' 
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8.3
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
50 mcg (2,000 IU)
250%
Top Medical Research Studies
9
Vitamin D3 improves ulcer healing
Improved Healing of Diabetic Foot Ulcers After High-dose Vitamin D: A Randomized Double-blinded Clinical Trial.
Study focuses on vitamin D3 impact
We set out to explore how different doses of vitamin D3, specifically Cholecalciferol, impact the healing of chronic diabetic foot ulcers. Our study included patients with diabetes who had one or more foot ulcers present for longer than six weeks. We assigned participants at random to receive either a high dose of 170 micrograms or a low dose of 20 micrograms daily. Throughout the experiment, both patients and assessors were kept unaware of who was receiving which treatment to ensure unbiased results.
Over our 48-week follow-up period, we observed that the high-dose vitamin D3 treatment yielded significantly better healing outcomes. Among the patients receiving the high dose, 70% of their ulcers healed, while only 35% of those on the low dose showed healing. The median ulcer reduction in the high-dose group was impressive, showing complete healing in many cases, while those on the low dose saw a more modest reduction.
In conclusion, our findings suggest that high-dose vitamin D3 can play a crucial role in promoting the healing of chronic diabetic foot ulcers. By effectively boosting healing rates, this treatment could provide an important avenue for improving health outcomes in patients suffering from these persistent wounds.
Over our 48-week follow-up period, we observed that the high-dose vitamin D3 treatment yielded significantly better healing outcomes. Among the patients receiving the high dose, 70% of their ulcers healed, while only 35% of those on the low dose showed healing. The median ulcer reduction in the high-dose group was impressive, showing complete healing in many cases, while those on the low dose saw a more modest reduction.
In conclusion, our findings suggest that high-dose vitamin D3 can play a crucial role in promoting the healing of chronic diabetic foot ulcers. By effectively boosting healing rates, this treatment could provide an important avenue for improving health outcomes in patients suffering from these persistent wounds.
Read More
9
Vitamin D3 protects against ulcers
Vitamin D3 mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-κB/MMP-9 signaling pathway.
High relevance to ulcer treatment
We explored the effects of Vitamin D3 in protecting the stomach from injuries caused by aspirin, a common pain relief medication known to trigger gastric ulcers. In a controlled study using 24 rats, we divided them into four groups: a control group, a group receiving Vitamin D3 without injury, a group suffering from aspirin-induced injury, and a group treated with Vitamin D3 after such injury.
Our findings were quite promising. We observed that Vitamin D3 supplementation led to significant improvements in the overall health of the gastric tissue. Notably, it enhanced the expression of vital proteins such as E-Cadherin and gastrokine 1 (GKN1), both critical for maintaining stomach lining integrity. Moreover, it reduced markers of inflammation and oxidative stress, suggesting a protective mechanism against ulcer formation.
The study points to Vitamin D3 as a potential ally in mitigating the damaging effects of aspirin on the gastric mucosa. By highlighting its ability to bolster the stomach's defenses, we bring attention to how simple dietary supplementation could serve as an effective strategy for those at risk of gastric ulcers.
Our findings were quite promising. We observed that Vitamin D3 supplementation led to significant improvements in the overall health of the gastric tissue. Notably, it enhanced the expression of vital proteins such as E-Cadherin and gastrokine 1 (GKN1), both critical for maintaining stomach lining integrity. Moreover, it reduced markers of inflammation and oxidative stress, suggesting a protective mechanism against ulcer formation.
The study points to Vitamin D3 as a potential ally in mitigating the damaging effects of aspirin on the gastric mucosa. By highlighting its ability to bolster the stomach's defenses, we bring attention to how simple dietary supplementation could serve as an effective strategy for those at risk of gastric ulcers.
Read More
9
Vitamin D aids diabetic ulcer healing
Effects of vitamin D supplementation on diabetic foot ulcer healing: a meta-analysis.
Strong relevance to diabetic treatment
We examined the effects of vitamin D supplementation on healing diabetic foot ulcers (DFUs). By reviewing a series of controlled trials, we aimed to understand how vitamin D might facilitate the healing process for individuals suffering from these painful sores that often arise in diabetes.
Our findings suggest that vitamin D can significantly aid the healing of DFUs. Specifically, it appears to lower blood sugar levels while also reducing inflammation and oxidative stress, which are known to impede healing. Such outcomes provide a positive outlook for using vitamin D as part of the treatment strategy for DFUs.
With diabetes being a major health challenge and DFUs contributing to severe complications, our research offers valuable insights. By demonstrating how vitamin D supplementation can improve healing, we hope to support medical professionals in enhancing patient care practices.
Overall, this evidence potentially shifts how we approach the treatment of diabetic foot ulcers, making a case for incorporating vitamin D into therapeutic protocols to promote faster recovery.
Our findings suggest that vitamin D can significantly aid the healing of DFUs. Specifically, it appears to lower blood sugar levels while also reducing inflammation and oxidative stress, which are known to impede healing. Such outcomes provide a positive outlook for using vitamin D as part of the treatment strategy for DFUs.
With diabetes being a major health challenge and DFUs contributing to severe complications, our research offers valuable insights. By demonstrating how vitamin D supplementation can improve healing, we hope to support medical professionals in enhancing patient care practices.
Overall, this evidence potentially shifts how we approach the treatment of diabetic foot ulcers, making a case for incorporating vitamin D into therapeutic protocols to promote faster recovery.
Read More
Most Useful Reviews
9.5
Stronger immunity
I regularly take vitamin D3, which is vital for my immune system and overall health. After taking 2000 units daily, I haven't faced respiratory issues in over a year, and my ulcer problems have improved significantly.
Read More
9.5
Leg ulcer relief
During the pandemic, I find vitamin D essential. After completing a course of 2000 units, my leg ulcers disappeared, showing its effectiveness.
Read More
9.5
Ulcer improvement
I take one for the winter to combat mini-ulcers caused by vitamin D deficiency. After taking these pills, everything improves.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8.3
- All Researches
9
Vitamin D3 protects against ulcers
Vitamin D3 mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-κB/MMP-9 signaling pathway.
High relevance to ulcer treatment
We explored the effects of Vitamin D3 in protecting the stomach from injuries caused by aspirin, a common pain relief medication known to trigger gastric ulcers. In a controlled study using 24 rats, we divided them into four groups: a control group, a group receiving Vitamin D3 without injury, a group suffering from aspirin-induced injury, and a group treated with Vitamin D3 after such injury.
Our findings were quite promising. We observed that Vitamin D3 supplementation led to significant improvements in the overall health of the gastric tissue. Notably, it enhanced the expression of vital proteins such as E-Cadherin and gastrokine 1 (GKN1), both critical for maintaining stomach lining integrity. Moreover, it reduced markers of inflammation and oxidative stress, suggesting a protective mechanism against ulcer formation.
The study points to Vitamin D3 as a potential ally in mitigating the damaging effects of aspirin on the gastric mucosa. By highlighting its ability to bolster the stomach's defenses, we bring attention to how simple dietary supplementation could serve as an effective strategy for those at risk of gastric ulcers.
Our findings were quite promising. We observed that Vitamin D3 supplementation led to significant improvements in the overall health of the gastric tissue. Notably, it enhanced the expression of vital proteins such as E-Cadherin and gastrokine 1 (GKN1), both critical for maintaining stomach lining integrity. Moreover, it reduced markers of inflammation and oxidative stress, suggesting a protective mechanism against ulcer formation.
The study points to Vitamin D3 as a potential ally in mitigating the damaging effects of aspirin on the gastric mucosa. By highlighting its ability to bolster the stomach's defenses, we bring attention to how simple dietary supplementation could serve as an effective strategy for those at risk of gastric ulcers.
Read More
9
Vitamin D aids corneal healing
Calcifediol and paricalcitol as adjunctive therapies for HSV-1 keratitis and corneal perforation: A case report.
Moderately relevant findings reported
We investigated the potential benefits of using vitamin D receptor ligands, specifically calcifediol and paricalcitol, as additional treatments for corneal perforations caused by herpes simplex keratitis. Our focus was on how these therapies could help in healing ulcers and preventing future HSV recurrences.
The case involved a 57-year-old woman with a history of recurring eye issues who experienced a burning sensation and pain in her right eye, leading to a diagnosis of HSV keratitis. Despite receiving standard treatments, she developed a perforated corneal ulcer. Following surgical intervention, including a specialized graft, we initiated oral vitamin D therapies to support healing and boost her immune response.
Remarkably, after starting these vitamin D treatments, we observed significant improvement. The patient's cornea began to thicken and heal nicely, without any signs of HSV recurrence during the treatment period. This outcome suggested that incorporating vitamin D could play a helpful role in managing such infections and promoting better recovery.
Our findings indicate that using vitamin D receptor ligands as adjunctive therapies might offer a promising avenue for treating severe corneal conditions and enhancing overall healing, reducing the need for more invasive procedures in the future.
The case involved a 57-year-old woman with a history of recurring eye issues who experienced a burning sensation and pain in her right eye, leading to a diagnosis of HSV keratitis. Despite receiving standard treatments, she developed a perforated corneal ulcer. Following surgical intervention, including a specialized graft, we initiated oral vitamin D therapies to support healing and boost her immune response.
Remarkably, after starting these vitamin D treatments, we observed significant improvement. The patient's cornea began to thicken and heal nicely, without any signs of HSV recurrence during the treatment period. This outcome suggested that incorporating vitamin D could play a helpful role in managing such infections and promoting better recovery.
Our findings indicate that using vitamin D receptor ligands as adjunctive therapies might offer a promising avenue for treating severe corneal conditions and enhancing overall healing, reducing the need for more invasive procedures in the future.
Read More
9
Vitamin D aids diabetic ulcer healing
Effects of vitamin D supplementation on diabetic foot ulcer healing: a meta-analysis.
Strong relevance to diabetic treatment
We examined the effects of vitamin D supplementation on healing diabetic foot ulcers (DFUs). By reviewing a series of controlled trials, we aimed to understand how vitamin D might facilitate the healing process for individuals suffering from these painful sores that often arise in diabetes.
Our findings suggest that vitamin D can significantly aid the healing of DFUs. Specifically, it appears to lower blood sugar levels while also reducing inflammation and oxidative stress, which are known to impede healing. Such outcomes provide a positive outlook for using vitamin D as part of the treatment strategy for DFUs.
With diabetes being a major health challenge and DFUs contributing to severe complications, our research offers valuable insights. By demonstrating how vitamin D supplementation can improve healing, we hope to support medical professionals in enhancing patient care practices.
Overall, this evidence potentially shifts how we approach the treatment of diabetic foot ulcers, making a case for incorporating vitamin D into therapeutic protocols to promote faster recovery.
Our findings suggest that vitamin D can significantly aid the healing of DFUs. Specifically, it appears to lower blood sugar levels while also reducing inflammation and oxidative stress, which are known to impede healing. Such outcomes provide a positive outlook for using vitamin D as part of the treatment strategy for DFUs.
With diabetes being a major health challenge and DFUs contributing to severe complications, our research offers valuable insights. By demonstrating how vitamin D supplementation can improve healing, we hope to support medical professionals in enhancing patient care practices.
Overall, this evidence potentially shifts how we approach the treatment of diabetic foot ulcers, making a case for incorporating vitamin D into therapeutic protocols to promote faster recovery.
Read More
9
Vitamin D aids colitis treatment
Co-administration of 1,25-dihydroxyvitamin D3 and infliximab improves colitis in mice by modulating Treg differentiation.
Highlights synergistic treatment benefits
We explored the impact of vitamin D, specifically 1,25-dihydroxyvitamin D3 (VitD3), when used alongside infliximab (IFX) in a mouse model of ulcerative colitis (UC). Our research aimed to uncover whether this combination could be more effective than using IFX alone.
To do this, we induced colitis in mice and then assessed their symptoms and conducted histopathological evaluations to determine the therapeutic effects of this combination therapy. The results revealed that when given together, VitD3 and IFX significantly reduced the severity of colitis, showcasing improvements in clinical signs and suppression of inflammation.
Additionally, we looked at how this combination affected regulatory T cells (Tregs), which play a crucial role in immune response. We observed that the combined therapy encouraged more effective Treg differentiation, leading to higher levels of anti-inflammatory markers in the system. Particularly in ulcerative colitis patients, we found that higher levels of serum vitamin D correlated positively with Treg levels, suggesting a beneficial relationship.
Thus, our study suggests that VitD3, in combination with IFX, offers a promising approach for managing ulcerative colitis, especially for patients who may have difficulty tolerating standard treatments.
To do this, we induced colitis in mice and then assessed their symptoms and conducted histopathological evaluations to determine the therapeutic effects of this combination therapy. The results revealed that when given together, VitD3 and IFX significantly reduced the severity of colitis, showcasing improvements in clinical signs and suppression of inflammation.
Additionally, we looked at how this combination affected regulatory T cells (Tregs), which play a crucial role in immune response. We observed that the combined therapy encouraged more effective Treg differentiation, leading to higher levels of anti-inflammatory markers in the system. Particularly in ulcerative colitis patients, we found that higher levels of serum vitamin D correlated positively with Treg levels, suggesting a beneficial relationship.
Thus, our study suggests that VitD3, in combination with IFX, offers a promising approach for managing ulcerative colitis, especially for patients who may have difficulty tolerating standard treatments.
Read More
9
Vitamin D3 mitigates gastric injury
Vitamin D3 mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-κB/MMP-9 signaling pathway.
Focused study on aspirin ulcers
We explored the effects of Vitamin D3 on stomach ulcers caused by aspirin, focusing specifically on how it influences certain molecules in the stomach lining. In our study, we divided 24 rats into four groups: a control group, a group receiving Vitamin D3 without any gastric injury, a group with aspirin-induced gastric injuries, and a group treated with Vitamin D3 after such injuries occurred.
Our findings were quite promising. Vitamin D3 seemed to play a protective role against the damage caused by aspirin. It significantly increased levels of important protective molecules like E-Cadherin, GKN1 (a type of gastrokine), and mucin 5AC. These molecules are essential for maintaining the integrity of the stomach lining, helping to mitigate the effects of oxidative stress and inflammation often seen in gastric injuries.
Furthermore, Vitamin D3 treatment helped improve both the structure and function of gastric tissue. By reducing inflammation pathways, particularly those involving NLRP3 and NF-κB, Vitamin D3 demonstrated its potential as a protective agent in the context of aspirin-induced gastric injury.
Our findings were quite promising. Vitamin D3 seemed to play a protective role against the damage caused by aspirin. It significantly increased levels of important protective molecules like E-Cadherin, GKN1 (a type of gastrokine), and mucin 5AC. These molecules are essential for maintaining the integrity of the stomach lining, helping to mitigate the effects of oxidative stress and inflammation often seen in gastric injuries.
Furthermore, Vitamin D3 treatment helped improve both the structure and function of gastric tissue. By reducing inflammation pathways, particularly those involving NLRP3 and NF-κB, Vitamin D3 demonstrated its potential as a protective agent in the context of aspirin-induced gastric injury.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Stronger immunity
I regularly take vitamin D3, which is vital for my immune system and overall health. After taking 2000 units daily, I haven't faced respiratory issues in over a year, and my ulcer problems have improved significantly.
9.5
Leg ulcer relief
During the pandemic, I find vitamin D essential. After completing a course of 2000 units, my leg ulcers disappeared, showing its effectiveness.
9.5
Ulcer improvement
I take one for the winter to combat mini-ulcers caused by vitamin D deficiency. After taking these pills, everything improves.
8.8
Ulcer healing
Drinking this makes me feel great. My ulcers heal much faster, and I find it beneficial to take it every three days.
6.8
Cautious treatment
It aids calcium absorption and boosts immunity. However, I must be cautious with ulcers and my chronic conditions to prevent complications.
