' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 5 Researches
7.4
USERS' SCORE
Excellent
Based on 43 Reviews
9.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
8
Vitamin D3 impacts allergy severity
Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis.
Strong correlation noted in study
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Read More
7
Vitamin D3 reduces allergy cytokines
Calcitriol Impairs the Secretion of IL-4 and IL-13 in Th2 Cells via Modulating the VDR-Gata3-Gfi1 Axis.
Key insights on allergy mechanisms
We explored how calcitriol, the active form of vitamin D3, influences the immune response related to allergies. Our focus was on two key cytokines—IL-4 and IL-13—which play a significant role in allergic reactions. Through our experiments, we found that calcitriol reduced the production of these cytokines in both murine and human T-helper 2 (Th2) cells.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Read More
7
Vitamin D3 may reduce eczema risk
Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age.
Some relevance to allergy outcomes
We delved into the potential impact of vitamin D3 on the development of eczema, a skin condition often tied to allergies. Our study measured levels of 25(OH)D3, a form of vitamin D, in dried blood spots from newborns at high risk for allergies. By observing these children over 25 years, we tracked the prevalence of eczema and other related allergy symptoms through skin prick tests at multiple points in their lives.
Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.
In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.
In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
Read More
Most Useful Reviews
10
No allergies
I give this vitamin to my child, and it does not cause any allergies. We monitor its effectiveness through tests.
Read More
9.5
Boosted energy
I didn't expect much from this vitamin, but I feel significantly better now. My mood improved, energy levels increased, and allergies decreased remarkably.
Read More
9
Enhanced clarity
I've taken this vitamin for over a month, and the results are astounding. My allergies have lessened, mental clarity has increased, and I feel more energetic.
Read More
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Medical Researches
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Most Likely Effective
Based on 5 Researches
7.4
8
Vitamin D3 may support asthma treatment
Correlation Analysis of Serum 25-Hydroxyvitamin D Levels With Immune Function and Calcium-Phosphate Metabolism in Patients With Bronchial Asthma Treated With Combination Therapy.
Limited isolated vitamin D3 effects
We investigated the effects of combining vitamin D3 with fluticasone propionate inhalation aerosol in children with bronchial asthma. Our study involved 110 patients who were divided into two groups: one receiving only the inhalation treatment and the other receiving both the inhalation treatment and vitamin D3. By comparing these groups, we aimed to understand how vitamin D3 could potentially enhance immune function and improve symptoms related to asthma.
Results indicated that the group receiving the combination treatment experienced a quicker relief from symptoms like wheezing and dyspnea. They also showed marked improvements in lung function and quality of life. Particularly interesting was the observation that this treatment regime increased serum levels of vitamin D3, several immunoglobulins, and T lymphocyte subsets, which are important for immune health. Furthermore, the combination was linked with beneficial changes in calcium and phosphorus levels in the bloodstream.
However, while our findings suggest a positive relationship between vitamin D3 levels and immune function, we should note that the isolated benefits of vitamin D3 alone on allergies could not be conclusively determined. The results highlight potential benefits, but more research would be necessary to pinpoint vitamin D3's role specifically in allergy management, independent of other treatments.
Overall, our exploration reinforces the need to consider vitamin D3 as a potential supportive treatment in asthma management, especially given its immunomodulatory effects. Yet, it's essential to approach these findings with caution until further evidence is gathered on its direct impact on allergies.
Results indicated that the group receiving the combination treatment experienced a quicker relief from symptoms like wheezing and dyspnea. They also showed marked improvements in lung function and quality of life. Particularly interesting was the observation that this treatment regime increased serum levels of vitamin D3, several immunoglobulins, and T lymphocyte subsets, which are important for immune health. Furthermore, the combination was linked with beneficial changes in calcium and phosphorus levels in the bloodstream.
However, while our findings suggest a positive relationship between vitamin D3 levels and immune function, we should note that the isolated benefits of vitamin D3 alone on allergies could not be conclusively determined. The results highlight potential benefits, but more research would be necessary to pinpoint vitamin D3's role specifically in allergy management, independent of other treatments.
Overall, our exploration reinforces the need to consider vitamin D3 as a potential supportive treatment in asthma management, especially given its immunomodulatory effects. Yet, it's essential to approach these findings with caution until further evidence is gathered on its direct impact on allergies.
Read More
8
Vitamin D3 impacts allergy severity
Correlation Between a Deficiency of D3 Levels and the Development of Allergic Rhinitis.
Strong correlation noted in study
We explored the relationship between vitamin D3 levels and allergic rhinitis (AR), a common condition characterized by sneezing, runny noses, and itchy eyes. In our research, we included two groups: thirty individuals with AR between the ages of 18 and 35 who had low levels of vitamin D3 and a control group of thirty people with sufficient vitamin D3 levels.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Our findings revealed a notable difference between the two groups. We observed that patients with AR had significantly lower levels of vitamin D3 compared to the control group. Additionally, there was a marked increase in immunoglobulin E (IgE) levels, which are often linked to allergic reactions, among those with AR.
Interestingly, our analysis indicated a clear inverse relationship between vitamin D3 levels and IgE levels. In fact, we found that changes in vitamin D3 levels accounted for about 58% of the variations in IgE among the participants. This suggests that increasing vitamin D3 might help reduce IgE levels and potentially lessen allergy symptoms.
Read More
7
Vitamin D3 reduces allergy cytokines
Calcitriol Impairs the Secretion of IL-4 and IL-13 in Th2 Cells via Modulating the VDR-Gata3-Gfi1 Axis.
Key insights on allergy mechanisms
We explored how calcitriol, the active form of vitamin D3, influences the immune response related to allergies. Our focus was on two key cytokines—IL-4 and IL-13—which play a significant role in allergic reactions. Through our experiments, we found that calcitriol reduced the production of these cytokines in both murine and human T-helper 2 (Th2) cells.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Interestingly, we noted that calcitriol not only diminished IL-4 and IL-13 secretion but also affected the expression of important regulatory proteins like Gata3 and Gfi1. Gata3 is crucial for promoting the expression of IL-4 and IL-13, while Gfi1 serves as a repressor of these cytokines. When we introduced calcitriol, Gata3 levels dropped. Meanwhile, Gfi1 expression also declined, yet it had a more complex role in modulating cytokine secretion.
Our findings suggest that calcitriol enhances the action of VDR (vitamin D receptor) and increases the presence of HDAC1—an enzyme that influences gene expression—in the regulatory regions for IL-4 and IL-13. This interplay results in a notable reduction of these cytokines, potentially explaining the observed link between low vitamin D3 levels and increased allergic reactions.
Overall, we believe our study sheds light on how vitamin D3 can affect allergy-related processes by intricately regulating immune cell behavior. This could pave the way for future therapeutic strategies in managing allergies through vitamin D3 supplementation.
Read More
7
Vitamin D3 may reduce eczema risk
Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age.
Some relevance to allergy outcomes
We delved into the potential impact of vitamin D3 on the development of eczema, a skin condition often tied to allergies. Our study measured levels of 25(OH)D3, a form of vitamin D, in dried blood spots from newborns at high risk for allergies. By observing these children over 25 years, we tracked the prevalence of eczema and other related allergy symptoms through skin prick tests at multiple points in their lives.
Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.
In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
Our findings indicate that higher levels of neonatal vitamin D3 may lower the risk of persistent eczema that starts early in life. Specifically, for each 10 nmol/L increase in vitamin D3, the odds of developing early-onset persistent eczema decreased by 26%. Interestingly, we also found that higher vitamin D3 levels were associated with a 30% increase in the odds of early-onset resolving eczema. However, when considering the overall link between neonatal vitamin D3 and prevalent eczema or other allergy symptoms at later ages, we did not find strong evidence to support a significant effect.
In essence, while higher neonatal vitamin D3 appears beneficial for reducing the risk of certain types of eczema, its influence on broader allergy outcomes remains uncertain. Further studies are needed to unravel these complex relations and fully understand the role of vitamin D in allergic conditions.
Read More
7
Vitamin D's role in allergies
Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study.
Moderate relevance to vitamin D treatment
We conducted a study focusing on the intriguing relationship between vitamin D3 levels and allergies, specifically in patients with chronic and allergic sinusitis. Our research involved 90 subjects divided into three groups: healthy controls, chronic sinusitis patients, and those suffering from allergic sinusitis.
Throughout the study, we measured serum levels of vitamin D3 and immunoglobulin E (IgE) using an ELISA method. The results revealed that a significant portion of our participants—60%—had insufficient vitamin D, with those afflicted by allergic sinusitis showing even higher deficiencies.
Interestingly, we observed that female participants were more likely to experience vitamin D deficiency. Additionally, cravings for higher levels of IgE protein were primarily noted in the allergic sinusitis group, further linking low vitamin D levels with allergy severity.
Our findings suggest that vitamin D deficiency may play a role in increasing susceptibility to allergic sinusitis, presenting a case for considering vitamin D supplementation as a potential adjunctive therapy for these patients.
Throughout the study, we measured serum levels of vitamin D3 and immunoglobulin E (IgE) using an ELISA method. The results revealed that a significant portion of our participants—60%—had insufficient vitamin D, with those afflicted by allergic sinusitis showing even higher deficiencies.
Interestingly, we observed that female participants were more likely to experience vitamin D deficiency. Additionally, cravings for higher levels of IgE protein were primarily noted in the allergic sinusitis group, further linking low vitamin D levels with allergy severity.
Our findings suggest that vitamin D deficiency may play a role in increasing susceptibility to allergic sinusitis, presenting a case for considering vitamin D supplementation as a potential adjunctive therapy for these patients.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 43 Reviews
9.1
10
No allergies
I give this vitamin to my child, and it does not cause any allergies. We monitor its effectiveness through tests.
9.5
Less allergies
I took these vitamins alongside similar ones from California, and they are equally good. They do not contain safflower oil, making them a better choice if you have allergies or are pregnant. The capsules, made with olive oil and bovine gelatin, are small and easy to swallow. I noticed less brittle nails and improved hair condition. My family takes Vitamin D3 every day, which helps prevent colds. This convenient bottle with 240 capsules is great for travel.
Read More
9.5
Allergy management
Excellent! While taking these vitamins, I felt fantastic and my skin improved. I followed the manufacturer's advice and noticed no allergies or gastrointestinal issues.
9.5
Stronger immunity
I’m in my 50s with many allergies, but these vitamins have helped me feel stronger and boosted my mood remarkably. My energy levels are impressive!
9.5
Boosted energy
I didn't expect much from this vitamin, but I feel significantly better now. My mood improved, energy levels increased, and allergies decreased remarkably.
