Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.2
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9
We set out to explore how different doses of vitamin D3, specifically Cholecalciferol, impact the healing of chronic diabetic foot ulcers. Our study included patients with diabetes who had one or more foot ulcers present for longer than six weeks. We assigned participants at random to receive either a high dose of 170 micrograms or a low dose of 20 micrograms daily. Throughout the experiment, both patients and assessors were kept unaware of who was receiving which treatment to ensure unbiased results.
Over our 48-week follow-up period, we observed that the high-dose vitamin D3 treatment yielded significantly better healing outcomes. Among the patients receiving the high dose, 70% of their ulcers healed, while only 35% of those on the low dose showed healing. The median ulcer reduction in the high-dose group was impressive, showing complete healing in many cases, while those on the low dose saw a more modest reduction.
In conclusion, our findings suggest that high-dose vitamin D3 can play a crucial role in promoting the healing of chronic diabetic foot ulcers. By effectively boosting healing rates, this treatment could provide an important avenue for improving health outcomes in patients suffering from these persistent wounds.
Over our 48-week follow-up period, we observed that the high-dose vitamin D3 treatment yielded significantly better healing outcomes. Among the patients receiving the high dose, 70% of their ulcers healed, while only 35% of those on the low dose showed healing. The median ulcer reduction in the high-dose group was impressive, showing complete healing in many cases, while those on the low dose saw a more modest reduction.
In conclusion, our findings suggest that high-dose vitamin D3 can play a crucial role in promoting the healing of chronic diabetic foot ulcers. By effectively boosting healing rates, this treatment could provide an important avenue for improving health outcomes in patients suffering from these persistent wounds.
Read More
9
Vitamin D3 protects against ulcers
We explored the effects of Vitamin D3 in protecting the stomach from injuries caused by aspirin, a common pain relief medication known to trigger gastric ulcers. In a controlled study using 24 rats, we divided them into four groups: a control group, a group receiving Vitamin D3 without injury, a group suffering from aspirin-induced injury, and a group treated with Vitamin D3 after such injury.
Our findings were quite promising. We observed that Vitamin D3 supplementation led to significant improvements in the overall health of the gastric tissue. Notably, it enhanced the expression of vital proteins such as E-Cadherin and gastrokine 1 (GKN1), both critical for maintaining stomach lining integrity. Moreover, it reduced markers of inflammation and oxidative stress, suggesting a protective mechanism against ulcer formation.
The study points to Vitamin D3 as a potential ally in mitigating the damaging effects of aspirin on the gastric mucosa. By highlighting its ability to bolster the stomach's defenses, we bring attention to how simple dietary supplementation could serve as an effective strategy for those at risk of gastric ulcers.
Our findings were quite promising. We observed that Vitamin D3 supplementation led to significant improvements in the overall health of the gastric tissue. Notably, it enhanced the expression of vital proteins such as E-Cadherin and gastrokine 1 (GKN1), both critical for maintaining stomach lining integrity. Moreover, it reduced markers of inflammation and oxidative stress, suggesting a protective mechanism against ulcer formation.
The study points to Vitamin D3 as a potential ally in mitigating the damaging effects of aspirin on the gastric mucosa. By highlighting its ability to bolster the stomach's defenses, we bring attention to how simple dietary supplementation could serve as an effective strategy for those at risk of gastric ulcers.
Read More
9
We examined the effects of vitamin D supplementation on healing diabetic foot ulcers (DFUs). By reviewing a series of controlled trials, we aimed to understand how vitamin D might facilitate the healing process for individuals suffering from these painful sores that often arise in diabetes.
Our findings suggest that vitamin D can significantly aid the healing of DFUs. Specifically, it appears to lower blood sugar levels while also reducing inflammation and oxidative stress, which are known to impede healing. Such outcomes provide a positive outlook for using vitamin D as part of the treatment strategy for DFUs.
With diabetes being a major health challenge and DFUs contributing to severe complications, our research offers valuable insights. By demonstrating how vitamin D supplementation can improve healing, we hope to support medical professionals in enhancing patient care practices.
Overall, this evidence potentially shifts how we approach the treatment of diabetic foot ulcers, making a case for incorporating vitamin D into therapeutic protocols to promote faster recovery.
Our findings suggest that vitamin D can significantly aid the healing of DFUs. Specifically, it appears to lower blood sugar levels while also reducing inflammation and oxidative stress, which are known to impede healing. Such outcomes provide a positive outlook for using vitamin D as part of the treatment strategy for DFUs.
With diabetes being a major health challenge and DFUs contributing to severe complications, our research offers valuable insights. By demonstrating how vitamin D supplementation can improve healing, we hope to support medical professionals in enhancing patient care practices.
Overall, this evidence potentially shifts how we approach the treatment of diabetic foot ulcers, making a case for incorporating vitamin D into therapeutic protocols to promote faster recovery.
Read More
Most Useful Reviews
9
Stronger immunity
I regularly take vitamin D3, which is vital for my immune system and overall health. After taking 2000 units daily, I haven't faced respiratory issues in over a year, and my ulcer problems have improved significantly.
Read More
9
Leg ulcer relief
During the pandemic, I find vitamin D essential. After completing a course of 2000 units, my leg ulcers disappeared, showing its effectiveness.
Read More
9
Ulcer improvement
I take one for the winter to combat mini-ulcers caused by vitamin D deficiency. After taking these pills, everything improves.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8.2
- All Researches
9
Vitamin D3 protects against ulcers
We explored the effects of Vitamin D3 in protecting the stomach from injuries caused by aspirin, a common pain relief medication known to trigger gastric ulcers. In a controlled study using 24 rats, we divided them into four groups: a control group, a group receiving Vitamin D3 without injury, a group suffering from aspirin-induced injury, and a group treated with Vitamin D3 after such injury.
Our findings were quite promising. We observed that Vitamin D3 supplementation led to significant improvements in the overall health of the gastric tissue. Notably, it enhanced the expression of vital proteins such as E-Cadherin and gastrokine 1 (GKN1), both critical for maintaining stomach lining integrity. Moreover, it reduced markers of inflammation and oxidative stress, suggesting a protective mechanism against ulcer formation.
The study points to Vitamin D3 as a potential ally in mitigating the damaging effects of aspirin on the gastric mucosa. By highlighting its ability to bolster the stomach's defenses, we bring attention to how simple dietary supplementation could serve as an effective strategy for those at risk of gastric ulcers.
Our findings were quite promising. We observed that Vitamin D3 supplementation led to significant improvements in the overall health of the gastric tissue. Notably, it enhanced the expression of vital proteins such as E-Cadherin and gastrokine 1 (GKN1), both critical for maintaining stomach lining integrity. Moreover, it reduced markers of inflammation and oxidative stress, suggesting a protective mechanism against ulcer formation.
The study points to Vitamin D3 as a potential ally in mitigating the damaging effects of aspirin on the gastric mucosa. By highlighting its ability to bolster the stomach's defenses, we bring attention to how simple dietary supplementation could serve as an effective strategy for those at risk of gastric ulcers.
Read More
9
We investigated the potential benefits of using vitamin D receptor ligands, specifically calcifediol and paricalcitol, as additional treatments for corneal perforations caused by herpes simplex keratitis. Our focus was on how these therapies could help in healing ulcers and preventing future HSV recurrences.
The case involved a 57-year-old woman with a history of recurring eye issues who experienced a burning sensation and pain in her right eye, leading to a diagnosis of HSV keratitis. Despite receiving standard treatments, she developed a perforated corneal ulcer. Following surgical intervention, including a specialized graft, we initiated oral vitamin D therapies to support healing and boost her immune response.
Remarkably, after starting these vitamin D treatments, we observed significant improvement. The patient's cornea began to thicken and heal nicely, without any signs of HSV recurrence during the treatment period. This outcome suggested that incorporating vitamin D could play a helpful role in managing such infections and promoting better recovery.
Our findings indicate that using vitamin D receptor ligands as adjunctive therapies might offer a promising avenue for treating severe corneal conditions and enhancing overall healing, reducing the need for more invasive procedures in the future.
The case involved a 57-year-old woman with a history of recurring eye issues who experienced a burning sensation and pain in her right eye, leading to a diagnosis of HSV keratitis. Despite receiving standard treatments, she developed a perforated corneal ulcer. Following surgical intervention, including a specialized graft, we initiated oral vitamin D therapies to support healing and boost her immune response.
Remarkably, after starting these vitamin D treatments, we observed significant improvement. The patient's cornea began to thicken and heal nicely, without any signs of HSV recurrence during the treatment period. This outcome suggested that incorporating vitamin D could play a helpful role in managing such infections and promoting better recovery.
Our findings indicate that using vitamin D receptor ligands as adjunctive therapies might offer a promising avenue for treating severe corneal conditions and enhancing overall healing, reducing the need for more invasive procedures in the future.
Read More
9
We examined the effects of vitamin D supplementation on healing diabetic foot ulcers (DFUs). By reviewing a series of controlled trials, we aimed to understand how vitamin D might facilitate the healing process for individuals suffering from these painful sores that often arise in diabetes.
Our findings suggest that vitamin D can significantly aid the healing of DFUs. Specifically, it appears to lower blood sugar levels while also reducing inflammation and oxidative stress, which are known to impede healing. Such outcomes provide a positive outlook for using vitamin D as part of the treatment strategy for DFUs.
With diabetes being a major health challenge and DFUs contributing to severe complications, our research offers valuable insights. By demonstrating how vitamin D supplementation can improve healing, we hope to support medical professionals in enhancing patient care practices.
Overall, this evidence potentially shifts how we approach the treatment of diabetic foot ulcers, making a case for incorporating vitamin D into therapeutic protocols to promote faster recovery.
Our findings suggest that vitamin D can significantly aid the healing of DFUs. Specifically, it appears to lower blood sugar levels while also reducing inflammation and oxidative stress, which are known to impede healing. Such outcomes provide a positive outlook for using vitamin D as part of the treatment strategy for DFUs.
With diabetes being a major health challenge and DFUs contributing to severe complications, our research offers valuable insights. By demonstrating how vitamin D supplementation can improve healing, we hope to support medical professionals in enhancing patient care practices.
Overall, this evidence potentially shifts how we approach the treatment of diabetic foot ulcers, making a case for incorporating vitamin D into therapeutic protocols to promote faster recovery.
Read More
9
We explored the impact of vitamin D, specifically 1,25-dihydroxyvitamin D3 (VitD3), when used alongside infliximab (IFX) in a mouse model of ulcerative colitis (UC). Our research aimed to uncover whether this combination could be more effective than using IFX alone.
To do this, we induced colitis in mice and then assessed their symptoms and conducted histopathological evaluations to determine the therapeutic effects of this combination therapy. The results revealed that when given together, VitD3 and IFX significantly reduced the severity of colitis, showcasing improvements in clinical signs and suppression of inflammation.
Additionally, we looked at how this combination affected regulatory T cells (Tregs), which play a crucial role in immune response. We observed that the combined therapy encouraged more effective Treg differentiation, leading to higher levels of anti-inflammatory markers in the system. Particularly in ulcerative colitis patients, we found that higher levels of serum vitamin D correlated positively with Treg levels, suggesting a beneficial relationship.
Thus, our study suggests that VitD3, in combination with IFX, offers a promising approach for managing ulcerative colitis, especially for patients who may have difficulty tolerating standard treatments.
To do this, we induced colitis in mice and then assessed their symptoms and conducted histopathological evaluations to determine the therapeutic effects of this combination therapy. The results revealed that when given together, VitD3 and IFX significantly reduced the severity of colitis, showcasing improvements in clinical signs and suppression of inflammation.
Additionally, we looked at how this combination affected regulatory T cells (Tregs), which play a crucial role in immune response. We observed that the combined therapy encouraged more effective Treg differentiation, leading to higher levels of anti-inflammatory markers in the system. Particularly in ulcerative colitis patients, we found that higher levels of serum vitamin D correlated positively with Treg levels, suggesting a beneficial relationship.
Thus, our study suggests that VitD3, in combination with IFX, offers a promising approach for managing ulcerative colitis, especially for patients who may have difficulty tolerating standard treatments.
Read More
9
Co-delivery improves colitis treatment
We investigated how the combination of resveratrol and vitamin D3 could help manage symptoms of ulcerative colitis in mice, especially in the context of a specially designed delivery system. Through the use of multilayer structural nanoparticles, we were able to efficiently encapsulate both compounds to enhance their stability and effectiveness.
In our evaluation, we observed that these nanoparticles successfully released vitamin D3 and resveratrol in a controlled manner, particularly in simulated intestinal environments. This sequential release means that the components are delivered in a timed fashion to potentially maximize their benefits.
Not only did we find that this system improved the symptoms of colitis—like weight loss and inflammation—but it also seemed to support the overall health of the colon tissue. The study's results indicated a significant reduction in inflammation markers and oxidative stress in the mice treated with this co-delivery of vitamins.
While we initially aimed to assess the standalone benefit of vitamin D3, it was challenging to isolate its effects because of the dual approach. Thus, while we can assert that the combination helped alleviate symptoms, more research would be necessary to fully understand the specific role that vitamin D3 plays in this treatment.
In our evaluation, we observed that these nanoparticles successfully released vitamin D3 and resveratrol in a controlled manner, particularly in simulated intestinal environments. This sequential release means that the components are delivered in a timed fashion to potentially maximize their benefits.
Not only did we find that this system improved the symptoms of colitis—like weight loss and inflammation—but it also seemed to support the overall health of the colon tissue. The study's results indicated a significant reduction in inflammation markers and oxidative stress in the mice treated with this co-delivery of vitamins.
While we initially aimed to assess the standalone benefit of vitamin D3, it was challenging to isolate its effects because of the dual approach. Thus, while we can assert that the combination helped alleviate symptoms, more research would be necessary to fully understand the specific role that vitamin D3 plays in this treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Stronger immunity
I regularly take vitamin D3, which is vital for my immune system and overall health. After taking 2000 units daily, I haven't faced respiratory issues in over a year, and my ulcer problems have improved significantly.
Read More
9
Leg ulcer relief
During the pandemic, I find vitamin D essential. After completing a course of 2000 units, my leg ulcers disappeared, showing its effectiveness.
Read More
9
Ulcer improvement
I take one for the winter to combat mini-ulcers caused by vitamin D deficiency. After taking these pills, everything improves.
Read More
7.5
Ulcer healing
Drinking this makes me feel great. My ulcers heal much faster, and I find it beneficial to take it every three days.
Read More
6
Cautious treatment
It aids calcium absorption and boosts immunity. However, I must be cautious with ulcers and my chronic conditions to prevent complications.
Read More
Frequently Asked Questions
9
Stronger immunity
I regularly take vitamin D3, which is vital for my immune system and overall health. After taking 2000 units daily, I haven't faced respiratory issues in over a year, and my ulcer problems have improved significantly.
9
Leg ulcer relief
During the pandemic, I find vitamin D essential. After completing a course of 2000 units, my leg ulcers disappeared, showing its effectiveness.
9
Ulcer improvement
I take one for the winter to combat mini-ulcers caused by vitamin D deficiency. After taking these pills, everything improves.
7.5
Ulcer healing
Drinking this makes me feel great. My ulcers heal much faster, and I find it beneficial to take it every three days.
6
Cautious treatment
It aids calcium absorption and boosts immunity. However, I must be cautious with ulcers and my chronic conditions to prevent complications.
9
Vitamin D3 protects against ulcers
We explored the effects of Vitamin D3 in protecting the stomach from injuries caused by aspirin, a common pain relief medication known to trigger gastric ulcers. In a controlled study using 24 rats, we divided them into four groups: a control group, a group receiving Vitamin D3 without injury, a group suffering from aspirin-induced injury, and a group treated with Vitamin D3 after such injury.
Our findings were quite promising. We observed that Vitamin D3 supplementation led to significant improvements in the overall health of the gastric tissue. Notably, it enhanced the expression of vital proteins such as E-Cadherin and gastrokine 1 (GKN1), both critical for maintaining stomach lining integrity. Moreover, it reduced markers of inflammation and oxidative stress, suggesting a protective mechanism against ulcer formation.
The study points to Vitamin D3 as a potential ally in mitigating the damaging effects of aspirin on the gastric mucosa. By highlighting its ability to bolster the stomach's defenses, we bring attention to how simple dietary supplementation could serve as an effective strategy for those at risk of gastric ulcers.
Our findings were quite promising. We observed that Vitamin D3 supplementation led to significant improvements in the overall health of the gastric tissue. Notably, it enhanced the expression of vital proteins such as E-Cadherin and gastrokine 1 (GKN1), both critical for maintaining stomach lining integrity. Moreover, it reduced markers of inflammation and oxidative stress, suggesting a protective mechanism against ulcer formation.
The study points to Vitamin D3 as a potential ally in mitigating the damaging effects of aspirin on the gastric mucosa. By highlighting its ability to bolster the stomach's defenses, we bring attention to how simple dietary supplementation could serve as an effective strategy for those at risk of gastric ulcers.
8
We aimed to explore the relationship between vitamin D and ulcerative colitis (UC), especially how washed microbiota transplantation (WMT) might affect vitamin D levels. Our study involved 121 UC patients and 53 healthy individuals for initial serum vitamin D level assessments.
Following this, we conducted a non-randomized control trial where we compared the effects of WMT on 28 UC patients against conventional treatment with 5-aminosalicylic acid (5-ASA) in 10 patients. Over three months, we observed that the WMT group significantly saw increases in serum vitamin D levels and vitamin D receptor (VDR) expression, while the conventional treatment group showed no such improvements.
Notably, our findings linked the increase in vitamin D levels post-WMT to specific changes in gut microbiota, particularly a rise in beneficial bacteria such as Adlercreutzia equolifaciens and Ruminococcus obeum. This suggests that vitamin D levels and UC activity may be influenced by the gut microbiome, highlighting an intriguing area for future research.
However, it is important to clarify that while we found an interesting association, the study did not directly isolate the effects of vitamin D treatment alone on ulcers, which limits the scope of our conclusions regarding vitamin D as a standalone treatment for UC.
Following this, we conducted a non-randomized control trial where we compared the effects of WMT on 28 UC patients against conventional treatment with 5-aminosalicylic acid (5-ASA) in 10 patients. Over three months, we observed that the WMT group significantly saw increases in serum vitamin D levels and vitamin D receptor (VDR) expression, while the conventional treatment group showed no such improvements.
Notably, our findings linked the increase in vitamin D levels post-WMT to specific changes in gut microbiota, particularly a rise in beneficial bacteria such as Adlercreutzia equolifaciens and Ruminococcus obeum. This suggests that vitamin D levels and UC activity may be influenced by the gut microbiome, highlighting an intriguing area for future research.
However, it is important to clarify that while we found an interesting association, the study did not directly isolate the effects of vitamin D treatment alone on ulcers, which limits the scope of our conclusions regarding vitamin D as a standalone treatment for UC.
8
We explored the connection between vitamin D levels and ulcerative colitis, a disease that impacts the gastrointestinal tract. Through a cross-sectional analysis, we compared newly diagnosed patients with healthy individuals, focusing on how vitamin D might influence disease severity and overall quality of life.
Our findings revealed that vitamin D levels were lower in ulcerative colitis patients compared to healthy controls. Moreover, those with vitamin D deficiency had significantly higher disease activity scores, indicating more severe symptoms. Additionally, the quality of life was notably poorer for individuals with low vitamin D levels.
This suggests that vitamin D may play an important role in managing ulcerative colitis symptoms. We observed that higher vitamin D levels were linked to reduced disease activity and improved health-related quality of life. Therefore, it seems that vitamin D could be beneficial for those navigating the challenges of ulcerative colitis.
Our findings revealed that vitamin D levels were lower in ulcerative colitis patients compared to healthy controls. Moreover, those with vitamin D deficiency had significantly higher disease activity scores, indicating more severe symptoms. Additionally, the quality of life was notably poorer for individuals with low vitamin D levels.
This suggests that vitamin D may play an important role in managing ulcerative colitis symptoms. We observed that higher vitamin D levels were linked to reduced disease activity and improved health-related quality of life. Therefore, it seems that vitamin D could be beneficial for those navigating the challenges of ulcerative colitis.
References
- El-Sayed SF, Mahmoud SM, Samy W, Wahid RM, Talaat A, et al. Vitamin D3 mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-κB/MMP-9 signaling pathway. Tissue Cell. 2025;93:102724. 10.1016/j.tice.2025.102724
- Nemet V, Matić S, Zielsdorf SJ, Tolj I, Jelić Vuković M, et al. Calcifediol and paricalcitol as adjunctive therapies for HSV-1 keratitis and corneal perforation: A case report. Medicine (Baltimore). 2024;103:e40654. 10.1097/MD.0000000000040654
- Liu L, Zhang F, Jamali M, Guimarães NS, Radkhah N, et al. The role of vitamin D in diabetic foot ulcer; an umbrella review of meta-analyses. Front Nutr. 2024;11:1454779. 10.3389/fnut.2024.1454779
- Wu X, Zeng J, Ye X, Peng M, Lan Y, et al. Effects of vitamin D supplementation on diabetic foot ulcer healing: a meta-analysis. Postgrad Med J. 2025;101:100. 10.1093/postmj/qgae107
- Zhang H, Xiao Y, Wen Q, Zhang S, Li P, et al. Washed microbiota transplantation improved the level of serum vitamin D in ulcerative colitis. J Gastroenterol Hepatol. 2024;39:2394. 10.1111/jgh.16717
- Li Y, Guo Y, Geng C, Song S, Yang W, et al. Vitamin D/vitamin D receptor protects intestinal barrier against colitis by positively regulating Notch pathway. Front Pharmacol. 2024;15:1421577. 10.3389/fphar.2024.1421577
- Hu Y, Wang Y, Chen Y, Li C, Long Y, et al. Co-administration of 1,25-dihydroxyvitamin D3 and infliximab improves colitis in mice by modulating Treg differentiation. Iran J Basic Med Sci. 2024;27:1172. 10.22038/IJBMS.2024.74640.16209
- Shalaby R, Nawawy ME, Selim K, Bahaa S, Refai SE, et al. The role of vitamin D in amelioration of oral lichen planus and its effect on salivary and tissue IFN-γ level: a randomized clinical trial. BMC Oral Health. 2024;24:813. 10.1186/s12903-024-04239-0
- Wang L, Wei Z, Lv L, Xue C. An efficient co-delivery system based on multilayer structural nanoparticles for programmed sequential release of resveratrol and vitamin D3 to combat dextran sodium sulfate-induced colitis in mice. Int J Biol Macromol. 2024;254:127962. 10.1016/j.ijbiomac.2023.127962
- Siregar FD, Hidayat W. The Role of Vitamin D on the Wound Healing Process: A Case Series. Int Med Case Rep J. 2023;16:227. 10.2147/IMCRJ.S402005
- Gao H, Zhou H, Zhang Z, Gao J, Li J, et al. Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway. Front Immunol. 2023;14:1135930. 10.3389/fimmu.2023.1135930
- Zhu C, Fan M, Zhu J, Cao L, Duan X, et al. Vitamin D Reduces the Helper T Cells 17 (Th17) Differentiation in Patients with Ulcerative Colitis by Targeting Long Non-coding RNA (lncRNA) OIP5-AS1/miR-26a-5p/IL-6 Axis. Iran J Immunol. 2022;19:150. 10.22034/iji.2022.90562.2014
- Ma GL, Cao SG, Xia SL, Zhu HQ, Jiang Y. [A preliminary study on the improved efficacy of mesalazine combined with vitamin D in ulcerative colitis]. Zhonghua Nei Ke Za Zhi. 2022;61:785. 10.3760/cma.j.cn112138-20210903-00613
- MacLeod BG, Klarich CS, Wessman LL, Gaddis KJ, Konstantinov NK, et al. Fluorescent Imaging as a Component of Diagnosing Pyoderma Gangrenosum: A Case Report. Adv Skin Wound Care. 2022;35:1. 10.1097/01.ASW.0000820248.26138.bc
- Lu Y, Chen J, He X, Xu S, Chen YE, et al. Combined Administration of Vitamin D and Geniposide Is Less Effective than Single Use of Vitamin D or Geniposide in the Treatment of Ulcerative Colitis. Front Pharmacol. 2021;12:714065. 10.3389/fphar.2021.714065
- Dash KR, Panda C, Das HS, Mishra D, Behera SK, et al. Association of Vitamin D Level With Disease Severity and Quality of Life in Newly Diagnosed Patients of Ulcerative Colitis: A Cross-Sectional Analysis. Cureus. 2021;13:e16481. 10.7759/cureus.16481
- Halschou-Jensen PM, Sauer J, Bouchelouche P, Fabrin J, Brorson S, et al. Improved Healing of Diabetic Foot Ulcers After High-dose Vitamin D: A Randomized Double-blinded Clinical Trial. Int J Low Extrem Wounds. 2023;22:466. 10.1177/15347346211020268
- Qiu F, Zhang Z, Yang L, Li R, Ma Y. Combined effect of vitamin C and vitamin D on intestinal epithelial barrier by regulating Notch signaling pathway. Nutr Metab (Lond). 2021;18:49. 10.1186/s12986-021-00576-x
- Osikov MV, Simonyan EV, Boyko MS, Ogneva OI, Ilyinykh MA, et al. Effect of Vitamin D3 in Composition of Original Rectal Suppositories on Parameter of Protein Oxidative Modification in Large Intestine in Experimental Ulcerative Colitis. Bull Exp Biol Med. 2021;170:608. 10.1007/s10517-021-05116-4
- Domazetovic V, Iantomasi T, Bonanomi AG, Stio M. Vitamin D regulates claudin-2 and claudin-4 expression in active ulcerative colitis by p-Stat-6 and Smad-7 signaling. Int J Colorectal Dis. 2020;35:1231. 10.1007/s00384-020-03576-0
- Cao R, Ma Y, Li S, Shen D, Yang S, et al. 1,25(OH) D alleviates DSS-induced ulcerative colitis via inhibiting NLRP3 inflammasome activation. J Leukoc Biol. 2020;108:283. 10.1002/JLB.3MA0320-406RR
