Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8.1
USERS' SCORE
Good
Based on 6 Reviews
8.9
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We examined a case involving a 56-year-old male who suffered from severe vitamin B12 deficiency. This deficiency led to dangerously high homocysteine levels, which are associated with blood clot formation. Despite effective treatment with B12, this case illustrates that vitamin deficiency can lead to significant health issues, including thrombosis and embolism.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
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8
We explored the relationship between nitrous oxide abuse and cerebral venous thrombosis in a 19-year-old female patient. After using nitrous oxide, her vitamin B12 levels dropped significantly, leading to increased homocysteine, a marker associated with clotting issues.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
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8
We explored a compelling case of pernicious anemia that led to a rare presentation of disseminated intravascular coagulation (DIC). The patient, a 63-year-old woman, faced severe anemia and a significant vitamin B12 deficiency.
After diagnosis, she received daily vitamin B12 injections which significantly improved her blood counts and overall health.
This case highlights the importance of early detection and treatment of vitamin B12 deficiency in preventing serious complications like DIC.
After diagnosis, she received daily vitamin B12 injections which significantly improved her blood counts and overall health.
This case highlights the importance of early detection and treatment of vitamin B12 deficiency in preventing serious complications like DIC.
Read More
Most Useful Reviews
9.5
No more numbness
This is not just help; it’s a solution. My hands were occasionally numb, so the therapist sent me for a blood test for vitamin B12, which was low. After a month of taking the prescribed biological supplement, the problem disappeared and has not returned for half a year.
Read More
9.5
Increased vitamin levels
After reading reviews, I chose this vitamin. It dissolves under the tongue and left a sweet-sour taste. I finished the entire package and saw an increase in my blood vitamin levels after a month. This product definitely aids in treatment.
Read More
10
Amazing results
My son struggled to raise his B12 levels due to coeliac disease and chemical sensitivities. After taking this vitamin for a month, his levels soared from 240 to 1,300, which amazed the doctor. I give it a perfect rating!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 20 Researches
8.1
- All Researches
9
This case report examined a 14-year-old girl who experienced cerebral venous thrombosis alongside high homocysteine levels due to a unique genetic mutation at the MTHFR locus.
After beginning treatment with anticoagulants and supplements, including vitamins B12, folate, and B6, we observed significant improvements. Within a month, her headaches vanished, her intracranial pressure dropped, and there was notable shrinkage of the blood clot.
Overall, this implies that proper treatment, including B12, may positively influence recovery in similar cases.
After beginning treatment with anticoagulants and supplements, including vitamins B12, folate, and B6, we observed significant improvements. Within a month, her headaches vanished, her intracranial pressure dropped, and there was notable shrinkage of the blood clot.
Overall, this implies that proper treatment, including B12, may positively influence recovery in similar cases.
Read More
9
We explored a unique case involving a 49-year-old woman who experienced postprandial hypoglycemia following Roux-en-Y gastric bypass surgery. While hypoglycemia is uncommon, her medical history of mesenteric thrombosis and prior anticoagulation treatment contributed to her condition.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
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9
We explored how elevated homocysteine levels, termed hyperhomocysteinemia (HHcy), impact patients with acute brain injuries in neurocritical care. Our systematic review of 33 studies revealed that HHcy is an independent risk factor for various brain injuries and a marker of poor prognosis.
Importantly, we noticed that B vitamins, particularly B12, along with folic acid and B6, play a potential role in mitigating the risk of thrombosis and other complications in these patients. However, the direct effectiveness of B12 treatment on blood clotting in the context of HHcy remains an area for further investigation.
Importantly, we noticed that B vitamins, particularly B12, along with folic acid and B6, play a potential role in mitigating the risk of thrombosis and other complications in these patients. However, the direct effectiveness of B12 treatment on blood clotting in the context of HHcy remains an area for further investigation.
Read More
9
We examined a fascinating case involving a 25-year-old male who experienced severe headaches and vertigo due to cerebral venous thrombosis (CVT). This unique situation arose after the patient had been abusing nitrous oxide, leading to a vitamin B12 deficiency.
After arriving at the hospital, he underwent a set of examinations which raised suspicions of a cerebrovascular accident. A CT scan and subsequent MRI confirmed the presence of clotting in the brain’s venous structures. His unusually high levels of homocysteine and low vitamin B12 pointed directly to a deficiency as a contributing factor to the blood clot.
Treatment for the patient included vitamin B12 supplementation alongside anticoagulants. Remarkably, within just a week, we saw significant improvement in his symptoms. This case underscores the potential importance of vitamin B12 in managing conditions associated with blood clotting, especially in individuals with deficiencies.
While vitamin B12 treatment was part of the regimen, it’s crucial to note that it was not administered in isolation but rather alongside other medications. This complicates our ability to draw definitive conclusions about its individual effectiveness in this specific scenario.
After arriving at the hospital, he underwent a set of examinations which raised suspicions of a cerebrovascular accident. A CT scan and subsequent MRI confirmed the presence of clotting in the brain’s venous structures. His unusually high levels of homocysteine and low vitamin B12 pointed directly to a deficiency as a contributing factor to the blood clot.
Treatment for the patient included vitamin B12 supplementation alongside anticoagulants. Remarkably, within just a week, we saw significant improvement in his symptoms. This case underscores the potential importance of vitamin B12 in managing conditions associated with blood clotting, especially in individuals with deficiencies.
While vitamin B12 treatment was part of the regimen, it’s crucial to note that it was not administered in isolation but rather alongside other medications. This complicates our ability to draw definitive conclusions about its individual effectiveness in this specific scenario.
Read More
9
Vitamin B12 and blood clot relationship
We explored a case involving cerebral venous thrombosis (CVT) coinciding with hyperhomocysteinemia and iron-deficiency anemia, a condition attributed to autoimmune gastritis. The patient, a 47-year-old woman, presented with various symptoms including impaired movement and consciousness. Imaging tests revealed significant brain swelling and clot formations in the venous sinuses.
During the assessment, we noted that the patient suffered from anemia and elevated levels of homocysteine, both contributing factors to the development of blood clots. Interestingly, she also tested positive for intrinsic factor antibodies, leading to the diagnosis of autoimmune gastritis, which further compounded her condition.
Treatment for the patient included anticoagulants, as well as the replacement of iron and vitamin B12. Although the treatment approach effectively alleviated her symptoms and allowed for recovery without neurological deficits, it was difficult to isolate the specific impact of vitamin B12 on blood clot resolution since it was administered alongside other therapies.
Ultimately, while the combination of treatments was beneficial, the study does not provide clear evidence that vitamin B12 alone significantly contributes to the prevention or treatment of blood clots.
During the assessment, we noted that the patient suffered from anemia and elevated levels of homocysteine, both contributing factors to the development of blood clots. Interestingly, she also tested positive for intrinsic factor antibodies, leading to the diagnosis of autoimmune gastritis, which further compounded her condition.
Treatment for the patient included anticoagulants, as well as the replacement of iron and vitamin B12. Although the treatment approach effectively alleviated her symptoms and allowed for recovery without neurological deficits, it was difficult to isolate the specific impact of vitamin B12 on blood clot resolution since it was administered alongside other therapies.
Ultimately, while the combination of treatments was beneficial, the study does not provide clear evidence that vitamin B12 alone significantly contributes to the prevention or treatment of blood clots.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.9
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
No more numbness
This is not just help; it’s a solution. My hands were occasionally numb, so the therapist sent me for a blood test for vitamin B12, which was low. After a month of taking the prescribed biological supplement, the problem disappeared and has not returned for half a year.
Read More
9.5
Increased vitamin levels
After reading reviews, I chose this vitamin. It dissolves under the tongue and left a sweet-sour taste. I finished the entire package and saw an increase in my blood vitamin levels after a month. This product definitely aids in treatment.
Read More
10
Amazing results
My son struggled to raise his B12 levels due to coeliac disease and chemical sensitivities. After taking this vitamin for a month, his levels soared from 240 to 1,300, which amazed the doctor. I give it a perfect rating!
Read More
9.5
Restored sensation
I had numbness in parts of my leg, but after consulting my GP and finding a B12 deficiency, I took these vitamins. After using them, normal sensation returned to my leg. I genuinely believe the vitamins restored my health.
Read More
8.8
Improved blood flow
I’m over 40 and have a blocked blood vessel in my right foot, leading to varicose veins and discomfort. A therapist advised me to take vitamin B12. After six months of one pill morning and night, I feel much healthier, and my feet are back to normal.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Bizouard T, Caplette C, Duval D, Savary D, Douillet D. Right iliac deep vein thrombosis and pulmonary embolism associated with recreational nitrous oxide: a case report. Int J Emerg Med. 2024;17:169. doi:10.1186/s12245-024-00689-z
- Turcu-Stiolica A, Naidin MS, Halmagean S, Ionescu AM, Pirici I. The Impact of the Dietary Intake of Vitamin B12, Folic Acid, and Vitamin D3 on Homocysteine Levels and the Health-Related Quality of Life of Levodopa-Treated Patients with Parkinson's Disease-A Pilot Study in Romania. Diagnostics (Basel). 2024;14. doi:10.3390/diagnostics14151609
- Baby N, George M, Rajasekharan A, Ajith S, Zabeer M, et al. Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification. Ann Afr Med. 2024;23:496. doi:10.4103/aam.aam_138_23
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. doi:10.7759/cureus.58601
- Khaliq L, Kabir KF, Pyai K, Hadid T, Collins-Hamel B. A Simple Vitamin Deficiency With Life-Threatening Complications: A Case of B12 Deficiency and Hyperhomocysteinemia-Induced Thrombosis. Cureus. 2023;15:e42908. doi:10.7759/cureus.42908
- Banjongjit A, Sutamnartpong P, Mahanupap P, Phanachet P, Thanakitcharu S. Nitrous Oxide-Induced Cerebral Venous Thrombosis: A Case Report, Potential Mechanisms, and Literature Review. Cureus. 2023;15:e41428. doi:10.7759/cureus.41428
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. doi:10.1186/s12883-023-03200-y
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. doi:10.3892/mi.2022.45
- Coelho T, Freitas A, Carmona Alexandrino H, Pinto S. Roux-en-Y Gastric Bypass Surgery Leading to Postprandial Hypoglycemia: A Case Report. Cureus. 2022;14:e32265. doi:10.7759/cureus.32265
- Mochizuki T, Ryu B, Kushi K, Shima S, Sato S, et al. Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review. Neuroradiol J. 2023;36:491. doi:10.1177/19714009221147224
- Aboona MB, Rapaich L, Etman A, Thomas SW. A Rare Presentation of Pernicious Anemia Manifesting as Disseminated Intravascular Coagulation. J Med Cases. 2022;13:557. doi:10.14740/jmc4020
- Lauretta MP, Melotti RM, Sangermano C, George AM, Badenes R, et al. Homocysteine Plasmatic Concentration in Brain-Injured Neurocritical Care Patients: Systematic Review of Clinical Evidence. J Clin Med. 2022;11. doi:10.3390/jcm11020394
- Mohamed Yile MEH, Berteau E, Ramdani N, Mouyen T, Ferrier N. Uncommon Thromboembolic Events in Young Adults: A Rare Cause Uncovered. Cureus. 2025;17:e76962. doi:10.7759/cureus.76962
- Baby N, George M, Rajasekharan A, Ajith S, Zabeer M, et al. Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification. Ann Afr Med. 2024;23:496. doi:10.4103/aam.aam_138_23
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. doi:10.7759/cureus.58601
- Khaliq L, Kabir KF, Pyai K, Hadid T, Collins-Hamel B. A Simple Vitamin Deficiency With Life-Threatening Complications: A Case of B12 Deficiency and Hyperhomocysteinemia-Induced Thrombosis. Cureus. 2023;15:e42908. doi:10.7759/cureus.42908
- Banjongjit A, Sutamnartpong P, Mahanupap P, Phanachet P, Thanakitcharu S. Nitrous Oxide-Induced Cerebral Venous Thrombosis: A Case Report, Potential Mechanisms, and Literature Review. Cureus. 2023;15:e41428. doi:10.7759/cureus.41428
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. doi:10.3892/mi.2022.45
- Mochizuki T, Ryu B, Kushi K, Shima S, Sato S, et al. Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review. Neuroradiol J. 2023;36:491. doi:10.1177/19714009221147224
- Landry I, Chowdhury T, Hussein S, Thomas L. Life-Threatening Microangiopathy or Vitamin Deficiency: A Case Report of the Clinical Manifestations of Pseudo-Thrombotic Microangiopathic Anemia. Cureus. 2021;13:e20228. doi:10.7759/cureus.20228
