Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.9
USERS' SCORE
Good
Based on 21 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Read More
8
Vitamin D's role in heart health
We explored the relationship between serum vitamin D levels and the risk of cardiovascular disease, as well as all-cause and cancer mortality. Using data from over 11,500 adults aged 40 and older, we wanted to understand whether having higher amounts of this nutrient in our blood could lead to better health outcomes.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Read More
8
We wanted to understand how vitamin D levels affect cardiovascular health, specifically among individuals with type 2 diabetes. Our study involved 1,378 hospitalized patients, examining their vitamin D status and its relationship with cardiovascular disease (CVD).
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
Read More
Most Useful Reviews
7.5
Vital supplement
119 people found this helpful
I'm pleased with the high efficiency of this 2000 IU dosage of Vitamin D3. It’s essential for maintaining adequate levels, supporting immunity and preventing issues linked to cardiovascular disease. I feel energised and healthier since I started taking it.
Read More
7.5
Bone and immune health
118 people found this helpful
Vitamin D is critical for overall health. Insufficient levels can lead to bone issues and various health problems, including cardiovascular disease. I appreciate its importance in my well-being.
Read More
7.5
Improved well-being
105 people found this helpful
Since I started taking Vitamin D3, I realised its positive impact on my health. I've experienced less muscle pain and improved overall wellness, with notable effects on my mood and energy. It’s vital for combating cardiovascular disease and enhancing immunity.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.9
- All Researches
9
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Read More
8
Our study delved into the potential benefits of vitamin D3 in improving cardiovascular health, particularly among hypertensive patients suffering from obesity and obstructive sleep apnea (OSA). We designed a randomized clinical trial where participants received either dapagliflozin (an SGLT-2 inhibitor), vitamin D3, a combination of both, or no treatment over a period of 16 weeks.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
Read More
8
Vitamin D benefits blood pressure management
We examined the role of vitamin D supplementation in managing hypertension, particularly its effects on cardiovascular health. After analyzing data from a systematic review and meta-analysis that included 24 relevant studies, we discovered that vitamin D has significant benefits for blood pressure.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
Read More
8
Vitamin D's role in heart health
We explored the relationship between serum vitamin D levels and the risk of cardiovascular disease, as well as all-cause and cancer mortality. Using data from over 11,500 adults aged 40 and older, we wanted to understand whether having higher amounts of this nutrient in our blood could lead to better health outcomes.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Read More
8
We wanted to understand how vitamin D levels affect cardiovascular health, specifically among individuals with type 2 diabetes. Our study involved 1,378 hospitalized patients, examining their vitamin D status and its relationship with cardiovascular disease (CVD).
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
We found that patients with lower levels of vitamin D were more likely to experience CVD. The research revealed that those deficient in vitamin D had a 1.25 times greater risk of heart disease compared to those with sufficient vitamin D levels. This relationship was particularly strong among women, older adults, and individuals dealing with obesity.
Additionally, we observed significant links between vitamin D deficiency and various cardiometabolic risk factors, including overweight/obesity, high blood pressure, and unhealthy lipid levels. This highlights the potential role of vitamin D in managing heart health, especially for those living with diabetes.
Read More
User Reviews
USERS' SCORE
Good
Based on 21 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Vital supplement
119 people found this helpful
I'm pleased with the high efficiency of this 2000 IU dosage of Vitamin D3. It’s essential for maintaining adequate levels, supporting immunity and preventing issues linked to cardiovascular disease. I feel energised and healthier since I started taking it.
Read More
7.5
Bone and immune health
118 people found this helpful
Vitamin D is critical for overall health. Insufficient levels can lead to bone issues and various health problems, including cardiovascular disease. I appreciate its importance in my well-being.
Read More
7.5
Improved well-being
105 people found this helpful
Since I started taking Vitamin D3, I realised its positive impact on my health. I've experienced less muscle pain and improved overall wellness, with notable effects on my mood and energy. It’s vital for combating cardiovascular disease and enhancing immunity.
Read More
7.5
Health enhancement
102 people found this helpful
I find Vitamin D to be an essential supplement. After taking it for three months, I noticed improvements in my health, especially regarding cardiovascular disease risk and overall mood. Regular intake is crucial for well-being.
Read More
9
Disease management
90 people found this helpful
I'm grateful for this dosage; it has significantly helped manage my health conditions. I highly recommend it for supporting immunity.
Read More
Frequently Asked Questions
9
Mood and energy
90 people found this helpful
I've been taking this vitamin for a few weeks now, and it has positively affected my cardiovascular health, energy levels, and mood. I recommend it as a quality supplement that delivers results.
7.5
Health enhancement
102 people found this helpful
I find Vitamin D to be an essential supplement. After taking it for three months, I noticed improvements in my health, especially regarding cardiovascular disease risk and overall mood. Regular intake is crucial for well-being.
7.5
Improved immunity
626 people found this helpful
Vitamin D3 is crucial for immunity and bone health. I noticed significant benefits in my health after correcting my deficiency, which dropped from 17 ng/ml to 40 ng/ml. I've been taking it for six months alongside vitamin K2 and omega-3. My endocrinologist emphasised its immunomodulatory role, confirming the link between vitamin D deficiency and various illnesses. Regular monitoring of vitamin D levels is essential to avoid excess.
7.5
Vital supplement
119 people found this helpful
I'm pleased with the high efficiency of this 2000 IU dosage of Vitamin D3. It’s essential for maintaining adequate levels, supporting immunity and preventing issues linked to cardiovascular disease. I feel energised and healthier since I started taking it.
7.5
Boosts family health
1 people found this helpful
This high-quality vitamin D is crucial, especially during winter and illness periods, enhancing mood and immunity. My family has stayed healthy, avoiding colds and viral diseases while taking it with Omega 3.
9
Reduces blood pressure
1 people found this helpful
My husband takes 4,000 IU daily for high blood pressure, coinciding with improved numbers. My daughter with Lyme disease has also benefited from vitamin D, enhancing her circulation and mood, affecting her cardiovascular health.
7.5
Important for heart health
5 people found this helpful
Daily supplementation of 2,000 IU of vitamin D is essential! It's often underestimated despite its vital role in calcium absorption and preventing osteoporosis, as well as its links to cardiovascular disease.
7.5
Enhances immune health
3 people found this helpful
Vitamin D3 is essential for overall health, particularly in combating cardiovascular disease. Doctor's Best Vitamin D3 5000 IU provides high-quality cholecalciferol to regulate calcium metabolism and support immune health.
6
Supports cardiovascular health
6 people found this helpful
Excellent vitamin D-3 at an optimal dosage is crucial for absorption of calcium and overall wellbeing. It helps maintain bone, teeth, and skin health and reduces risks of cardiovascular disease. Before starting, it's advisable to check vitamin D levels and consult with a doctor about the dosage.
7
We examined how vitamin D levels, specifically 25-hydroxyvitamin D [25(OH)D], relate to the risk of cardiovascular disease and overall mortality in patients with gout. This study included data from 7,337 gout patients enrolled in the UK Biobank, following them for an average of 11.4 years. We looked closely at serum 25(OH)D measurements taken at the beginning of the study to draw connections between vitamin D levels and health outcomes.
Our findings suggested an interesting pattern. Patients with low 25(OH)D levels, specifically those below 45 nmol/L, had a higher risk of death from any cause compared to those with higher levels. In fact, those with levels of 45 nmol/L or more had about a 28% lower risk of dying from any cause. We also noted that increasing vitamin D levels above the deficiency threshold might help lower the risk of cardiovascular disease, with evidence suggesting that reaching at least 50 nmol/L is beneficial.
These results highlight the importance of maintaining adequate vitamin D levels for gout patients, as it appears to be linked to reduced mortality risk, particularly related to cardiovascular issues. This study adds to the growing conversation about vitamin D's role in heart health and suggest we may need to consider vitamin D supplementation in patient care strategies.
Our findings suggested an interesting pattern. Patients with low 25(OH)D levels, specifically those below 45 nmol/L, had a higher risk of death from any cause compared to those with higher levels. In fact, those with levels of 45 nmol/L or more had about a 28% lower risk of dying from any cause. We also noted that increasing vitamin D levels above the deficiency threshold might help lower the risk of cardiovascular disease, with evidence suggesting that reaching at least 50 nmol/L is beneficial.
These results highlight the importance of maintaining adequate vitamin D levels for gout patients, as it appears to be linked to reduced mortality risk, particularly related to cardiovascular issues. This study adds to the growing conversation about vitamin D's role in heart health and suggest we may need to consider vitamin D supplementation in patient care strategies.
8
Vitamin D benefits blood pressure management
We examined the role of vitamin D supplementation in managing hypertension, particularly its effects on cardiovascular health. After analyzing data from a systematic review and meta-analysis that included 24 relevant studies, we discovered that vitamin D has significant benefits for blood pressure.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
8
Our study delved into the potential benefits of vitamin D3 in improving cardiovascular health, particularly among hypertensive patients suffering from obesity and obstructive sleep apnea (OSA). We designed a randomized clinical trial where participants received either dapagliflozin (an SGLT-2 inhibitor), vitamin D3, a combination of both, or no treatment over a period of 16 weeks.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
8
Vitamin D's role in heart health
We explored the relationship between serum vitamin D levels and the risk of cardiovascular disease, as well as all-cause and cancer mortality. Using data from over 11,500 adults aged 40 and older, we wanted to understand whether having higher amounts of this nutrient in our blood could lead to better health outcomes.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
Our investigation focused on seeing if the connections between vitamin D and mortality were influenced by inflammation in the body. What we found was intriguing: higher serum levels of vitamin D were linked to lower risks of dying from heart disease and other causes, suggesting that maintaining sufficient vitamin D could be beneficial for heart health.
Additionally, we observed that these benefits might be partly due to reduced inflammation, as measured by biomarkers like C-reactive protein and white blood cell counts. This points to a promising area of research where vitamin D not only plays a role in overall health but could also reduce inflammation, which is a key player in cardiovascular conditions.
References
- Vanreusel I, Hens W, Van Craenenbroeck EM, Paelinck BP, Segers VFM, et al. Vitamin D levels correlate with exercise capacity in adults with CHD. Cardiol Young. 2025. doi:10.1017/S1047951125000526
- Fang X, Zhang J, Zhang Z, Ye D. Association between Vitamin D and mortality risk in gout patients. J Public Health (Oxf). 2025. doi:10.1093/pubmed/fdaf010
- Loh HH, Tay SP, Koa AJ, Yong MC, Said A, et al. Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients. J Transl Med. 2025;23:296. doi:10.1186/s12967-025-06312-w
- Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. doi:10.1186/s12906-025-04809-x
- Checa-Ros A, Locascio A, Okojie OJ, Abellán-Galiana P, D'Marco L. Perirenal fat differs in patients with chronic kidney disease receiving different vitamin D-based treatments: a preliminary study. BMC Nephrol. 2025;26:119. doi:10.1186/s12882-025-04041-2
- Liu C, Wongsonegoro H, Sheng T, Fan H, Zhang J. Associations between serum micronutrients and all-cause, cancer, and cardiovascular mortality in a national representative population: Mediated by inflammatory biomarkers. Redox Biol. 2025;81:103573. doi:10.1016/j.redox.2025.103573
- Zhang N, Wang Y, Li W, Wang Y, Zhang H, et al. Association between serum vitamin D level and cardiovascular disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study. Sci Rep. 2025;15:6454. doi:10.1038/s41598-025-90785-8
- Zhang X, Liu J, Han L, Luo G, Jiang P, et al. Vitamin D reduces VSMC foam cell formation and protects against AS progression. J Endocrinol. 2025;265. doi:10.1530/JOE-24-0056
- Haghighatafshar M, Shekasteband B, Firuzyar T, Etemadi Z, Farhoudi F, et al. The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study. Iran J Med Sci. 2025;50:31. doi:10.30476/ijms.2024.101112.3372
- Bulfone L, Vacca A, Brosolo G, Da Porto A, Bertin N, et al. Subclinical Carotid Disease Is Associated with Low Serum Vitamin D in Nondiabetic Middle-Aged Hypertensive Patients. Nutrients. 2025;17. doi:10.3390/nu17030480
- Li Q, Tong Y, Guo J, Liang X, Shao H, et al. Vitamin D Receptor Regulates Oxidative Stress and Apoptosis Via the HIF-1α/HO-1 Pathway in Cardiomyocytes. Cell Biochem Biophys. 2025. doi:10.1007/s12013-025-01681-x
- Astani A, Maroofi A, Hekmatimoghaddam S, Sarebanhassanabadi M, Safari F. Sirtuin 1 mediates the pro-survival effects of vitamin D in angiotensin II-induced hypertrophy of H9c2 cardiomyoblasts. Mol Biol Rep. 2024;52:96. doi:10.1007/s11033-024-10168-6
- Qi RQ, Chen YF, Cheng J, Song JW, Chen YH, et al. Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling. Mol Med. 2024;30:223. doi:10.1186/s10020-024-00997-3
- France-Ratcliffe M, Harrison SL, Verma LA, Abdul-Rahim AH, McCallum L, et al. Vitamin D and cardiovascular outcomes in multiple sclerosis. Mult Scler Relat Disord. 2024;92:106155. doi:10.1016/j.msard.2024.106155
- Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. doi:10.4103/abr.abr_380_23
- Pan YX, Fu YC, Chen H, Zhao MY. [Association of serum 25(OH)D with cardiovascular risk-related indicators: cross-sectional analysis of NHANES]. Zhonghua Yu Fang Yi Xue Za Zhi. 2024;58:1388. doi:10.3760/cma.j.cn112150-20240519-00403
