Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
8
We aimed to understand how vitamin D influences the progression of Alzheimer’s disease (AD) by examining its effects on the brain. Our study involved male 5xFAD mice that underwent various dietary regimes and received vitamin D injections. This allowed us to investigate both vitamin D deficiency and supplementation in relation to AD symptoms.
Through careful analysis of brain tissue, we looked for changes in amyloid-β (Aβ) plaques and the presence of reactive astrocytes—important cells that interact with neurons in the brain. Our findings demonstrated a noteworthy association between vitamin D levels and reductions in harmful Aβ pathways and reactive astrogliosis.
This is significant since it suggests that maintaining adequate vitamin D levels might be a promising strategy for preventing or treating Alzheimer’s disease. Overall, our study provides crucial insights into how vitamin D could potentially alter the course of AD, opening the door for new therapeutic approaches.
Through careful analysis of brain tissue, we looked for changes in amyloid-β (Aβ) plaques and the presence of reactive astrocytes—important cells that interact with neurons in the brain. Our findings demonstrated a noteworthy association between vitamin D levels and reductions in harmful Aβ pathways and reactive astrogliosis.
This is significant since it suggests that maintaining adequate vitamin D levels might be a promising strategy for preventing or treating Alzheimer’s disease. Overall, our study provides crucial insights into how vitamin D could potentially alter the course of AD, opening the door for new therapeutic approaches.
Read More
9
Vitamin D3 shows promise for Alzheimer's
We explored the impact of vitamin D3 supplementation on cognitive decline in transgenic mice that model Alzheimer's disease. Over a 20-week treatment period, we conducted a series of tests, including a Morris Water Maze test to assess cognitive function and various analyses to gauge oxidative stress and Alzheimer-related pathology.
Our observations indicated that vitamin D3 treatment not only improved the memory performance of the mice but also positively influenced brain health. Specifically, we found that vitamin D3 led to a reduction in amyloid beta (Aβ) buildup, a hallmark of Alzheimer's, and decreased levels of proteins associated with the disease, such as APP, tau, and phosphorylated tau (p-tau).
Moreover, vitamin D3 appeared to bolster the brain's defenses against oxidative stress, enhancing key antioxidant levels while lowering harmful substances related to oxidative damage. The treatment activated important pathways involved in cellular protection, further supporting the notion that vitamin D3 may offer neuroprotective effects.
In conclusion, our study suggests that vitamin D3 could play a beneficial role in improving cognition and reducing Alzheimer-like changes in the brain. These findings invite further exploration into the potential of vitamin D3 as a supportive treatment in Alzheimer’s disease management.
Our observations indicated that vitamin D3 treatment not only improved the memory performance of the mice but also positively influenced brain health. Specifically, we found that vitamin D3 led to a reduction in amyloid beta (Aβ) buildup, a hallmark of Alzheimer's, and decreased levels of proteins associated with the disease, such as APP, tau, and phosphorylated tau (p-tau).
Moreover, vitamin D3 appeared to bolster the brain's defenses against oxidative stress, enhancing key antioxidant levels while lowering harmful substances related to oxidative damage. The treatment activated important pathways involved in cellular protection, further supporting the notion that vitamin D3 may offer neuroprotective effects.
In conclusion, our study suggests that vitamin D3 could play a beneficial role in improving cognition and reducing Alzheimer-like changes in the brain. These findings invite further exploration into the potential of vitamin D3 as a supportive treatment in Alzheimer’s disease management.
Read More
8
We examined the relationship between 25-OH vitamin D and Alzheimer's disease (AD) through an innovative approach called Mendelian randomization. This method allows us to analyze the effect of different nutrients on brain health by leveraging genetic data, while also assessing how these nutrients may influence MRI findings related to AD.
Our findings reveal a significant negative association between 25-OH vitamin D levels and the likelihood of developing Alzheimer's. Specifically, we observed that higher vitamin D is linked to a lower risk of Alzheimer's, with a notable odds ratio suggesting a protective effect. Remarkably, we also discovered that about 7% of the impact of vitamin D on Alzheimer's could be explained by changes in specific brain regions, particularly the Superior_fronto-occipital_fasciculus_L.
Overall, our study provides compelling evidence that vitamin D may serve as a protective factor against Alzheimer's disease. However, we note that its mediating role in brain structures is relatively small, indicating further research is needed to fully understand these relationships and mechanisms.
Our findings reveal a significant negative association between 25-OH vitamin D levels and the likelihood of developing Alzheimer's. Specifically, we observed that higher vitamin D is linked to a lower risk of Alzheimer's, with a notable odds ratio suggesting a protective effect. Remarkably, we also discovered that about 7% of the impact of vitamin D on Alzheimer's could be explained by changes in specific brain regions, particularly the Superior_fronto-occipital_fasciculus_L.
Overall, our study provides compelling evidence that vitamin D may serve as a protective factor against Alzheimer's disease. However, we note that its mediating role in brain structures is relatively small, indicating further research is needed to fully understand these relationships and mechanisms.
Read More
Most Useful Reviews
8
Improved mood
I discovered Vitamin D through Anton's videos, noting its importance in regulating various bodily functions. Despite its fat-soluble nature, I learned that high dosages are safe and beneficial. After ordering this supplement, I found that it alleviated my autumn blues and helped me recover quickly from illnesses. Vitamin D appears crucial in combating Alzheimer’s and other conditions, emphasising its role in overall health.
Read More
5.8
Supports cognitive health
Vitamin D is essential from birth, yet its importance is often overlooked. I ordered D3 capsules for both my husband and myself. This vitamin supports various bodily functions, including immunity and cognitive health, which is vital for conditions like Alzheimer’s. However, there is no childproof cap on the product, which is concerning. Overall, its benefits for mood regulation and cognitive function are worth noting.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 22 Researches
7.3
- All Researches
9
We conducted a study to assess the effects of a new combination treatment on memory recovery in rats with scopolamine-induced dementia, a model for Alzheimer's disease. This combination included α-lipoic acid, citicoline, olive tree and green tea extracts, vitamin D3, selenium, and an immune-supporting complex.
During our evaluation, we observed that this combination significantly improved both short- and long-term memory as well as spatial memory. Interestingly, while vitamin D3 was one of the components in the treatment, our study does not allow us to determine its isolated impact.
We monitored several biochemical markers and noted encouraging changes in brain activity, with enhanced SOD, catalase, and GPx activities, and higher levels of BDNF and pCREB. Importantly, we found no significant negative effects, making this combination appear as a safe option in a multitargeted approach to treat Alzheimer's.
During our evaluation, we observed that this combination significantly improved both short- and long-term memory as well as spatial memory. Interestingly, while vitamin D3 was one of the components in the treatment, our study does not allow us to determine its isolated impact.
We monitored several biochemical markers and noted encouraging changes in brain activity, with enhanced SOD, catalase, and GPx activities, and higher levels of BDNF and pCREB. Importantly, we found no significant negative effects, making this combination appear as a safe option in a multitargeted approach to treat Alzheimer's.
Read More
9
We explored the impact of vitamin D3 on the brain’s health in a model of Alzheimer’s disease (AD) induced by aluminum chloride. In our study, we used forty male Wistar rats and divided them into four groups: a control group, an AD group, an AD group treated with vitamin D3 alongside the AD model, and an AD group that received vitamin D3 after the onset of AD symptoms.
Through our experiments, we found that the AD rats exhibited significant changes in their hippocampal region, including increased mitochondrial calcium, decreased levels of ATP and ADP, elevated calpain-1 and calpain-2 levels, and disruptions in the cytochrome C pathway—factors that are linked to mitochondrial dysfunction and neuronal degeneration. Interestingly, when we supplemented the AD rats with vitamin D3, we noted improvements in mitochondrial function, reduced neuronal degeneration, and even improvements in histological changes in the brain.
This improvement suggests that vitamin D3 may play a vital role in breaking the harmful cycle associated with AD, which involves high calcium levels and calpain activation leading to further neurodegeneration. The findings emphasize the potential of vitamin D3 as a supplemental treatment in early intervention and management strategies against Alzheimer’s disease.
Through our experiments, we found that the AD rats exhibited significant changes in their hippocampal region, including increased mitochondrial calcium, decreased levels of ATP and ADP, elevated calpain-1 and calpain-2 levels, and disruptions in the cytochrome C pathway—factors that are linked to mitochondrial dysfunction and neuronal degeneration. Interestingly, when we supplemented the AD rats with vitamin D3, we noted improvements in mitochondrial function, reduced neuronal degeneration, and even improvements in histological changes in the brain.
This improvement suggests that vitamin D3 may play a vital role in breaking the harmful cycle associated with AD, which involves high calcium levels and calpain activation leading to further neurodegeneration. The findings emphasize the potential of vitamin D3 as a supplemental treatment in early intervention and management strategies against Alzheimer’s disease.
Read More
9
Vitamin D3 improves Alzheimer's symptoms
We investigated whether vitamin D3 (Vit.D) could help mitigate cognitive decline and restore mitochondrial function in an Alzheimer's disease (AD) rat model. The study involved groups of rats exposed to Alzheimer's-inducing substances, as well as groups receiving vitamin D3 treatment. By employing various cognitive tests and analyzing brain tissue, we aimed to understand how vitamin D3 affects memory and brain health.
Our findings revealed that vitamin D3 did have a positive effect. It was shown to reduce brain injury, cognitive decline, and levels of amyloid beta, a protein involved in Alzheimer's. Furthermore, vitamin D3 also influenced key proteins in the brain that support mitochondrial health, which plays a critical role in cell energy and function. We observed that vitamin D3 helped restore normal levels of calcium in the brain and elevated the function of proteins responsible for energy metabolism.
Overall, it appears that vitamin D3 can alleviate some of the cognitive challenges associated with AD by improving mitochondrial function and reducing oxidative stress. This suggests potential pathways through which vitamin D3 might exert protective effects against Alzheimer's disease.
Our findings revealed that vitamin D3 did have a positive effect. It was shown to reduce brain injury, cognitive decline, and levels of amyloid beta, a protein involved in Alzheimer's. Furthermore, vitamin D3 also influenced key proteins in the brain that support mitochondrial health, which plays a critical role in cell energy and function. We observed that vitamin D3 helped restore normal levels of calcium in the brain and elevated the function of proteins responsible for energy metabolism.
Overall, it appears that vitamin D3 can alleviate some of the cognitive challenges associated with AD by improving mitochondrial function and reducing oxidative stress. This suggests potential pathways through which vitamin D3 might exert protective effects against Alzheimer's disease.
Read More
9
We investigated the effects of vitamin D3 supplementation on cognitive impairment linked to Alzheimer's disease. Using a rat model, we induced cognitive deficits through scopolamine injections and then provided vitamin D for 21 days. Our findings highlighted significant improvements in cognitive abilities, including learning and memory functions, thanks to the vitamin D treatment.
We observed that rats receiving vitamin D showed lower levels of toxic Aβ plaques and hyperphosphorylated tau proteins—both key players in Alzheimer's pathology. This suggests that vitamin D may help enhance the brain's ability to clear away harmful proteins while simultaneously reducing inflammation and oxidative stress.
The results were reinforced by detailed analyses of brain tissue and behavior, indicating a promising role for vitamin D3 in delaying Alzheimer's progression. These outcomes support the notion that vitamin D supplementation could be beneficial for cognitive health and management of Alzheimer's disease.
We observed that rats receiving vitamin D showed lower levels of toxic Aβ plaques and hyperphosphorylated tau proteins—both key players in Alzheimer's pathology. This suggests that vitamin D may help enhance the brain's ability to clear away harmful proteins while simultaneously reducing inflammation and oxidative stress.
The results were reinforced by detailed analyses of brain tissue and behavior, indicating a promising role for vitamin D3 in delaying Alzheimer's progression. These outcomes support the notion that vitamin D supplementation could be beneficial for cognitive health and management of Alzheimer's disease.
Read More
9
Vitamin D3 shows promise for Alzheimer's
We explored the impact of vitamin D3 supplementation on cognitive decline in transgenic mice that model Alzheimer's disease. Over a 20-week treatment period, we conducted a series of tests, including a Morris Water Maze test to assess cognitive function and various analyses to gauge oxidative stress and Alzheimer-related pathology.
Our observations indicated that vitamin D3 treatment not only improved the memory performance of the mice but also positively influenced brain health. Specifically, we found that vitamin D3 led to a reduction in amyloid beta (Aβ) buildup, a hallmark of Alzheimer's, and decreased levels of proteins associated with the disease, such as APP, tau, and phosphorylated tau (p-tau).
Moreover, vitamin D3 appeared to bolster the brain's defenses against oxidative stress, enhancing key antioxidant levels while lowering harmful substances related to oxidative damage. The treatment activated important pathways involved in cellular protection, further supporting the notion that vitamin D3 may offer neuroprotective effects.
In conclusion, our study suggests that vitamin D3 could play a beneficial role in improving cognition and reducing Alzheimer-like changes in the brain. These findings invite further exploration into the potential of vitamin D3 as a supportive treatment in Alzheimer’s disease management.
Our observations indicated that vitamin D3 treatment not only improved the memory performance of the mice but also positively influenced brain health. Specifically, we found that vitamin D3 led to a reduction in amyloid beta (Aβ) buildup, a hallmark of Alzheimer's, and decreased levels of proteins associated with the disease, such as APP, tau, and phosphorylated tau (p-tau).
Moreover, vitamin D3 appeared to bolster the brain's defenses against oxidative stress, enhancing key antioxidant levels while lowering harmful substances related to oxidative damage. The treatment activated important pathways involved in cellular protection, further supporting the notion that vitamin D3 may offer neuroprotective effects.
In conclusion, our study suggests that vitamin D3 could play a beneficial role in improving cognition and reducing Alzheimer-like changes in the brain. These findings invite further exploration into the potential of vitamin D3 as a supportive treatment in Alzheimer’s disease management.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
8
Improved mood
I discovered Vitamin D through Anton's videos, noting its importance in regulating various bodily functions. Despite its fat-soluble nature, I learned that high dosages are safe and beneficial. After ordering this supplement, I found that it alleviated my autumn blues and helped me recover quickly from illnesses. Vitamin D appears crucial in combating Alzheimer’s and other conditions, emphasising its role in overall health.
Read More
5.8
Supports cognitive health
Vitamin D is essential from birth, yet its importance is often overlooked. I ordered D3 capsules for both my husband and myself. This vitamin supports various bodily functions, including immunity and cognitive health, which is vital for conditions like Alzheimer’s. However, there is no childproof cap on the product, which is concerning. Overall, its benefits for mood regulation and cognitive function are worth noting.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Liu W, Zheng D, Li X, Wang T, Wang L, et al. Effects of Vitamin D3 Combined with Folic Acid on Domain and Specific Cognitive Function among Patients with Mild Cognitive Impairment: A Randomized Clinical Trial. J Prev Alzheimers Dis. 2024;11:1626. doi:10.14283/jpad.2024.165
- Zaman Z, Islam R, Koganti B, Falki V, Osentoski T, et al. Highly prevalent geriatric medications and their effect on β-amyloid fibril formation. BMC Neurol. 2024;24:445. doi:10.1186/s12883-024-03930-7
- Fu Q, DeJager J, Gardner EM. Supplementation and Mitigating Cognitive Decline in Older Adults With or Without Mild Cognitive Impairment or Dementia: A Systematic Review. Nutrients. 2024;16. doi:10.3390/nu16203567
- Park J, Byun MS, Yi D, Ahn H, Jung JH, et al. The Moderating Effect of Serum Vitamin D on the Relationship between Beta-amyloid Deposition and Neurodegeneration. Clin Psychopharmacol Neurosci. 2024;22:646. doi:10.9758/cpn.24.1189
- Fu LL, Vollkommer T, Fuest S, Gosau M, Feng H, et al. The role of 25-OH vitamin D in Alzheimer's disease through Mendelian randomization and MRI. QJM. 2025;118:24. doi:10.1093/qjmed/hcae166
- Zhang J, Zhang A. Association between serum 25-hydroxyvitamin D3 level and cognitive impairment in older chronic kidney disease patients. Sci Rep. 2024;14:12403. doi:10.1038/s41598-024-63350-y
- Zhang XX, Wang HR, Hu YZ, Sun HM, Feng YX, et al. Association of Vitamin D Levels with Risk of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Prospective Studies. J Alzheimers Dis. 2024;98:373. doi:10.3233/JAD-231381
- Kang J, Park M, Kim T. Vitamin D Reduces GABA-Positive Astrocytes in the 5xFAD Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2024;97:1939. doi:10.3233/JAD-231033
- Chen LJ, Sha S, Stocker H, Brenner H, Schöttker B. The associations of serum vitamin D status and vitamin D supplements use with all-cause dementia, Alzheimer's disease, and vascular dementia: a UK Biobank based prospective cohort study. Am J Clin Nutr. 2024;119:1052. doi:10.1016/j.ajcnut.2024.01.020
- Liu W, Zheng D, Li X, Wang T, Wang L, et al. Effects of Vitamin D3 Combined with Folic Acid on Domain and Specific Cognitive Function among Patients with Mild Cognitive Impairment: A Randomized Clinical Trial. J Prev Alzheimers Dis. 2024;11:1626. doi:10.14283/jpad.2024.165
- Zaman Z, Islam R, Koganti B, Falki V, Osentoski T, et al. Highly prevalent geriatric medications and their effect on β-amyloid fibril formation. BMC Neurol. 2024;24:445. doi:10.1186/s12883-024-03930-7
- Zhang J, Zhang A. Association between serum 25-hydroxyvitamin D3 level and cognitive impairment in older chronic kidney disease patients. Sci Rep. 2024;14:12403. doi:10.1038/s41598-024-63350-y
- Tancheva L, Kalfin R, Minchev B, Uzunova D, Tasheva K, et al. Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12122050
- Alrefaie Z, Bashraheel J, Hammad HA, Ali SS, Alahmadi A. Hippocampal mitochondrial Ca in experimentally induced Alzheimer's disease, link to calpains and impact of vitamin D3 supplementation. Saudi Pharm J. 2023;31:101834. doi:10.1016/j.jsps.2023.101834
- Richter AL, Diepeveen-de Bruin M, Balvers MGJ, De Groot LCPGM, De Deyn PP, et al. Association between Low Vitamin D Status, Serotonin, and Clinico-Biobehavioral Parameters in Alzheimer's Disease. Dement Geriatr Cogn Disord. 2023;52:318. doi:10.1159/000534492
- Mohanad M, Mohamed SK, Aboulhoda BE, Ahmed MAE. Neuroprotective effects of vitamin D in an Alzheimer's disease rat model: Improvement of mitochondrial dysfunction via calcium/calmodulin-dependent protein kinase kinase 2 activation of Sirtuin1 phosphorylation. Biofactors. 2024;50:371. doi:10.1002/biof.2013
- Thu VTA, Hoang TX, Kim JY. 1,25-Dihydroxy Vitamin D Facilitates the M2 Polarization and -Amyloid Uptake by Human Microglia in a TREM2-Dependent Manner. Biomed Res Int. 2023;2023:3483411. doi:10.1155/2023/3483411
- Vieira ADC, Medeiros EB, Zabot GC, Pereira NS, do Nascimento NB, et al. Neuroprotective effects of combined therapy with memantine, donepezil, and vitamin D in ovariectomized female mice subjected to dementia model. Prog Neuropsychopharmacol Biol Psychiatry. 2023;122:110653. doi:10.1016/j.pnpbp.2022.110653
- Patel P, Shah J. Vitamin D supplementation ameliorates cognitive impairment and alters neurodegenerative and inflammatory markers in scopolamine induced rat model. Metab Brain Dis. 2022;37:2653. doi:10.1007/s11011-022-01086-2
- Gomes FC, Santos IBF, Stephani CM, Ferrari MFR, Galvis-Alonso OY, et al. Vitamin D3 supplementation may attenuate morphological and molecular abnormalities of the olfactory bulb in a mouse model of Down syndrome. Tissue Cell. 2022;78:101898. doi:10.1016/j.tice.2022.101898
- Lin J, Niu Z, Xue Y, Gao J, Zhang M, et al. Chronic vitamin D supplementation alleviates cognition impairment via inhibition of oxidative stress regulated by PI3K/AKT/Nrf2 in APP/PS1 transgenic mice. Neurosci Lett. 2022;783:136725. doi:10.1016/j.neulet.2022.136725
- Bashraheel JK, Alrefaie ZA, Hammad HEAA, Ali SS. The Possible Effects of Vitamin D3 on AlCl-Induced Histological and Morphometric Alterations of Adult Male Albino Rat Hippocampus. J Microsc Ultrastruct. 2023;11:52. doi:10.4103/jmau.jmau_42_21
