Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.4
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
9
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Read More
9
Methylcobalamin improves nerve myelination
We delved into the effects of methylcobalamin, a form of vitamin B12, on nerve myelination in rats suffering from moderate hepatic encephalopathy, a condition caused by ammonia toxicity due to liver dysfunction. In our study, we established a model of hepatic encephalopathy by administering thioacetamide to induce liver damage, subsequently leading to changes in nerve myelination in specific brain regions.
We focused on the hippocampus, an area crucial for memory and learning, where we noted significant reductions in myelin levels and myelin basic protein (MBP) quantities in the affected rats. However, after administering methylcobalamin for a week, we observed a remarkable recovery in the myelination status, alongside normalized levels of harmful homocysteine, which is regulated by the enzyme methionine synthase that methylcobalamin helps activate.
Our findings suggest that methylcobalamin effectively restores nerve myelination in the context of liver disease by addressing underlying biochemical changes. The treatment not only improved myelination but also showed promise in restoring neurobehavioral functions in the rats. This research indicates a potential therapeutic role for vitamin B12 in managing liver-related nerve damage, making it worth further exploration in human studies.
We focused on the hippocampus, an area crucial for memory and learning, where we noted significant reductions in myelin levels and myelin basic protein (MBP) quantities in the affected rats. However, after administering methylcobalamin for a week, we observed a remarkable recovery in the myelination status, alongside normalized levels of harmful homocysteine, which is regulated by the enzyme methionine synthase that methylcobalamin helps activate.
Our findings suggest that methylcobalamin effectively restores nerve myelination in the context of liver disease by addressing underlying biochemical changes. The treatment not only improved myelination but also showed promise in restoring neurobehavioral functions in the rats. This research indicates a potential therapeutic role for vitamin B12 in managing liver-related nerve damage, making it worth further exploration in human studies.
Read More
9
We explored the intriguing question of whether vitamin B12 can provide a protective effect against liver damage caused by acetaminophen, a common painkiller known for its potential hepatotoxicity. In our study, we used male Wister rats and organized them into three groups: one receiving acetaminophen, another treated with vitamin B12, and a control group given distilled water. Each group was administered their respective treatments for a week before we evaluated their liver health.
Our findings indicate that vitamin B12 supplementation significantly improved hepatic health in the rats exposed to acetaminophen. We observed a notable reduction in liver enzyme levels, which is a key marker of liver damage. Additionally, vitamin B12 helped boost antioxidant levels in the body, compensated for a decline in tissue glutathione, and reduced harmful inflammatory markers such as TNF-α and interleukin-6.
Overall, the results of our study suggest that vitamin B12 effectively mitigates acetaminophen-induced liver toxicity by enhancing liver function and reducing inflammation. This insight opens up interesting avenues for considering vitamin B12 as a supportive treatment in managing liver health in cases of acetaminophen exposure.
Our findings indicate that vitamin B12 supplementation significantly improved hepatic health in the rats exposed to acetaminophen. We observed a notable reduction in liver enzyme levels, which is a key marker of liver damage. Additionally, vitamin B12 helped boost antioxidant levels in the body, compensated for a decline in tissue glutathione, and reduced harmful inflammatory markers such as TNF-α and interleukin-6.
Overall, the results of our study suggest that vitamin B12 effectively mitigates acetaminophen-induced liver toxicity by enhancing liver function and reducing inflammation. This insight opens up interesting avenues for considering vitamin B12 as a supportive treatment in managing liver health in cases of acetaminophen exposure.
Read More
Most Useful Reviews
9
Supports liver health
9 people found this helpful
Methylcobalamin, a natural form of vitamin B12, is better absorbed and retained in the body compared to synthetic cyanocobalamin. It aids in neuronal lipid production, nerve regeneration, and has properties that help with conditions like Alzheimer's and liver disease. At 1000mcg, the dose is safe and effective as any excess is excreted. The small, sweet tablets should be kept in the mouth until they melt for optimal absorption.
Read More
9
Aids liver function
8 people found this helpful
I highly recommend this form of B12, especially for those with methylation issues like myself. My body doesn't absorb regular B12 due to a genetic condition, so methyl-B12 is essential for me. This brand is effective and helps reduce leg pains, and regulates my sugar and cholesterol levels which is crucial for avoiding liver disease.
Read More
7.5
Supports liver function
Vitamin B12 (methylcobalamin) is vital for energy metabolism and many biological processes. It is easily absorbed and supports both cardiovascular and nervous health. It may alleviate pain associated with peripheral nerve diseases and likewise has a beneficial impact on liver function, particularly in cases of liver disease.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.7
- All Researches
9
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Read More
9
Methylcobalamin improves nerve myelination
We delved into the effects of methylcobalamin, a form of vitamin B12, on nerve myelination in rats suffering from moderate hepatic encephalopathy, a condition caused by ammonia toxicity due to liver dysfunction. In our study, we established a model of hepatic encephalopathy by administering thioacetamide to induce liver damage, subsequently leading to changes in nerve myelination in specific brain regions.
We focused on the hippocampus, an area crucial for memory and learning, where we noted significant reductions in myelin levels and myelin basic protein (MBP) quantities in the affected rats. However, after administering methylcobalamin for a week, we observed a remarkable recovery in the myelination status, alongside normalized levels of harmful homocysteine, which is regulated by the enzyme methionine synthase that methylcobalamin helps activate.
Our findings suggest that methylcobalamin effectively restores nerve myelination in the context of liver disease by addressing underlying biochemical changes. The treatment not only improved myelination but also showed promise in restoring neurobehavioral functions in the rats. This research indicates a potential therapeutic role for vitamin B12 in managing liver-related nerve damage, making it worth further exploration in human studies.
We focused on the hippocampus, an area crucial for memory and learning, where we noted significant reductions in myelin levels and myelin basic protein (MBP) quantities in the affected rats. However, after administering methylcobalamin for a week, we observed a remarkable recovery in the myelination status, alongside normalized levels of harmful homocysteine, which is regulated by the enzyme methionine synthase that methylcobalamin helps activate.
Our findings suggest that methylcobalamin effectively restores nerve myelination in the context of liver disease by addressing underlying biochemical changes. The treatment not only improved myelination but also showed promise in restoring neurobehavioral functions in the rats. This research indicates a potential therapeutic role for vitamin B12 in managing liver-related nerve damage, making it worth further exploration in human studies.
Read More
9
We explored the intriguing question of whether vitamin B12 can provide a protective effect against liver damage caused by acetaminophen, a common painkiller known for its potential hepatotoxicity. In our study, we used male Wister rats and organized them into three groups: one receiving acetaminophen, another treated with vitamin B12, and a control group given distilled water. Each group was administered their respective treatments for a week before we evaluated their liver health.
Our findings indicate that vitamin B12 supplementation significantly improved hepatic health in the rats exposed to acetaminophen. We observed a notable reduction in liver enzyme levels, which is a key marker of liver damage. Additionally, vitamin B12 helped boost antioxidant levels in the body, compensated for a decline in tissue glutathione, and reduced harmful inflammatory markers such as TNF-α and interleukin-6.
Overall, the results of our study suggest that vitamin B12 effectively mitigates acetaminophen-induced liver toxicity by enhancing liver function and reducing inflammation. This insight opens up interesting avenues for considering vitamin B12 as a supportive treatment in managing liver health in cases of acetaminophen exposure.
Our findings indicate that vitamin B12 supplementation significantly improved hepatic health in the rats exposed to acetaminophen. We observed a notable reduction in liver enzyme levels, which is a key marker of liver damage. Additionally, vitamin B12 helped boost antioxidant levels in the body, compensated for a decline in tissue glutathione, and reduced harmful inflammatory markers such as TNF-α and interleukin-6.
Overall, the results of our study suggest that vitamin B12 effectively mitigates acetaminophen-induced liver toxicity by enhancing liver function and reducing inflammation. This insight opens up interesting avenues for considering vitamin B12 as a supportive treatment in managing liver health in cases of acetaminophen exposure.
Read More
8
We aimed to understand how vitamin B12 impacts the risk of developing nonalcoholic fatty liver disease (NAFLD). In this study, we used a method called Mendelian randomization, utilizing genetic data as a tool to draw connections between circulating nutrient levels and liver health. By analyzing information from a large group of participants—8434 cases of NAFLD and 770,180 controls—we sought to uncover any potential causal relationships.
Our findings indicated that higher levels of vitamin B12 were associated with a slight increase in the risk of developing NAFLD. Specifically, we observed an odds ratio of 1.08, suggesting that genetic predispositions linked to higher vitamin B12 levels could elevate NAFLD risk. However, it's important to note that this increase may not translate into beneficial effects for liver health as we initially hoped.
Despite thorough sensitivity analyses, the connection we discovered raises questions about the role of vitamin B12 in liver disease, warranting further exploration into its biological mechanisms. The implications of these findings challenge preconceived notions about vitamin B12 and highlight the complexities of nutrient interactions with liver health.
Our findings indicated that higher levels of vitamin B12 were associated with a slight increase in the risk of developing NAFLD. Specifically, we observed an odds ratio of 1.08, suggesting that genetic predispositions linked to higher vitamin B12 levels could elevate NAFLD risk. However, it's important to note that this increase may not translate into beneficial effects for liver health as we initially hoped.
Despite thorough sensitivity analyses, the connection we discovered raises questions about the role of vitamin B12 in liver disease, warranting further exploration into its biological mechanisms. The implications of these findings challenge preconceived notions about vitamin B12 and highlight the complexities of nutrient interactions with liver health.
Read More
We conducted a study to explore the potential benefits of vitamin B12 for liver health in the context of Trypanosoma brucei rhodesiense infection, which causes Human African Trypanosomiasis. Mice were divided into groups, with some receiving vitamin B12 either before or after the infection.
Our findings indicate that vitamin B12 significantly improved the survival rates of infected mice and alleviated liver damage indicators. Specifically, we observed reductions in liver enzymes like alanine aminotransferase and aspartate aminotransferase, which are often elevated in liver disease.
Furthermore, vitamin B12 also lowered levels of total bilirubin and other markers associated with kidney damage. This shows that vitamin B12 not only plays a role in protecting liver functions but also addresses broader health concerns caused by the T.b.r infection.
Overall, our results suggest that vitamin B12 may be a valuable adjunct therapy for managing severe stages of Human African Trypanosomiasis, particularly concerning its protective effects on the liver.
Our findings indicate that vitamin B12 significantly improved the survival rates of infected mice and alleviated liver damage indicators. Specifically, we observed reductions in liver enzymes like alanine aminotransferase and aspartate aminotransferase, which are often elevated in liver disease.
Furthermore, vitamin B12 also lowered levels of total bilirubin and other markers associated with kidney damage. This shows that vitamin B12 not only plays a role in protecting liver functions but also addresses broader health concerns caused by the T.b.r infection.
Overall, our results suggest that vitamin B12 may be a valuable adjunct therapy for managing severe stages of Human African Trypanosomiasis, particularly concerning its protective effects on the liver.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports liver health
9 people found this helpful
Methylcobalamin, a natural form of vitamin B12, is better absorbed and retained in the body compared to synthetic cyanocobalamin. It aids in neuronal lipid production, nerve regeneration, and has properties that help with conditions like Alzheimer's and liver disease. At 1000mcg, the dose is safe and effective as any excess is excreted. The small, sweet tablets should be kept in the mouth until they melt for optimal absorption.
Read More
9
Aids liver function
8 people found this helpful
I highly recommend this form of B12, especially for those with methylation issues like myself. My body doesn't absorb regular B12 due to a genetic condition, so methyl-B12 is essential for me. This brand is effective and helps reduce leg pains, and regulates my sugar and cholesterol levels which is crucial for avoiding liver disease.
Read More
7.5
Supports liver function
Vitamin B12 (methylcobalamin) is vital for energy metabolism and many biological processes. It is easily absorbed and supports both cardiovascular and nervous health. It may alleviate pain associated with peripheral nerve diseases and likewise has a beneficial impact on liver function, particularly in cases of liver disease.
Read More
7.5
Potential liver benefits
1 people found this helpful
I believe this product can help prevent vascular diseases, particularly as I struggle with high blood pressure and cholesterol, which could lead to liver disease.
Read More
7.5
Improves liver health
1 people found this helpful
I am very satisfied with NOW Foods Methyl B-12. This active form of B12 is crucial for human health as it cannot be produced by the body. It also aids in reducing homocysteine levels, which can cause cardiovascular issues and liver disease. I noticed a positive effect in managing my health with this product.
Read More
Frequently Asked Questions
7.5
Supports liver function
Vitamin B12 (methylcobalamin) is vital for energy metabolism and many biological processes. It is easily absorbed and supports both cardiovascular and nervous health. It may alleviate pain associated with peripheral nerve diseases and likewise has a beneficial impact on liver function, particularly in cases of liver disease.
7.5
Improves liver health
1 people found this helpful
I am very satisfied with NOW Foods Methyl B-12. This active form of B12 is crucial for human health as it cannot be produced by the body. It also aids in reducing homocysteine levels, which can cause cardiovascular issues and liver disease. I noticed a positive effect in managing my health with this product.
9
Aids liver function
8 people found this helpful
I highly recommend this form of B12, especially for those with methylation issues like myself. My body doesn't absorb regular B12 due to a genetic condition, so methyl-B12 is essential for me. This brand is effective and helps reduce leg pains, and regulates my sugar and cholesterol levels which is crucial for avoiding liver disease.
7.5
Promotes liver health
It helps with hand numbness, supports red blood cell formation, and improves nervous health. Additionally, it encourages better sleep and reduces cardiovascular disease risk, which is vital for combating liver disease.
7.5
Potential liver benefits
1 people found this helpful
I believe this product can help prevent vascular diseases, particularly as I struggle with high blood pressure and cholesterol, which could lead to liver disease.
9
Supports liver health
9 people found this helpful
Methylcobalamin, a natural form of vitamin B12, is better absorbed and retained in the body compared to synthetic cyanocobalamin. It aids in neuronal lipid production, nerve regeneration, and has properties that help with conditions like Alzheimer's and liver disease. At 1000mcg, the dose is safe and effective as any excess is excreted. The small, sweet tablets should be kept in the mouth until they melt for optimal absorption.
7.5
Relieves liver dryness
It improves skin condition, relieving dryness, while also benefiting the nervous system and supporting liver health. These lozenges are tasty and can be either chewed or sucked, which helps maintain the necessary B12 levels for my liver.
9
We explored how methylcobalamin, a form of vitamin B12, impacts liver disease, particularly in the context of cholestatic liver failure. The study utilized high-throughput screening to identify methylcobalamin as a specific inhibitor of gasdermin E (GSDME), a protein that plays a key role in pyroptotic cell death—a form of inflammatory cell death contributing to liver damage.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
Our findings showed that when tested on mouse models with liver failure due to cholestasis, cisplatin, or concanavalin A, methylcobalamin effectively reduced liver damage. It significantly lowered liver transaminase levels, indicating less liver inflammation and cellular injury, and helped alleviate overall liver cell death.
Furthermore, methylcobalamin worked by preventing the cleavage of GSDME, which is essential for uncontrolled inflammatory cell death. By binding to a specific site on the GSDME protein, it blocked the interactions that trigger this damaging process. Overall, our study highlighted the potential of methylcobalamin as a promising therapeutic option for managing cholestatic liver failure and related conditions.
7
We explored the connection between high levels of Vitamin B12 and various health conditions, particularly focusing on liver disease. Our study involved analyzing medical records from 3,511 patients who had elevated serum Vitamin B12 levels over a year at King Salman Medical City in Madinah.
One significant finding was that a notable percentage of patients with elevated B12 levels also had diabetes mellitus, often linked to the use of Vitamin B12 as a supplement. Additionally, we observed associations with other health issues, including liver diseases among patients. However, the relationship between high B12 levels and liver disease was not isolated or definitively established; other factors played a role in these patients' health.
While the study did indicate a correlation between high Vitamin B12 levels and certain comorbidities, including liver conditions, further investigation is recommended to clarify the effects of Vitamin B12 treatment specifically on liver disease, as our findings were not conclusive. Thus, while we found that high serum levels of Vitamin B12 were prominent among patients with liver disease, we cannot definitively credit the treatment itself as a beneficial factor in this context.
One significant finding was that a notable percentage of patients with elevated B12 levels also had diabetes mellitus, often linked to the use of Vitamin B12 as a supplement. Additionally, we observed associations with other health issues, including liver diseases among patients. However, the relationship between high B12 levels and liver disease was not isolated or definitively established; other factors played a role in these patients' health.
While the study did indicate a correlation between high Vitamin B12 levels and certain comorbidities, including liver conditions, further investigation is recommended to clarify the effects of Vitamin B12 treatment specifically on liver disease, as our findings were not conclusive. Thus, while we found that high serum levels of Vitamin B12 were prominent among patients with liver disease, we cannot definitively credit the treatment itself as a beneficial factor in this context.
References
- Xu W, Wang Y, Cui S, Zheng Q, Lin Y, et al. Methylcobalamin protects against liver failure via engaging gasdermin E. Nat Commun. 2025;16:1233. 10.1038/s41467-024-54826-6
- Abu-Zahab ZA, Qureshi H, Adham GM, Elzefzafy WM, Zalam SS, et al. Frequency of comorbid diseases with high serum Vitamin B12 levels in patients attending King Salman Medical City (KSAMC), at Madinah. Int J Health Sci (Qassim). 2025;19:15.
- Espina S, Casas-Deza D, Bernal-Monterde V, Royo-Esteban A, García-Sobreviela MP, et al. Unraveling the Association of Liver Steatosis and Fibrosis with Vitamin B12: A Cross-Sectional Study. Metabolites. 2024;14. 10.3390/metabo14110618
- Roy A, Trigun SK. The restoration of hippocampal nerve de-myelination by methylcobalamin relates with the enzymatic regulation of homocysteine level in a rat model of moderate grade hepatic encephalopathy. J Biochem Mol Toxicol. 2024;38:e23695. 10.1002/jbt.23695
- Pai SL, Torp KD, Insignares VC, DeMaria S, Giordano CR, et al. Use of hydroxocobalamin to treat intraoperative vasoplegic syndrome refractory to vasopressors and methylene blue during liver transplantation. Clin Transplant. 2024;38:e15271. 10.1111/ctr.15271
- Liu K, Chen Y, Chen J, Chen W, Sun X, et al. Genetically determined circulating micronutrients and the risk of nonalcoholic fatty liver disease. Sci Rep. 2024;14:1105. 10.1038/s41598-024-51609-3
- Boachie J, Zammit V, Saravanan P, Adaikalakoteswari A. Metformin Inefficiency to Lower Lipids in Vitamin B12 Deficient HepG2 Cells Is Alleviated via Adiponectin-AMPK Axis. Nutrients. 2023;15. 10.3390/nu15245046
- Oula JO, Mose JM, Waiganjo NN, Chepukosi KW, Mitalo NS, et al. Vitamin B12 blocked Trypanosoma brucei rhodesiense-driven disruption of the blood brain barrier, and normalized nitric oxide and malondialdehyde levels in a mouse model. Parasitol Int. 2023;96:102775. 10.1016/j.parint.2023.102775
- Ujianti I, Sianipar IR, Prijanti AR, Hasan I, Arozal W, et al. Effect of Roselle Flower Extract ( Linn.) on Reducing Steatosis and Steatohepatitis in Vitamin B12 Deficiency Rat Model. Medicina (Kaunas). 2023;59. 10.3390/medicina59061044
- Ahmed Mohammed R, Fadheel QJ. Hepatoprotective Effect of Vitamin B12 in Acetaminophen Induce Hepatotoxicity in Male Rats. Arch Razi Inst. 2023;78:419. 10.22092/ARI.2022.359353.2408
