Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
1 g (1,000 mg)
1111%
Rose Hips Powder (Rosa canina) (fruit)
25 mg
†
Top Medical Research Studies
9
Vitamin C improves heart perfusion
We explored the impact of vitamin C on heart blood flow in patients undergoing a procedure called percutaneous coronary intervention (PCI) for stable angina. In our study, we enrolled 56 participants and divided them into two groups: one received a vitamin C infusion and the other a placebo.
Our findings were quite promising. Before the procedure, a significant percentage of patients in both groups had impaired heart blood flow. However, after the intervention, those who received vitamin C showed a notable improvement in microcirculatory perfusion, meaning their heart's small blood vessels were working better.
Specifically, only 4% of the vitamin C group had poor blood flow post-procedure, compared to 32% in the placebo group. Furthermore, most patients treated with vitamin C achieved complete micro-circulatory reperfusion. Additionally, we observed that oxidative stress markers in the vitamin C group significantly decreased, indicating reduced damage to the heart.
This suggests that vitamin C infusion could play a critical role in enhancing heart health by mitigating oxidative stress during such procedures.
Our findings were quite promising. Before the procedure, a significant percentage of patients in both groups had impaired heart blood flow. However, after the intervention, those who received vitamin C showed a notable improvement in microcirculatory perfusion, meaning their heart's small blood vessels were working better.
Specifically, only 4% of the vitamin C group had poor blood flow post-procedure, compared to 32% in the placebo group. Furthermore, most patients treated with vitamin C achieved complete micro-circulatory reperfusion. Additionally, we observed that oxidative stress markers in the vitamin C group significantly decreased, indicating reduced damage to the heart.
This suggests that vitamin C infusion could play a critical role in enhancing heart health by mitigating oxidative stress during such procedures.
Read More
9
Our study looked into how vitamin C might help improve the health of blood vessels and insulin sensitivity in patients struggling with coronary spastic angina (CSA). We worked with 22 patients diagnosed with CSA and 20 control subjects, measuring how well their arteries could expand in response to blood flow—a process known as flow-mediated dilation.
We found that patients with CSA often had impaired glucose tolerance, meaning their bodies struggled to manage blood sugar levels effectively. When we administered vitamin C, we observed significant improvements in the CSA group; their blood vessels expanded more easily, and their blood sugar levels decreased. Specifically, the flow-mediated dilation rose and blood sugar levels showed a favorable drop after treatment.
Interestingly, these effects were not seen in the control group, indicating that vitamin C has unique beneficial effects for those with CSA. Importantly, we noted that the levels of insulin in the blood did not change after vitamin C infusion for either group, focusing our findings on its effects on blood vessel function and glucose management rather than insulin levels.
We found that patients with CSA often had impaired glucose tolerance, meaning their bodies struggled to manage blood sugar levels effectively. When we administered vitamin C, we observed significant improvements in the CSA group; their blood vessels expanded more easily, and their blood sugar levels decreased. Specifically, the flow-mediated dilation rose and blood sugar levels showed a favorable drop after treatment.
Interestingly, these effects were not seen in the control group, indicating that vitamin C has unique beneficial effects for those with CSA. Importantly, we noted that the levels of insulin in the blood did not change after vitamin C infusion for either group, focusing our findings on its effects on blood vessel function and glucose management rather than insulin levels.
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8
We explored how vitamin C, known for its antioxidant properties, impacts abnormal blood vessel reactions in patients suffering from coronary spastic angina. In a well-structured study, responses of the left coronary arteries were measured in 32 patients before and during the infusion of vitamin C and compared to 34 control subjects who received saline.
Our results revealed that vitamin C significantly reduced the constriction of the arteries in patients experiencing spastic angina when given acetylcholine, a substance that normally causes blood vessels to widen. In contrast, the control group didn’t show any significant change in their artery reactions from vitamin C. This suggests that oxygen free radicals, which cause blood vessel dysfunction, could be a contributing factor to the abnormal coronary reactions observed in spasm patients.
Overall, this study indicates that vitamin C can play a beneficial role in improving blood flow in the coronary arteries of those with spastic angina, offering hope for managing this condition.
Our results revealed that vitamin C significantly reduced the constriction of the arteries in patients experiencing spastic angina when given acetylcholine, a substance that normally causes blood vessels to widen. In contrast, the control group didn’t show any significant change in their artery reactions from vitamin C. This suggests that oxygen free radicals, which cause blood vessel dysfunction, could be a contributing factor to the abnormal coronary reactions observed in spasm patients.
Overall, this study indicates that vitamin C can play a beneficial role in improving blood flow in the coronary arteries of those with spastic angina, offering hope for managing this condition.
Read More
Most Useful Reviews
9
No angina experienced
1 people found this helpful
Excellent, I can take 2 together! The quality and price of this product are very good. I have been taking 2000 mg daily for 2.5 years, and I haven't had angina, nor Covid, nor a cold or flu. This is an excellent way to boost your immune system almost naturally with non-GMO ingredients. The pill size is fairly large, but you can easily open it and mix the powder with water.
Read More
7.5
Disease recedes quickly
This is a good supplement with a solid dosage and a reasonable price-quality ratio. It has helped me significantly during the initial stage of SARS and angina. I take 4-5 tablets a day, and the disease recedes.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 13 Researches
8.1
- All Researches
9
Vitamin C improves heart perfusion
We explored the impact of vitamin C on heart blood flow in patients undergoing a procedure called percutaneous coronary intervention (PCI) for stable angina. In our study, we enrolled 56 participants and divided them into two groups: one received a vitamin C infusion and the other a placebo.
Our findings were quite promising. Before the procedure, a significant percentage of patients in both groups had impaired heart blood flow. However, after the intervention, those who received vitamin C showed a notable improvement in microcirculatory perfusion, meaning their heart's small blood vessels were working better.
Specifically, only 4% of the vitamin C group had poor blood flow post-procedure, compared to 32% in the placebo group. Furthermore, most patients treated with vitamin C achieved complete micro-circulatory reperfusion. Additionally, we observed that oxidative stress markers in the vitamin C group significantly decreased, indicating reduced damage to the heart.
This suggests that vitamin C infusion could play a critical role in enhancing heart health by mitigating oxidative stress during such procedures.
Our findings were quite promising. Before the procedure, a significant percentage of patients in both groups had impaired heart blood flow. However, after the intervention, those who received vitamin C showed a notable improvement in microcirculatory perfusion, meaning their heart's small blood vessels were working better.
Specifically, only 4% of the vitamin C group had poor blood flow post-procedure, compared to 32% in the placebo group. Furthermore, most patients treated with vitamin C achieved complete micro-circulatory reperfusion. Additionally, we observed that oxidative stress markers in the vitamin C group significantly decreased, indicating reduced damage to the heart.
This suggests that vitamin C infusion could play a critical role in enhancing heart health by mitigating oxidative stress during such procedures.
Read More
9
We assessed how vitamin C influences coronary vasodilation in patients suffering from stable angina, a type of chest pain associated with reduced blood flow to the heart. In our study, we included 28 patients with coronary artery disease. They underwent a series of tests where they received intravenous infusions of vitamin C or normal saline in conjunction with L-arginine, a compound that helps expand blood vessels.
We observed that the infusion of L-arginine led to significant expansion of coronary arteries, with an increase in diameter by 4.87% in proximal segments and 6.33% in distal segments. Notably, when vitamin C was administered alongside L-arginine, the dilation was even more pronounced—8.68% for proximal segments and 13.07% for distal segments. This suggests that vitamin C enhances the effects of L-arginine.
While vitamin C alone resulted in a slight increase in coronary artery diameter, this change was not statistically significant. This indicates that although vitamin C can enhance the vasodilation effect of L-arginine, its direct impact on coronary artery diameters may not be as strong. Overall, our findings suggest that vitamin C may play a beneficial role in improving nitric oxide availability when used with L-arginine, potentially offering a more effective treatment strategy for patients with angina.
We observed that the infusion of L-arginine led to significant expansion of coronary arteries, with an increase in diameter by 4.87% in proximal segments and 6.33% in distal segments. Notably, when vitamin C was administered alongside L-arginine, the dilation was even more pronounced—8.68% for proximal segments and 13.07% for distal segments. This suggests that vitamin C enhances the effects of L-arginine.
While vitamin C alone resulted in a slight increase in coronary artery diameter, this change was not statistically significant. This indicates that although vitamin C can enhance the vasodilation effect of L-arginine, its direct impact on coronary artery diameters may not be as strong. Overall, our findings suggest that vitamin C may play a beneficial role in improving nitric oxide availability when used with L-arginine, potentially offering a more effective treatment strategy for patients with angina.
Read More
9
Effects of vitamins on angina
We explored the impact of vitamins A and C on patients with different heart conditions, specifically those experiencing stable angina and those with post-infarction cardiosclerosis. Our study focused on 22 patients with stable exercise-induced angina and 28 patients with post-infarction cardiosclerosis who did not have circulation failure.
We observed that in patients with stable angina, the blood levels of vitamin C were higher, suggesting a potential role of this vitamin in managing their condition. Meanwhile, those with post-infarction cardiosclerosis exhibited increased vitamin A in their red blood cells and a rise in vitamin C in their blood plasma.
After successful antianginal therapy, we noted normalization of vitamin C levels in both the blood plasma and red blood cells, while vitamin A levels in red cells also returned to normal. However, it’s important to explain that while vitamin C showed increased levels, we cannot definitively attribute the improvement in angina symptoms solely to vitamin C, as successful antianginal therapy was also involved.
We observed that in patients with stable angina, the blood levels of vitamin C were higher, suggesting a potential role of this vitamin in managing their condition. Meanwhile, those with post-infarction cardiosclerosis exhibited increased vitamin A in their red blood cells and a rise in vitamin C in their blood plasma.
After successful antianginal therapy, we noted normalization of vitamin C levels in both the blood plasma and red blood cells, while vitamin A levels in red cells also returned to normal. However, it’s important to explain that while vitamin C showed increased levels, we cannot definitively attribute the improvement in angina symptoms solely to vitamin C, as successful antianginal therapy was also involved.
Read More
9
We explored how vitamin C, or ascorbic acid, can impact the treatment of angina, particularly in combination with nitroglycerine. Our observations revealed that when vitamin C was given, it significantly boosted the antianginal effects of nitroglycerine, a common medication used to relieve angina symptoms. This interaction helps to prevent heart muscle damage by reducing ischemic reactions during stress tests.
Through our analysis, we found that when we incubated vitamin C with nitric oxide donors and blood from patients already using long-acting nitroglycerine, gas bubbles identified as nitrogen oxide were released. This crucial finding points to the activation of internal nitric oxide donors by vitamin C, suggesting that it could enhance the effectiveness of nitrate therapy for patients suffering from angina.
In conclusion, taking vitamin C alongside traditional antianginal treatments like nitroglycerine appears to offer additional benefits, enhancing both the therapy's effectiveness and possibly improving patients’ quality of life. Our findings support the idea that incorporating vitamin C into angina treatment regimens might be a worthwhile consideration.
Through our analysis, we found that when we incubated vitamin C with nitric oxide donors and blood from patients already using long-acting nitroglycerine, gas bubbles identified as nitrogen oxide were released. This crucial finding points to the activation of internal nitric oxide donors by vitamin C, suggesting that it could enhance the effectiveness of nitrate therapy for patients suffering from angina.
In conclusion, taking vitamin C alongside traditional antianginal treatments like nitroglycerine appears to offer additional benefits, enhancing both the therapy's effectiveness and possibly improving patients’ quality of life. Our findings support the idea that incorporating vitamin C into angina treatment regimens might be a worthwhile consideration.
Read More
9
Our study looked into how vitamin C might help improve the health of blood vessels and insulin sensitivity in patients struggling with coronary spastic angina (CSA). We worked with 22 patients diagnosed with CSA and 20 control subjects, measuring how well their arteries could expand in response to blood flow—a process known as flow-mediated dilation.
We found that patients with CSA often had impaired glucose tolerance, meaning their bodies struggled to manage blood sugar levels effectively. When we administered vitamin C, we observed significant improvements in the CSA group; their blood vessels expanded more easily, and their blood sugar levels decreased. Specifically, the flow-mediated dilation rose and blood sugar levels showed a favorable drop after treatment.
Interestingly, these effects were not seen in the control group, indicating that vitamin C has unique beneficial effects for those with CSA. Importantly, we noted that the levels of insulin in the blood did not change after vitamin C infusion for either group, focusing our findings on its effects on blood vessel function and glucose management rather than insulin levels.
We found that patients with CSA often had impaired glucose tolerance, meaning their bodies struggled to manage blood sugar levels effectively. When we administered vitamin C, we observed significant improvements in the CSA group; their blood vessels expanded more easily, and their blood sugar levels decreased. Specifically, the flow-mediated dilation rose and blood sugar levels showed a favorable drop after treatment.
Interestingly, these effects were not seen in the control group, indicating that vitamin C has unique beneficial effects for those with CSA. Importantly, we noted that the levels of insulin in the blood did not change after vitamin C infusion for either group, focusing our findings on its effects on blood vessel function and glucose management rather than insulin levels.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
No angina experienced
1 people found this helpful
Excellent, I can take 2 together! The quality and price of this product are very good. I have been taking 2000 mg daily for 2.5 years, and I haven't had angina, nor Covid, nor a cold or flu. This is an excellent way to boost your immune system almost naturally with non-GMO ingredients. The pill size is fairly large, but you can easily open it and mix the powder with water.
Read More
7.5
Disease recedes quickly
This is a good supplement with a solid dosage and a reasonable price-quality ratio. It has helped me significantly during the initial stage of SARS and angina. I take 4-5 tablets a day, and the disease recedes.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Das D, Sen S, Bhakta S, Sen K. Preclusion of methemoglobinemia caused by nitrate drugs in diabetics and nondiabetics: Possible role of Vitamin C. Blood Cells Mol Dis. 2022;94:102643. doi:10.1016/j.bcmd.2021.102643
- Axton ER, Cristobal E, Choi J, Miranda CL, Stevens JF. Metabolomics-Driven Elucidation of Cellular Nitrate Tolerance Reveals Ascorbic Acid Prevents Nitroglycerin-Induced Inactivation of Xanthine Oxidase. Front Pharmacol. 2018;9:1085. doi:10.3389/fphar.2018.01085
- Basili S, Tanzilli G, Mangieri E, Raparelli V, Di Santo S, et al. Intravenous ascorbic acid infusion improves myocardial perfusion grade during elective percutaneous coronary intervention: relationship with oxidative stress markers. JACC Cardiovasc Interv. 2010;3:221. doi:10.1016/j.jcin.2009.10.025
- Tousoulis D, Xenakis C, Tentolouris C, Davies G, Antoniades C, et al. Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina. Heart. 2005;91:1319.
- Aikawa K, Saitoh S, Muto M, Osugi T, Matsumoto K, et al. Effects of antioxidants on coronary microvascular spasm induced by epicardial coronary artery endothelial injury in pigs. Coron Artery Dis. 2004;15:21.
- Boev SS. [Changes in the blood content of some vitamins in patients with ischemic heart disease]. Lik Sprava. 2003.
- Vodoevich VP, Vinogradova TA, Serafimovich IA, Stepuro II, Chaĭkovskaia NA, et al. [Use of ascorbic acid for raising clinical response to long-acting nitrates]. Klin Med (Mosk). 2002;80:55.
- Hamabe A, Takase B, Uehata A, Kurita A, Ohsuzu F, et al. Impaired endothelium-dependent vasodilation in the brachial artery in variant angina pectoris and the effect of intravenous administration of vitamin C. Am J Cardiol. 2001;87:1154.
- Hirashima O, Kawano H, Motoyama T, Hirai N, Ohgushi M, et al. Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina: possible role of reactive oxygen species. J Am Coll Cardiol. 2000;35:1860.
- Simon JA, Hudes ES. Serum ascorbic acid and cardiovascular disease prevalence in U.S. adults: the Third National Health and Nutrition Examination Survey (NHANES III). Ann Epidemiol. 1999;9:358.
- Kugiyama K, Motoyama T, Hirashima O, Ohgushi M, Soejima H, et al. Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina. J Am Coll Cardiol. 1998;32:103.
- Ness AR, Khaw KT, Bingham S, Day NE. Vitamin c status and undiagnosed angina. J Cardiovasc Risk. 1996;3:373.
- Singh RB, Niaz MA, Rastogi SS, Rastogi S. Usefulness of antioxidant vitamins in suspected acute myocardial infarction (the Indian experiment of infarct survival-3). Am J Cardiol. 1996;77:232.
