Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9
We explored how vitamin D influences immune responses in women with systemic lupus erythematosus (SLE). Blood samples from 27 patients were used to isolate immune cells and examine the impact of 1,25 dihydroxyvitamin D3 on various cytokines.
Our findings revealed that this form of vitamin D significantly reduced certain pro-inflammatory cytokines while simultaneously increasing beneficial ones, suggesting its potential to improve immune regulation in lupus. However, not all cytokine levels were affected.
Overall, vitamin D shows promise in helping manage inflammatory responses related to SLE.
Our findings revealed that this form of vitamin D significantly reduced certain pro-inflammatory cytokines while simultaneously increasing beneficial ones, suggesting its potential to improve immune regulation in lupus. However, not all cytokine levels were affected.
Overall, vitamin D shows promise in helping manage inflammatory responses related to SLE.
Read More
8
We conducted a double-blind, randomized controlled trial to examine the effects of cholecalciferol on disease activity in systemic lupus erythematosus (SLE) patients. Over 12 weeks, women with SLE received either a daily supplement of 5000 IU of cholecalciferol or a placebo.
While we observed a significant increase in vitamin D levels and a reduction in disease activity scores among the cholecalciferol group, quality of life measurements showed no significant differences between the two groups.
This suggests that cholecalciferol can positively impact disease activity in SLE, but may not enhance patients’ life quality.
While we observed a significant increase in vitamin D levels and a reduction in disease activity scores among the cholecalciferol group, quality of life measurements showed no significant differences between the two groups.
This suggests that cholecalciferol can positively impact disease activity in SLE, but may not enhance patients’ life quality.
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9
We investigated how vitamin D, specifically its active form, interacts with immune cells in systemic lupus erythematosus (SLE), an autoimmune condition. Our findings revealed that vitamin D helps to inhibit activation of specific immune cells triggered by autoantigens.
While vitamin D did show promise in balancing immune responses and directly affecting these immune cells' behavior, the overall therapeutic benefit in treating SLE remains unclear. Though it may play a supportive role in managing SLE, significant evidence for direct treatment efficacy is still needed.
While vitamin D did show promise in balancing immune responses and directly affecting these immune cells' behavior, the overall therapeutic benefit in treating SLE remains unclear. Though it may play a supportive role in managing SLE, significant evidence for direct treatment efficacy is still needed.
Read More
Most Useful Reviews
9.5
Improved energy levels
I have been taking this vitamin D3 for a few months, and I have noticed a significant improvement in my energy and mood. I highly recommend it for anyone looking for a vegan-friendly option. The quality is excellent, and the size is suitable. I was advised to take this 2000 IU dosage, which has greatly enhanced my immunity as I cannot be out in the sun due to my lupus. The packaging is also good.
Read More
8.8
Great quality supplement
Great value D3 supplement that I take for lupus as advised by my specialist. I have found them to be of excellent quality, the appropriate potency, and a reasonable price. They are also easy to swallow.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
- All Researches
9
We investigated how vitamin D, specifically its active form, interacts with immune cells in systemic lupus erythematosus (SLE), an autoimmune condition. Our findings revealed that vitamin D helps to inhibit activation of specific immune cells triggered by autoantigens.
While vitamin D did show promise in balancing immune responses and directly affecting these immune cells' behavior, the overall therapeutic benefit in treating SLE remains unclear. Though it may play a supportive role in managing SLE, significant evidence for direct treatment efficacy is still needed.
While vitamin D did show promise in balancing immune responses and directly affecting these immune cells' behavior, the overall therapeutic benefit in treating SLE remains unclear. Though it may play a supportive role in managing SLE, significant evidence for direct treatment efficacy is still needed.
Read More
9
We explored how vitamin D influences immune responses in women with systemic lupus erythematosus (SLE). Blood samples from 27 patients were used to isolate immune cells and examine the impact of 1,25 dihydroxyvitamin D3 on various cytokines.
Our findings revealed that this form of vitamin D significantly reduced certain pro-inflammatory cytokines while simultaneously increasing beneficial ones, suggesting its potential to improve immune regulation in lupus. However, not all cytokine levels were affected.
Overall, vitamin D shows promise in helping manage inflammatory responses related to SLE.
Our findings revealed that this form of vitamin D significantly reduced certain pro-inflammatory cytokines while simultaneously increasing beneficial ones, suggesting its potential to improve immune regulation in lupus. However, not all cytokine levels were affected.
Overall, vitamin D shows promise in helping manage inflammatory responses related to SLE.
Read More
8
We explored the effect of vitamin D on systemic lupus erythematosus using mice models. Our findings showed that while vitamin D didn’t significantly impact body weight, it did reduce harmful antibodies and cell apoptosis linked to lupus.
Additionally, we noted that vitamin D appeared to decrease the expression of specific proteins and mRNA involved in the Wnt signaling pathway, suggesting a potential mechanism for its beneficial effects. However, the results were not groundbreaking, which means further research may be needed to establish its effectiveness in clinical applications.
Additionally, we noted that vitamin D appeared to decrease the expression of specific proteins and mRNA involved in the Wnt signaling pathway, suggesting a potential mechanism for its beneficial effects. However, the results were not groundbreaking, which means further research may be needed to establish its effectiveness in clinical applications.
Read More
8
Combined treatment shows significant benefits
We conducted a three-month double-blind clinical trial with 45 female patients suffering from systemic lupus erythematosus (SLE).
Participants received either vitamin D, curcumin-piperine, or a combination of both.
Our findings showed that while each treatment improved symptoms and inflammatory markers, the combination of curcumin-piperine and vitamin D was particularly effective in reducing disease activity and lowering cytokine levels.
This suggests that these supplements could be valuable in managing SLE.
Participants received either vitamin D, curcumin-piperine, or a combination of both.
Our findings showed that while each treatment improved symptoms and inflammatory markers, the combination of curcumin-piperine and vitamin D was particularly effective in reducing disease activity and lowering cytokine levels.
This suggests that these supplements could be valuable in managing SLE.
Read More
8
We investigated how vitamin D levels affect lupus, focusing on hospitalized patients. Our study included records from over 1,200 patients and revealed that many had low vitamin D levels.
We found that improved vitamin D levels, especially through supplementation, were linked to better disease management, lower glucocorticoid doses, and reduced kidney complications.
This suggests that keeping vitamin D levels in check could play a significant role in managing systemic lupus erythematosus symptoms and supporting kidney health.
We found that improved vitamin D levels, especially through supplementation, were linked to better disease management, lower glucocorticoid doses, and reduced kidney complications.
This suggests that keeping vitamin D levels in check could play a significant role in managing systemic lupus erythematosus symptoms and supporting kidney health.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Improved energy levels
I have been taking this vitamin D3 for a few months, and I have noticed a significant improvement in my energy and mood. I highly recommend it for anyone looking for a vegan-friendly option. The quality is excellent, and the size is suitable. I was advised to take this 2000 IU dosage, which has greatly enhanced my immunity as I cannot be out in the sun due to my lupus. The packaging is also good.
Read More
8.8
Great quality supplement
Great value D3 supplement that I take for lupus as advised by my specialist. I have found them to be of excellent quality, the appropriate potency, and a reasonable price. They are also easy to swallow.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Karnopp TE, Chapacais GF, Gasparini ML, Dos Santos NG, Freitas VDS, et al. The role of vitamin D: a promising pathway to combat neuropsychiatric lupus disorders. Clin Exp Immunol. 2025;219. doi:10.1093/cei/uxae099
- Zou M, Song Q, Yin T, Xu H, Nie G. Vitamin D improves autoimmune diseases by inhibiting Wnt signaling pathway. Immun Inflamm Dis. 2024;12:e1192. doi:10.1002/iid3.1192
- Wahono CS, Susianti H, Hakim AL, Rosita F, Pratama MZ, et al. Randomised Clinical Trial Study: The Combination of Vitamin D and Curcumin Piperine Attenuates Disease Activity and Pro-inflammatory Cytokines Levels Insystemic Lupus Erythematosus Patients. Curr Rheumatol Rev. 2024;20:586. doi:10.2174/0115733971276106231226071002
- Zhang X, Guo Q, Sun S, Tang X, Shen W, et al. Factors associated with 25-hydroxyvitamin D level in Chinese hospitalized patients with systemic lupus erythematosus: a retrospective cohort study. Rheumatol Int. 2024;44:2067. doi:10.1007/s00296-023-05465-5
- Kim JW, Baek WY, Jung JY, Kim HA, In Yang C, et al. Seasonal vitamin D levels and lupus low disease activity state in systemic lupus erythematosus. Eur J Clin Invest. 2024;54:e14092. doi:10.1111/eci.14092
- Li M, Luo L, Lin C, Ni B, Zou L, et al. Vitamin D3 mitigates autoimmune inflammation caused by activation of myeloid dendritic cells in SLE. Exp Dermatol. 2024;33:e14926. doi:10.1111/exd.14926
- Zhao SS, Mason A, Gjekmarkaj E, Yanaoka H, Burgess S. Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis. Semin Arthritis Rheum. 2023;62:152238. doi:10.1016/j.semarthrit.2023.152238
- Ren YQ, Liu JP, Cui Y. [Associations between vitamin D levels and systemic lupus erythematosus risk:a Mendelian randomized study]. Zhonghua Yu Fang Yi Xue Za Zhi. 2023;57:891. doi:10.3760/cma.j.cn112150-20220622-00643
- Su K, Jia Z, Wu Y, Sun Y, Gao Q, et al. A network causal relationship between type-1 diabetes mellitus, 25-hydroxyvitamin D level and systemic lupus erythematosus: Mendelian randomization study. PLoS One. 2023;18:e0285915. doi:10.1371/journal.pone.0285915
- Zou MS, Song QJ, Yin TY, Xu HT, Nie GM. Vitamin D Activates miR-126a-5p to Target GSK-3β and Alleviates Systemic Lupus Erythematosus in MRL/LPR Mice. Curr Pharm Biotechnol. 2023;24:1803. doi:10.2174/1389201024666230330075550
- Kavadichanda C, Singh P, Maurya S, Tota S, Kiroubagarin A, et al. Clinical and serological association of plasma 25-hydroxyvitamin D (25(OH)D) levels in lupus and the short-term effects of oral vitamin D supplementation. Arthritis Res Ther. 2023;25:2. doi:10.1186/s13075-022-02976-7
- Mariz HA, Sato EI, Cardoso PRG, Gonçalves R, Duarte ALBP, et al. Vitamin D Presented In Vitro Immunomodulatory Property on T Lymphocyte-Related Cytokines in Systemic Lupus Erythematosus. Inflammation. 2023;46:730. doi:10.1007/s10753-022-01768-0
- Li X, Xu S, Liu J, Zhao Y, Han H, et al. Treatment with 1,25-Dihydroxyvitamin D3 Delays Choroid Plexus Infiltration and BCSFB Injury in MRL/lpr Mice Coinciding with Activation of the PPARγ/NF-κB/TNF-α Pathway and Suppression of TGF-β/Smad Signaling. Inflammation. 2023;46:556. doi:10.1007/s10753-022-01755-5
- Fiblia F, Rengganis I, Purnamasari D, Widhani A, Karjadi TH, et al. Effect of Cholecalciferol Supplementation on Disease Activity and Quality of Life of Systemic Lupus Erythematosus Patients: A Randomized Clinical Trial Study. Acta Med Indones. 2022;54:406.
- Bilgin M, Keskin A, Aci R, Baklacioglu HS, Arslanbek Erdem M. Darkness hormone or daylight hormone in women with systemic lupus erythematosus?. Clin Rheumatol. 2023;42:93. doi:10.1007/s10067-022-06379-6
- Dos Santos M, de Souza Silva JM, Bartikoski BJ, Freitas EC, Busatto A, et al. Vitamin D supplementation modulates autophagy in the pristane-induced lupus model. Adv Rheumatol. 2022;62:27. doi:10.1186/s42358-022-00261-4
