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SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.8
USERS' SCORE
Good
Based on 6 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9
Vitamin D3 may reduce influenza severity
Oral Supplementation of the Vitamin D Metabolite 25(OH)D Against Influenza Virus Infection in Mice.
Direct examination of vitamin D3 effectiveness
We aimed to understand how oral supplementation of 25-hydroxyvitamin D, a key metabolite of vitamin D3, influences influenza A virus infection in mice. In our study, mice were given a diet enriched with a high dose of 25(OH)D before they were exposed to the influenza virus.
The results were promising. Mice that received the vitamin D3 supplement showed significantly lower viral levels in their lungs compared to mice that were fed a standard diet. Furthermore, we noticed a decrease in certain pro-inflammatory cytokines, namely IL-5 and IFN-γ, which are involved in the body's inflammatory response to infection. Importantly, we found that the anti-inflammatory cytokines did not see a significant increase.
These findings suggest that 25(OH)D can help to suppress excessive inflammatory responses and may reduce both the replication of the virus and the overall severity of influenza in this mouse model. It opens the door to further exploration on vitamin D3's role in combating influenza in humans.
The results were promising. Mice that received the vitamin D3 supplement showed significantly lower viral levels in their lungs compared to mice that were fed a standard diet. Furthermore, we noticed a decrease in certain pro-inflammatory cytokines, namely IL-5 and IFN-γ, which are involved in the body's inflammatory response to infection. Importantly, we found that the anti-inflammatory cytokines did not see a significant increase.
These findings suggest that 25(OH)D can help to suppress excessive inflammatory responses and may reduce both the replication of the virus and the overall severity of influenza in this mouse model. It opens the door to further exploration on vitamin D3's role in combating influenza in humans.
Read More
4
Vitamin D3 shows limited flu benefit
Effects of vitamin D supplements on influenza A illness during the 2009 H1N1 pandemic: a randomized controlled trial.
Direct efficacy investigation noted
A recent study sought to understand how vitamin D3 supplements can affect the incidence of influenza, particularly during the 2009 H1N1 pandemic. We engaged 247 high school students in Japan, randomly assigning them to receive either vitamin D3 supplements or a placebo for two months. This double-blind trial aimed to objectively measure how effective vitamin D3 would be against influenza A.
The results were revealing. Initially, we found that the occurrence of influenza A was significantly lower among students taking vitamin D3 compared to those on the placebo during the first month. Specifically, just 1.4% of the vitamin D3 group got sick, compared to 8.1% in the placebo group—a clear early benefit.
However, as the study continued into the second month, the trend shifted. We observed that the vitamin D3 group began to experience more influenza A cases, catching up with the placebo group. Ultimately, there was no significant overall effect of vitamin D3 in reducing influenza A incidence throughout the entire study duration.
While it's exciting to see potential benefits early on, the findings indicate that vitamin D3 supplementation did not consistently lower the overall risk of influenza A during this pandemic.
The results were revealing. Initially, we found that the occurrence of influenza A was significantly lower among students taking vitamin D3 compared to those on the placebo during the first month. Specifically, just 1.4% of the vitamin D3 group got sick, compared to 8.1% in the placebo group—a clear early benefit.
However, as the study continued into the second month, the trend shifted. We observed that the vitamin D3 group began to experience more influenza A cases, catching up with the placebo group. Ultimately, there was no significant overall effect of vitamin D3 in reducing influenza A incidence throughout the entire study duration.
While it's exciting to see potential benefits early on, the findings indicate that vitamin D3 supplementation did not consistently lower the overall risk of influenza A during this pandemic.
Read More
9
Vitamin D3 aids in influenza defense
Analysis of influenza virus-induced perturbation in autophagic flux and its modulation during Vitamin D3 mediated anti-apoptotic signaling.
High relevance to IAV infection
We aimed to understand how Vitamin D3 might influence the effects of influenza A virus (IAV), particularly in terms of cell death and tissue damage. Utilizing human alveolar cells, we investigated how IAV infection prompts apoptosis, or programmed cell death.
Our findings revealed that IAV reduces the effectiveness of autophagy, a crucial process that helps cells dispose of damaged components. This disruption in autophagy increases cell death, leading to more severe inflammation and tissue damage during infection.
Importantly, we found that Vitamin D3 can counteract this negative effect by restoring autophagic activity. By boosting the expression of specific proteins involved in autophagy, Vitamin D3 helps reduce apoptosis, allowing the cells to survive better during IAV infection. This suggests that Vitamin D3 may play a valuable role in protecting our cells from influenza-related injury.
Our findings revealed that IAV reduces the effectiveness of autophagy, a crucial process that helps cells dispose of damaged components. This disruption in autophagy increases cell death, leading to more severe inflammation and tissue damage during infection.
Importantly, we found that Vitamin D3 can counteract this negative effect by restoring autophagic activity. By boosting the expression of specific proteins involved in autophagy, Vitamin D3 helps reduce apoptosis, allowing the cells to survive better during IAV infection. This suggests that Vitamin D3 may play a valuable role in protecting our cells from influenza-related injury.
Read More
Most Useful Reviews
9.5
Improves immunity
Vitamin D3 is essential for everyone. I recommend this manufacturer to my friends. It's particularly important for office workers living in areas with limited sunlight. It enhances immunity, supports bone health, and lowers the risk of ARVI and influenza. My family takes it for prevention with 2,000 IU every other day, and daily when ill.
Read More
9.5
Reduces infections
Vitamin D3 enhances the immune system, aiding in the synthesis of endogenous antibiotics with antibacterial and antiviral properties. Adequate intake decreases the incidence of respiratory infections, including influenza, while deficiencies can lead to autoimmune diseases.
Read More
9.5
Prevents infections
Vitamin D reduces the risk of respiratory infections and regulates cytokine production, potentially limiting viral diseases such as influenza.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 12 Researches
6.8
9
Vitamin D3 may reduce influenza severity
Oral Supplementation of the Vitamin D Metabolite 25(OH)D Against Influenza Virus Infection in Mice.
Direct examination of vitamin D3 effectiveness
We aimed to understand how oral supplementation of 25-hydroxyvitamin D, a key metabolite of vitamin D3, influences influenza A virus infection in mice. In our study, mice were given a diet enriched with a high dose of 25(OH)D before they were exposed to the influenza virus.
The results were promising. Mice that received the vitamin D3 supplement showed significantly lower viral levels in their lungs compared to mice that were fed a standard diet. Furthermore, we noticed a decrease in certain pro-inflammatory cytokines, namely IL-5 and IFN-γ, which are involved in the body's inflammatory response to infection. Importantly, we found that the anti-inflammatory cytokines did not see a significant increase.
These findings suggest that 25(OH)D can help to suppress excessive inflammatory responses and may reduce both the replication of the virus and the overall severity of influenza in this mouse model. It opens the door to further exploration on vitamin D3's role in combating influenza in humans.
The results were promising. Mice that received the vitamin D3 supplement showed significantly lower viral levels in their lungs compared to mice that were fed a standard diet. Furthermore, we noticed a decrease in certain pro-inflammatory cytokines, namely IL-5 and IFN-γ, which are involved in the body's inflammatory response to infection. Importantly, we found that the anti-inflammatory cytokines did not see a significant increase.
These findings suggest that 25(OH)D can help to suppress excessive inflammatory responses and may reduce both the replication of the virus and the overall severity of influenza in this mouse model. It opens the door to further exploration on vitamin D3's role in combating influenza in humans.
Read More
9
Vitamin D3 aids in influenza defense
Analysis of influenza virus-induced perturbation in autophagic flux and its modulation during Vitamin D3 mediated anti-apoptotic signaling.
High relevance to IAV infection
We aimed to understand how Vitamin D3 might influence the effects of influenza A virus (IAV), particularly in terms of cell death and tissue damage. Utilizing human alveolar cells, we investigated how IAV infection prompts apoptosis, or programmed cell death.
Our findings revealed that IAV reduces the effectiveness of autophagy, a crucial process that helps cells dispose of damaged components. This disruption in autophagy increases cell death, leading to more severe inflammation and tissue damage during infection.
Importantly, we found that Vitamin D3 can counteract this negative effect by restoring autophagic activity. By boosting the expression of specific proteins involved in autophagy, Vitamin D3 helps reduce apoptosis, allowing the cells to survive better during IAV infection. This suggests that Vitamin D3 may play a valuable role in protecting our cells from influenza-related injury.
Our findings revealed that IAV reduces the effectiveness of autophagy, a crucial process that helps cells dispose of damaged components. This disruption in autophagy increases cell death, leading to more severe inflammation and tissue damage during infection.
Importantly, we found that Vitamin D3 can counteract this negative effect by restoring autophagic activity. By boosting the expression of specific proteins involved in autophagy, Vitamin D3 helps reduce apoptosis, allowing the cells to survive better during IAV infection. This suggests that Vitamin D3 may play a valuable role in protecting our cells from influenza-related injury.
Read More
9
Vitamin D3 enhances flu vaccine
Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine.
Highly relevant immune response study
We explored how the psoriasis medication Oxarol, when used as an ointment, can enhance the effectiveness of influenza vaccines. In our investigation involving a mouse model, we applied the ointment to the skin and noticed a significant boost in the immune response. This treatment not only ramped up humoral responses but also strengthened germinal center reactions—critical processes where the immune system prepares to fight infections.
Importantly, we found that the activation of the vitamin D3 receptor in skin cells played a crucial role in this enhanced response. The application of Oxarol led to the higher expression of thymic stromal lymphopoietin (TSLP), a molecule essential for the immune process. By using experiments with recombinant TSLP and specific cell-type deletions, we clarified that certain immune cells were pivotal in these positive reactions triggered by Oxarol.
Overall, our results indicate that vitamin D3 can significantly improve the body's response to influenza vaccines, serving as a promising new adjuvant. This could pave the way for safer and more effective vaccination strategies in the future.
Importantly, we found that the activation of the vitamin D3 receptor in skin cells played a crucial role in this enhanced response. The application of Oxarol led to the higher expression of thymic stromal lymphopoietin (TSLP), a molecule essential for the immune process. By using experiments with recombinant TSLP and specific cell-type deletions, we clarified that certain immune cells were pivotal in these positive reactions triggered by Oxarol.
Overall, our results indicate that vitamin D3 can significantly improve the body's response to influenza vaccines, serving as a promising new adjuvant. This could pave the way for safer and more effective vaccination strategies in the future.
Read More
9
Vitamin D3 boosts flu vaccine response
Effect of 25-hydroxyvitamin D status on serological response to influenza vaccine in prostate cancer patients.
Moderate relevance due to confounding factors
We explored how vitamin D3 levels might influence the immune response to the influenza vaccine in patients with prostate cancer. Our study involved 35 participants who received the trivalent influenza vaccine during the 2006-2007 flu season. We measured their vitamin D3 levels before vaccination and assessed their serum response three months later.
The findings were promising, showing that a higher vitamin D3 status was associated with a better serological response to the vaccine. Specifically, 80% of the participants responded positively against at least one flu strain. It was noteworthy that all patients in the upper quartile of vitamin D3 levels had a strong immune response, suggesting a clear connection between adequate vitamin D3 levels and vaccine effectiveness.
However, we also noted that other factors like age, race, and chemotherapy status did not significantly impact how well participants responded to the vaccine. This indicates that vitamin D3 levels might play a crucial role in bolstering the immune response to influenza vaccination, particularly in this specific patient group.
The findings were promising, showing that a higher vitamin D3 status was associated with a better serological response to the vaccine. Specifically, 80% of the participants responded positively against at least one flu strain. It was noteworthy that all patients in the upper quartile of vitamin D3 levels had a strong immune response, suggesting a clear connection between adequate vitamin D3 levels and vaccine effectiveness.
However, we also noted that other factors like age, race, and chemotherapy status did not significantly impact how well participants responded to the vaccine. This indicates that vitamin D3 levels might play a crucial role in bolstering the immune response to influenza vaccination, particularly in this specific patient group.
Read More
8
Vitamin D3 reduces influenza incidence
Vitamin D3 Supplementation at 5000 IU Daily for the Prevention of Influenza-like Illness in Healthcare Workers: A Pragmatic Randomized Clinical Trial.
High relevance to vitamin D3 efficacy
We conducted a controlled trial to explore whether taking vitamin D3 supplements at a daily dose of 5000 IU could help reduce the occurrence of influenza-like illnesses (ILIs), including COVID-19, among healthcare workers. During the study, 255 healthcare professionals voluntarily took vitamin D3 for nine months, while an additional 2827 individuals in our healthcare system served as a comparison group.
Our findings revealed that those taking vitamin D3 experienced a lower rate of ILIs. Specifically, there was a significant decrease in non-COVID-19 ILIs among those who supplemented with vitamin D3, suggesting that this vitamin may bolster respiratory health in high-risk environments.
However, when it came to COVID-19-related ILIs, we did not find a statistically significant difference between the two groups. This means that while vitamin D3 may help with certain respiratory illnesses, its effectiveness against COVID-19 specifically remains unclear. Overall, daily vitamin D3 supplementation can be beneficial in reducing flu-like symptoms in healthcare settings.
Our findings revealed that those taking vitamin D3 experienced a lower rate of ILIs. Specifically, there was a significant decrease in non-COVID-19 ILIs among those who supplemented with vitamin D3, suggesting that this vitamin may bolster respiratory health in high-risk environments.
However, when it came to COVID-19-related ILIs, we did not find a statistically significant difference between the two groups. This means that while vitamin D3 may help with certain respiratory illnesses, its effectiveness against COVID-19 specifically remains unclear. Overall, daily vitamin D3 supplementation can be beneficial in reducing flu-like symptoms in healthcare settings.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
Improves immunity
Vitamin D3 is essential for everyone. I recommend this manufacturer to my friends. It's particularly important for office workers living in areas with limited sunlight. It enhances immunity, supports bone health, and lowers the risk of ARVI and influenza. My family takes it for prevention with 2,000 IU every other day, and daily when ill.
Read More
9.5
Reduces infections
Vitamin D3 enhances the immune system, aiding in the synthesis of endogenous antibiotics with antibacterial and antiviral properties. Adequate intake decreases the incidence of respiratory infections, including influenza, while deficiencies can lead to autoimmune diseases.
9.5
Prevents infections
Vitamin D reduces the risk of respiratory infections and regulates cytokine production, potentially limiting viral diseases such as influenza.
8.8
Supports immunity
Working! Vitamin D supports healthy bone mineralisation, strengthens the musculoskeletal system, boosts muscle tissue density, and positively affects brain function. It reduces the risk of SARS and influenza and aids in hormone synthesis, including anabolic ones, while benefitting skin health.
Read More
8.8
Protective effect
I’ve learned about vitamin D’s benefits in preventing ARVI, influenza, and coronavirus. Regular small doses provide protective effects, while large single doses may not. Everyone differs in body fat, which may influence how vitamin D accumulates.
