is improving! After experiencing back pain due to Heberden's nodules during menopause, I discovered that B12 is effective. I took one tablet under my tongue morning and evening. After about a month, the pain in my fingers diminished significantly. My pinky still hurts, but overall I'm feeling better and intend to keep using it.
Read More
9
Back pain relief
18 people found this helpful
This product has been remarkable for my back pain. I initially took it for nerve perception but was surprised to find relief in my lumbar region. My sedentary job caused significant discomfort, but after taking 10,000 mcg daily, the severe pain lessened remarkably. Now, I split my dosage and take 5,000 mcg twice a day.
Read More
9
Pain vanished
7 people found this helpful
After half a year of sciatica causing persistent back pain, I began taking B12 with vitamin D. Just three days in, the pain vanished! My feet have been numb for long, but I hope that will improve too. The tablets are easy to take, and I highly recommend trying them for nerve pain.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 17 Researches
8.3
- All Researches
9.5
We investigated the impact of a treatment combining mannitol and vitamin B on piriformis syndrome (PS), which is characterized by sciatic nerve entrapment. In a study involving 22 patients, participants received a five-day intravenous infusion of mannitol alongside a six-week regimen of vitamin B, including B1, B2, and B12.
Our observations highlighted significant improvements in clinical assessments, particularly in tenderness and pain levels assessed by various tests and scales. Notably, the Numeric Rating Scale demonstrated a marked reduction in pain at rest, at night, and during activities, which were all statistically significant. Additionally, the swelling around the sciatic nerve also showed a noteworthy decrease.
While vitamin B12 was part of this combination treatment, we must acknowledge that the study's focus on mannitol alongside the vitamins makes it challenging to isolate vitamin B12's specific effects on back pain alone.
Nevertheless, the results suggest that the combined approach might be a promising alternative for managing PS effectively.
Our observations highlighted significant improvements in clinical assessments, particularly in tenderness and pain levels assessed by various tests and scales. Notably, the Numeric Rating Scale demonstrated a marked reduction in pain at rest, at night, and during activities, which were all statistically significant. Additionally, the swelling around the sciatic nerve also showed a noteworthy decrease.
While vitamin B12 was part of this combination treatment, we must acknowledge that the study's focus on mannitol alongside the vitamins makes it challenging to isolate vitamin B12's specific effects on back pain alone.
Nevertheless, the results suggest that the combined approach might be a promising alternative for managing PS effectively.
Read More
9
We evaluated the effectiveness of intramuscular vitamin B12 in treating low back pain among 60 patients aged 18 to 65 with mechanical pain lasting at least six months.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
Read More
9
Mixed results from vitamin treatment
We investigated the effectiveness of Dolo-Neurobion, a combination of vitamins B1, B6, and B12 along with an analgesic, for patients with acute lumbosacral pain. The treatment began with a parenteral application followed by oral dosing.
Out of 53 patients, we observed that 77.4% experienced good to excellent relief from their pain, while 15.1% noted moderate effects. There were no notable side effects, which makes this treatment a viable option for managing pain associated with intrapelvic organ issues.
Out of 53 patients, we observed that 77.4% experienced good to excellent relief from their pain, while 15.1% noted moderate effects. There were no notable side effects, which makes this treatment a viable option for managing pain associated with intrapelvic organ issues.
Read More
9
We explored the effects of vitamin B12 treatment on a patient experiencing severe back pain, along with other symptoms associated with subacute combined degeneration (SCD) from prolonged vitamin B12 deficiency. This case involved a 49-year-old man who faced a year of worsening weakness, pain, and gait abnormalities.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Read More
9
Gelatin sponge aids postoperative recovery
We conducted a study to understand if a "cocktail treatment," which includes a gelatin sponge soaked in ropivacaine, dexamethasone, and vitamin B12, could improve recovery after a procedure known as percutaneous endoscopic lumbar discectomy (PELD). This treatment aimed to address not just the mechanical issues of a herniated disc but also the inflammatory responses that often lead to prolonged pain.
Our research involved 100 patients who underwent PELD for single-level lumbar disc herniation. Half of them received the cocktail treatment, while the other half were given a gelatin sponge without any medication as a control group. We evaluated the outcomes based on pain relief and functional recovery, using tools like the Visual Analog Scale (VAS) for assessing back and leg pain and the Oswestry Disability Index (ODI) for measuring disability.
The inclusion of vitamin B12 in the cocktail treatment seems to promote earlier pain relief and functional recovery after surgery. However, because this treatment was mixed with other medications, it’s hard to isolate the specific effect of vitamin B12 on its own. While we saw positive results in terms of overall recovery, we can't definitively claim that vitamin B12 alone contributed significantly to alleviating back pain.
Our research involved 100 patients who underwent PELD for single-level lumbar disc herniation. Half of them received the cocktail treatment, while the other half were given a gelatin sponge without any medication as a control group. We evaluated the outcomes based on pain relief and functional recovery, using tools like the Visual Analog Scale (VAS) for assessing back and leg pain and the Oswestry Disability Index (ODI) for measuring disability.
The inclusion of vitamin B12 in the cocktail treatment seems to promote earlier pain relief and functional recovery after surgery. However, because this treatment was mixed with other medications, it’s hard to isolate the specific effect of vitamin B12 on its own. While we saw positive results in terms of overall recovery, we can't definitively claim that vitamin B12 alone contributed significantly to alleviating back pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 22 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Pain relief
26 people found this helpful
Hebaden is improving! After experiencing back pain due to Heberden's nodules during menopause, I discovered that B12 is effective. I took one tablet under my tongue morning and evening. After about a month, the pain in my fingers diminished significantly. My pinky still hurts, but overall I'm feeling better and intend to keep using it.
Read More
9
Back pain relief
18 people found this helpful
This product has been remarkable for my back pain. I initially took it for nerve perception but was surprised to find relief in my lumbar region. My sedentary job caused significant discomfort, but after taking 10,000 mcg daily, the severe pain lessened remarkably. Now, I split my dosage and take 5,000 mcg twice a day.
Read More
9
Pain vanished
7 people found this helpful
After half a year of sciatica causing persistent back pain, I began taking B12 with vitamin D. Just three days in, the pain vanished! My feet have been numb for long, but I hope that will improve too. The tablets are easy to take, and I highly recommend trying them for nerve pain.
Read More
9
No more pain
5 people found this helpful
I purchased this for my husband who suffered from back pain while working on his feet. After taking the supplement, he felt revitalised and pain-free. The lozenge form makes it easy to take without water.
Read More
9
Effective for back pain
2 people found this helpful
I was referred to this for my husband who had a severe B12 deficiency affecting his haemoglobin and causing back pain. The ingredients are excellent, and he takes one tablet twice daily. They dissolve easily and taste pleasant. The effectiveness is commendable; he feels great and it's good value for money. I consider it one of the most essential vitamins.
Read More
Frequently Asked Questions
9
Pain vanished
7 people found this helpful
After half a year of sciatica causing persistent back pain, I began taking B12 with vitamin D. Just three days in, the pain vanished! My feet have been numb for long, but I hope that will improve too. The tablets are easy to take, and I highly recommend trying them for nerve pain.
6
Stiffness reduction
15 people found this helpful
I found this helpful! After taking one tablet twice daily, I noticed my back pain and stiffness significantly improved by the next morning. The clarity in my vision was also a nice bonus. I might not eat as much meat, so perhaps my B12 was lacking.
7.5
Pain relief
26 people found this helpful
Hebaden is improving! After experiencing back pain due to Heberden's nodules during menopause, I discovered that B12 is effective. I took one tablet under my tongue morning and evening. After about a month, the pain in my fingers diminished significantly. My pinky still hurts, but overall I'm feeling better and intend to keep using it.
6
Pain relief noticed
5 people found this helpful
I initially struggled to notice its effects. However, after continuing the B12 for about a week, my back pain significantly alleviated. Although I still have trouble sleeping, I believe it benefits my nervous system. It tastes nice enough to feel like a treat, so I'm considering repurchasing.
7.5
Compression no longer needed
10 people found this helpful
I suffered from sciatica which caused back pain and heaviness in my legs. After taking this product for about ten days, I no longer needed a compress. The dullness improved significantly, and my shoulders feel lighter as a result. This is a product I’d like to keep stocked!
7.5
Eased back pain
1 people found this helpful
Taking one of these each morning gives me energy and somehow alleviates my back pain. I previously suffered from anaemia and noted a decrease in fatigue as well. A package of 100 lozenges is a great size, and the inclusion of methylcobalamin instead of cyanocobalamin is advantageous. B12 also promotes relaxation, stabilises the nervous system, and aids in metabolism.
7.5
Stopped leg pain
1 people found this helpful
Combined with B-1 and B-6, this vitamin is excellent for my superficial nervous system. It has completely stopped the pain in my legs.
9
Back pain relief
18 people found this helpful
This product has been remarkable for my back pain. I initially took it for nerve perception but was surprised to find relief in my lumbar region. My sedentary job caused significant discomfort, but after taking 10,000 mcg daily, the severe pain lessened remarkably. Now, I split my dosage and take 5,000 mcg twice a day.
9
Resolved leg issues
1 people found this helpful
I experienced numbness in my leg, and after consulting my GP, I discovered I had a B12 deficiency. Since taking the vitamins, the issue has disappeared, and I truly believe they've restored my B12 levels and helped with my back pain.
9
We evaluated the effectiveness of intramuscular vitamin B12 in treating low back pain among 60 patients aged 18 to 65 with mechanical pain lasting at least six months.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
In this double-blind, placebo-controlled study, both groups showed improvement in pain levels. However, those receiving B12 had a more significant reduction in pain and dependence on pain medication compared to the placebo group.
Overall, B12 appears to be a safe option for alleviating low back pain, helping to reduce discomfort and medication use for those without nutritional deficiencies.
8
We conducted a study to examine whether combining diclofenac with B vitamins (B1, B6, and B12) would be more effective in treating back pain than diclofenac alone. In a double-blind trial with 418 patients, we found that those receiving the combination therapy had statistically significant improvements in pain relief, especially patients with severe pain initially.
Out of those treated with the combination, 53 achieved total relief within a week, compared to 48 patients on diclofenac alone. Importantly, both treatment groups reported similar side effects. This suggests that adding B vitamins may enhance pain management for back pain sufferers.
Out of those treated with the combination, 53 achieved total relief within a week, compared to 48 patients on diclofenac alone. Importantly, both treatment groups reported similar side effects. This suggests that adding B vitamins may enhance pain management for back pain sufferers.
8
We conducted a randomized, double-blind study to evaluate the effect of B vitamins alongside diclofenac on lumbago relief. Participants received either the combination of diclofenac and B1, B6, and B12 or diclofenac alone for up to seven days.
We found that a higher percentage of those receiving the vitamin combination reported significant pain relief compared to the diclofenac-only group after three days. Not only did the combination improve pain reduction, but it also enhanced mobility and functionality. Importantly, both treatments showed similar safety profiles.
We found that a higher percentage of those receiving the vitamin combination reported significant pain relief compared to the diclofenac-only group after three days. Not only did the combination improve pain reduction, but it also enhanced mobility and functionality. Importantly, both treatments showed similar safety profiles.
References
- He C, Li J, Hu W, Xiao B, Fan T, et al. Effects of dexamethasone combined with vitamin B12 on percutaneous endoscopic interlaminar discectomy early outcomes: a randomized controlled trial. J Orthop Surg Res. 2024;19:733. 10.1186/s13018-024-05210-z
- Mibielli MA, Geller M, Cohen JC, Goldberg SG, Cohen MT, et al. Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR study. Curr Med Res Opin. 2009;25:2589. 10.3111/13696990903246911
- Mauro GL, Martorana U, Cataldo P, Brancato G, Letizia G. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000;4:53.
- Brüggemann G, Koehler CO, Koch EM. [Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study]. Klin Wochenschr. 1990;68:116.
- Kuhlwein A, Meyer HJ, Koehler CO. [Reduced diclofenac administration by B vitamins: results of a randomized double-blind study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitamins) in acute lumbar vertebral syndromes]. Klin Wochenschr. 1990;68:107.
- Kunt T. [Complaints in the lumbosacral region and their management with Dolo-Neurobion]. Fortschr Med. 1978;96:299.
- Demko AW, Rustom DH. Progressive Decrease in Function and Ambulation Potential: A Case of Subacute Combined Degeneration. Cureus. 2024;16:e64027. 10.7759/cureus.64027
- Li QD, Yang JS, Gong HL, Wei JM, Wang XF, et al. Can Additional Facet Joint Block Improve the Clinical Outcome of Kyphoplasty for Acute Osteoporotic Vertebral Compression Fractures?. Pain Physician. 2021;24:283.
- Mibielli MAN, Nunes CP, Goldberg H, Buchman L, Oliveira L, et al. Nucleotides Cytidine and Uridine Associated with Vitamin B12 vs B-Complex Vitamins in the Treatment of Low Back Pain: The NUBES Study. J Pain Res. 2020;13:2531. 10.2147/JPR.S277024
- Yang JS, Liu KX, Chu L, Chan YK, Fan H, et al. Cocktail Treatment with a Gelatin Sponge Impregnated with Ropivacaine, Dexamethasone, and Vitamin B12 Promotes Early Postoperative Recovery after Percutaneous Endoscopic Lumbar Discectomy: A Retrospective, Case-Controlled Study. Pain Physician. 2020;23:E211.
- Buesing S, Costa M, Schilling JM, Moeller-Bertram T. Vitamin B12 as a Treatment for Pain. Pain Physician. 2019;22:E45.
- Huang ZF, Lin BQ, Torsha TT, Dilshad S, Yang DS, et al. Effect of Mannitol plus Vitamins B in the management of patients with piriformis syndrome. J Back Musculoskelet Rehabil. 2019;32:329. 10.3233/BMR-170983
- Zhang M, Han W, Hu S, Xu H. Methylcobalamin: a potential vitamin of pain killer. Neural Plast. 2013;2013:424651. 10.1155/2013/424651
- Chiu CK, Low TH, Tey YS, Singh VA, Shong HK. The efficacy and safety of intramuscular injections of methylcobalamin in patients with chronic nonspecific low back pain: a randomised controlled trial. Singapore Med J. 2011;52:868.
- Mibielli MA, Nunes CP, Cohen JC, Scussel AB, Higashi R, et al. Treatment of acute, non-traumatic pain using a combination of diclofenac-cholestyramine, uridine triphosphate, cytidine monophosphate, and hydroxycobalamin. Proc West Pharmacol Soc. 2010;53:5.
- Jurna I. [Analgesic and analgesia-potentiating action of B vitamins]. Schmerz. 1998;12:136.
- Vetter G, Brüggemann G, Lettko M, Schwieger G, Asbach H, et al. [Shortening diclofenac therapy by B vitamins. Results of a randomized double-blind study, diclofenac 50 mg versus diclofenac 50 mg plus B vitamins, in painful spinal diseases with degenerative changes]. Z Rheumatol. 1988;47:351.
