Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.1
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9.5
We explored the potential benefits of vitamin D supplementation for individuals suffering from Chronic Rhinosinusitis (CRS), a common condition marked by inflammation of the nose and sinus linings. In a study involving 200 patients with vitamin D deficiency, we divided participants into two groups: one receiving oral vitamin D supplements and the other receiving a placebo.
Over the course of three months, we observed a significant increase in vitamin D levels among those taking the supplements, rising from an average of 12.31 ng/ml to 29.71 ng/ml. Additionally, the participants reported a notable decrease in symptoms derived from their Total Nasal Symptom Scores (TNSS), which fell by an average of 10.65 points.
This study indicates that many CRS patients suffer from vitamin D deficiency and that supplementation can effectively alleviate their symptoms. Ultimately, our findings suggest that addressing vitamin D levels could become a valuable part of the treatment strategy for CRS.
Over the course of three months, we observed a significant increase in vitamin D levels among those taking the supplements, rising from an average of 12.31 ng/ml to 29.71 ng/ml. Additionally, the participants reported a notable decrease in symptoms derived from their Total Nasal Symptom Scores (TNSS), which fell by an average of 10.65 points.
This study indicates that many CRS patients suffer from vitamin D deficiency and that supplementation can effectively alleviate their symptoms. Ultimately, our findings suggest that addressing vitamin D levels could become a valuable part of the treatment strategy for CRS.
Read More
9
Vitamin D treatment aids sinus health
We explored the impact of intranasal delivery of calcitriol, the active form of vitamin D, on chronic sinonasal inflammation linked to cigarette smoke exposure. In our study, mice were exposed to cigarette smoke for an extended period, which helped recreate the conditions of sinus inflammation often seen in smokers.
After the exposure, we administered calcitriol three times a week for four weeks. We utilized various methods, including micro-CT scans and RNA sequencing, to assess the inflammatory status and overall health of the sinonasal region. Our findings revealed that calcitriol resulted in a significant reduction of inflammation and improved olfactory function. Notably, there was an 18% decrease in nasal opacification, which was markedly better than the 5% reduction seen in mice that only underwent smoke cessation.
Additionally, the treatment led to decreased neutrophil infiltration, a common indicator of inflammation, and improved olfactory function, indicating that calcitriol might be a promising treatment option for modulating sinonasal inflammation. This research underlines the beneficial role that vitamin D can play in addressing inflammation related to smoking and potential sinus issues.
After the exposure, we administered calcitriol three times a week for four weeks. We utilized various methods, including micro-CT scans and RNA sequencing, to assess the inflammatory status and overall health of the sinonasal region. Our findings revealed that calcitriol resulted in a significant reduction of inflammation and improved olfactory function. Notably, there was an 18% decrease in nasal opacification, which was markedly better than the 5% reduction seen in mice that only underwent smoke cessation.
Additionally, the treatment led to decreased neutrophil infiltration, a common indicator of inflammation, and improved olfactory function, indicating that calcitriol might be a promising treatment option for modulating sinonasal inflammation. This research underlines the beneficial role that vitamin D can play in addressing inflammation related to smoking and potential sinus issues.
Read More
8
We aimed to investigate the impact of vitamin D on eosinophil movement in patients suffering from eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). To do this, we collected nasal tissue samples from different groups, including healthy patients and those with varying forms of sinusitis. Our research utilized various methods, such as enzyme-linked immunosorbent assay (ELISA) for measuring vitamin D and CCL26 levels, as well as observing eosinophil behavior in response to vitamin D treatment.
Our findings indicated that vitamin D discourages eosinophil chemotaxis, which is the movement of eosinophils to areas of inflammation in the nasal passages. We discovered that this effect occurs by reducing the expression of CCL26, a protein involved in the eosinophil recruitment process. Additionally, vitamin D appears to inhibit certain metabolic pathways that normally lead to increased eosinophil movement.
Overall, our results suggest that vitamin D supplementation could be a promising new approach for managing ECRSwNP. By targeting the underlying mechanisms of eosinophil infiltration, vitamin D may offer a way to reduce the recurrence of symptoms and improve the quality of life for those affected by this condition.
Our findings indicated that vitamin D discourages eosinophil chemotaxis, which is the movement of eosinophils to areas of inflammation in the nasal passages. We discovered that this effect occurs by reducing the expression of CCL26, a protein involved in the eosinophil recruitment process. Additionally, vitamin D appears to inhibit certain metabolic pathways that normally lead to increased eosinophil movement.
Overall, our results suggest that vitamin D supplementation could be a promising new approach for managing ECRSwNP. By targeting the underlying mechanisms of eosinophil infiltration, vitamin D may offer a way to reduce the recurrence of symptoms and improve the quality of life for those affected by this condition.
Read More
Most Useful Reviews
9
Sinusitis relief
In today's world, money is tight, so this company's vitamin D3 is both economical and effective. I have been taking it for two years, and thanks to it, my chronic sinusitis has ceased. Whenever I feel unwell, I supplement with zinc from the same brand, and I haven't been ill in about two years, which is fantastic for a postpartum mother.
Read More
9
No sinusitis episodes
I have been giving this product to my teenage son for almost two years after a blood test revealed a significant deficiency. The doctor prescribed it for constant use. After six months, his level improved slightly, and he hasn't had sinusitis or angina since. His immune system seems stronger now that the deficiency is addressed.
Read More
7.5
Improved immunity
I began taking this alongside vitamin C during a prolonged bout of sinusitis, when nothing seemed effective. Gradually, I started to improve as if all my medications had finally worked. This product genuinely delivers, and the supply lasts a long time.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.1
- All Researches
9.5
We explored the potential benefits of vitamin D supplementation for individuals suffering from Chronic Rhinosinusitis (CRS), a common condition marked by inflammation of the nose and sinus linings. In a study involving 200 patients with vitamin D deficiency, we divided participants into two groups: one receiving oral vitamin D supplements and the other receiving a placebo.
Over the course of three months, we observed a significant increase in vitamin D levels among those taking the supplements, rising from an average of 12.31 ng/ml to 29.71 ng/ml. Additionally, the participants reported a notable decrease in symptoms derived from their Total Nasal Symptom Scores (TNSS), which fell by an average of 10.65 points.
This study indicates that many CRS patients suffer from vitamin D deficiency and that supplementation can effectively alleviate their symptoms. Ultimately, our findings suggest that addressing vitamin D levels could become a valuable part of the treatment strategy for CRS.
Over the course of three months, we observed a significant increase in vitamin D levels among those taking the supplements, rising from an average of 12.31 ng/ml to 29.71 ng/ml. Additionally, the participants reported a notable decrease in symptoms derived from their Total Nasal Symptom Scores (TNSS), which fell by an average of 10.65 points.
This study indicates that many CRS patients suffer from vitamin D deficiency and that supplementation can effectively alleviate their symptoms. Ultimately, our findings suggest that addressing vitamin D levels could become a valuable part of the treatment strategy for CRS.
Read More
9
Vitamin D treatment aids sinus health
We explored the impact of intranasal delivery of calcitriol, the active form of vitamin D, on chronic sinonasal inflammation linked to cigarette smoke exposure. In our study, mice were exposed to cigarette smoke for an extended period, which helped recreate the conditions of sinus inflammation often seen in smokers.
After the exposure, we administered calcitriol three times a week for four weeks. We utilized various methods, including micro-CT scans and RNA sequencing, to assess the inflammatory status and overall health of the sinonasal region. Our findings revealed that calcitriol resulted in a significant reduction of inflammation and improved olfactory function. Notably, there was an 18% decrease in nasal opacification, which was markedly better than the 5% reduction seen in mice that only underwent smoke cessation.
Additionally, the treatment led to decreased neutrophil infiltration, a common indicator of inflammation, and improved olfactory function, indicating that calcitriol might be a promising treatment option for modulating sinonasal inflammation. This research underlines the beneficial role that vitamin D can play in addressing inflammation related to smoking and potential sinus issues.
After the exposure, we administered calcitriol three times a week for four weeks. We utilized various methods, including micro-CT scans and RNA sequencing, to assess the inflammatory status and overall health of the sinonasal region. Our findings revealed that calcitriol resulted in a significant reduction of inflammation and improved olfactory function. Notably, there was an 18% decrease in nasal opacification, which was markedly better than the 5% reduction seen in mice that only underwent smoke cessation.
Additionally, the treatment led to decreased neutrophil infiltration, a common indicator of inflammation, and improved olfactory function, indicating that calcitriol might be a promising treatment option for modulating sinonasal inflammation. This research underlines the beneficial role that vitamin D can play in addressing inflammation related to smoking and potential sinus issues.
Read More
9
Vitamin D reduces inflammation in sinusitis
Our research aimed to understand how vitamin D, particularly its derivatives, affects the health of nasal tissue in patients suffering from chronic rhinosinusitis with nasal polyps (CRSwNP). We conducted experiments using fibroblast cells taken from nasal polyp tissues during surgery. Specifically, we looked at how these fibroblasts responded when stimulated with tumor necrosis factor-α (TNF-α), a protein that promotes inflammation.
After exposing the fibroblasts to TNF-α, we treated them with vitamin D derivatives, including calcitriol and tacalcitol. The results were promising! We found that TNF-α significantly increased the secretion of matrix metalloproteinases (MMP-2 and MMP-9), proteins linked to inflammation and tissue remodeling. Importantly, introducing vitamin D derivatives effectively suppressed this excess secretion, indicating a potential therapeutic role for vitamin D in managing inflammation related to sinusitis.
Though the study shines a light on the positive effects of vitamin D derivatives in this context, it also highlights the need for more specific studies on vitamin D3 alone. Nevertheless, our findings support the idea that vitamin D could be a useful addition to treatment strategies for individuals with CRSwNP, especially among Taiwanese patients.
After exposing the fibroblasts to TNF-α, we treated them with vitamin D derivatives, including calcitriol and tacalcitol. The results were promising! We found that TNF-α significantly increased the secretion of matrix metalloproteinases (MMP-2 and MMP-9), proteins linked to inflammation and tissue remodeling. Importantly, introducing vitamin D derivatives effectively suppressed this excess secretion, indicating a potential therapeutic role for vitamin D in managing inflammation related to sinusitis.
Though the study shines a light on the positive effects of vitamin D derivatives in this context, it also highlights the need for more specific studies on vitamin D3 alone. Nevertheless, our findings support the idea that vitamin D could be a useful addition to treatment strategies for individuals with CRSwNP, especially among Taiwanese patients.
Read More
9
Vitamin D reduces inflammatory responses
We explored how vitamin D derivatives, specifically calcitriol and tacalcitol, influence the secretion of certain inflammatory chemicals in nasal polyp cells from patients suffering from chronic rhinosinusitis with nasal polyps (CRSwNP). In our study, we focused on eotaxin and RANTES, two key substances that attract eosinophils, a type of white blood cell linked to inflammation.
To conduct our research, we collected nasal polyp samples from patients with eosinophilic CRSwNP. The samples were cultured in a laboratory setting, allowing us to examine how these fibroblast cells respond to stimulation. After exposing the cells to interleukin-1 beta, a protein that triggers inflammation, we treated them with vitamin D derivatives to see their effects on eotaxin and RANTES levels.
Our findings showed that treatment with vitamin D compounds effectively reduced the secretion of both eotaxin and RANTES in the stimulated cells. The significant decrease in these inflammatory agents suggests that vitamin D could have beneficial roles beyond its well-known contributions to bone health. This opens potential avenues for using vitamin D in treating CRSwNP, particularly for our Taiwanese patient population.
Overall, this research highlights a potentially new therapeutic angle for vitamin D in managing chronic sinusitis, emphasizing its role in modulating inflammatory responses associated with this challenging condition.
To conduct our research, we collected nasal polyp samples from patients with eosinophilic CRSwNP. The samples were cultured in a laboratory setting, allowing us to examine how these fibroblast cells respond to stimulation. After exposing the cells to interleukin-1 beta, a protein that triggers inflammation, we treated them with vitamin D derivatives to see their effects on eotaxin and RANTES levels.
Our findings showed that treatment with vitamin D compounds effectively reduced the secretion of both eotaxin and RANTES in the stimulated cells. The significant decrease in these inflammatory agents suggests that vitamin D could have beneficial roles beyond its well-known contributions to bone health. This opens potential avenues for using vitamin D in treating CRSwNP, particularly for our Taiwanese patient population.
Overall, this research highlights a potentially new therapeutic angle for vitamin D in managing chronic sinusitis, emphasizing its role in modulating inflammatory responses associated with this challenging condition.
Read More
9
We explored the impact of vitamin D derivatives on a key player in sinusitis inflammation: RANTES, a known chemoattractant for eosinophils. In a study involving nasal polyp fibroblast cultures from 16 patients, we first stimulated the cells with bacterial components before treating them with increasing concentrations of vitamin D3 compounds, including calcitriol and tacalcitol, alongside the medication budesonide.
We observed that higher doses of calcitriol and tacalcitol significantly reduced RANTES production compared to untreated cells. Notably, when combined with budesonide in specific ratios, these vitamin D compounds managed to suppress RANTES levels even more effectively than when either drug was used alone. This suggests that vitamin D derivatives have a complementary role in treating chronic rhinosinusitis with nasal polyps by helping to regulate inflammatory responses.
Overall, our findings indicate that these vitamin D compounds, particularly when used alongside budesonide, could enhance therapeutic approaches for managing sinus inflammation. This underscores the importance of considering vitamin D not just as a supplement, but as an integrative part of sinusitis treatment strategies.
We observed that higher doses of calcitriol and tacalcitol significantly reduced RANTES production compared to untreated cells. Notably, when combined with budesonide in specific ratios, these vitamin D compounds managed to suppress RANTES levels even more effectively than when either drug was used alone. This suggests that vitamin D derivatives have a complementary role in treating chronic rhinosinusitis with nasal polyps by helping to regulate inflammatory responses.
Overall, our findings indicate that these vitamin D compounds, particularly when used alongside budesonide, could enhance therapeutic approaches for managing sinus inflammation. This underscores the importance of considering vitamin D not just as a supplement, but as an integrative part of sinusitis treatment strategies.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Sinusitis relief
In today's world, money is tight, so this company's vitamin D3 is both economical and effective. I have been taking it for two years, and thanks to it, my chronic sinusitis has ceased. Whenever I feel unwell, I supplement with zinc from the same brand, and I haven't been ill in about two years, which is fantastic for a postpartum mother.
Read More
9
No sinusitis episodes
I have been giving this product to my teenage son for almost two years after a blood test revealed a significant deficiency. The doctor prescribed it for constant use. After six months, his level improved slightly, and he hasn't had sinusitis or angina since. His immune system seems stronger now that the deficiency is addressed.
Read More
7.5
Improved immunity
I began taking this alongside vitamin C during a prolonged bout of sinusitis, when nothing seemed effective. Gradually, I started to improve as if all my medications had finally worked. This product genuinely delivers, and the supply lasts a long time.
Read More
7.5
Less severe symptoms
This vitamin is beneficial for the immune system, especially during this time. My daughter is sensitive and suffers from sinusitis. Since she started taking vitamin D3, the severity of her condition has reduced. Thanks, I Herb.
Read More
Frequently Asked Questions
9
No sinusitis episodes
I have been giving this product to my teenage son for almost two years after a blood test revealed a significant deficiency. The doctor prescribed it for constant use. After six months, his level improved slightly, and he hasn't had sinusitis or angina since. His immune system seems stronger now that the deficiency is addressed.
7.5
Improved immunity
I began taking this alongside vitamin C during a prolonged bout of sinusitis, when nothing seemed effective. Gradually, I started to improve as if all my medications had finally worked. This product genuinely delivers, and the supply lasts a long time.
9
Sinusitis relief
In today's world, money is tight, so this company's vitamin D3 is both economical and effective. I have been taking it for two years, and thanks to it, my chronic sinusitis has ceased. Whenever I feel unwell, I supplement with zinc from the same brand, and I haven't been ill in about two years, which is fantastic for a postpartum mother.
7.5
Less severe symptoms
This vitamin is beneficial for the immune system, especially during this time. My daughter is sensitive and suffers from sinusitis. Since she started taking vitamin D3, the severity of her condition has reduced. Thanks, I Herb.
7
Vitamin D's role in sinusitis studied
We looked into how vitamin D levels might impact chronic rhinosinusitis (CRS), especially focusing on the different types: eosinophilic (ECRSwNP) and non-eosinophilic (nECRSwNP) chronic rhinosinusitis with nasal polyps. The study involved a robust methodology with 275 CRS patients and 298 healthy controls. By using logistic regression and propensity score matching, we examined the relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and CRS risk.
Our findings revealed that patients with CRS had significantly lower serum 25(OH)D levels compared to healthy individuals. Notably, ECRSwNP patients had the lowest vitamin D levels compared to those with nECRSwNP. We also identified eosinophil percentages and IgE levels as key independent risk factors for ECRSwNP, while serum 25(OH)D appeared to provide a protective effect against this condition.
The results suggest that a deficiency in vitamin D contributes to an increased risk of ECRSwNP, with an odds ratio indicating a threefold risk for those with low vitamin D levels. Predictive markers for ECRSwNP were established, including a combination of an eosinophil percentage equal to or above 5% and low vitamin D levels.
In summary, while we found connections between vitamin D deficiency and CRS, the exact direct role of vitamin D in treating sinusitis needs further exploration, as this study emphasized observational data over treatment efficacy.
Our findings revealed that patients with CRS had significantly lower serum 25(OH)D levels compared to healthy individuals. Notably, ECRSwNP patients had the lowest vitamin D levels compared to those with nECRSwNP. We also identified eosinophil percentages and IgE levels as key independent risk factors for ECRSwNP, while serum 25(OH)D appeared to provide a protective effect against this condition.
The results suggest that a deficiency in vitamin D contributes to an increased risk of ECRSwNP, with an odds ratio indicating a threefold risk for those with low vitamin D levels. Predictive markers for ECRSwNP were established, including a combination of an eosinophil percentage equal to or above 5% and low vitamin D levels.
In summary, while we found connections between vitamin D deficiency and CRS, the exact direct role of vitamin D in treating sinusitis needs further exploration, as this study emphasized observational data over treatment efficacy.
8
We aimed to investigate the impact of vitamin D on eosinophil movement in patients suffering from eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). To do this, we collected nasal tissue samples from different groups, including healthy patients and those with varying forms of sinusitis. Our research utilized various methods, such as enzyme-linked immunosorbent assay (ELISA) for measuring vitamin D and CCL26 levels, as well as observing eosinophil behavior in response to vitamin D treatment.
Our findings indicated that vitamin D discourages eosinophil chemotaxis, which is the movement of eosinophils to areas of inflammation in the nasal passages. We discovered that this effect occurs by reducing the expression of CCL26, a protein involved in the eosinophil recruitment process. Additionally, vitamin D appears to inhibit certain metabolic pathways that normally lead to increased eosinophil movement.
Overall, our results suggest that vitamin D supplementation could be a promising new approach for managing ECRSwNP. By targeting the underlying mechanisms of eosinophil infiltration, vitamin D may offer a way to reduce the recurrence of symptoms and improve the quality of life for those affected by this condition.
Our findings indicated that vitamin D discourages eosinophil chemotaxis, which is the movement of eosinophils to areas of inflammation in the nasal passages. We discovered that this effect occurs by reducing the expression of CCL26, a protein involved in the eosinophil recruitment process. Additionally, vitamin D appears to inhibit certain metabolic pathways that normally lead to increased eosinophil movement.
Overall, our results suggest that vitamin D supplementation could be a promising new approach for managing ECRSwNP. By targeting the underlying mechanisms of eosinophil infiltration, vitamin D may offer a way to reduce the recurrence of symptoms and improve the quality of life for those affected by this condition.
9
Vitamin D treatment aids sinus health
We explored the impact of intranasal delivery of calcitriol, the active form of vitamin D, on chronic sinonasal inflammation linked to cigarette smoke exposure. In our study, mice were exposed to cigarette smoke for an extended period, which helped recreate the conditions of sinus inflammation often seen in smokers.
After the exposure, we administered calcitriol three times a week for four weeks. We utilized various methods, including micro-CT scans and RNA sequencing, to assess the inflammatory status and overall health of the sinonasal region. Our findings revealed that calcitriol resulted in a significant reduction of inflammation and improved olfactory function. Notably, there was an 18% decrease in nasal opacification, which was markedly better than the 5% reduction seen in mice that only underwent smoke cessation.
Additionally, the treatment led to decreased neutrophil infiltration, a common indicator of inflammation, and improved olfactory function, indicating that calcitriol might be a promising treatment option for modulating sinonasal inflammation. This research underlines the beneficial role that vitamin D can play in addressing inflammation related to smoking and potential sinus issues.
After the exposure, we administered calcitriol three times a week for four weeks. We utilized various methods, including micro-CT scans and RNA sequencing, to assess the inflammatory status and overall health of the sinonasal region. Our findings revealed that calcitriol resulted in a significant reduction of inflammation and improved olfactory function. Notably, there was an 18% decrease in nasal opacification, which was markedly better than the 5% reduction seen in mice that only underwent smoke cessation.
Additionally, the treatment led to decreased neutrophil infiltration, a common indicator of inflammation, and improved olfactory function, indicating that calcitriol might be a promising treatment option for modulating sinonasal inflammation. This research underlines the beneficial role that vitamin D can play in addressing inflammation related to smoking and potential sinus issues.
5
We investigated how vitamin D levels before surgery might influence the outcomes of endoscopic sinus surgery (ESS) for patients with chronic rhinosinusitis (CRS). The study included 25 patients suffering from CRS with nasal polyps and 18 healthy individuals for comparison. We evaluated the severity of their condition through various questionnaires and scoring systems before and after the surgery.
Interestingly, our findings revealed no significant differences in vitamin D levels between the CRS patients and the healthy controls. While we found that vitamin D status did not correlate with the severity of the disease, it was noteworthy that participants with higher vitamin D levels experienced better outcomes six weeks after surgery.
Despite the intriguing role of vitamin D in the immune response, this study does not support the idea that vitamin D treatment improves the occurrence or severity of CRS. However, it does suggest that maintaining adequate vitamin D levels might contribute to more favorable surgery results for individuals undergoing ESS.
Interestingly, our findings revealed no significant differences in vitamin D levels between the CRS patients and the healthy controls. While we found that vitamin D status did not correlate with the severity of the disease, it was noteworthy that participants with higher vitamin D levels experienced better outcomes six weeks after surgery.
Despite the intriguing role of vitamin D in the immune response, this study does not support the idea that vitamin D treatment improves the occurrence or severity of CRS. However, it does suggest that maintaining adequate vitamin D levels might contribute to more favorable surgery results for individuals undergoing ESS.
8
We conducted a study to understand how a natural supplement containing Ribes nigrum, Boswellia serrata, Bromelain, and Vitamin D can help alleviate symptoms of chronic sinusitis. In this case-control setup, 60 patients were divided into three groups: one only using nasal steroids, another using nasal steroids plus one dose of the supplement daily for 30 days, and the last group using nasal steroids with two doses of the supplement each day for 15 days.
Our findings showed that patients taking the supplement experienced notable improvements in their nasal symptoms, such as reduced hyperemia and rhinorrhea, compared to the control group. The statistical differences indicated that the addition of this supplement could be beneficial in managing local inflammation associated with chronic sinusitis. While we could not isolate the specific effect of Vitamin D alone due to its combination with other ingredients, our preliminary observations suggest it plays a supportive role in enhancing the overall treatment for this stubborn condition.
Overall, the research indicates that integrating such natural products alongside conventional treatments may offer a promising avenue to better manage chronic sinusitis.
Our findings showed that patients taking the supplement experienced notable improvements in their nasal symptoms, such as reduced hyperemia and rhinorrhea, compared to the control group. The statistical differences indicated that the addition of this supplement could be beneficial in managing local inflammation associated with chronic sinusitis. While we could not isolate the specific effect of Vitamin D alone due to its combination with other ingredients, our preliminary observations suggest it plays a supportive role in enhancing the overall treatment for this stubborn condition.
Overall, the research indicates that integrating such natural products alongside conventional treatments may offer a promising avenue to better manage chronic sinusitis.
References
- Wang J, Jiang Y, Chen X, Ma J, Li Y, et al. Serum 25-hydroxyvitamin D levels and peripheral blood eosinophil percentages as predictive indicators for eosinophilic chronic sinusitis with nasal polyps. Eur Arch Otorhinolaryngol. 2025. doi:10.1007/s00405-025-09263-6
- Huang W, Zhang Y, Li Y, Ma J, Li X, et al. Vitamin D impedes eosinophil chemotaxis via inhibiting glycolysis-induced CCL26 expression in eosinophilic chronic rhinosinusitis with nasal polyps. Cell Commun Signal. 2025;23:104. doi:10.1186/s12964-025-02078-2
- Langerude L, McQuiston A, Atkinson C, Mulligan JK. Intranasal Calcitriol Accelerates Improvement of Sinonasal Inflammation and Olfactory Impairment in Mice After Cessation of Chronic Cigarette-Smoke Exposure. Int Forum Allergy Rhinol. 2025. doi:10.1002/alr.23504
- Brociek-Piłczyńska A, Trebinska-Stryjewska A, Jurkiewicz D. Preoperative serum 25(OH)D status and its correlation with an early endoscopic sinus surgery outcome and chronic rhinosinusitis severity. Otolaryngol Pol. 2024;78:1. doi:10.5604/01.3001.0054.7429
- Alharthi GNA, Alzarei A. The Correlation Between Vitamin D Deficiency and Chronic Rhinosinusitis: A Systematic Review. Cureus. 2024;16:e55955. doi:10.7759/cureus.55955
- Bagheri P, Nouri M, Eskandarzadeh H, Darvishi M. Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study. Recent Adv Inflamm Allergy Drug Discov. 2024;18:108. doi:10.2174/0127722708281623240116100806
- Pantazidou G, Papaioannou I, Skoulakis C, Petinaki E, Hajiioannou J. Vitamin D Levels in Chronic Rhinosinusitis in Patients With or Without Nasal Polyposis: A Systematic Review. Cureus. 2023;15:e46275. doi:10.7759/cureus.46275
- De Luca P, D'Ascanio L, Cingolani C, Latini G, Grigaliute E, et al. A Supplement with Ribes Nigrum, Boswellia Serrata, Bromelain and Vitamin D to Stop Local Inflammation in Chronic Sinusitis: A Case-Control Study. J Clin Med. 2023;12. doi:10.3390/jcm12082929
- Wang L, Zhao Y, Yao S, Lou H, Zhang L. Vitamin D Improves the Effect of Glucocorticoids on Attenuating Lipopolysaccharide-Induced IL-6 Production via TLR4/NF-κB Pathway in Human Respiratory Epithelial Cells. Int Arch Allergy Immunol. 2022;183:1017. doi:10.1159/000524855
- Kalińczak-Górna P, Radajewski K, Burduk P. Relationship between the Severity of Inflammatory Changes in Chronic Sinusitis and the Level of Vitamin D before and after the FESS Procedure. J Clin Med. 2021;10. doi:10.3390/jcm10132836
- Kagoya R, Kondo K, Kishimoto-Urata M, Shimizu Y, Kikuta S, et al. A murine model of eosinophilic chronic rhinosinusitis using the topical application of a vitamin D3 analog. Allergy. 2021;76:1432. doi:10.1111/all.14627
- Baruah B, Gupta A, Kumar A, Kumar A. The role of oral vitamin D3 supplementation in the treatment of Chronic Rhinosinusitis in adults with Vitamin D deficiency. J Family Med Prim Care. 2020;9:2877. doi:10.4103/jfmpc.jfmpc_448_20
- Kowalik K, Waniewska-Łęczycka M, Sarnowska E, Rusetska N, Sierdziński J, et al. Role of chromatin remodeling complex SWI/SNF and VDR in chronic rhinosinusitis. Adv Clin Exp Med. 2020;29:313. doi:10.17219/acem/117683
- Zand V, Baradaranfar M, Vaziribozorg S, Mandegari M, Mansourimanesh M, et al. Correlation of Serum Vitamin D Levels with Chronic Rhinosinusitis Disease Severity. Iran J Otorhinolaryngol. 2020;32:35. doi:10.22038/ijorl.2019.31926.2050
- Ma SW, Ende JA, Alvarado R, Christensen JM, Kalish L, et al. Topical Vitamin D May Modulate Human Sinonasal Mucosal Responses to House Dust Mite Antigen. Am J Rhinol Allergy. 2020;34:471. doi:10.1177/1945892420905432
- Faghih Habibi A, Gerami H, Banan R, Kazemnezhad Leily E, Khoshkhat P, et al. Serum 25-Hydroxy Vitamin D in Chronic Rhinosinusitis with and Without Nasal Polyposis: A Case-Control Study. Iran J Otorhinolaryngol. 2019;31:19.
- Xiao Q, Wang H, Song J, Qin ZY, Pan L, et al. Impaired local Vitamin D3 metabolism contributes to IL-36g overproduction in epithelial cells in chronic rhinosinusitis with nasal polyps. Rhinology. 2024;62:236. doi:10.4193/RhinRhin23.123
- Zhou FW, Zhang T, Jin Y, Ma YF, Xian ZP, et al. [Predictive diagnostic value of serum 25-hydroxyvitamin D3 in eosinophilic chronic rhinosinusitis with nasal polyps]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021;56:1051. doi:10.3760/cma.j.cn115330-20210427-00232
- Wang F, Yang Y, Chen H. Vitamin D deficiency are associated with subjective disease severity in Chinese patients with chronic rhinosinusitis with nasal polyps. Am J Otolaryngol. 2019;40:36. doi:10.1016/j.amjoto.2018.09.003
- Carroll WW, Schlosser RJ, O'Connell BP, Soler ZM, Mulligan JK. Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2016;6:605. doi:10.1002/alr.21704
- Wang LF, Tai CF, Chien CY, Chiang FY, Chen JY. Vitamin D decreases the secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis. Kaohsiung J Med Sci. 2015;31:235. doi:10.1016/j.kjms.2015.02.001
- Wang LF, Chien CY, Tai CF, Chiang FY, Chen JY. Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps. Kaohsiung J Med Sci. 2015;31:63. doi:10.1016/j.kjms.2014.11.011
- Sansoni ER, Sautter NB, Mace JC, Smith TL, Yawn JR, et al. Vitamin D3 as a novel regulator of basic fibroblast growth factor in chronic rhinosinusitis with nasal polyposis. Int Forum Allergy Rhinol. 2015;5:191. doi:10.1002/alr.21474
- Mulligan JK, Nagel W, O'Connell BP, Wentzel J, Atkinson C, et al. Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2014;134:342. doi:10.1016/j.jaci.2014.01.039
- Schlosser RJ, Soler ZM, Schmedes GW, Storck K, Mulligan JK. Impact of vitamin D deficiency upon clinical presentation in nasal polyposis. Int Forum Allergy Rhinol. 2014;4:196. doi:10.1002/alr.21274
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