Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.2
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.6
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Read More
8
We investigated how a mixture of vitamins B6, B9, and B12 (VITB) affects heart health in mice with Marfan syndrome. Over 20 weeks, VITB treatment led to reduced heart rate and smaller aorta size in these mice. Notably, VITB helped restore important gene expressions and improved TGF-β signaling, which is crucial for collagen maturation in the aorta. While this study shows promise for VITB in managing heart disease related to Marfan syndrome, further research is needed to confirm its efficacy in humans.
Read More
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
Read More
Most Useful Reviews
9
Essential daily intake
6 people found this helpful
Everyone needs vitamin B12 daily, as it supports numerous body functions. Symptoms of deficiency include fatigue and heart problems. I prefer Now Foods Methyl B-12 for its taste and effectiveness, especially since I avoid animal products.
Read More
9
Supports heart health
2 people found this helpful
I sought an effective way to support my energy and nervous system, and this vitamin B12 is perfect. The methylcobalamin boosts my energy levels, supports nerve health, and is easily absorbed. It also helps maintain metabolism and reduces homocysteine, important for heart disease. Its antioxidant properties support overall health, and regular use enhances my mood and well-being.
Read More
7.5
Aids nerve health
9 people found this helpful
Methylcobalamin is better absorbed than cyanocobalamin and aids in nerve regeneration, benefiting conditions like Alzheimer's and Parkinson's. At 1000mcg, the dosage is safe and effective. The tablets are small and sweet, designed to melt in your mouth.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 10 Researches
6.2
- All Researches
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Read More
8
We investigated how cow’s milk intake influences the risk of coronary heart disease (CHD) in postmenopausal women. Analyzing data from the Korea National Health and Nutrition Examination Survey, we included 1,825 women aged 50–64.
Our findings indicated that those consuming cow’s milk more frequently (more than three times a week) had better levels of HDL cholesterol and lower CHD risk factors compared to those who did not consume milk.
This suggests that regular cow’s milk consumption could be beneficial for heart health in this group.
Our findings indicated that those consuming cow’s milk more frequently (more than three times a week) had better levels of HDL cholesterol and lower CHD risk factors compared to those who did not consume milk.
This suggests that regular cow’s milk consumption could be beneficial for heart health in this group.
Read More
8
We investigated how a mixture of vitamins B6, B9, and B12 (VITB) affects heart health in mice with Marfan syndrome. Over 20 weeks, VITB treatment led to reduced heart rate and smaller aorta size in these mice. Notably, VITB helped restore important gene expressions and improved TGF-β signaling, which is crucial for collagen maturation in the aorta. While this study shows promise for VITB in managing heart disease related to Marfan syndrome, further research is needed to confirm its efficacy in humans.
Read More
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
Read More
7
B-vitamins reduce mortality risk
We explored how using calcium channel blockers (CCBs) affects survival in patients with suspected stable angina and the potential role of B-vitamin treatment. A study with nearly 4,000 patients found that those who used CCBs without receiving B-vitamins had a higher mortality risk.
Conversely, patients treated with B-vitamins showed no significant increase in mortality rates related to CCB use. This suggests that B-vitamins may offer protective benefits for heart health, particularly for those on CCBs.
Conversely, patients treated with B-vitamins showed no significant increase in mortality rates related to CCB use. This suggests that B-vitamins may offer protective benefits for heart health, particularly for those on CCBs.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Essential daily intake
6 people found this helpful
Everyone needs vitamin B12 daily, as it supports numerous body functions. Symptoms of deficiency include fatigue and heart problems. I prefer Now Foods Methyl B-12 for its taste and effectiveness, especially since I avoid animal products.
Read More
9
Supports heart health
2 people found this helpful
I sought an effective way to support my energy and nervous system, and this vitamin B12 is perfect. The methylcobalamin boosts my energy levels, supports nerve health, and is easily absorbed. It also helps maintain metabolism and reduces homocysteine, important for heart disease. Its antioxidant properties support overall health, and regular use enhances my mood and well-being.
Read More
7.5
Aids nerve health
9 people found this helpful
Methylcobalamin is better absorbed than cyanocobalamin and aids in nerve regeneration, benefiting conditions like Alzheimer's and Parkinson's. At 1000mcg, the dosage is safe and effective. The tablets are small and sweet, designed to melt in your mouth.
Read More
10
Relieves pain
8 people found this helpful
I experienced bone pain and fatigue from vitamin deficiency. After taking B-12, my condition improved significantly.
Read More
7.5
Boosts energy levels
3 people found this helpful
I appreciate the easy absorption and energy boost from this vitamin. Methyl cobalamin is more effectively absorbed, aiding energy production and maintaining vital DNA functions, which can help prevent heart disease.
Read More
Frequently Asked Questions
7.5
Reduces heart palpitations
Taking B12 has helped lessen heart palpitations and the discomfort of irregular heartbeats.
9
Supports heart health
2 people found this helpful
I sought an effective way to support my energy and nervous system, and this vitamin B12 is perfect. The methylcobalamin boosts my energy levels, supports nerve health, and is easily absorbed. It also helps maintain metabolism and reduces homocysteine, important for heart disease. Its antioxidant properties support overall health, and regular use enhances my mood and well-being.
6
Improves sleep quality
1 people found this helpful
NOW Foods Methyl B-12 has many benefits, including aiding red blood cell formation and improving sleep. I took it for high homocysteine levels, and it has greatly assisted in preventing heart disease.
7.5
Boosts energy levels
3 people found this helpful
I appreciate the easy absorption and energy boost from this vitamin. Methyl cobalamin is more effectively absorbed, aiding energy production and maintaining vital DNA functions, which can help prevent heart disease.
7.5
Reduces hypertension
6 people found this helpful
The product arrived quickly. B-12 tablets are small and easy to use. B-12 plays an essential role in metabolic processes, including reducing homocysteine levels, which can lead to hypertension and heart failure if deficient.
10
Relieves pain
8 people found this helpful
I experienced bone pain and fatigue from vitamin deficiency. After taking B-12, my condition improved significantly.
8
Improves sleep quality
It has improved my hand numbness, aided red blood cell formation, benefitted my nervous system and helped with stress resistance. I've noted better sleep, increased metabolism, and a lower risk of heart disease.
6
Supports heart health
25 people found this helpful
I trust Now Foods, so I chose their B-12. The price is low, and the cherry-flavoured tablets are enjoyable. B-12 lowers homocysteine levels and collaborates with folic acid for heart disease prevention.
7.5
Reduces heart risks
Vitamin B12, or cobalamin, is crucial for metabolic processes. It lowers homocysteine levels, which protects against heart disease and is vital for blood cell formation and nervous system function. The product has reliable quality.
7.5
Aids nerve health
9 people found this helpful
Methylcobalamin is better absorbed than cyanocobalamin and aids in nerve regeneration, benefiting conditions like Alzheimer's and Parkinson's. At 1000mcg, the dosage is safe and effective. The tablets are small and sweet, designed to melt in your mouth.
7
Vitamin B12 may lower inflammation
We examined how vitamin B12 levels relate to heart disease risk by looking at inflammatory markers in 136 individuals at high risk. Our findings revealed that those with higher vitamin B12 had lower levels of IL-6 and CRP, both linked to inflammation.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
To further validate our results, we studied aged mice and found similar trends. While these observations suggest vitamin B12 might help reduce inflammation, we indicate that further research is needed to fully understand its role in heart disease.
8
We explored the potential of high doses of vitamin B12 to protect against heart damage caused by ischemia/reperfusion injury. By researching mice subjected to heart injury, we found that vitamin B12 showed promising effects in reducing oxidative stress and improving heart function.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
Our findings suggest that this vitamin works through specific pathways that lessen inflammation and cell death in heart tissue. However, more studies are needed to fully understand its therapeutic value in treating heart disease.
5
We explored the relationship between serum levels of vitamin B12 and folate and cardiovascular disease (CVD) mortality in patients with type 2 diabetes. This large study analyzed data from over 8,000 individuals to identify risks associated with different levels of these vitamins.
Our findings showed that both low and high levels of vitamin B12, along with low folate, were linked to a higher chance of dying from heart disease. This suggests a complex role of these vitamins in heart health for those with diabetes.
Our findings showed that both low and high levels of vitamin B12, along with low folate, were linked to a higher chance of dying from heart disease. This suggests a complex role of these vitamins in heart health for those with diabetes.
4
Vitamin B12 deficiency and heart disease
We explored a unique case involving a young man diagnosed with Cobalamin C deficiency, a rare genetic condition affecting vitamin B12 metabolism. This condition can lead to serious health issues, including structural heart defects and severe heart failure.
Throughout his life, the patient received multiple treatments for his deficiency, including vitamin B12 supplements. However, he eventually developed severe heart failure due to dilated cardiomyopathy. Despite earlier improvements from medical treatments, his heart condition worsened, requiring advanced interventions such as a left ventricular assist device (LVAD) and ultimately a heart transplant.
Although vitamin B12 played a role in his overall treatment regime, the real focus was on managing his severe heart failure through these significant medical interventions. This case, unprecedented in its combination of LVAD implantation and heart transplant for someone with Cobalamin C deficiency, demonstrates that while vitamin B12 is essential, it is the advanced cardiac procedures that addressed the dire heart condition effectively.
In short, while vitamin B12 may improve symptoms of deficiency, advanced heart failure requires intensive medical strategies that go beyond vitamin supplementation alone.
Throughout his life, the patient received multiple treatments for his deficiency, including vitamin B12 supplements. However, he eventually developed severe heart failure due to dilated cardiomyopathy. Despite earlier improvements from medical treatments, his heart condition worsened, requiring advanced interventions such as a left ventricular assist device (LVAD) and ultimately a heart transplant.
Although vitamin B12 played a role in his overall treatment regime, the real focus was on managing his severe heart failure through these significant medical interventions. This case, unprecedented in its combination of LVAD implantation and heart transplant for someone with Cobalamin C deficiency, demonstrates that while vitamin B12 is essential, it is the advanced cardiac procedures that addressed the dire heart condition effectively.
In short, while vitamin B12 may improve symptoms of deficiency, advanced heart failure requires intensive medical strategies that go beyond vitamin supplementation alone.
References
- Chen B, Wang C, Li W. Genetic insights into the effect of trace elements on cardiovascular diseases: multi-omics Mendelian randomization combined with linkage disequilibrium score regression analysis. Front Immunol. 2024;15:1459465. 10.3389/fimmu.2024.1459465
- Domínguez-López I, Kovatcheva M, Casas R, Toledo E, Fitó M, et al. Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice. J Sci Food Agric. 2024;104:875. 10.1002/jsfa.12976
- Qin Y, Shi Y, Yu Q, Yang S, Wang Y, et al. Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Biomed Pharmacother. 2023;163:114761. 10.1016/j.biopha.2023.114761
- Dhar I, Svingen GF, Bjørnestad EØ, Ulvik A, Saeed S, et al. B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study. Am J Clin Nutr. 2023;118:77. 10.1016/j.ajcnut.2023.04.033
- Ha AW, Kim WK, Kim SH. Cow's Milk Intake and Risk of Coronary Heart Disease in Korean Postmenopausal Women. Nutrients. 2022;14. 10.3390/nu14051092
- Liu Y, Geng T, Wan Z, Lu Q, Zhang X, et al. Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes. JAMA Netw Open. 2022;5:e2146124. 10.1001/jamanetworkopen.2021.46124
- Huang TH, Chang HH, Guo YR, Chang WC, Chen YF. Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway. Int J Mol Sci. 2021;22. 10.3390/ijms222111737
- Aggarwal P, Sinha SK, Khanra D, Razi M, Nath RK, et al. Hematinic deficiency in patients with heart failure with reduced ejection fraction (HFrEF). Ann Cardiol Angeiol (Paris). 2022;71:153. 10.1016/j.ancard.2021.09.014
- Hjalmarsson C, Backelin C, Thoren A, Bergh N, Sloan JL, et al. Severe heart failure in a unique case of cobalamin-C-deficiency resolved with LVAD implantation and subsequent heart transplantation. Mol Genet Metab Rep. 2024;39:101089. 10.1016/j.ymgmr.2024.101089
- Mohan A, Kumar R, Kumar V, Yadav M. Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders. Curr Cardiol Rev. 2023;19:e090223213539. 10.2174/1573403X19666230209111854
